Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

[Display omitted] •Sepsis infects more than 48.9 million people world-wide, with 19.7 million deaths.•Cytokine storm plays a significant role in sepsis, along with severe COVID-19.•TLR signaling pathways plays a crucial role in generating the cytokine storm.•Endogenous negative regulators of TLR sig...

Full description

Saved in:
Bibliographic Details
Published inInternational immunopharmacology Vol. 89; no. Pt B; p. 107087
Main Author Kumar, V.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.2020
Elsevier BV
Subjects
Animals
Chemokines
Coronaviruses
COVID-19
COVID-19 - immunology
Cytokine Release Syndrome - etiology
Cytokine storm
Cytokines
Damage patterns
Down-regulation
Feedback
Homeostasis
Humans
Immune system
Immunomodulation
Immunosuppressive agents
Inflammation
Inflammatory diseases
Inflammatory response
Innate Immunity
Interferon
Mice
Microorganisms
Negative feedback
PAMPs
Pandemics
Pathogens
Pattern recognition
Pattern recognition receptors
Proteins
Reactive nitrogen species
Reactive oxygen species
Receptors
Regulators
SARS-CoV-2
Sepsis
Sepsis - immunology
Signal transduction
Signal Transduction - physiology
Signaling
State-of-the-art reviews
Storm damage
TLRs
Toll-like receptors
Toll-Like Receptors - physiology
Ubiquitination
PAMPs
Sepsis
Cytokines
Cytokine storm
TLRs
Innate Immunity
Online AccessGet full text
ISSN1567-5769
1878-1705
1878-1705
DOI10.1016/j.intimp.2020.107087

Cover

Abstract [Display omitted] •Sepsis infects more than 48.9 million people world-wide, with 19.7 million deaths.•Cytokine storm plays a significant role in sepsis, along with severe COVID-19.•TLR signaling pathways plays a crucial role in generating the cytokine storm.•Endogenous negative regulators of TLR signaling are crucial to regulate cytokine storm. Cytokine storm generates during various systemic acute infections, including sepsis and current pandemic called COVID-19 (severe) causing devastating inflammatory conditions, which include multi-organ failure or multi-organ dysfunction syndrome (MODS) and death of the patient. Toll-like receptors (TLRs) are one of the major pattern recognition receptors (PRRs) expressed by immune cells as well as non-immune cells, including neurons, which play a crucial role in generating cytokine storm. They recognize microbial-associated molecular patterns (MAMPs, expressed by pathogens) and damage or death-associate molecular patterns (DAMPs; released and/expressed by damaged/killed host cells). Upon recognition of MAMPs and DAMPs, TLRs activate downstream signaling pathways releasing several pro-inflammatory mediators [cytokines, chemokines, interferons, and reactive oxygen and nitrogen species (ROS or RNS)], which cause acute inflammation meant to control the pathogen and repair the damage. Induction of an exaggerated response due to genetic makeup of the host and/or persistence of the pathogen due to its evasion mechanisms may lead to severe systemic inflammatory condition called sepsis in response to the generation of cytokine storm and organ dysfunction. The activation of TLR-induced inflammatory response is hardwired to the induction of several negative feedback mechanisms that come into play to conclude the response and maintain immune homeostasis. This state-of-the-art review describes the importance of TLR signaling in the onset of the sepsis-associated cytokine storm and discusses various host-derived endogenous negative regulators of TLR signaling pathways. The subject is very important as there is a vast array of genes and processes implicated in these negative feedback mechanisms. These molecules and mechanisms can be targeted for developing novel therapeutic drugs for cytokine storm-associated diseases, including sepsis, severe COVID-19, and other inflammatory diseases, where TLR-signaling plays a significant role.
AbstractList [Display omitted] •Sepsis infects more than 48.9 million people world-wide, with 19.7 million deaths.•Cytokine storm plays a significant role in sepsis, along with severe COVID-19.•TLR signaling pathways plays a crucial role in generating the cytokine storm.•Endogenous negative regulators of TLR signaling are crucial to regulate cytokine storm. Cytokine storm generates during various systemic acute infections, including sepsis and current pandemic called COVID-19 (severe) causing devastating inflammatory conditions, which include multi-organ failure or multi-organ dysfunction syndrome (MODS) and death of the patient. Toll-like receptors (TLRs) are one of the major pattern recognition receptors (PRRs) expressed by immune cells as well as non-immune cells, including neurons, which play a crucial role in generating cytokine storm. They recognize microbial-associated molecular patterns (MAMPs, expressed by pathogens) and damage or death-associate molecular patterns (DAMPs; released and/expressed by damaged/killed host cells). Upon recognition of MAMPs and DAMPs, TLRs activate downstream signaling pathways releasing several pro-inflammatory mediators [cytokines, chemokines, interferons, and reactive oxygen and nitrogen species (ROS or RNS)], which cause acute inflammation meant to control the pathogen and repair the damage. Induction of an exaggerated response due to genetic makeup of the host and/or persistence of the pathogen due to its evasion mechanisms may lead to severe systemic inflammatory condition called sepsis in response to the generation of cytokine storm and organ dysfunction. The activation of TLR-induced inflammatory response is hardwired to the induction of several negative feedback mechanisms that come into play to conclude the response and maintain immune homeostasis. This state-of-the-art review describes the importance of TLR signaling in the onset of the sepsis-associated cytokine storm and discusses various host-derived endogenous negative regulators of TLR signaling pathways. The subject is very important as there is a vast array of genes and processes implicated in these negative feedback mechanisms. These molecules and mechanisms can be targeted for developing novel therapeutic drugs for cytokine storm-associated diseases, including sepsis, severe COVID-19, and other inflammatory diseases, where TLR-signaling plays a significant role.
Cytokine storm generates during various systemic acute infections, including sepsis and current pandemic called COVID-19 (severe) causing devastating inflammatory conditions, which include multi-organ failure or multi-organ dysfunction syndrome (MODS) and death of the patient. Toll-like receptors (TLRs) are one of the major pattern recognition receptors (PRRs) expressed by immune cells as well as non-immune cells, including neurons, which play a crucial role in generating cytokine storm. They recognize microbial-associated molecular patterns (MAMPs, expressed by pathogens) and damage or death-associate molecular patterns (DAMPs; released and/expressed by damaged/killed host cells). Upon recognition of MAMPs and DAMPs, TLRs activate downstream signaling pathways releasing several pro-inflammatory mediators [cytokines, chemokines, interferons, and reactive oxygen and nitrogen species (ROS or RNS)], which cause acute inflammation meant to control the pathogen and repair the damage. Induction of an exaggerated response due to genetic makeup of the host and/or persistence of the pathogen due to its evasion mechanisms may lead to severe systemic inflammatory condition called sepsis in response to the generation of cytokine storm and organ dysfunction. The activation of TLR-induced inflammatory response is hardwired to the induction of several negative feedback mechanisms that come into play to conclude the response and maintain immune homeostasis. This state-of-the-art review describes the importance of TLR signaling in the onset of the sepsis-associated cytokine storm and discusses various host-derived endogenous negative regulators of TLR signaling pathways. The subject is very important as there is a vast array of genes and processes implicated in these negative feedback mechanisms. These molecules and mechanisms can be targeted for developing novel therapeutic drugs for cytokine storm-associated diseases, including sepsis, severe COVID-19, and other inflammatory diseases, where TLR-signaling plays a significant role.
• Sepsis infects more than 48.9 million people world-wide, with 19.7 million deaths. • Cytokine storm plays a significant role in sepsis, along with severe COVID-19. • TLR signaling pathways plays a crucial role in generating the cytokine storm. • Endogenous negative regulators of TLR signaling are crucial to regulate cytokine storm. Cytokine storm generates during various systemic acute infections, including sepsis and current pandemic called COVID-19 (severe) causing devastating inflammatory conditions, which include multi-organ failure or multi-organ dysfunction syndrome (MODS) and death of the patient. Toll-like receptors (TLRs) are one of the major pattern recognition receptors (PRRs) expressed by immune cells as well as non-immune cells, including neurons, which play a crucial role in generating cytokine storm. They recognize microbial-associated molecular patterns (MAMPs, expressed by pathogens) and damage or death-associate molecular patterns (DAMPs; released and/expressed by damaged/killed host cells). Upon recognition of MAMPs and DAMPs, TLRs activate downstream signaling pathways releasing several pro-inflammatory mediators [cytokines, chemokines, interferons, and reactive oxygen and nitrogen species (ROS or RNS)], which cause acute inflammation meant to control the pathogen and repair the damage. Induction of an exaggerated response due to genetic makeup of the host and/or persistence of the pathogen due to its evasion mechanisms may lead to severe systemic inflammatory condition called sepsis in response to the generation of cytokine storm and organ dysfunction. The activation of TLR-induced inflammatory response is hardwired to the induction of several negative feedback mechanisms that come into play to conclude the response and maintain immune homeostasis. This state-of-the-art review describes the importance of TLR signaling in the onset of the sepsis-associated cytokine storm and discusses various host-derived endogenous negative regulators of TLR signaling pathways. The subject is very important as there is a vast array of genes and processes implicated in these negative feedback mechanisms. These molecules and mechanisms can be targeted for developing novel therapeutic drugs for cytokine storm-associated diseases, including sepsis, severe COVID-19, and other inflammatory diseases, where TLR-signaling plays a significant role.
Cytokine storm generates during various systemic acute infections, including sepsis and current pandemic called COVID-19 (severe) causing devastating inflammatory conditions, which include multi-organ failure or multi-organ dysfunction syndrome (MODS) and death of the patient. Toll-like receptors (TLRs) are one of the major pattern recognition receptors (PRRs) expressed by immune cells as well as non-immune cells, including neurons, which play a crucial role in generating cytokine storm. They recognize microbial-associated molecular patterns (MAMPs, expressed by pathogens) and damage or death-associate molecular patterns (DAMPs; released and/expressed by damaged/killed host cells). Upon recognition of MAMPs and DAMPs, TLRs activate downstream signaling pathways releasing several pro-inflammatory mediators [cytokines, chemokines, interferons, and reactive oxygen and nitrogen species (ROS or RNS)], which cause acute inflammation meant to control the pathogen and repair the damage. Induction of an exaggerated response due to genetic makeup of the host and/or persistence of the pathogen due to its evasion mechanisms may lead to severe systemic inflammatory condition called sepsis in response to the generation of cytokine storm and organ dysfunction. The activation of TLR-induced inflammatory response is hardwired to the induction of several negative feedback mechanisms that come into play to conclude the response and maintain immune homeostasis. This state-of-the-art review describes the importance of TLR signaling in the onset of the sepsis-associated cytokine storm and discusses various host-derived endogenous negative regulators of TLR signaling pathways. The subject is very important as there is a vast array of genes and processes implicated in these negative feedback mechanisms. These molecules and mechanisms can be targeted for developing novel therapeutic drugs for cytokine storm-associated diseases, including sepsis, severe COVID-19, and other inflammatory diseases, where TLR-signaling plays a significant role.Cytokine storm generates during various systemic acute infections, including sepsis and current pandemic called COVID-19 (severe) causing devastating inflammatory conditions, which include multi-organ failure or multi-organ dysfunction syndrome (MODS) and death of the patient. Toll-like receptors (TLRs) are one of the major pattern recognition receptors (PRRs) expressed by immune cells as well as non-immune cells, including neurons, which play a crucial role in generating cytokine storm. They recognize microbial-associated molecular patterns (MAMPs, expressed by pathogens) and damage or death-associate molecular patterns (DAMPs; released and/expressed by damaged/killed host cells). Upon recognition of MAMPs and DAMPs, TLRs activate downstream signaling pathways releasing several pro-inflammatory mediators [cytokines, chemokines, interferons, and reactive oxygen and nitrogen species (ROS or RNS)], which cause acute inflammation meant to control the pathogen and repair the damage. Induction of an exaggerated response due to genetic makeup of the host and/or persistence of the pathogen due to its evasion mechanisms may lead to severe systemic inflammatory condition called sepsis in response to the generation of cytokine storm and organ dysfunction. The activation of TLR-induced inflammatory response is hardwired to the induction of several negative feedback mechanisms that come into play to conclude the response and maintain immune homeostasis. This state-of-the-art review describes the importance of TLR signaling in the onset of the sepsis-associated cytokine storm and discusses various host-derived endogenous negative regulators of TLR signaling pathways. The subject is very important as there is a vast array of genes and processes implicated in these negative feedback mechanisms. These molecules and mechanisms can be targeted for developing novel therapeutic drugs for cytokine storm-associated diseases, including sepsis, severe COVID-19, and other inflammatory diseases, where TLR-signaling plays a significant role.
ArticleNumber 107087
Author Kumar, V.
Author_xml – sequence: 1
  givenname: V.
  surname: Kumar
  fullname: Kumar, V.
