Age-related differential sensitivity to MK-801-induced locomotion and stereotypy in C57BL/6 mice
Psychomotor effects elicited by systemic administration of the noncompetitive NMDA ( N-methyl- d-aspartate) receptor antagonist MK-801 (dizocilpine maleate) represent perturbation of glutamatergic pathways, providing an animal model for psychotic symptoms of schizophrenia. Hyperlocomotion and stereo...
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| Published in | European journal of pharmacology Vol. 580; no. 1; pp. 161 - 168 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
02.02.2008
Elsevier |
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| Abstract | Psychomotor effects elicited by systemic administration of the noncompetitive NMDA (
N-methyl-
d-aspartate) receptor antagonist MK-801 (dizocilpine maleate) represent perturbation of glutamatergic pathways, providing an animal model for psychotic symptoms of schizophrenia. Hyperlocomotion and stereotypy are the two main psychomotor behaviors induced by MK-801. This study compared MK-801-induced hyperlocomotion and stereotypy in young (1-month old) and aged mice (12-month old), in order to determine how the aging process may influence these behaviors. The tested MK-801 doses ranged from 0.015 to 1 mg/kg. The data indicated that MK-801 impacted the aged mice more pronouncedly than the young mice, as both hyperlocomotion and stereotypy were increased significantly more in the aged mice relative to the young mice. These results suggest an age-related increase in MK-801 sensitivity in mice. |
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| AbstractList | Psychomotor effects elicited by systemic administration of the noncompetitive NMDA (N-methyl-D-aspartate) receptor antagonist MK-801 (dizocilpine maleate) represent perturbation of glutamatergic pathways, providing an animal model for psychotic symptoms of schizophrenia. Hyperlocomotion and stereotypy are the two main psychomotor behaviors induced by MK-801. This study compared MK-801-induced hyperlocomotion and stereotypy in young (1-month old) and aged mice (12-month old), in order to determine how the aging process may influence these behaviors. The tested MK-801 doses ranged from 0.015 to 1 mg/kg. The data indicated that MK-801 impacted the aged mice more pronouncedly than the young mice, as both hyperlocomotion and stereotypy were increased significantly more in the aged mice relative to the young mice. These results suggest an age-related increase in MK-801 sensitivity in mice. Psychomotor effects elicited by systemic administration of the noncompetitive NMDA ( N-methyl- d-aspartate) receptor antagonist MK-801 (dizocilpine maleate) represent perturbation of glutamatergic pathways, providing an animal model for psychotic symptoms of schizophrenia. Hyperlocomotion and stereotypy are the two main psychomotor behaviors induced by MK-801. This study compared MK-801-induced hyperlocomotion and stereotypy in young (1-month old) and aged mice (12-month old), in order to determine how the aging process may influence these behaviors. The tested MK-801 doses ranged from 0.015 to 1 mg/kg. The data indicated that MK-801 impacted the aged mice more pronouncedly than the young mice, as both hyperlocomotion and stereotypy were increased significantly more in the aged mice relative to the young mice. These results suggest an age-related increase in MK-801 sensitivity in mice. |
| Author | Zou, Hong Jin, Meilei Qi, Chunting Zhang, Ruizhong Zhao, Guoping Yu, Lei |
| AuthorAffiliation | b Department of Genetics and Center of Alcohol Studies, Rutgers University, 607 Allison Road, Piscataway, New Jersey 08854, USA a Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Cao Bao Road, Shanghai 200233, China |
| AuthorAffiliation_xml | – name: a Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Cao Bao Road, Shanghai 200233, China – name: b Department of Genetics and Center of Alcohol Studies, Rutgers University, 607 Allison Road, Piscataway, New Jersey 08854, USA |
| Author_xml | – sequence: 1 givenname: Chunting surname: Qi fullname: Qi, Chunting organization: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Cao Bao Road, Shanghai 200233, China – sequence: 2 givenname: Hong surname: Zou fullname: Zou, Hong organization: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Cao Bao Road, Shanghai 200233, China – sequence: 3 givenname: Ruizhong surname: Zhang fullname: Zhang, Ruizhong organization: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Cao Bao Road, Shanghai 200233, China – sequence: 4 givenname: Guoping surname: Zhao fullname: Zhao, Guoping organization: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Cao Bao Road, Shanghai 200233, China – sequence: 5 givenname: Meilei surname: Jin fullname: Jin, Meilei email: mljin@sibs.ac.cn organization: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 500 Cao Bao Road, Shanghai 200233, China – sequence: 6 givenname: Lei surname: Yu fullname: Yu, Lei email: yu@biology.rutgers.edu organization: Department of Genetics and Center of Alcohol Studies, Rutgers University, 607 Allison Road, Piscataway, New Jersey 08854, USA |
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| Keywords | Differential drug sensitivity Aging Locomotion Noncompetitive NMDA receptor antagonist Dizocilpine maleate Stereotypy Drug Senescence Dizocilpine Rodentia Neuroprotective agent Glutamate receptor Vertebrata Sensitivity Mammalia Mouse Animal Antagonist NMDA receptor Age |
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| Notes | Send proofs to: Lei Yu, Department of Genetics & Center of Alcohol Studies, Rutgers University, 607 Allison Road, Piscataway, New Jersey 08854-8001, USA; Tel.: +1-732-445-0794, fax: +1-732-445-3500, E-mail: yu@biology.rutgers.edu |
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N-methyl-
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| SubjectTerms | Age Factors Aging Aging - physiology Animals Biological and medical sciences Differential drug sensitivity Disease Models, Animal Dizocilpine maleate Dizocilpine Maleate - administration & dosage Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - pharmacology Locomotion Locomotion - drug effects Male Medical sciences Mice Mice, Inbred C57BL Noncompetitive NMDA receptor antagonist Pharmacology. Drug treatments Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Schizophrenia - physiopathology Stereotyped Behavior - drug effects Stereotypy |
| Title | Age-related differential sensitivity to MK-801-induced locomotion and stereotypy in C57BL/6 mice |
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