Improving Prognostic Accuracy in Subjects at Clinical High Risk for Psychosis: Systematic Review of Predictive Models and Meta-analytical Sequential Testing Simulation

• Published in: Schizophrenia bulletin Vol. 43; no. 2; pp. sbw098 - 388
• Main Authors: Schmidt, André, Cappucciati, Marco, Radua, Joaquim, Rutigliano, Grazia, Rocchetti, Matteo, Dell’Osso, Liliana, Politi, Pierluigi, Borgwardt, Stefan, Reilly, Thomas, Valmaggia, Lucia, McGuire, Philip, Fusar-Poli, Paolo
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.03.2017
• Subjects: Humans; Models, Theoretical; Prognosis; Psychotic Disorders - diagnosis; Psychotic Disorders - diagnostic imaging; Psychotic Disorders - physiopathology; Regular; prediction; clinical high-risk; early interventions; prognostic accuracy; psychosis; treatment prognosis

Discriminating subjects at clinical high risk (CHR) for psychosis who will develop psychosis from those who will not is a prerequisite for preventive treatments. However, it is not yet possible to make any personalized prediction of psychosis onset relying only on the initial clinical baseline asses...