  email: vij_tox@yahoo.com
  organization: Children Health Clinical Unit, Faculty of Medicine, Mater Research, University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33075714$$D View this record in MEDLINE/PubMed
BookMark eNqFkstu1DAUhi1URC_wBghZYsMmgy9xnLBAqioKSJXYlLXlcU5STxM72M5Is-bFcZqhgi5gZfv4O7_O5T9HJ847QOg1JRtKaPV-t7Eu2XHaMMKWkCS1fIbOaC3rgkoiTvJdVLIQsmpO0XmMO0JyvKQv0CnnRApJyzP089YPQzHYe8ABDEzJh4itwxGmaGOhY_TG6gQtNofk760DHDMzYu1anO7ABgyu9T04P0fsoNfJ7hetfh70g5iOuJvTHADbcZydH327fh1w0qGHFF-i550eIrw6nhfo-_Wn26svxc23z1-vLm8KUzY0FZS1rDRUA9-yklVbDqITndYdBWCi1A2lFTOipg3nhmnW5WcltQQuiOQ14Rfo46o7zdsRWgMuBT2oKdhRh4Py2qq_f5y9U73fKylEHh3PAu-OAsH_mCEmNdpoYBi0g9y-YqVgZVNJ0mT07RN05-fgcnuZkpLlbdEqU2_-rOixlN_7yUC5Aib4GAN0jwglarGB2qnVBmqxgVptkNM-PEkzNuXN-KUvO_wv-TgmyLvYWwgqGgvOQGuzRZJqvf23wC89qNPo
CitedBy_id crossref_primary_10_1038_s41392_023_01452_1
crossref_primary_10_3390_ijms24021010
crossref_primary_10_3390_ph16081088
crossref_primary_10_3390_ijms23095076
crossref_primary_10_1016_j_intimp_2023_111271
crossref_primary_10_3390_molecules29245938
crossref_primary_10_1186_s13071_023_06021_7
crossref_primary_10_1016_j_heliyon_2024_e29769
crossref_primary_10_2147_JIR_S426007
crossref_primary_10_3389_fimmu_2021_739592
crossref_primary_10_1016_j_compbiomed_2022_105389
crossref_primary_10_1080_1744666X_2024_2366301
crossref_primary_10_1172_JCI150224
crossref_primary_10_3390_ijms24033001
crossref_primary_10_3389_fimmu_2023_1133355
crossref_primary_10_3390_antiox12010172
crossref_primary_10_1007_s10439_024_03523_y
crossref_primary_10_1021_acsanm_4c02964
crossref_primary_10_1111_vec_13359
crossref_primary_10_3389_fpubh_2022_927527
crossref_primary_10_3390_diagnostics14242845
crossref_primary_10_3389_fimmu_2020_624597
crossref_primary_10_1016_j_enzmictec_2023_110380
crossref_primary_10_1002_bab_2569
crossref_primary_10_1002_tox_24385
crossref_primary_10_1007_s11739_022_03036_3
crossref_primary_10_1016_j_csbr_2024_100015
crossref_primary_10_3892_ijmm_2023_5307
crossref_primary_10_7759_cureus_45530
crossref_primary_10_1016_j_fsi_2025_110208
crossref_primary_10_3389_fimmu_2023_1101918
crossref_primary_10_1038_s41598_021_92912_7
crossref_primary_10_3390_ijms222313009
crossref_primary_10_3389_fmed_2023_1265398
crossref_primary_10_3389_fcimb_2021_653843
crossref_primary_10_1186_s13287_023_03253_3
crossref_primary_10_1007_s00262_024_03723_4
crossref_primary_10_1016_j_intimp_2024_113552
crossref_primary_10_1007_s10753_022_01738_6
crossref_primary_10_1155_2022_2154485
crossref_primary_10_2174_1389557522666220304231537
crossref_primary_10_1016_j_burns_2024_07_024
crossref_primary_10_12938_bmfh_2022_018
crossref_primary_10_3390_ijms25179709
crossref_primary_10_1016_j_mito_2024_101967
crossref_primary_10_3390_ijms23105661
crossref_primary_10_3390_jcm12041373
crossref_primary_10_2147_IDR_S368772
crossref_primary_10_1177_09603271241282584
crossref_primary_10_1177_0976500X221147798
crossref_primary_10_3389_fimmu_2022_975848
crossref_primary_10_1016_j_fsi_2022_06_012
crossref_primary_10_1155_2024_8626082
crossref_primary_10_3390_jcm10215190
crossref_primary_10_1016_j_jss_2022_10_030
crossref_primary_10_1016_j_lfs_2021_119882
crossref_primary_10_1186_s13071_024_06540_x
crossref_primary_10_1016_j_mad_2021_111560
crossref_primary_10_3389_fcimb_2024_1384420
crossref_primary_10_1089_jir_2022_0029
crossref_primary_10_3389_fendo_2023_1124334
crossref_primary_10_4049_jimmunol_2200706
crossref_primary_10_1016_j_ijpharm_2024_124493
crossref_primary_10_1038_s41598_021_99595_0
crossref_primary_10_1177_15353702221084933
crossref_primary_10_1002_adfm_202402785
crossref_primary_10_1002_jcla_23805
crossref_primary_10_1080_08923973_2024_2415115
crossref_primary_10_3389_fphys_2022_1094199
crossref_primary_10_1016_j_compbiomed_2024_108222
crossref_primary_10_3389_fphar_2021_769190
crossref_primary_10_2147_JIR_S486753
crossref_primary_10_1159_000539278
crossref_primary_10_3390_microorganisms11040824
crossref_primary_10_1038_s41392_021_00679_0
crossref_primary_10_1186_s10020_025_01089_6
crossref_primary_10_1021_acsami_4c01270
crossref_primary_10_1186_s12887_025_05424_y
crossref_primary_10_2147_DDDT_S475005
crossref_primary_10_1016_j_intimp_2021_107813
crossref_primary_10_1096_fj_202401927R
crossref_primary_10_3390_ijms25020962
crossref_primary_10_1002_fsn3_3907
crossref_primary_10_3390_microorganisms12122488
crossref_primary_10_3389_fimmu_2022_909341
crossref_primary_10_5847_wjem_j_1920_8642_2024_016
crossref_primary_10_3390_life15010088
crossref_primary_10_1186_s40635_023_00491_w
crossref_primary_10_1097_SLA_0000000000005898
crossref_primary_10_3390_vaccines10040614
crossref_primary_10_3390_pathogens10121648
crossref_primary_10_29413_ABS_2024_9_6_12
crossref_primary_10_1172_jci_insight_186456
crossref_primary_10_1002_ehf2_14383
crossref_primary_10_1016_j_mtbio_2024_101421
crossref_primary_10_1080_14728222_2023_2257888
crossref_primary_10_3390_ijms25179751
crossref_primary_10_3389_fmed_2024_1429370
crossref_primary_10_6023_A21120615
crossref_primary_10_3390_ijms252111411
crossref_primary_10_3390_ijms22042108
crossref_primary_10_1007_s00018_024_05348_3
crossref_primary_10_1152_ajpgi_00090_2023
crossref_primary_10_1093_nutrit_nuad156
crossref_primary_10_1186_s12950_024_00411_z
crossref_primary_10_1007_s12035_024_04505_w
crossref_primary_10_1016_j_ijbiomac_2024_137836
crossref_primary_10_1002_cbf_4026
crossref_primary_10_1016_j_phymed_2022_154549
crossref_primary_10_1007_s12026_023_09400_5
crossref_primary_10_3390_toxins15070440
crossref_primary_10_1038_s41392_025_02174_2
crossref_primary_10_1007_s11033_024_09436_2
crossref_primary_10_1155_2022_4326695
crossref_primary_10_1007_s12026_022_09302_y
crossref_primary_10_3892_ijmm_2022_5198
crossref_primary_10_1016_j_biopha_2024_116633
crossref_primary_10_3390_biomedicines10051094
crossref_primary_10_2147_JIR_S459185
crossref_primary_10_1038_s41571_023_00850_2
crossref_primary_10_1159_000543608
crossref_primary_10_3390_medicina60030434
crossref_primary_10_3389_fimmu_2024_1516145
crossref_primary_10_3390_ijms25052760
crossref_primary_10_3390_pathogens14010043
crossref_primary_10_1177_08853282231179634
crossref_primary_10_14218_JCTH_2021_00055
crossref_primary_10_1016_j_prmcm_2024_100360
crossref_primary_10_1002_ame2_12221
Cites_doi 10.1038/nrmicro1248
10.1002/j.1460-2075.1994.tb06367.x
10.4049/jimmunol.166.11.6633
10.1038/cddis.2014.90
10.1073/pnas.93.16.8241
10.1038/nature20597
10.1016/j.tips.2012.06.007
10.1038/nm.2557
10.4161/viru.1.5.12983
10.1038/nri2707
10.2174/1568010042634523
10.1007/s00134-013-3006-9
10.1038/nri2093
10.1093/emboj/cdg273
10.1097/CCM.0000000000001053
10.1038/ni.3321
10.1016/j.cyto.2017.10.004
10.1371/journal.ppat.1003480
10.1038/nrd4657
10.1073/pnas.0605200103
10.4049/jimmunol.179.6.3622
10.1371/journal.pone.0148987
10.1096/fj.202000600RR
10.1097/SHK.0000000000000294
10.1073/pnas.0508327102
10.1038/s41589-020-0553-6
10.1038/cr.2012.56
10.1038/nri2998
10.1111/j.0019-2805.2003.01803.x
10.1016/j.jsbmb.2015.04.016
10.1371/journal.pone.0193003
10.1073/pnas.151236098
10.1074/jbc.M111.328187
10.1378/chest.129.6.1432
10.1038/nature01803
10.1371/journal.pone.0037584
10.1038/18044
10.1186/s12882-016-0415-3
10.1126/scisignal.2003801
10.1038/35074114
10.1038/ni1204
10.1038/s41598-020-67549-7
10.1038/ni1577
10.1016/j.tibs.2016.09.002
10.4049/jimmunol.1301301
10.1016/j.molimm.2019.12.013
10.1189/jlb.0409289
10.1128/MCB.01690-12
10.1038/35075603
10.1016/S0140-6736(19)32989-7
10.1155/2019/3737890
10.1073/pnas.0306880101
10.1007/s00281-017-0639-8
10.1179/joc.2008.20.6.672
10.1074/jbc.M501363200
10.1186/s12950-016-0112-9
10.1016/j.cyto.2014.11.025
10.1152/ajpendo.00542.2019
10.1038/s41598-017-07631-9
10.1159/000135685
10.1038/cmi.2016.58
10.1038/nri.2016.49
10.1001/jama.2016.0287
10.4161/cc.9.13.12269
10.1189/jlb.3A1116-492R
10.1016/j.immuni.2010.03.012
10.1038/ni.1640
10.1002/1873-3468.13879
10.1016/j.immuni.2005.09.015
10.1007/s00134-010-1773-0
10.1038/nature03464
10.1128/MCB.19.10.6665
10.1038/ni.3745
10.1038/gene.2012.53
10.1038/s41598-017-07316-3
10.4049/jimmunol.1102157
10.1097/CCM.0000000000002294
10.1016/j.immuni.2011.02.022
10.1086/500147
10.1038/ni.1727
10.3389/fimmu.2019.00482
10.1073/pnas.1324266111
10.4103/1673-5374.228718
10.3389/fimmu.2017.00511
10.1073/pnas.1424626112
10.1128/MCB.01101-07
10.15252/embj.201490791
10.1146/annurev.biochem.78.101807.093809
10.1074/jbc.M111.255570
10.1038/s41419-019-2015-1
10.1083/jcb.201511039
10.1038/ni.2378
10.1016/j.imlet.2013.11.003
10.1038/s41598-017-01868-0
10.1093/emboj/cdg139
10.1007/s00109-015-1288-9
10.4049/jimmunol.1601982
10.1586/1744666X.2014.971014
10.1038/ni1464
10.1038/nri2014
10.1038/ni1457
10.1016/j.intimp.2020.106980
10.1016/j.ajpath.2016.01.005
10.1007/s10753-013-9641-z
10.1074/jbc.M109537200
10.1038/ni.3395
10.1097/01.CCM.0000233875.93866.88
10.1371/journal.pone.0188050
10.3389/fcell.2016.00056
10.1097/ALN.0000000000000337
10.1038/35056591
10.1038/srep12738
10.4049/jimmunol.1002094
10.1159/000362647
10.1371/journal.ppat.1003650
10.1038/emboj.2008.256
10.3803/EnM.2016.31.1.17
10.1006/cyto.1998.0452
10.1016/j.immuni.2007.02.012
10.1038/ni.2109
10.1016/j.micinf.2011.12.007
10.1517/17425255.2011.558190
10.1080/08830185.2019.1707479
10.1074/jbc.M109.074971
10.3892/ijmm.2016.2749
10.15252/emmm.201707698
10.3109/08977198909029123
10.1007/s11033-010-0146-7
10.1016/j.cytogfr.2020.05.003
10.1002/eji.200425932
10.1038/ni1066
10.1016/j.sbi.2007.08.018
10.1006/cyto.1998.0359
10.4049/jimmunol.179.5.3119
10.1016/S0378-1119(98)00080-8
10.1016/j.it.2012.05.002
10.1074/jbc.M406638200
10.1016/j.cell.2010.03.040
10.1074/jbc.273.18.11349
10.1038/nri3399
10.1038/ni1382
10.1084/jem.20101326
10.1016/j.bcp.2014.04.012
10.4110/in.2020.20.e21
10.1016/j.molimm.2004.03.009
10.1038/nri1630
10.1016/S0167-4781(00)00289-X
10.1371/journal.pone.0022200
10.3389/fimmu.2020.00229
10.1074/jbc.275.15.11100
10.4049/jimmunol.177.1.548
10.1177/1721727X1401200102
10.1038/ni.2169
10.1126/science.1220363
10.1001/jama.2010.851
10.1126/science.1182364
10.1084/jem.20041817
10.1155/2013/716481
10.1038/ni.3342
10.1038/nm1638
10.1189/jlb.0809549
10.1042/BST0390688
10.1038/s41598-019-40537-2
10.4049/jimmunol.174.5.2942
10.1083/jcb.145.7.1471
10.1038/ni.2823
10.1177/1753425908100928
10.1371/journal.ppat.1004462
10.1038/nri2748
10.1074/jbc.274.41.29242
10.1126/science.1094351
10.1038/ni.1644
10.1126/scitranslmed.3000678
10.1038/nri1391
10.1016/S0092-8674(02)00827-9
10.1038/cr.2012.83
10.1164/rccm.201504-0781OC
10.1111/j.1600-065X.2009.00844.x
10.1177/1559325820938543
10.1371/journal.pntd.0000305
10.1016/j.it.2013.10.005
10.1186/s12865-015-0137-5
10.4049/jimmunol.1300496
10.1097/SHK.0b013e318181af2a
10.1038/nature03308
10.4049/jimmunol.179.7.4598
10.1111/j.1462-5822.2008.01204.x
10.1016/j.immuni.2019.04.005
10.1038/nrd2660
10.1038/srep18327
10.1074/jbc.M308620200
10.1016/j.immuni.2006.10.014
10.1186/cc9413
10.1080/14728222.2017.1279146
10.1126/science.289.5488.2350
10.1073/pnas.1114194108
10.1073/pnas.0308680101
10.1186/s10020-020-00172-4
10.1101/gad.10.8.963
10.1080/08830185.2016.1261318
10.1016/j.molimm.2008.05.006
10.1001/jama.2013.2194
10.1074/jbc.M109078200
10.1038/nature12118
10.1016/S1097-2765(00)80133-1
10.1038/srep46097
10.1038/ncomms8229
10.1002/eji.201545828
10.1016/j.smim.2013.10.004
10.4049/jimmunol.0904127
10.1016/j.cell.2009.01.038
10.1038/ni.2064
10.1038/nature01802
10.1038/ni968
10.1074/jbc.M704768200
10.1074/jbc.M706906200
10.3390/nu10020203
10.1016/j.jped.2013.12.012
10.1084/jem.20031220
10.1093/emboj/19.19.5114
10.1038/nrd3011
10.1158/0008-5472.CAN-06-2164
10.4049/jimmunol.1601647
10.1038/nrm3011
10.1016/j.it.2009.05.007
10.1016/j.celrep.2016.09.076
10.1016/j.immuni.2008.06.004
10.1371/journal.ppat.1008622
10.1186/1478-811X-12-8
10.1007/s00109-004-0622-4
10.1016/j.cyto.2008.07.012
10.1038/ni.1604
10.1146/annurev.cellbio.22.010605.093503
10.1016/j.intimp.2019.106044
10.7554/eLife.50458
10.1016/S0925-4773(99)00314-7
10.1073/pnas.1518615113
10.1189/jlb.0408238
10.1016/j.celrep.2014.11.020
10.1038/srep34672
10.1038/s41419-019-1808-6
10.1038/ncb3386
10.1038/nri3313
10.4049/jimmunol.1403027
10.1083/jcb.201505091
10.1016/j.cell.2010.02.016
10.1097/MD.0000000000014756
10.1007/s00134-013-3106-6
10.1182/blood-2013-09-528752
10.21873/invivo.11428
10.1128/IAI.00128-06
10.1038/nrd3162
10.3109/07388551.2011.594423
10.1124/mol.118.112300
10.1002/eji.200940034
10.1177/1559325819827436
10.1038/cdd.2009.43
10.1016/j.cell.2007.10.034
10.7189/jogh.01.010404
10.1007/s10753-016-0428-x
10.1189/jlb.2MR0317-105R
10.1038/ni.1771
10.1128/MCB.12.4.1535
10.1186/s42269-019-0227-2
10.4049/jimmunol.1003551
10.1056/NEJMp1707170
10.1038/ni1050
10.1097/00003246-200107000-00002
10.1371/journal.pbio.1002026
10.1128/MCB.20.15.5479-5489.2000
10.1073/pnas.1110946108
10.7448/IAS.16.1.17344
10.1038/ni1110
10.1074/jbc.M114.547547
10.1038/35014038
10.1038/cr.2012.53
10.1038/ni.1944
10.1016/j.molimm.2011.08.016
10.4049/jimmunol.157.10.4277
10.1016/j.immuni.2006.12.005
10.1038/nature04768
10.1038/nri2939
10.1016/S0014-5793(98)01645-7
10.1016/j.immuni.2008.08.012
10.1016/j.chom.2016.03.001
10.1016/j.dci.2016.10.009
10.1080/09537104.2018.1445841
10.1016/j.cell.2008.03.026
10.1371/journal.pone.0103734
10.1038/sj.ki.5002293
10.1371/journal.ppat.1000650
10.1042/BJ20040217
10.1016/S0378-1119(01)00551-0
10.1371/journal.pone.0127170
10.1126/science.1145918
10.1002/iid3.159
10.1016/j.immuni.2012.09.016
10.1101/cshperspect.a009076
10.1096/fj.201700711R
10.1074/jbc.M209685200
10.1016/j.bbaexp.2004.08.013
10.1016/S0161-5890(96)00043-0
10.1093/infdis/jiz246
10.1007/s00395-020-0779-1
10.1016/j.intimp.2010.08.012
10.1146/annurev-immunol-032414-112103
10.1074/jbc.C400063200
10.1038/cddis.2016.326
10.1007/s00441-017-2767-9
10.1091/mbc.e04-12-1052
10.1172/JCI64096
10.1128/MMBR.05015-11
10.1126/scisignal.2005533
10.1016/j.it.2009.06.001
10.1152/physrev.2000.80.4.1483
10.1006/bbrc.1997.6810
10.3892/ijmm.2014.1943
10.4049/jimmunol.1502599
10.1002/hep.26100
10.1074/jbc.M509526200
10.1016/0014-5793(93)81333-U
10.1074/jbc.M116.733451
10.1016/j.immuni.2018.08.016
10.1042/BST0391086
10.1007/s00018-015-1931-1
10.1084/jem.20051725
10.1016/j.ajic.2014.05.029
10.1124/jpet.102.044487
10.4049/jimmunol.0901888
10.1084/jem.20050986
10.1016/S0065-230X(08)00002-X
10.4049/jimmunol.1003300
10.1111/imr.12499
10.1016/j.cell.2010.01.022
10.1128/MCB.19.4.3029
10.1371/journal.pone.0023989
10.1128/IAI.68.12.7010-7017.2000
10.4049/jimmunol.0903900
10.1016/j.jneuroim.2019.03.012
10.1016/j.cell.2006.02.015
10.1073/pnas.1410293111
10.1038/nri2413
10.2119/molmed.2017.00022
10.1161/JAHA.116.004078
10.1164/rccm.201510-1976ED
10.1002/bies.950190606
10.1038/s41418-019-0347-0
10.1074/jbc.M700017200
10.1038/ni.3103
10.1016/j.immuni.2005.04.008
ContentType Journal Article
Copyright 2020 Elsevier B.V.
