Pro-inflammatory cytokines serve as communicating molecules between the liver and brain for hepatic encephalopathy pathogenesis and Lycium barbarum polysaccharides protection

• Published in: Journal of Ethnopharmacology Vol. 248; no. NA; p. 112357
• Main Authors: Sun, Xiaoming, Lv, Yi, Huang, Lu, Gao, Hao, Ren, Chaoran, Li, Jingjing, Bie, Man, Li, Wei, Koike, Kazuo, So, Kwok-Fai, Xiao, Jia
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 10.02.2020; Elsevier BV
• Subjects: ammonia; animal models; Animals; apoptosis; Brain; brain damage; Brain injury; Cell Line; Cytokine; Cytokines; dietary supplements; Disease Models, Animal; East Asia; encephalopathy; enzyme activity; Fruit; Hepatic Encephalopathy; histology; Inflammation Mediators; Interleukin-6; LBP; Liver; Locomotion; Lycium; Lycium barbarum; Male; MAPK; mice; Mice, Inbred C57BL; Mice, Knockout; mitogen-activated protein kinase; Mitogen-Activated Protein Kinases; mortality; neuroglia; oral administration; oxidative stress; pathogenesis; phenotype; Plant Extracts; Polysaccharides; protective effect; Signal Transduction; Thioacetamide; traditional foods; traditional medicine; tryptophan; Tumor Necrosis Factor-alpha; East Asia; LBP; MAPK; Brain injury; hepatic encephalopathy; Cytokine

Gogi berry is a traditional food supplement and medical herbal which has been widely used in Eastern Asian countries. Lycium barbarum polysaccharides (LBP) are the major active components of Gogi berry and have been proved to possess a lot of biological activities. We aimed to delineate the protecti...