Copyright © 2020 Elsevier B.V. All rights reserved.
Copyright Elsevier BV Dec 2020
2020 Elsevier B.V. All rights reserved. 2020 Elsevier B.V.
Copyright_xml – notice: 2020 Elsevier B.V.
– notice: Copyright © 2020 Elsevier B.V. All rights reserved.
– notice: Copyright Elsevier BV Dec 2020
– notice: 2020 Elsevier B.V. All rights reserved. 2020 Elsevier B.V.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QO
7T5
7U7
7U9
8FD
C1K
FR3
H94
P64
7X8
5PM
DOI 10.1016/j.intimp.2020.107087
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Biotechnology Research Abstracts
Immunology Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Virology and AIDS Abstracts
Biotechnology Research Abstracts
Technology Research Database
Toxicology Abstracts
AIDS and Cancer Research Abstracts
Immunology Abstracts
Engineering Research Database
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
MEDLINE - Academic
DatabaseTitleList
MEDLINE
Virology and AIDS Abstracts

MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Pharmacy, Therapeutics, & Pharmacology
EISSN 1878-1705
EndPage 107087
ExternalDocumentID PMC7550173
33075714
10_1016_j_intimp_2020_107087
S1567576920329179
Genre Journal Article
Review
GroupedDBID ---
--K
--M
.GJ
.~1
0R~
1B1
1RT
1~.
1~5
29J
4.4
457
4G.
53G
5GY
5VS
7-5
71M
8P~
AAAJQ
AABNK
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARKO
AATCM
AAXUO
ABBQC
ABFNM
ABFRF
ABJNI
ABLVK
ABMAC
ABMZM
ABXDB
ABYKQ
ABZDS
ACDAQ
ACGFO
ACGFS
ACIUM
ACIWK
ACPRK
ACRLP
ADBBV
ADEZE
ADMUD
AEBSH
AEFWE
AEKER
AENEX
AFKWA
AFRAH
AFTJW
AFXIZ
AGEKW
AGHFR
AGUBO
AGYEJ
AI.
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJRQY
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
C45
CJTIS
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-Q
GBLVA
HVGLF
HZ~
IHE
J1W
KOM
L7B
LCYCR
LUGTX
M41
MO0
N9A
O-L
O9-
OAUVE
OGGZJ
OVD
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SCC
SDF
SDG
SDP
SES
SEW
SPCBC
SSH
SSI
SSP
SSZ
T5K
TEORI
UNMZH
VH1
ZGI
~G-
AATTM
AAXKI
AAYWO
AAYXX
ABWVN
ACIEU
ACRPL
ACVFH
ADCNI
ADNMO
AEIPS
AEUPX
AFJKZ
AFPUW
AGCQF
AGQPQ
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
CITATION
CGR
CUY
CVF
ECM
EFKBS
EIF
NPM
7QO
7T5
7U7
7U9
8FD
C1K
FR3
H94
P64
7X8
5PM
ID FETCH-LOGICAL-c491t-12d24c1ae3b2426b3e5f5faaf1ee254a91162c581933c2a2f16267a7e35073803
IEDL.DBID .~1
ISSN 1567-5769
1878-1705
IngestDate Thu Aug 21 14:33:35 EDT 2025
Mon Jul 21 11:56:31 EDT 2025
Sat Jul 26 02:20:24 EDT 2025
Mon Jul 21 05:43:39 EDT 2025
Tue Jul 01 03:39:41 EDT 2025
Thu Apr 24 23:04:25 EDT 2025
Fri Feb 23 02:46:39 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue Pt B
Keywords PAMPs
Sepsis
Cytokines
Cytokine storm
TLRs
Innate Immunity
Language English
License Copyright © 2020 Elsevier B.V. All rights reserved.
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c491t-12d24c1ae3b2426b3e5f5faaf1ee254a91162c581933c2a2f16267a7e35073803
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC7550173
PMID 33075714
PQID 2477270816
PQPubID 2045469
PageCount 1
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7550173
proquest_miscellaneous_2452496709
proquest_journals_2477270816
pubmed_primary_33075714
crossref_primary_10_1016_j_intimp_2020_107087
crossref_citationtrail_10_1016_j_intimp_2020_107087
elsevier_sciencedirect_doi_10_1016_j_intimp_2020_107087
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-12-01
PublicationDateYYYYMMDD 2020-12-01
PublicationDate_xml – month: 12
  year: 2020
  text: 2020-12-01
  day: 01
PublicationDecade 2020
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
– name: Amsterdam
PublicationTitle International immunopharmacology
PublicationTitleAlternate Int Immunopharmacol
PublicationYear 2020
Publisher Elsevier B.V
Elsevier BV
Publisher_xml – name: Elsevier B.V
– name: Elsevier BV
References Kumar, Tzimas, Griswold, Young (b1510) 1997; 235
Schworer, Smirnova, Kurbatova, Bagina, Churova, Fowler, Roy, Degterev (b0915) 2014; 289
Li, Gu, Yu, Yang, Zhang, Ba, Yin, Wang, Yin, Zhou, Li (b1265) 2019; 10
Barochia, Solomon, Cui, Natanson, Eichacker (b1765) 2011; 7
Lemke (b0575) 2013; 5
Zhou, Collins, Wu, Brown (b0730) 2010; 87
Park, Ko, Lee (b0755) 2017; 7
Ozato, Shin, Chang, Morse (b1235) 2008; 8
Li, Wu, Liu, Zhang, Du, Liu, Song, Shi, Li (b0355) 2019; 2019
Deng, Cheng, Newstead, Zeng, Kobayashi, Flavell, Standiford (b0645) 2006; 116
Fleischmann, Scherag, Adhikari, Hartog, Tsaganos, Schlattmann, Angus, Reinhart (b0005) 2016; 193
Yang, Cheung, Peng, He, Wu, Xie, Jiang, Huang, Chen, Lin, Kung (b1205) 2008; 283
Sakurai (b1745) 2012; 33
El-Zayat, Sibaii, Mannaa (b0415) 2019; 43
McMorrow, Murphy (b1015) 2011; 39
Burkart, Fan, Zhang (b0960) 2012; 287
Lee, Kok, Jaume, Cheung, Yip, Lai, Guan, Webster, Jin, Peiris (b1600) 2014; 111
Kovalenko, Chable-Bessia, Cantarella, Israel, Wallach, Courtois (b0880) 2003; 424
Vermeulen, De Wilde, Van Damme, Vanden Berghe, Haegeman (b1090) 2003; 22
Dong, Gong, Li, Luo, Li, Li, He (b0660) 2013; 36
Vogl, Tenbrock, Ludwig, Leukert, Ehrhardt, van Zoelen, Nacken, Foell, van der Poll, Sorg, Roth (b1785) 2007; 13
Akira, Takeda (b0380) 2004; 4
Ponting, Phillips, Davies, Blake (b1180) 1997; 19
Kamitani, Kito, Nguyen, Fukuda-Kamitani, Yeh (b1280) 1998; 273
Ferrara, Abhyankar, Gilliland (b0110) 1993; 25
Yuen, Wong (b0115) 2005
Iwahana, Hayakawa, Kuroiwa, Tago, Yanagisawa, Noji, Tominaga (b1480) 2004; 1681
Hug, Mohajeri, La Fata (b0315) 2018; 10
Farber (b1650) 1992; 12
Bakopoulos, Kapelouzou, Tsilimigras, Katsimpoulas, Schizas, Aravanis, Balafas, Mavroidis, Pavlakis, Machairas, Liakakos (b0290) 2017; 12
Shinohara, Inoue, Toyama-Sorimachi, Nagai, Yasuda, Suzuki, Horai, Iwakura, Yamamoto, Karasuyama, Miyake, Yamanashi (b0560) 2005; 201
Cosin-Roger, Spalinger, Ruiz, Stanzel, Terhalle, Wolfram, Melhem, Atrott, Lang, Frey-Wagner, Fried, Scharl, Hausmann, Rogler (b0280) 2018; 13
Bernstock, Ye, Smith, Lee, Gessler, Yasgar, Kouznetsova, Jadhav, Wang, Pluchino, Zheng, Simeonov, Hallenbeck, Yang (b1350) 2018; 32
Tominaga, Mita, Kikuchi, Hitoshi, Takatsu, Nishikawa, Ogawa (b1445) 1989; 1
Xu, An, Hou, Han, Wang, Yu, Cao (b0795) 2008; 45
Bouchon, Facchetti, Weigand, Colonna (b0555) 2001; 410
Carty, Kearney, Shanahan, Hams, Sugisawa, Connolly, Doran, Muñoz-Wolf, Gürtler, Fitzgerald, Lavelle, Fallon, Bowie (b0465) 2019; 50
Kumar (b0135) 2014; 157
Vandewalle, Tourneur, Bens, Chassin, Werts (b0765) 2014; 12
Decque, Joffre, Magalhaes, Cossec, Blecher-Gonen, Lapaquette, Silvin, Manel, Joubert, Seeler, Albert, Amit, Amigorena, Dejean (b1320) 2016; 17
An, Hou, Zhou, Zhao, Xu, Zheng, Yu, Liu, Cao (b0715) 2008; 9
Brint, Xu, Liu, Dunne, McKenzie, O'Neill, Liew (b1485) 2004; 5
Delano, Ward (b0220) 2016; 274
Li, Hu, Li (b0680) 2004; 41
Peng, Long, Malhotra, Humphrey (b0540) 2013; 6
Glass, Saijo (b1330) 2010; 10
Hu (b1435) 2015
Tibrewal, Wu, D'Mello, Akakura, George, Varnum, Birge (b0625) 2008; 283
Cui, Zhu, Xia, Wang, Legras, Hong, Ji, Shen, Zheng, Chen, Wang (b1410) 2010; 141
Wald, Qin, Zhao, Qian, Naramura, Tian, Towne, Sims, Stark, Li (b1530) 2003; 4
Honke, Shaabani, Cadeddu, Sorg, Zhang, Trilling, Klingel, Sauter, Kandolf, Gailus, van Rooijen, Burkart, Baldus, Grusdat, Lohning, Hengel, Pfeffer, Tanaka, Haussinger, Recher, Lang, Lang (b0945) 2011; 13
Kawagoe, Takeuchi, Takabatake, Kato, Isaka, Tsujimura, Akira (b1145) 2009; 10
Kowalski, Li (b0700) 2017; 8
Turnbull, McDunn, Takai, Townsend, Cobb, Colonna (b0550) 2005; 202
Tartey, Takeuchi (b1830) 2017; 36
Krivan, Kapelouzou, Vagios, Tsilimigras, Katsimpoulas, Moris, Aravanis, Demesticha, Schizas, Mavroidis, Pavlakis, Machairas, Misiakos, Liakakos (b0350) 2019; 9
Palsson-McDermott, Doyle, McGettrick, Hardy, Husebye, Banahan, Gong, Golenbock, Espevik, O'Neill (b0425) 2009; 10
Bendickova, Tidu, Fric (b0785) 2017; 9
Oosting, Cheng, Bolscher, Vestering-Stenger, Plantinga, Verschueren, Arts, Garritsen, van Eenennaam, Sturm, Kullberg, Hoischen, Adema, van der Meer, Netea, Joosten (b1630) 2014; 111
Yoshida, Jono, Kai, Li (b0870) 2005; 280
Feuillet, Medjane, Mondor, Demaria, Pagni, Galán, Flavell, Alexopoulou (b0375) 2006; 103
Rothlin, Carrera-Silva, Bosurgi, Ghosh (b0585) 2015; 33
Mullarkey, Rose, Bristol, Kawata, Kimura, Kobayashi, Przetak, Chow, Gusovsky, Christ, Rossignol (b1750) 2003; 304
Rajan, Jang, Kim, Kim, Toh, Jeon, Song, Serra, Lescar, Yoo, Beldar, Ye, Kang, Liu, Feitosa, Kim, Hwang, Goh, Lim, Park, Lee, Oh, Petsko, Yoon, Kim (b1050) 2020; 16
Ye, Hu, Lei, Zhou, Lin, Sun, Shu (b1250) 2017
Turnbull, Colonna (b0545) 2007; 7
Takaoka, Yanai, Kondo, Duncan, Negishi, Mizutani, Kano, Honda, Ohba, Mak, Taniguchi (b0470) 2005; 434
Tanaka, Soriano, Grusby (b1165) 2005; 22
Drysdale, Howard, Johnson (b1645) 1996; 33
Shembade, Ma, Harhaj (b0840) 2010; 327
A.J. Hoogendijk, M.I. Garcia-Laorden, L.A. van Vught, M.A. Wiewel, H. Belkasim-Bohoudi, J. Duitman, J. Horn, M.J. Schultz, B.P. Scicluna, C. van ‘t Veer, A.F. de Vos, T. van der Poll, Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types*, Critical care medicine 45(5) (2017) e524-e531.
Cario, Podolsky (b0300) 2000; 68
Loughran, Healy, Kiely, Huigsloot, Kedersha, O'Connor (b1160) 2005; 16
Kakkar, Lee (b1450) 2008; 7
Ke, Shen, Kamo, Ji, Yue, Gao, Busuttil, Kupiec-Weglinski (b1775) 2013; 57
Reinhart, Daniels, Kissoon, Machado, Schachter, Finfer (b0075) 2017
Honda, Yanai, Negishi, Asagiri, Sato, Mizutani, Shimada, Ohba, Takaoka, Yoshida, Taniguchi (b0450) 2005; 434
Carrión, Link, Ledo, Mellström, Naranjo (b0865) 1999; 398
Moretti, Bozza, Oikonomou, Renga, Casagrande, Iannitti, Puccetti, Garlanda, Kim, Li, van de Veerdonk, Dinarello, Romani (b1730) 2014; 10
Nold, Nold-Petry, Zepp, Palmer, Bufler, Dinarello (b1705) 2010; 11
Vereecke, Beyaert, van Loo (b1800) 2009; 30
Deng, Scott, Loughran, Gibson, Sodhi, Watkins, Hackam, Billiar (b0235) 2013; 190
Zhang, Sun, Du, Gou, Liu, Wang, Xu (b0485) 2020; 18
O'Neill (b0610) 2008; 29
Li, Neff, Barber, Hong, Luo, Azam, Palmer, Fujita, Garlanda, Mantovani, Kim, Dinarello (b1740) 2015; 112
Bruck, Vitoux, Ferry, Duong, Bauer, de The, Rochette-Egly (b1095) 2009; 28
Hoetzenecker, Echtenacher, Guenova, Hoetzenecker, Woelbing, Brück, Teske, Valtcheva, Fuchs, Kneilling, Park, Kim, Kim, Hoffmann, Krenn, Hai, Ghoreschi, Biedermann, Röcken (b1680) 2012; 18
Zhang, Zhu, Liu, Qu, Chen, Ren, Wang, Wei, Zhang, Yi (b0505) 2015; 93
Goldmann, Zeller, Raasch, Kierdorf, Frenzel, Ketscher, Basters, Staszewski, Brendecke, Spiess, Tay, Kreutz, Timmer, Mancini, Blank, Fritz, Biber, Lang, Malo, Merkler, Heikenwalder, Knobeloch, Prinz (b0970) 2015; 34
Akira, Uematsu, Takeuchi (b0385) 2006; 124
Lee, Miyata, Lim, Li (b0905) 2016; 113
Romani (b0190) 2011; 11
Atalan, Karagedik, Acar, Isbir, Yilmaz, Ergen, Isbir (b0335) 2016; 30
Lee, Boone, Chai, Libby, Chien, Lodolce, Ma (b0825) 2000; 289
Wang, Yang, Gao, Wu, Huang, Li (b1325) 2020; 45
Huang, Hazlett, Du, Barrett (b1585) 2006; 177
González-Navajas, Law, Nguyen, Bhargava, Corr, Varki, Eckmann, Hoffman, Lee, Raz (b0990) 2010; 207
Abu-Dayyeh, Shio, Sato, Akira, Cousineau, Olivier (b0720) 2008; 2
Li, Zhang, He, Guo, Lu, Wang, Li, Wu (b1020) 2016; 13
Scott, McMahon, Pop, Reap, Caricchio, Cohen, Earp, Matsushima (b0630) 2001; 411
Sharif, Sosic, Rothlin, Kelly, Lemke, Olson, Ivashkiv (b0605) 2006; 203
Abreu (b0295) 2010; 10
Yao, Wang, Chen, Huang, Zhu, Leng, Wang, Shi, Qian (b1420) 2012; 22
Sun, Gong, Carmody, Hilliard, Li, Sun, Kong, Xu, Hilliard, Hu, Shen, Yang, Chen (b0490) 2008; 133
Nakhaei, Mesplede, Solis, Sun, Zhao, Yang, Chuang, Ware, Lin, Hiscott (b1260) 2009; 5
Fore, Indriputri, Mamutse, Nugraha (b1855) 2020; 20
Yuk, Jin, Jo (b1065) 2016; 31
Desterro, Rodriguez, Hay (b1310) 1998; 2
Patel, Webster, Varfolomeev, Kwon, Cheng, Zhang, Dugger, Wickliffe, Maltzman, Sujatha-Bhaskar, Bir Kohli, Ramaswamy, Deshmukh, Liederer, Fong, Hamilton, Lupardus, Caplazi, Lee, van Lookeren Campagne, Johnson, McKenzie, Junttila, Newton, Vucic (b0920) 2020; 27
Yang, Li, Duan, Ren, Liang, Yakoumatos, Kang, Uriarte, Shang, Li, Wang (b1780) 2020; 118
Shuto, Xu, Wang, Han, Kai, Gu, Murphy, Lim, Li (b0910) 2001; 98
Liu, Iwanowycz, Fan (b0265) 2017; 131
Kolaczkowska, Kubes (b0155) 2013; 13
Mayr, Yende, Linde-Zwirble, Peck-Palmer, Barnato, Weissfeld, Angus (b0060) 2010; 303
Nisole, Stoye, Saib (b1230) 2005; 3
Abulkhir, Samarani, Amre, Duval, Haddad, Sinnett, Leclerc, Diorio, Ahmad (b1595) 2016
Lech, Garlanda, Mantovani, Kirschning, Schlondorff, Anders (b1545) 2007; 72
Thomassen, Renshaw, Sims (b1540) 1999; 11
Galli, Borregaard, Wynn (b0150) 2011; 12
Sun (b0890) 2010; 17
Abram, Lowell (b0710) 2017; 102
Hacker, Tseng, Karin (b0980) 2011; 11
Weichhart, Costantino, Poglitsch, Rosner, Zeyda, Stuhlmeier, Kolbe, Stulnig, Horl, Hengstschlager, Muller, Saemann (b1390) 2008; 29
Opal, Laterre, Francois, LaRosa, Angus, Mira, Wittebole, Dugernier, Perrotin, Tidswell, Jauregui, Krell, Pachl, Takahashi, Peckelsen, Cordasco, Chang, Oeyen, Aikawa, Maruyama, Schein, Kalil, Van Nuffelen, Lynn, Rossignol, Gogate, Roberts, Wheeler, Vincent (b1760) 2013; 309
Reyskens, Arthur (b1105) 2016; 4
Oh, Kim, Gil, Byun, Cha, Ku, Lee, Kim, Oh, Lee, Bae, Lee, Han (b1045) 2020; 10
Bashirova, Markelov, Shlykova, Levshenkova, Alibaeva, Frolova (b1175) 1998; 210
Deshaies, Joazeiro (b1215) 2009; 78
Peng, Yuan, Lin, Panneerselvam, Wang, Luan, Lim, Leung, Ho, Ding (b0455) 2010; 40
Pomies, Macalma, Beckerle (b1170) 1999; 274
Benko, Magalhaes, Philpott, Girardin (b1405) 2010; 185
Zhou, Zhang, van Dam, Ten Dijke, Huang, Zhang (b0925) 2012; 287
Kim, Sano, Todorova, Carlson, Arpa, Celada, Lawrence, Otsu, Brissette, Arthur, Park (b1115) 2008; 9
Garlanda, Anders, Mantovani (b1575) 2009; 30
Coperchini, Chiovato, Croce, Magri, Rotondi (b0105) 2020; 53
Diao, Zhang, Chen, Yuan, Lee, Geng, Kowalski, Guo, Xiong, Li, Li (b0690) 2016; 6
Rebl, Rebl, Köbis, Goldammer, Seyfert (b1440) 2017; 67
He, Hara, Núñez (b1070) 2016; 41
Lin, Jian, Song, Chen, Ding, Xie, Hu (b0735) 2020
Finfer, Machado (b0015) 2016; 193
Bibeau-Poirier, Servant (b0975) 2008; 43
Schmit
10.1016/j.intimp.2020.107087_b0070
Heyninck (10.1016/j.intimp.2020.107087_b0820) 1999; 145
Hamonic (10.1016/j.intimp.2020.107087_b0310) 2018; 372
Rothlin (10.1016/j.intimp.2020.107087_b0585) 2015; 33
Yu (10.1016/j.intimp.2020.107087_b0305) 2015; 72
Lee (10.1016/j.intimp.2020.107087_b1665) 2018; 9
Hamerman (10.1016/j.intimp.2020.107087_b0530) 2005; 6
Jiang (10.1016/j.intimp.2020.107087_b1610) 2016; 196
Vereecke (10.1016/j.intimp.2020.107087_b1805) 2011; 39
Kho (10.1016/j.intimp.2020.107087_b1335) 2015; 6
Sakurai (10.1016/j.intimp.2020.107087_b1745) 2012; 33
Rudd (10.1016/j.intimp.2020.107087_b0010) 2020; 395
Ponting (10.1016/j.intimp.2020.107087_b1180) 1997; 19
Yuk (10.1016/j.intimp.2020.107087_b1060) 2011; 12
Goldmann (10.1016/j.intimp.2020.107087_b0970) 2015; 34
Deshaies (10.1016/j.intimp.2020.107087_b1215) 2009; 78
Kumar (10.1016/j.intimp.2020.107087_b0140) 2010; 10
Jono (10.1016/j.intimp.2020.107087_b0900) 2004; 279
Henrick (10.1016/j.intimp.2020.107087_b1850) 2019; 10
Zhou (10.1016/j.intimp.2020.107087_b0925) 2012; 287
Deng (10.1016/j.intimp.2020.107087_b0645) 2006; 116
Gilchrist (10.1016/j.intimp.2020.107087_b1655) 2006; 441
Schmitz (10.1016/j.intimp.2020.107087_b1465) 2005; 23
Rosenthal (10.1016/j.intimp.2020.107087_b0020) 2014; 42
Glass (10.1016/j.intimp.2020.107087_b1035) 2010; 140
Mashima (10.1016/j.intimp.2020.107087_b0565) 2009; 232
Adib-Conquy (10.1016/j.intimp.2020.107087_b1565) 2006; 34
10.1016/j.intimp.2020.107087_b0085
Liew (10.1016/j.intimp.2020.107087_b0675) 2005; 5
Kayagaki (10.1016/j.intimp.2020.107087_b0985) 2007; 318
Shirey (10.1016/j.intimp.2020.107087_b1770) 2013; 497
Hutti (10.1016/j.intimp.2020.107087_b0850) 2007; 27
Barochia (10.1016/j.intimp.2020.107087_b1765) 2011; 7
Reyskens (10.1016/j.intimp.2020.107087_b1075) 2016; 4
Tibrewal (10.1016/j.intimp.2020.107087_b0625) 2008; 283
Chuang (10.1016/j.intimp.2020.107087_b1255) 2004; 5
Atalan (10.1016/j.intimp.2020.107087_b0340) 2018; 32
Safe (10.1016/j.intimp.2020.107087_b1005) 2016; 157
Xu (10.1016/j.intimp.2020.107087_b0795) 2008; 45
Shembade (10.1016/j.intimp.2020.107087_b0845) 2010; 9
Kamitani (10.1016/j.intimp.2020.107087_b1280) 1998; 273
Ozato (10.1016/j.intimp.2020.107087_b1235) 2008; 8
Patidar (10.1016/j.intimp.2020.107087_b1820) 2018; 104
Guignant (10.1016/j.intimp.2020.107087_b0615) 2013; 39
Caenepeel (10.1016/j.intimp.2020.107087_b1080) 2004; 101
Fleer (10.1016/j.intimp.2020.107087_b1810) 2007; 92
Das (10.1016/j.intimp.2020.107087_b1835) 2016; 17
Lim (10.1016/j.intimp.2020.107087_b0895) 2008; 10
Delano (10.1016/j.intimp.2020.107087_b0220) 2016; 274
Yoshimura (10.1016/j.intimp.2020.107087_b0595) 2007; 7
Desterro (10.1016/j.intimp.2020.107087_b1310) 1998; 2
Ranjan (10.1016/j.intimp.2020.107087_b0775) 2014; 6
Soloaga (10.1016/j.intimp.2020.107087_b1085) 2003; 22
10.1016/j.intimp.2020.107087_b1385
Opal (10.1016/j.intimp.2020.107087_b1760) 2013; 309
Vogl (10.1016/j.intimp.2020.107087_b1785) 2007; 13
Austermann (10.1016/j.intimp.2020.107087_b1790) 2014; 9
Bernstock (10.1016/j.intimp.2020.107087_b1340) 2017; 7
Hug (10.1016/j.intimp.2020.107087_b0315) 2018; 10
Andersson (10.1016/j.intimp.2020.107087_b0255) 2020; 26
Takeuchi (10.1016/j.intimp.2020.107087_b0200) 2010; 140
Deng (10.1016/j.intimp.2020.107087_b0250) 2018; 49
Rajan (10.1016/j.intimp.2020.107087_b1050) 2020; 16
Shinohara (10.1016/j.intimp.2020.107087_b0560) 2005; 201
Saccani (10.1016/j.intimp.2020.107087_b1505) 1998; 10
Tominaga (10.1016/j.intimp.2020.107087_b1445) 1989; 1
Muller (10.1016/j.intimp.2020.107087_b1275) 2001; 2
Shaked (10.1016/j.intimp.2020.107087_b1030) 2015; 16
Kovalenko (10.1016/j.intimp.2020.107087_b0880) 2003; 424
Hacker (10.1016/j.intimp.2020.107087_b0980) 2011; 11
10.1016/j.intimp.2020.107087_b0065
Kumar (10.1016/j.intimp.2020.107087_b0345) 2020; 11
O'Neill (10.1016/j.intimp.2020.107087_b0610) 2008; 29
Zhan (10.1016/j.intimp.2020.107087_b1725) 2017; 23
Yao (10.1016/j.intimp.2020.107087_b1420) 2012; 22
Capili (10.1016/j.intimp.2020.107087_b1300) 2007; 17
Krivan (10.1016/j.intimp.2020.107087_b0350) 2019; 9
Wang (10.1016/j.intimp.2020.107087_b1325) 2020; 45
Bauerfeld (10.1016/j.intimp.2020.107087_b1380) 2012; 188
Garlanda (10.1016/j.intimp.2020.107087_b1555) 2004; 101
10.1016/j.intimp.2020.107087_b0855
Abulkhir (10.1016/j.intimp.2020.107087_b1595) 2016
Lee (10.1016/j.intimp.2020.107087_b1600) 2014; 111
Iwahana (10.1016/j.intimp.2020.107087_b1480) 2004; 1681
Bouchon (10.1016/j.intimp.2020.107087_b0555) 2001; 410
Kang (10.1016/j.intimp.2020.107087_b0770) 2007; 179
Qin (10.1016/j.intimp.2020.107087_b1570) 2005; 280
Silva (10.1016/j.intimp.2020.107087_b0025) 2013; 16
He (10.1016/j.intimp.2020.107087_b1070) 2016; 41
Hasan (10.1016/j.intimp.2020.107087_b1620) 2005; 174
Kumar (10.1016/j.intimp.2020.107087_b0210) 2019; 332
Reyskens (10.1016/j.intimp.2020.107087_b1105) 2016; 4
Yuen (10.1016/j.intimp.2020.107087_b0115) 2005
Galli (10.1016/j.intimp.2020.107087_b0150) 2011; 12
Brint (10.1016/j.intimp.2020.107087_b1485) 2004; 5
El-Zayat (10.1016/j.intimp.2020.107087_b0415) 2019; 43
Park (10.1016/j.intimp.2020.107087_b0755) 2017; 7
Xiao (10.1016/j.intimp.2020.107087_b1550) 2007; 26
Shi (10.1016/j.intimp.2020.107087_b1240) 2008; 9
Kumar (10.1016/j.intimp.2020.107087_b1425) 2011; 186
Zhang (10.1016/j.intimp.2020.107087_b0285) 2014; 121
Gareau (10.1016/j.intimp.2020.107087_b1305) 2010; 11
Carty (10.1016/j.intimp.2020.107087_b0465) 2019; 50
Nguyen (10.1016/j.intimp.2020.107087_b1815) 2020; 16
Malakhov (10.1016/j.intimp.2020.107087_b0940) 2002; 277
Honke (10.1016/j.intimp.2020.107087_b0945) 2011; 13
Li (10.1016/j.intimp.2020.107087_b1245) 2011; 108
Guan (10.1016/j.intimp.2020.107087_b1605) 2010; 184
Steiger (10.1016/j.intimp.2020.107087_b0650) 2017; 199
Kolaczkowska (10.1016/j.intimp.2020.107087_b0155) 2013; 13
Yoshida (10.1016/j.intimp.2020.107087_b0870) 2005; 280
Hawn (10.1016/j.intimp.2020.107087_b0405) 2003; 198
Meissner (10.1016/j.intimp.2020.107087_b1400) 2012; 14
Yanagisawa (10.1016/j.intimp.2020.107087_b1475) 1993; 318
Saijo (10.1016/j.intimp.2020.107087_b1040) 2009; 137
Vallenius (10.1016/j.intimp.2020.107087_b1225) 2000; 275
Trompouki (10.1016/j.intimp.2020.107087_b0885) 2003; 424
Rebl (10.1016/j.intimp.2020.107087_b1440) 2017; 67
Wang (10.1016/j.intimp.2020.107087_b1715) 2019; 98
Liu (10.1016/j.intimp.2020.107087_b1315) 2013; 9
Bergers (10.1016/j.intimp.2020.107087_b1470) 1994; 13
Maitra (10.1016/j.intimp.2020.107087_b0695) 2011; 186
Lee (10.1016/j.intimp.2020.107087_b0905) 2016; 113
Yang (10.1016/j.intimp.2020.107087_b0965) 2015; 5
MacKenzie (10.1016/j.intimp.2020.107087_b1120) 2013; 33
Sharif (10.1016/j.intimp.2020.107087_b0605) 2006; 203
Ragab (10.1016/j.intimp.2020.107087_b0095) 2020; 11
Kerscher (10.1016/j.intimp.2020.107087_b1295) 2006; 22
Song (10.1016/j.intimp.2020.107087_b0685) 2011; 15
Sweet (10.1016/j.intimp.2020.107087_b1515) 2001; 166
Tisoncik (10.1016/j.intimp.2020.107087_b0120) 2012; 76
Tian (10.1016/j.intimp.2020.107087_b1845) 2007; 8
Xu (10.1016/j.intimp.2020.107087_b0875) 2004; 279
Hai (10.1016/j.intimp.2020.107087_b1640) 2001; 273
Li (10.1016/j.intimp.2020.107087_b0995) 2010; 285
Oosting (10.1016/j.intimp.2020.107087_b1630) 2014; 111
Li (10.1016/j.intimp.2020.107087_b1740) 2015; 112
Ke (10.1016/j.intimp.2020.107087_b1775) 2013; 57
Zhou (10.1016/j.intimp.2020.107087_b0435) 2015; 10
Areschoug (10.1016/j.intimp.2020.107087_b0195) 2008; 15
Li (10.1016/j.intimp.2020.107087_b0245) 2020; 11
Bernstock (10.1016/j.intimp.2020.107087_b1350) 2018; 32
Chin (10.1016/j.intimp.2020.107087_b1140) 1999; 19
An (10.1016/j.intimp.2020.107087_b0715) 2008; 9
Palsson-McDermott (10.1016/j.intimp.2020.107087_b0425) 2009; 10
Brint (10.1016/j.intimp.2020.107087_b1490) 2002; 277
Abreu (10.1016/j.intimp.2020.107087_b0295) 2010; 10
Garlanda (10.1016/j.intimp.2020.107087_b1590) 2007; 179
Fleischmann (10.1016/j.intimp.2020.107087_b0005) 2016; 193
Cao (10.1016/j.intimp.2020.107087_b0225) 2019; 10
Jennings (10.1016/j.intimp.2020.107087_b0780) 2009; 15
Tanaka (10.1016/j.intimp.2020.107087_b1190) 2007; 8
Bernstock (10.1016/j.intimp.2020.107087_b1355) 2018; 13
van der Meer (10.1016/j.intimp.2020.107087_b0600) 2014; 123
Shin (10.1016/j.intimp.2020.107087_b1210) 2017; 7
Zhang (10.1016/j.intimp.2020.107087_b0505) 2015; 93
Kowalski (10.1016/j.intimp.2020.107087_b0700) 2017; 8
Diao (10.1016/j.intimp.2020.107087_b0690) 2016; 6
Nisole (10.1016/j.intimp.2020.107087_b1230) 2005; 3
Chousterman (10.1016/j.intimp.2020.107087_b0080) 2017; 39
Yang (10.1016/j.intimp.2020.107087_b1780) 2020; 118
Vermeulen (10.1016/j.intimp.2020.107087_b1090) 2003; 22
Zhou (10.1016/j.intimp.2020.107087_b0730) 2010; 87
Li (10.1016/j.intimp.2020.107087_b1020) 2016; 13
Kraft (10.1016/j.intimp.2020.107087_b0440) 2015; 43
Shuto (10.1016/j.intimp.2020.107087_b0910) 2001; 98
Lu (10.1016/j.intimp.2020.107087_b1270) 2020; 115
Linger (10.1016/j.intimp.2020.107087_b0580) 2008; 100
Loughran (10.1016/j.intimp.2020.107087_b1160) 2005; 16
Bakopoulos (10.1016/j.intimp.2020.107087_b0290) 2017; 12
Carty (10.1016/j.intimp.2020.107087_b0445) 2006; 7
Gong (10.1016/j.intimp.2020.107087_b0460) 2016; 39
Dong (10.1016/j.intimp.2020.107087_b0660) 2013; 36
González-Navajas (10.1016/j.intimp.2020.107087_b0990) 2010; 207
Liew (10.1016/j.intimp.2020.107087_b0420) 2005; 5
Rothe (10.1016/j.intimp.2020.107087_b1135) 1996; 93
Xia (10.1016/j.intimp.2020.107087_b1360) 2011; 34
Finfer (10.1016/j.intimp.2020.107087_b0015) 2016; 193
Zhang (10.1016/j.intimp.2020.107087_b0485) 2020; 18
Farber (10.1016/j.intimp.2020.107087_b1650) 1992; 12
Whitmore (10.1016/j.intimp.2020.107087_b1660) 2007; 179
Li (10.1016/j.intimp.2020.107087_b0680) 2004; 41
Kawagoe (10.1016/j.intimp.2020.107087_b1145) 2009; 10
Abu-Dayyeh (10.1016/j.intimp.2020.107087_b0720) 2008; 2
Chen (10.1016/j.intimp.2020.107087_b0705) 2017; 6
Kondo (10.1016/j.intimp.2020.107087_b0430) 2012; 33
Pasupuleti (10.1016/j.intimp.2020.107087_b0170) 2012; 32
Zhou (10.1016/j.intimp.2020.107087_b0745) 2016; 17
Yang (10.1016/j.intimp.2020.107087_b1345) 2018
Danai (10.1016/j.intimp.2020.107087_b0030) 2006; 129
Kumar (10.1016/j.intimp.2020.107087_b0050) 2020
de Oliveira (10.1016/j.intimp.2020.107087_b0160) 2016; 16
Kim (10.1016/j.intimp.2020.107087_b1115) 2008; 9
Karki (10.1016/j.intimp.2020.107087_b1375) 20
References_xml – volume: 5
  start-page: 12738
  year: 2015
  ident: b0965
  article-title: USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms
  publication-title: Sci Rep
– volume: 40
  start-page: 1738
  year: 2010
  end-page: 1747
  ident: b0455
  article-title: SARM inhibits both TRIF- and MyD88-mediated AP-1 activation
  publication-title: Eur J Immunol
– volume: 112
  start-page: 2497
  year: 2015
  end-page: 2502
  ident: b1740
  article-title: Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8
  publication-title: Proc Natl Acad Sci U S A
– volume: 104
  start-page: 114
  year: 2018
  end-page: 123
  ident: b1820
  article-title: DAMP-TLR-cytokine axis dictates the fate of tumor
  publication-title: Cytokine
– volume: 12
  year: 2017
  ident: b0290
  article-title: Expression of Toll-like receptors (TLRs) in the lungs of an experimental sepsis mouse model
  publication-title: PLOS ONE
– reference: V. Francois-Newton, G. Magno de Freitas Almeida, B. Payelle-Brogard, D. Monneron, L. Pichard-Garcia, J. Piehler, S. Pellegrini, G. Uze, USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon alpha response, PLoS One 6(7) (2011) e22200.
– volume: 5
  start-page: 495
  year: 2004
  end-page: 502
  ident: b1255
  article-title: Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
  publication-title: Nat Immunol
– volume: 72
  start-page: 182
  year: 2007
  end-page: 192
  ident: b1545
  article-title: Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells
  publication-title: Kidney Int
– volume: 57
  start-page: 1203
  year: 2013
  end-page: 1214
  ident: b1775
  article-title: beta-catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury
  publication-title: Hepatology
– volume: 29
  start-page: 12
  year: 2008
  end-page: 20
  ident: b0610
  article-title: When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction
  publication-title: Immunity
– volume: 5
  start-page: 373
  year: 2004
  end-page: 379
  ident: b1485
  article-title: ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
  publication-title: Nat Immunol
– volume: 111
  start-page: E4478
  year: 2014
  end-page: E4484
  ident: b1630
  article-title: Human TLR10 is an anti-inflammatory pattern-recognition receptor
  publication-title: Proceedings of the National Academy of Sciences
– volume: 12
  start-page: 742
  year: 2011
  end-page: 751
  ident: b1060
  article-title: The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors
  publication-title: Nat Immunol
– volume: 92
  start-page: 145
  year: 2007
  end-page: 157
  ident: b1810
  article-title: Innate immunity: toll-like receptors and some more
  publication-title: A brief history, basic organization and relevance for the human newborn, Neonatology
– volume: 16
  year: 2020
  ident: b1815
  article-title: TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes
  publication-title: PLOS Pathogens
– year: 2017
  ident: b1635
  article-title: TLR10 suppresses the activation and differentiation of monocytes with effects on DC-mediated adaptive immune responses
  publication-title: Journal of Leukocyte Biology
– volume: 9
  start-page: 2112
  year: 2014
  end-page: 2123
  ident: b1790
  article-title: Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions
  publication-title: Cell Rep
– volume: 185
  start-page: 1681
  year: 2010
  end-page: 1691
  ident: b1405
  article-title: NLRC5 limits the activation of inflammatory pathways
  publication-title: J Immunol
– volume: 33
  start-page: 522
  year: 2012
  end-page: 530
  ident: b1745
  article-title: Targeting of TAK1 in inflammatory disorders and cancer
  publication-title: Trends Pharmacol Sci
– volume: 202
  start-page: 363
  year: 2005
  end-page: 369
  ident: b0550
  article-title: DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
  publication-title: J Exp Med
– volume: 22
  start-page: 822
  year: 2012
  end-page: 835
  ident: b1415
  article-title: Enhanced TLR-induced NF-kappaB signaling and type I interferon responses in NLRC5 deficient mice
  publication-title: Cell Res
– volume: 157
  start-page: 4277
  year: 1996
  end-page: 4281
  ident: b1290
  article-title: Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin
  publication-title: J Immunol
– volume: 2
  year: 2008
  ident: b0720
  article-title: Leishmania-Induced IRAK-1 Inactivation Is Mediated by SHP-1 Interacting with an Evolutionarily Conserved KTIM Motif
  publication-title: PLOS Neglected Tropical Diseases
– volume: 277
  start-page: 9976
  year: 2002
  end-page: 9981
  ident: b0940
  article-title: UBP43 (USP18) specifically removes ISG15 from conjugated proteins
  publication-title: J Biol Chem
– volume: 279
  start-page: 36171
  year: 2004
  end-page: 36174
  ident: b0900
  article-title: NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway
  publication-title: J Biol Chem
– volume: 19
  start-page: 6665
  year: 1999
  end-page: 6672
  ident: b1140
  article-title: TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway
  publication-title: Mol Cell Biol
– volume: 398
  start-page: 80
  year: 1999
  end-page: 84
  ident: b0865
  article-title: DREAM is a Ca2+-regulated transcriptional repressor
  publication-title: Nature
– volume: 111
  start-page: 173
  year: 2004
  end-page: 178
  ident: b0230
  article-title: Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria
  publication-title: Immunology
– volume: 157
  start-page: 23
  year: 2014
  end-page: 37
  ident: b0135
  article-title: Innate lymphoid cells: new paradigm in immunology of inflammation
  publication-title: Immunol Lett
– volume: 303
  start-page: 2495
  year: 2010
  end-page: 2503
  ident: b0060
  article-title: Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis
  publication-title: Jama
– volume: 19
  start-page: 5114
  year: 2000
  end-page: 5122
  ident: b0570
  article-title: p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction
  publication-title: Embo j
– volume: 5
  year: 2014
  ident: b0800
  article-title: Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge
  publication-title: Cell Death Dis
– volume: 38
  start-page: 119
  year: 2013
  end-page: 130
  ident: b1865
  article-title: Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii
  publication-title: Immunity
– volume: 309
  start-page: 1154
  year: 2013
  end-page: 1162
  ident: b1760
  article-title: Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial
  publication-title: Jama
– volume: 15
  start-page: 45
  year: 2008
  end-page: 60
  ident: b0195
  article-title: Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands
  publication-title: Contrib Microbiol
– volume: 179
  start-page: 4598
  year: 2007
  end-page: 4607
  ident: b0770
  article-title: Calcineurin negatively regulates TLR-mediated activation pathways
  publication-title: J Immunol
– volume: 13
  start-page: 51
  year: 2011
  end-page: 57
  ident: b0945
  article-title: Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus
  publication-title: Nat Immunol
– volume: 4
  year: 2016
  ident: b1075
  article-title: Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2
  publication-title: Frontiers in Cell and Developmental Biology
– volume: 21
  start-page: 291
  year: 2017
  end-page: 304
  ident: b1010
  article-title: The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases
  publication-title: Expert Opin Ther Targets
– volume: 33
  start-page: 449
  year: 2012
  end-page: 458
  ident: b0430
  article-title: Dissecting negative regulation of Toll-like receptor signaling
  publication-title: Trends Immunol
– volume: 43
  start-page: 187
  year: 2019
  ident: b0415
  article-title: Toll-like receptors activation, signaling, and targeting: an overview
  publication-title: Bulletin of the National Research Centre
– volume: 43
  start-page: 359
  year: 2008
  end-page: 367
  ident: b0975
  article-title: Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling
  publication-title: Cytokine
– volume: 131
  start-page: 1124
  year: 2007
  end-page: 1136
  ident: b0590
  article-title: TAM receptors are pleiotropic inhibitors of the innate immune response
  publication-title: Cell
– volume: 108
  start-page: 17093
  year: 2011
  end-page: 17098
  ident: b1155
  article-title: The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling
  publication-title: Proc Natl Acad Sci U S A
– volume: 540
  start-page: 583
  year: 2016
  end-page: 587
  ident: b1375
  article-title: NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer
  publication-title: Nature
– volume: 118
  start-page: 153
  year: 2020
  end-page: 164
  ident: b1780
  article-title: TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling
  publication-title: Mol Immunol
– volume: 184
  start-page: 5802
  year: 2010
  end-page: 5808
  ident: b1495
  article-title: ST2 negatively regulates TLR2 signaling, but is not required for bacterial lipoprotein-induced tolerance
  publication-title: J Immunol
– volume: 20
  start-page: 672
  year: 2008
  end-page: 683
  ident: b0185
  article-title: Innate immunity in sepsis pathogenesis and its modulation: new immunomodulatory targets revealed
  publication-title: J Chemother
– volume: 2
  start-page: 202
  year: 2001
  end-page: 210
  ident: b1275
  article-title: SUMO, ubiquitin's mysterious cousin
  publication-title: Nat Rev Mol Cell Biol
– volume: 179
  start-page: 3622
  year: 2007
  end-page: 3630
  ident: b1660
  article-title: Negative regulation of TLR-signaling pathways by activating transcription factor-3
  publication-title: J Immunol
– volume: 10
  start-page: 773
  year: 1998
  end-page: 780
  ident: b1505
  article-title: Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo
  publication-title: Cytokine
– volume: 9
  year: 2018
  ident: b1665
  article-title: ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection
  publication-title: Frontiers in Immunology
– volume: 67
  start-page: 139
  year: 2017
  end-page: 152
  ident: b1440
  article-title: ST2 from rainbow trout quenches TLR signalling, localises at the nuclear membrane and allows the nuclear translocation of MYD88
  publication-title: Developmental & Comparative Immunology
– volume: 188
  start-page: 2847
  year: 2012
  end-page: 2857
  ident: b1380
  article-title: TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages
  publication-title: J Immunol
– volume: 19
  start-page: 3029
  year: 1999
  end-page: 3038
  ident: b0935
  article-title: A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation
  publication-title: Mol Cell Biol
– volume: 29
  start-page: 1303
  year: 2001
  end-page: 1310
  ident: b0040
  article-title: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
  publication-title: Crit Care Med
– volume: 6
  start-page: 579
  year: 2005
  end-page: 586
  ident: b0530
  article-title: Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
  publication-title: Nat Immunol
– volume: 14
  start-page: 211
  year: 2003
  end-page: 218
  ident: b1560
  article-title: Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR
  publication-title: Eur Cytokine Netw
– volume: 277
  start-page: 49205
  year: 2002
  end-page: 49211
  ident: b1490
  article-title: Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
  publication-title: J Biol Chem
– volume: 131
  start-page: 6
  year: 2017
  ident: b0265
  article-title: Dendritic cell-intrinsic TLR signaling regulates polymicrobial sepsis
  publication-title: The Journal of Immunology 198(1 Supplement)
– volume: 11
  year: 2020
  ident: b0345
  article-title: Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury
  publication-title: Frontiers in Immunology
– volume: 26
  start-page: 461
  year: 2007
  end-page: 475
  ident: b1550
  article-title: The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis
  publication-title: Immunity
– volume: 434
  start-page: 243
  year: 2005
  end-page: 249
  ident: b0470
  article-title: Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
  publication-title: Nature
– volume: 11
  year: 2016
  ident: b0395
  article-title: Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms
  publication-title: PLOS ONE
– volume: 10
  start-page: 963
  year: 1996
  end-page: 973
  ident: b1130
  article-title: TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation
  publication-title: Genes Dev
– volume: 28
  start-page: 34
  year: 2009
  end-page: 47
  ident: b1095
  article-title: A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters
  publication-title: Embo j
– volume: 16
  start-page: 17344
  year: 2013
  ident: b0025
  article-title: Sepsis in AIDS patients: clinical, etiological and inflammatory characteristics
  publication-title: Journal of the International AIDS Society
– volume: 16
  start-page: 378
  year: 2016
  end-page: 391
  ident: b0160
  article-title: Neutrophil migration in infection and wound repair: going forward in reverse
  publication-title: Nat Rev Immunol
– volume: 1
  start-page: 440
  year: 2010
  end-page: 464
  ident: b0175
  article-title: Antimicrobial peptides: the ancient arm of the human immune system
  publication-title: Virulence
– volume: 13
  start-page: 711
  year: 2016
  end-page: 721
  ident: b0205
  article-title: Cellular and molecular regulation of innate inflammatory responses
  publication-title: Cell Mol Immunol
– volume: 201
  start-page: 333
  year: 2005
  end-page: 339
  ident: b0560
  article-title: Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling
  publication-title: J Exp Med
– volume: 39
  start-page: 688
  year: 2011
  end-page: 693
  ident: b1015
  article-title: Inflammation: a role for NR4A orphan nuclear receptors?
  publication-title: Biochemical Society transactions
– volume: 10
  start-page: 782
  year: 2019
  ident: b0225
  article-title: Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis
  publication-title: Cell Death & Disease
– volume: 4
  start-page: 499
  year: 2004
  end-page: 511
  ident: b0380
  article-title: Toll-like receptor signalling
  publication-title: Nat Rev Immunol
– volume: 67
  start-page: 318
  year: 2007
  end-page: 325
  ident: b1055
  article-title: Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor
  publication-title: Cancer Res
– volume: 186
  start-page: 994
  year: 2011
  end-page: 1000
  ident: b1425
  article-title: NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections
  publication-title: J Immunol
– volume: 8
  start-page: 584
  year: 2007
  end-page: 591
  ident: b1190
  article-title: PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit
  publication-title: Nat Immunol
– volume: 166
  start-page: 6633
  year: 2001
  end-page: 6639
  ident: b1515
  article-title: A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression
  publication-title: J Immunol
– volume: 32
  start-page: 1653
  year: 2018
  end-page: 1658
  ident: b0340
  article-title: The Relationship Between Sepsis-induced Immunosuppression and Serum Toll-like Receptor 9 Level
  publication-title: Vivo
– volume: 14
  start-page: 477
  year: 2012
  end-page: 484
  ident: b1400
  article-title: NLRC5: a newly discovered MHC class I transactivator (CITA)
  publication-title: Microbes and Infection / Institut Pasteur
– volume: 3
  start-page: 799
  year: 2005
  end-page: 808
  ident: b1230
  article-title: TRIM family proteins: retroviral restriction and antiviral defence
  publication-title: Nat Rev Microbiol
– volume: 30
  start-page: 639
  year: 2016
  end-page: 643
  ident: b0335
  article-title: Analysis of Toll-like Receptor 9 Gene Polymorphisms in Sepsis
  publication-title: Vivo
– volume: 85
  start-page: 481
  year: 2009
  end-page: 490
  ident: b1200
  article-title: Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB
  publication-title: J Leukoc Biol
– volume: 1518
  start-page: 157
  year: 2001
  end-page: 161
  ident: b1615
  article-title: Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells
  publication-title: Biochim Biophys Acta
– reference: K. V, Toll-like receptors in immunity and inflammatory diseases: Past, present, and future, Int Immunopharmacol 59 (2018) 391-412.
– volume: 102
  start-page: 15989
  year: 2005
  end-page: 15994
  ident: b0475
  article-title: Negative regulation of Toll-like-receptor signaling by IRF-4
  publication-title: Proc Natl Acad Sci U S A
– year: 2020
  ident: b0735
  article-title: SHP-1 ameliorates nonalcoholic steatohepatitis by inhibiting proinflammatory cytokine production
  publication-title: FEBS Lett
– volume: 12
  year: 2014
  ident: b1100
  article-title: Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock
  publication-title: PLoS Biol
– year: 2017
  ident: b1685
  article-title: The emerging role of interleukin-37 in cardiovascular diseases
  publication-title: Immun Inflamm Dis
– volume: 207
  start-page: 2799
  year: 2010
  end-page: 2807
  ident: b0990
  article-title: Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9–driven antiinflammatory cytokine production
  publication-title: The Journal of Experimental Medicine
– volume: 434
  start-page: 772
  year: 2005
  end-page: 777
  ident: b0450
  article-title: IRF-7 is the master regulator of type-I interferon-dependent immune responses
  publication-title: Nature
– volume: 101
  start-page: 11707
  year: 2004
  end-page: 11712
  ident: b1080
  article-title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases
  publication-title: Proc Natl Acad Sci U S A
– volume: 157
  start-page: 48
  year: 2016
  end-page: 60
  ident: b1005
  article-title: Nuclear receptor 4A (NR4A) family - orphans no more
  publication-title: J Steroid Biochem Mol Biol
– volume: 235
  start-page: 474
  year: 1997
  end-page: 478
  ident: b1510
  article-title: Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli
  publication-title: Biochem Biophys Res Commun
– volume: 303
  start-page: 1522
  year: 2004
  end-page: 1526
  ident: b0390
  article-title: A toll-like receptor that prevents infection by uropathogenic bacteria
  publication-title: Science
– volume: 22
  start-page: 2788
  year: 2003
  end-page: 2797
  ident: b1085
  article-title: MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
  publication-title: Embo j
– volume: 6
  start-page: 7229
  year: 2015
  ident: b1335
  article-title: Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure
  publication-title: Nat Commun
– volume: 10
  start-page: 1703
  year: 2014
  end-page: 1709
  ident: b1690
  article-title: Immunobiology of Interleukin-37: Mechanism of Action and Clinical Perspectives
  publication-title: Expert review of clinical immunology
– volume: 101
  start-page: 3522
  year: 2004
  end-page: 3526
  ident: b1555
  article-title: Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family
  publication-title: Proc Natl Acad Sci U S A
– volume: 98
  start-page: 8774
  year: 2001
  end-page: 8779
  ident: b0910
  article-title: Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells
  publication-title: Proc Natl Acad Sci U S A
– volume: 46
  start-page: 1067
  year: 2016
  end-page: 1081
  ident: b1735
  article-title: Suppression of innate inflammation and immunity by interleukin-37
  publication-title: Eur J Immunol
– volume: 39
  start-page: 2217
  year: 2013
  end-page: 2219
  ident: b0620
  article-title: A Janus role for MerTK in the outcome of septic shock
  publication-title: Intensive Care Medicine
– volume: 10
  start-page: 965
  year: 2009
  end-page: 972
  ident: b1145
  article-title: TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis
  publication-title: Nat Immunol
– volume: 30
  start-page: 383
  year: 2009
  end-page: 391
  ident: b1800
  article-title: The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
  publication-title: Trends Immunol
– volume: 18
  start-page: 10
  year: 2017
  ident: b1670
  article-title: Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury
  publication-title: BMC Nephrol
– volume: 121
  start-page: 1270
  year: 2014
  end-page: 1280
  ident: b0285
  article-title: Toll-like Receptor 4 Is Essential to Preserving Cardiac Function and Survival in Low-grade Polymicrobial Sepsis
  publication-title: Anesthesiology: The Journal of the American Society of Anesthesiologists
– volume: 274
  start-page: 330
  year: 2016
  end-page: 353
  ident: b0220
  article-title: The immune system's role in sepsis progression, resolution, and long-term outcome
  publication-title: Immunol Rev
– volume: 7
  start-page: 454
  year: 2007
  end-page: 465
  ident: b0595
  article-title: SOCS proteins, cytokine signalling and immune regulation
  publication-title: Nat Rev Immunol
– volume: 8
  start-page: 487
  year: 2007
  end-page: 496
  ident: b1845
  article-title: Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
  publication-title: Nat Immunol
– year: 2020
  ident: b0740
  article-title: SHP-1 suppresses the antiviral innate immune response by targeting TRAF3
  publication-title: Faseb j
– volume: 100
  start-page: 35
  year: 2008
  end-page: 83
  ident: b0580
  article-title: TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer
  publication-title: Adv Cancer Res
– volume: 36
  start-page: 1087
  year: 2013
  end-page: 1093
  ident: b0660
  article-title: Association Between Gene Polymorphisms of IRAK-M and the Susceptibility of Sepsis
  publication-title: Inflammation
– volume: 9
  year: 2014
  ident: b0365
  article-title: MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response
  publication-title: PloS one
– volume: 6
  year: 2017
  ident: b0705
  article-title: Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy
  publication-title: J Am Heart Assoc
– volume: 140
  start-page: 918
  year: 2010
  end-page: 934
  ident: b1035
  article-title: Mechanisms underlying inflammation in neurodegeneration
  publication-title: Cell
– volume: 275
  start-page: 11100
  year: 2000
  end-page: 11105
  ident: b1225
  article-title: CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4
  publication-title: J Biol Chem
– volume: 103
  start-page: 12487
  year: 2006
  end-page: 12492
  ident: b0375
  article-title: Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria
  publication-title: Proc Natl Acad Sci U S A
– volume: 199
  start-page: 1440
  year: 2017
  end-page: 1452
  ident: b0650
  article-title: Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis
  publication-title: J Immunol
– volume: 39
  start-page: 517
  year: 2017
  end-page: 528
  ident: b0080
  article-title: Cytokine storm and sepsis disease pathogenesis
  publication-title: Semin Immunopathol
– volume: 497
  start-page: 498
  year: 2013
  end-page: 502
  ident: b1770
  article-title: The TLR4 antagonist Eritoran protects mice from lethal influenza infection
  publication-title: Nature
– volume: 90
  start-page: 62
  year: 2014
  end-page: 72
  ident: b1125
  article-title: Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes
  publication-title: Biochem Pharmacol
– volume: 13
  start-page: 1042
  year: 2007
  end-page: 1049
  ident: b1785
  article-title: Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
  publication-title: Nat Med
– volume: 16
  start-page: 1228
  year: 2015
  end-page: 1234
  ident: b1030
  article-title: Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation
  publication-title: Nat Immunol
– volume: 190
  start-page: 5152
  year: 2013
  end-page: 5160
  ident: b0235
  article-title: Lipopolysaccharide clearance, bacterial clearance, and systemic inflammatory responses are regulated by cell type-specific functions of TLR4 during sepsis
  publication-title: J Immunol
– start-page: 1
  year: 2020
  end-page: 49
  ident: b0050
  article-title: Emerging Human Coronavirus Infections (SARS, MERS, and COVID-19): Where They Are Leading Us
  publication-title: International Reviews of Immunology
– volume: 93
  start-page: 1033
  year: 2015
  end-page: 1043
  ident: b0505
  article-title: TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses in myocardial ischemia/reperfusion injury
  publication-title: J Mol Med (Berl)
– volume: 110
  start-page: 191
  year: 2002
  end-page: 202
  ident: b0635
  article-title: IRAK-M is a negative regulator of Toll-like receptor signaling
  publication-title: Cell
– volume: 7
  start-page: 1074
  year: 2006
  end-page: 1081
  ident: b0445
  article-title: The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
  publication-title: Nat Immunol
– volume: 232
  start-page: 273
  year: 2009
  end-page: 285
  ident: b0565
  article-title: The roles of Dok family adapters in immunoreceptor signaling
  publication-title: Immunol Rev
– volume: 10
  start-page: 131
  year: 2010
  end-page: 144
  ident: b0295
  article-title: Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
  publication-title: Nat Rev Immunol
– volume: 39
  start-page: 1930
  year: 2016
  end-page: 1938
  ident: b0460
  article-title: Reduced Expression of SARM in Mouse Spleen during Polymicrobial Sepsis
  publication-title: Inflammation
– volume: 11
  start-page: 389
  year: 1999
  end-page: 399
  ident: b1540
  article-title: Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily
  publication-title: Cytokine
– volume: 179
  start-page: 3119
  year: 2007
  end-page: 3125
  ident: b1590
  article-title: Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling
  publication-title: J Immunol
– volume: 140
  start-page: 805
  year: 2010
  end-page: 820
  ident: b0200
  article-title: Pattern recognition receptors and inflammation
  publication-title: Cell
– volume: 18
  start-page: 622
  year: 2017
  end-page: 632
  ident: b1795
  article-title: S100-alarmin-induced innate immune programming protects newborn infants from sepsis
  publication-title: Nat Immunol
– volume: 19
  start-page: 469
  year: 1997
  end-page: 479
  ident: b1180
  article-title: PDZ domains: targeting signalling molecules to sub-membranous sites
  publication-title: Bioessays
– reference: C. Healthcare, P. Utilization, HCUP Facts and Figures, HCUP Facts and Figures, 2006: Statistics on Hospital-Based Care in the United States, Agency for Healthcare Research and Quality (US), Rockville (MD), 2008.
– volume: 273
  start-page: 11349
  year: 1998
  end-page: 11353
  ident: b1280
  article-title: Characterization of a second member of the sentrin family of ubiquitin-like proteins
  publication-title: J Biol Chem
– volume: 9
  start-page: 360
  year: 2010
  end-page: 361
  ident: b0090
  article-title: Calming the cytokine storm
  publication-title: Nature Reviews Drug Discovery
– volume: 13
  start-page: 159
  year: 2013
  end-page: 175
  ident: b0155
  article-title: Neutrophil recruitment and function in health and inflammation
  publication-title: Nat Rev Immunol
– volume: 11
  start-page: 457
  year: 2011
  end-page: 468
  ident: b0980
  article-title: Expanding TRAF function: TRAF3 as a tri-faced immune regulator
  publication-title: Nat Rev Immunol
– volume: 11
  start-page: 1014
  year: 2010
  end-page: 1022
  ident: b1705
  article-title: IL-37 is a fundamental inhibitor of innate immunity
  publication-title: Nat Immunol
– volume: 211
  start-page: 1025
  year: 2015
  end-page: 1040
  ident: b1430
  article-title: Reversible ubiquitination shapes NLRC5 function and modulates NF-kappaB activation switch
  publication-title: J Cell Biol
– volume: 20
  year: 2020
  ident: b1855
  article-title: TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics
  publication-title: Immune Netw
– volume: 18
  year: 2020
  ident: b0485
  article-title: Protective Effect of Metformin on Sepsis Myocarditis in Zebrafish
  publication-title: Dose-Response
– volume: 29
  start-page: 565
  year: 2008
  end-page: 577
  ident: b1390
  article-title: The TSC-mTOR signaling pathway regulates the innate inflammatory response
  publication-title: Immunity
– volume: 113
  start-page: E165
  year: 2016
  end-page: E171
  ident: b0905
  article-title: Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88
  publication-title: Proceedings of the National Academy of Sciences
– volume: 195
  start-page: 3515
  year: 2015
  end-page: 3519
  ident: b1025
  article-title: Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8+ T Cell Expansion and Effector Function through Direct Repression of Irf4
  publication-title: J Immunol
– volume: 10
  start-page: 579
  year: 2009
  end-page: 586
  ident: b0425
  article-title: TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway
  publication-title: Nat Immunol
– volume: 220
  start-page: 1008
  year: 2019
  end-page: 1018
  ident: b0500
  article-title: TIPE2 Suppresses Pseudomonas aeruginosa Keratitis by Inhibiting NF-κB Signaling and the Infiltration of Inflammatory Cells
  publication-title: J Infect Dis
– volume: 49
  start-page: 219
  year: 2011
  end-page: 226
  ident: b0510
  article-title: Expression of tumor necrosis factor-α induced protein 8 like-2 contributes to the immunosuppressive property of CD4(+)CD25(+) regulatory T cells in mice
  publication-title: Mol Immunol
– volume: 41
  start-page: 85
  year: 2004
  end-page: 92
  ident: b0680
  article-title: Characterization of Tollip protein upon Lipopolysaccharide challenge
  publication-title: Mol Immunol
– volume: 7
  start-page: 46097
  year: 2017
  ident: b1210
  article-title: MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-kappaB and negatively regulates inflammatory responses
  publication-title: Sci Rep
– volume: 19
  start-page: 515
  year: 2016
  end-page: 528
  ident: b1365
  article-title: NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses
  publication-title: Cell Host Microbe
– volume: 22
  start-page: 836
  year: 2012
  end-page: 847
  ident: b1420
  article-title: NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens
  publication-title: Cell Res
– year: 2017
  ident: b1250
  article-title: TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction
  publication-title: J Immunol
– volume: 10
  year: 2014
  ident: b1730
  article-title: IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis
  publication-title: PLoS Pathog
– volume: 38
  start-page: 1419
  year: 2016
  end-page: 1432
  ident: b0515
  article-title: Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression
  publication-title: Int J Mol Med
– volume: 17
  start-page: 25
  year: 2010
  end-page: 34
  ident: b0890
  article-title: CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes
  publication-title: Cell Death Differ
– volume: 11
  year: 2020
  ident: b0095
  article-title: The COVID-19 Cytokine Storm; What We Know So Far
  publication-title: Frontiers in Immunology
– reference: R. Salomão, P.S. Martins, M.K.C. Brunialti, M.d.L. Fernandes, L.S.W. Martos, M.E. Mendes, N.E. Gomes, O. Rigato, TLR SIGNALING PATHWAY IN PATIENTS WITH SEPSIS, Shock 30(7) (2008) 73-77.
– reference: C.M. Torio, B.J. Moore, National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2013: Statistical Brief #204, Healthcare Cost and Utilization Project (HCUP) Statistical Briefs, Agency for Healthcare Research and Quality (US), Rockville (MD), 2006.
– volume: 198
  start-page: 1563
  year: 2003
  end-page: 1572
  ident: b0405
  article-title: A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease
  publication-title: J Exp Med
– volume: 442
  start-page: 147
  year: 1999
  end-page: 150
  ident: b0830
  article-title: The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6
  publication-title: FEBS Lett
– volume: 22
  start-page: 1099
  year: 2012
  end-page: 1101
  ident: b1395
  article-title: NLRC5: a NOD-like receptor protein with many faces in immune regulation
  publication-title: Cell Research
– volume: 26
  start-page: 215
  year: 2007
  end-page: 226
  ident: b0270
  article-title: Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages
  publication-title: Immunity
– volume: 32
  start-page: 305
  year: 2010
  end-page: 315
  ident: b1825
  article-title: Intracellular Toll-like Receptors
  publication-title: Immunity
– volume: 13
  start-page: 823
  year: 2012
  end-page: 831
  ident: b1370
  article-title: The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-[kappa]B
  publication-title: Nat Immunol
– volume: 210
  start-page: 239
  year: 1998
  end-page: 245
  ident: b1175
  article-title: The human RIL gene: mapping to human chromosome 5q31.1, genomic organization and alternative transcripts
  publication-title: Gene
– volume: 72
  start-page: 3343
  year: 2015
  end-page: 3353
  ident: b0305
  article-title: Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance
  publication-title: Cell Mol Life Sci
– volume: 193
  start-page: 228
  year: 2016
  end-page: 230
  ident: b0015
  article-title: The Global Epidemiology of Sepsis. Does It Matter That We Know So Little?
  publication-title: Am J Respir Crit Care Med
– volume: 7
  start-page: 479
  year: 2011
  end-page: 494
  ident: b1765
  article-title: Eritoran tetrasodium (E5564) Treatment for Sepsis: Review of Preclinical and Clinical Studies
  publication-title: Expert opinion on drug metabolism & toxicology
– reference: A.J. Hoogendijk, M.I. Garcia-Laorden, L.A. van Vught, M.A. Wiewel, H. Belkasim-Bohoudi, J. Duitman, J. Horn, M.J. Schultz, B.P. Scicluna, C. van ‘t Veer, A.F. de Vos, T. van der Poll, Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types*, Critical care medicine 45(5) (2017) e524-e531.
– volume: 2
  start-page: 346
  year: 2000
  end-page: 351
  ident: b0665
  article-title: Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
  publication-title: Nat Cell Biol
– volume: 12
  start-page: 774
  year: 2012
  end-page: 785
  ident: b0810
  article-title: A20: linking a complex regulator of ubiquitylation to immunity and human disease
  publication-title: Nat Rev Immunol
– volume: 17
  start-page: 726
  year: 2007
  end-page: 735
  ident: b1300
  article-title: Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways
  publication-title: Curr Opin Struct Biol
– volume: 102
  start-page: 657
  year: 2017
  end-page: 675
  ident: b0710
  article-title: Shp1 function in myeloid cells
  publication-title: J Leukoc Biol
– volume: 15
  year: 2011
  ident: b0685
  article-title: Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population
  publication-title: Critical Care
– volume: 372
  start-page: 1
  year: 2018
  end-page: 11
  ident: b0310
  article-title: Recognizing conserved non-canonical localization patterns of toll-like receptors in tissues and across species
  publication-title: Cell Tissue Res
– volume: 424
  start-page: 793
  year: 2003
  end-page: 796
  ident: b0885
  article-title: CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
  publication-title: Nature
– volume: 318
  start-page: 83
  year: 1993
  end-page: 87
  ident: b1475
  article-title: Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1
  publication-title: FEBS Lett
– volume: 12
  start-page: 8
  year: 2014
  ident: b0765
  article-title: Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions
  publication-title: Cell Commun Signal
– volume: 13
  start-page: 971
  year: 1996
  end-page: 982
  ident: b1285
  article-title: PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia
  publication-title: Oncogene
– volume: 33
  start-page: 989
  year: 1996
  end-page: 998
  ident: b1645
  article-title: Identification of a lipopolysaccharide inducible transcription factor in murine macrophages
  publication-title: Mol Immunol
– volume: 9
  start-page: 369
  year: 2008
  end-page: 377
  ident: b1240
  article-title: TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation
  publication-title: Nat Immunol
– volume: 332
  start-page: 16
  year: 2019
  end-page: 30
  ident: b0210
  article-title: Toll-like receptors in the pathogenesis of neuroinflammation
  publication-title: Journal of Neuroimmunology
– volume: 304
  start-page: 1093
  year: 2003
  end-page: 1102
  ident: b1750
  article-title: Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist
  publication-title: J Pharmacol Exp Ther
– volume: 7
  start-page: ra119
  year: 2014
  ident: b1195
  article-title: HSP70 mediates degradation of the p65 subunit of nuclear factor kappaB to inhibit inflammatory signaling
  publication-title: Sci Signal
– volume: 141
  start-page: 483
  year: 2010
  end-page: 496
  ident: b1410
  article-title: NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
  publication-title: Cell
– volume: 26
  start-page: 42
  year: 2020
  ident: b0255
  article-title: Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?
  publication-title: Mol Med
– volume: 10
  year: 2015
  ident: b0435
  article-title: Interleukin-8 for Diagnosis of Neonatal Sepsis: A Meta-Analysis
  publication-title: PLOS ONE
– volume: 10
  start-page: 586
  year: 2019
  ident: b1265
  article-title: Inhibition of transmembrane TNF-α shedding by a specific antibody protects against septic shock
  publication-title: Cell Death & Disease
– volume: 184
  start-page: 5094
  year: 2010
  end-page: 5103
  ident: b1605
  article-title: Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling
  publication-title: The Journal of Immunology
– year: 2017
  ident: b0075
  article-title: Recognizing Sepsis as a Global Health Priority - A WHO Resolution
  publication-title: N Engl J Med
– volume: 42
  start-page: 942
  year: 2014
  end-page: 956
  ident: b0020
  article-title: International Nosocomial Infection Control Consortium (INICC) report, data summary of 43 countries for 2007–2012
  publication-title: Device-associated module, Am J Infect Control
– volume: 30
  start-page: 439
  year: 2009
  end-page: 446
  ident: b1575
  article-title: TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization
  publication-title: Trends Immunol
– volume: 5
  year: 2009
  ident: b1260
  article-title: The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
  publication-title: PLoS Pathog
– volume: 5
  year: 2005
  ident: b0675
  article-title: Negative regulation of toll-like receptor-mediated immune responses
  publication-title: Nat Rev Immunol
– volume: 129
  start-page: 1432
  year: 2006
  end-page: 1440
  ident: b0030
  article-title: The epidemiology of sepsis in patients with malignancy
  publication-title: Chest
– volume: 5
  start-page: 446
  year: 2005
  end-page: 458
  ident: b0420
  article-title: Negative regulation of toll-like receptor-mediated immune responses
  publication-title: Nature reviews. Immunology
– volume: 31
  start-page: 17
  year: 2016
  end-page: 24
  ident: b1065
  article-title: Small Heterodimer Partner and Innate Immune Regulation
  publication-title: Endocrinology and Metabolism
– volume: 23
  start-page: 83
  year: 2017
  end-page: 91
  ident: b1725
  article-title: IL-37 Suppresses MyD88-mediated Inflammatory Responses in Human Aortic Valve Interstitial Cells
  publication-title: Molecular Medicine
– volume: 17
  start-page: 1128
  year: 2016
  end-page: 1140
  ident: b1835
  article-title: HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia
  publication-title: Cell Rep
– year: 2020
  ident: b0100
  article-title: Is a “Cytokine Storm” Relevant to COVID-19?, JAMA
  publication-title: Internal Medicine
– volume: 7
  year: 2012
  ident: b0360
  article-title: TLR2, TLR4 and the MYD88 Signaling Pathway Are Crucial for Neutrophil Migration in Acute Kidney Injury Induced by Sepsis
  publication-title: PLOS ONE
– volume: 9
  start-page: 2481
  year: 2010
  end-page: 2482
  ident: b0845
  article-title: A20 inhibition of NFkappaB and inflammation: targeting E2:E3 ubiquitin enzyme complexes
  publication-title: Cell Cycle
– year: 2016
  ident: b1595
  article-title: A protective role of IL-37 in cancer: a new hope for cancer patients
  publication-title: Journal of leukocyte biology
– volume: 10
  start-page: 203
  year: 2018
  ident: b0315
  article-title: Toll-Like Receptors: Regulators of the Immune Response in the Human Gut
  publication-title: Nutrients
– volume: 17
  start-page: 205
  year: 2012
  end-page: 209
  ident: b1525
  article-title: Soluble ST2 levels in patients with cardiogenic and septic shock are not predictors of mortality
  publication-title: Experimental & Clinical Cardiology
– volume: 1
  start-page: 135
  year: 1989
  end-page: 146
  ident: b1445
  article-title: Establishment of IL-5-dependent early B cell lines by long-term bone marrow cultures
  publication-title: Growth Factors
– volume: 191
  start-page: 4818
  year: 2013
  end-page: 4827
  ident: b1860
  article-title: Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin
  publication-title: J Immunol
– volume: 177
  start-page: 548
  year: 2006
  end-page: 556
  ident: b1585
  article-title: SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling
  publication-title: J Immunol
– volume: 111
  start-page: 3793
  year: 2014
  end-page: 3798
  ident: b1600
  article-title: Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection
  publication-title: Proc Natl Acad Sci U S A
– volume: 14
  start-page: 52
  year: 2013
  end-page: 57
  ident: b1625
  article-title: Variation in the TLR10/TLR1/TLR6 Locus is the Major Genetic Determinant of Inter-Individual Difference in TLR1/2-Mediated Responses
  publication-title: Genes and immunity
– volume: 441
  start-page: 173
  year: 2006
  end-page: 178
  ident: b1655
  article-title: Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
  publication-title: Nature
– volume: 22
  start-page: 1313
  year: 2003
  end-page: 1324
  ident: b1090
  article-title: Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
  publication-title: Embo j
– volume: 174
  start-page: 2942
  year: 2005
  end-page: 2950
  ident: b1620
  article-title: Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88
  publication-title: J Immunol
– volume: 49
  start-page: 740
  year: 2018
  end-page: 753.e7
  ident: b0250
  article-title: The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis
  publication-title: Immunity
– volume: 20
  start-page: 5479
  year: 2000
  end-page: 5489
  ident: b0790
  article-title: Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
  publication-title: Mol Cell Biol
– volume: 280
  start-page: 25233
  year: 2005
  end-page: 25241
  ident: b1570
  article-title: SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms
  publication-title: J Biol Chem
– volume: 36
  start-page: 57
  year: 2017
  end-page: 73
  ident: b1830
  article-title: Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells
  publication-title: International Reviews of Immunology
– volume: 22
  start-page: 159
  year: 2006
  end-page: 180
  ident: b1295
  article-title: Modification of proteins by ubiquitin and ubiquitin-like proteins
  publication-title: Annu Rev Cell Dev Biol
– volume: 12
  start-page: 11
  year: 2014
  end-page: 20
  ident: b0410
  article-title: Innate Lymphoid Cells: Immunoregulatory Cells of Mucosal Inflammation
  publication-title: European Journal of Inflammation
– volume: 16
  start-page: 876
  year: 2020
  end-page: 886
  ident: b1050
  article-title: PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
  publication-title: Nat Chem Biol
– volume: 10
  start-page: 10755
  year: 2020
  ident: b1045
  article-title: Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation
  publication-title: Sci Rep
– volume: 291
  start-page: 22650
  year: 2016
  end-page: 22660
  ident: b0495
  article-title: TIPE2 (Tumor Necrosis Factor alpha-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal
  publication-title: J Biol Chem
– volume: 203
  start-page: 1891
  year: 2006
  end-page: 1901
  ident: b0605
  article-title: Twist mediates suppression of inflammation by type I IFNs and Axl
  publication-title: J Exp Med
– volume: 25
  start-page: 919
  year: 2006
  end-page: 928
  ident: b0750
  article-title: SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production
  publication-title: Immunity
– volume: 39
  start-page: 1086
  year: 2011
  end-page: 1091
  ident: b1805
  article-title: Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease
  publication-title: Biochem Soc Trans
– volume: 10
  start-page: 482
  year: 2019
  ident: b1850
  article-title: TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection
  publication-title: Front Immunol
– volume: 279
  start-page: 6629
  year: 2004
  end-page: 6634
  ident: b0640
  article-title: Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages
  publication-title: J Biol Chem
– volume: 17
  start-page: 397
  year: 2016
  end-page: 405
  ident: b0745
  article-title: The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3
  publication-title: Nat Immunol
– volume: 79
  year: 2020
  ident: b0525
  article-title: Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation
  publication-title: Int Immunopharmacol
– volume: 33
  start-page: 355
  year: 2015
  end-page: 391
  ident: b0585
  article-title: TAM receptor signaling in immune homeostasis
  publication-title: Annu Rev Immunol
– volume: 11
  start-page: 275
  year: 2011
  end-page: 288
  ident: b0190
  article-title: Immunity to fungal infections
  publication-title: Nat Rev Immunol
– volume: 78
  start-page: 399
  year: 2009
  end-page: 434
  ident: b1215
  article-title: RING domain E3 ubiquitin ligases
  publication-title: Annu Rev Biochem
– volume: 279
  start-page: 17278
  year: 2004
  end-page: 17282
  ident: b0875
  article-title: TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis
  publication-title: J Biol Chem
– volume: 287
  start-page: 4883
  year: 2012
  end-page: 4893
  ident: b0960
  article-title: Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus
  publication-title: J Biol Chem
– volume: 15
  start-page: 1586
  year: 2018
  end-page: 1593
  ident: b0655
  article-title: Interleukin-1 receptor-associated kinase 3 downregulation in peripheral blood mononuclear cells attenuates immunosuppression in sepsis
  publication-title: Exp Ther Med
– volume: 2
  year: 2012
  ident: b0045
  article-title: Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality
  publication-title: Journal of Global Health
– reference: N.R. London, W. Zhu, F.A. Bozza, M.C. Smith, D.M. Greif, L.K. Sorensen, L. Chen, Y. Kaminoh, A.C. Chan, S.F. Passi, Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza, Science translational medicine 2(23) (2010) 23ra19-23ra19.
– volume: 424
  start-page: 801
  year: 2003
  end-page: 805
  ident: b0880
  article-title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
  publication-title: Nature
– volume: 88
  year: 2020
  ident: b0055
  article-title: Understanding the complexities of SARS-CoV2 infection and its immunology: A road to immune-based therapeutics
  publication-title: Int Immunopharmacol
– volume: 289
  start-page: 2350
  year: 2000
  end-page: 2354
  ident: b0825
  article-title: Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
  publication-title: Science
– volume: 13
  year: 2018
  ident: b0280
  article-title: Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation
  publication-title: PLOS ONE
– volume: 277
  start-page: 7059
  year: 2002
  end-page: 7065
  ident: b0670
  article-title: Negative regulation of toll-like receptor-mediated signaling by Tollip
  publication-title: J Biol Chem
– volume: 9
  start-page: 43
  year: 2010
  end-page: 56
  ident: b0180
  article-title: Therapeutic potential of complement modulation
  publication-title: Nat Rev Drug Discov
– volume: 6
  start-page: ra72
  year: 2013
  ident: b0540
  article-title: A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages
  publication-title: Sci Signal
– year: 2015
  ident: b1435
  article-title: A feedforward loop of NLRC5 (de)ubiquitination keeps IKK–NF-κB in check
  publication-title: The Journal of Cell Biology
– volume: 32
  start-page: 143
  year: 2012
  end-page: 171
  ident: b0170
  article-title: Antimicrobial peptides: key components of the innate immune system
  publication-title: Crit Rev Biotechnol
– volume: 13
  start-page: 1176
  year: 1994
  end-page: 1188
  ident: b1470
  article-title: Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor
  publication-title: Embo j
– volume: 10
  start-page: 365
  year: 2010
  end-page: 376
  ident: b1330
  article-title: Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
  publication-title: Nat Rev Immunol
– volume: 8
  start-page: 849
  year: 2008
  end-page: 860
  ident: b1235
  article-title: TRIM family proteins and their emerging roles in innate immunity
  publication-title: Nature reviews. Immunology
– volume: 285
  start-page: 4291
  year: 2010
  end-page: 4297
  ident: b0995
  article-title: Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6
  publication-title: The Journal of biological chemistry
– volume: 17
  start-page: 140
  year: 2016
  end-page: 149
  ident: b1320
  article-title: Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing
  publication-title: Nat Immunol
– volume: 36
  start-page: 630
  year: 2010
  end-page: 637
  ident: b1520
  article-title: Soluble ST2 plasma concentrations predict mortality in severe sepsis
  publication-title: Intensive Care Medicine
– volume: 5
  start-page: 18327
  year: 2015
  ident: b1220
  article-title: PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm
  publication-title: Scientific Reports
– volume: 186
  start-page: 4467
  year: 2011
  end-page: 4473
  ident: b0695
  article-title: Low-dose endotoxin induces inflammation by selectively removing nuclear receptors and activating CCAAT/enhancer-binding protein delta
  publication-title: J Immunol
– volume: 186
  start-page: 1234
  year: 2016
  end-page: 1244
  ident: b0805
  article-title: Protein Tyrosine Phosphatase-1B Negatively Impacts Host Defense against Pseudomonas aeruginosa Infection
  publication-title: Am J Pathol
– year: 2018
  ident: b1345
  article-title: Small molecular inhibitors targeting protein SUMOylation as novel anticancer compounds
  publication-title: Molecular Pharmacology
– reference: T.A.M. Claushuis, A.I.P. Van Der Veen, J. Horn, M.J. Schultz, R.H. Houtkooper, C. Van ’T Veer, T. Van Der Poll, Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis, Platelets 30(3) (2019) 296-304.
– volume: 80
  start-page: 1483
  year: 2000
  end-page: 1521
  ident: b0760
  article-title: Calcineurin: form and function
  publication-title: Physiol Rev
– volume: 133
  start-page: 415
  year: 2008
  end-page: 426
  ident: b0490
  article-title: TIPE2, a novel negative regulator of innate and adaptive immunity that maintains immune homeostasis
  publication-title: Cell
– volume: 7
  year: 2016
  ident: b0955
  article-title: Multiple functions of USP18
  publication-title: Cell Death Dis
– volume: 283
  start-page: 3618
  year: 2008
  end-page: 3627
  ident: b0625
  article-title: Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation
  publication-title: J Biol Chem
– volume: 27
  start-page: 161
  year: 2020
  end-page: 175
  ident: b0920
  article-title: RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
  publication-title: Cell Death & Differentiation
– volume: 16
  start-page: 73
  year: 2015
  ident: b1535
  article-title: SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells
  publication-title: BMC Immunol
– volume: 76
  start-page: 16
  year: 2012
  end-page: 32
  ident: b0120
  article-title: Into the eye of the cytokine storm
  publication-title: Microbiol Mol Biol Rev
– volume: 15
  start-page: 239
  year: 2014
  end-page: 247
  ident: b0860
  article-title: The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation
  publication-title: Nature immunology
– volume: 2013
  year: 2013
  ident: b1675
  article-title: ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression
  publication-title: Evid Based Complement Alternat Med
– volume: 32
  start-page: 1677
  year: 2018
  end-page: 1691
  ident: b1350
  article-title: Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2
  publication-title: Faseb j
– volume: 34
  start-page: 843
  year: 2011
  end-page: 853
  ident: b1360
  article-title: NLRX1 negatively regulates TLR-induced NF-kappaB signaling by targeting TRAF6 and IKK
  publication-title: Immunity
– reference: K. Bulek, S. Swaidani, J. Qin, Y. Lu, M.F. Gulen, T. Herjan, B. Min, R.A. Kastelein, M. Aronica, M. Kosz-Vnenchak, X. Li, The essential role of SIGIRR/TIR8 in regulation of Th2 immune response, Journal of immunology (Baltimore, Md. : 1950) 182(5) (2009) 2601-2609.
– volume: 18
  start-page: 839
  year: 2016
  end-page: 850
  ident: b1840
  article-title: Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL
  publication-title: Nat Cell Biol
– volume: 7
  start-page: 6807
  year: 2017
  ident: b0755
  article-title: Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β
  publication-title: Scientific Reports
– volume: 33
  start-page: 1456
  year: 2013
  end-page: 1467
  ident: b1120
  article-title: MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop
  publication-title: Mol Cell Biol
– volume: 2
  start-page: 233
  year: 1998
  end-page: 239
  ident: b1310
  article-title: SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation
  publication-title: Mol Cell
– volume: 9
  year: 2013
  ident: b1315
  article-title: Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6
  publication-title: PLoS Pathog
– volume: 12
  start-page: 1035
  year: 2011
  end-page: 1044
  ident: b0150
  article-title: Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
  publication-title: Nat Immunol
– volume: 318
  start-page: E1004
  year: 2020
  end-page: E1013
  ident: b0275
  article-title: GRP94 regulates M1 macrophage polarization and insulin resistance
  publication-title: Am J Physiol Endocrinol Metab
– volume: 145
  start-page: 1471
  year: 1999
  end-page: 1482
  ident: b0820
  article-title: The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN
  publication-title: The Journal of cell biology
– volume: 13
  start-page: 415
  year: 2018
  end-page: 416
  ident: b1355
  article-title: Drugging SUMOylation for neuroprotection and oncotherapy
  publication-title: Neural Regen Res
– volume: 83
  start-page: 258
  year: 2005
  end-page: 266
  ident: b1460
  article-title: Modulation of Toll-interleukin 1 receptor mediated signaling
  publication-title: J Mol Med (Berl)
– volume: 6
  year: 2011
  ident: b1500
  article-title: In Silico Approach to Inhibition of Signaling Pathways of Toll-Like Receptors 2 and 4 by ST2L
  publication-title: PLOS ONE
– volume: 43
  start-page: 1779
  year: 2015
  end-page: 1781
  ident: b0035
  article-title: HIV-infection and severe sepsis: a bitter pill to swallow
  publication-title: Critical care medicine
– volume: 280
  start-page: 41111
  year: 2005
  end-page: 41121
  ident: b0870
  article-title: The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7
  publication-title: J Biol Chem
– volume: 10
  start-page: 2247
  year: 2008
  end-page: 2256
  ident: b0895
  article-title: CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia
  publication-title: Cell Microbiol
– volume: 14
  start-page: 857
  year: 2015
  end-page: 877
  ident: b0165
  article-title: Complement, a target for therapy in inflammatory and degenerative diseases
  publication-title: Nat Rev Drug Discov
– volume: 186
  start-page: 5443
  year: 2011
  end-page: 5456
  ident: b0725
  article-title: IL-6 production is positively regulated by two distinct Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1)-dependent CCAAT/enhancer-binding protein β and NF-κB pathways and an SHP-1-independent NF-κB pathway in lipopolysaccharide-stimulated bone marrow-derived macrophages
  publication-title: J Immunol
– volume: 35
  start-page: 22
  year: 2014
  end-page: 31
  ident: b0815
  article-title: A20 in inflammation and autoimmunity
  publication-title: Trends Immunol
– volume: 41
  start-page: 1012
  year: 2016
  end-page: 1021
  ident: b1070
  article-title: Mechanism and Regulation of NLRP3 Inflammasome Activation
  publication-title: Trends in Biochemical Sciences
– volume: 193
  start-page: 259
  year: 2016
  end-page: 272
  ident: b0005
  article-title: Assessment of Global Incidence and Mortality of Hospital-treated Sepsis
  publication-title: Current Estimates and Limitations, Am J Respir Crit Care Med
– volume: 8
  start-page: 511
  year: 2017
  ident: b0700
  article-title: Toll-Interacting Protein in Resolving and Non-Resolving Inflammation
  publication-title: Front Immunol
– volume: 93
  start-page: 8241
  year: 1996
  end-page: 8246
  ident: b1135
  article-title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction
  publication-title: Proc Natl Acad Sci U S A
– volume: 9
  start-page: 1019
  year: 2008
  end-page: 1027
  ident: b1115
  article-title: The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
  publication-title: Nat Immunol
– volume: 27
  start-page: 7451
  year: 2007
  end-page: 7461
  ident: b0850
  article-title: IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway
  publication-title: Mol Cell Biol
– volume: 43
  start-page: 222
  year: 2015
  end-page: 227
  ident: b0440
  article-title: Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury: A Clinical Study
  publication-title: Shock
– volume: 108
  start-page: 19341
  year: 2011
  end-page: 19346
  ident: b1245
  article-title: Tripartite motif 8 (TRIM8) modulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination
  publication-title: Proc Natl Acad Sci U S A
– volume: 90
  start-page: 472
  year: 2014
  end-page: 478
  ident: b0320
  article-title: TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis
  publication-title: Jornal de Pediatria
– volume: 116
  start-page: 2532
  year: 2006
  end-page: 2542
  ident: b0645
  article-title: Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M
  publication-title: The Journal of Clinical Investigation
– volume: 5
  start-page: 1052
  year: 2004
  end-page: 1060
  ident: b0835
  article-title: The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
  publication-title: Nat Immunol
– volume: 23
  start-page: 479
  year: 2005
  end-page: 490
  ident: b1465
  article-title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
  publication-title: Immunity
– volume: 6
  start-page: 754
  year: 2014
  end-page: 764
  ident: b0775
  article-title: The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis
  publication-title: J Innate Immun
– volume: 18
  start-page: 128
  year: 2012
  end-page: 134
  ident: b1680
  article-title: ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression
  publication-title: Nature Medicine
– volume: 196
  start-page: 3834
  year: 2016
  end-page: 3841
  ident: b1610
  article-title: TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling
  publication-title: J Immunol
– volume: 124
  start-page: 783
  year: 2006
  end-page: 801
  ident: b0385
  article-title: Pathogen recognition and innate immunity
  publication-title: Cell
– volume: 337
  start-page: 1111
  year: 2012
  end-page: 1115
  ident: b1870
  article-title: TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
  publication-title: Science
– reference: A.A. FQ Younis, NH Zaki, TLR2 AND TLR4 AS A BIOMARKER IN ADULT AND CHILDREN IRAQI BACTERIAL SEPSIS SYNDROME PATIENTS, Pak. J. Biotechnol. 15(3) (2018) 837-842.
– volume: 5
  year: 2013
  ident: b0575
  article-title: Biology of the TAM receptors
  publication-title: Cold Spring Harb Perspect Biol
– volume: 6
  start-page: 34672
  year: 2016
  ident: b0690
  article-title: Deficiency in Toll-interacting protein (Tollip) skews inflamed yet incompetent innate leukocytes in vivo during DSS-induced septic colitis
  publication-title: Scientific Reports
– volume: 72
  start-page: 113
  year: 2015
  end-page: 114
  ident: b1700
  article-title: IL-37: a new player in immune tolerance
  publication-title: Cytokine
– volume: 35
  start-page: 1670
  year: 2005
  end-page: 1677
  ident: b0535
  article-title: KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions
  publication-title: Eur J Immunol
– volume: 45
  start-page: 3545
  year: 2008
  end-page: 3552
  ident: b0795
  article-title: Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages
  publication-title: Mol Immunol
– volume: 16
  start-page: 354
  year: 2015
  end-page: 365
  ident: b1720
  article-title: IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
  publication-title: Nat Immunol
– volume: 4
  start-page: 56
  year: 2016
  ident: b1105
  article-title: Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2
  publication-title: Frontiers in Cell and Developmental Biology
– volume: 98
  year: 2019
  ident: b1715
  article-title: Elevated serum IL-37 concentrations in patients with sepsis
  publication-title: Medicine (Baltimore)
– volume: 39
  start-page: 1556
  year: 2013
  end-page: 1564
  ident: b0615
  article-title: Increased MerTK expression in circulating innate immune cells of patients with septic shock
  publication-title: Intensive Care Med
– volume: 9
  start-page: 4010
  year: 2019
  ident: b0350
  article-title: Increased expression of Toll-like receptors 2, 3, 4 and 7 mRNA in the kidney and intestine of a septic mouse model
  publication-title: Scientific Reports
– volume: 74
  start-page: 3538
  year: 2006
  end-page: 3546
  ident: b0370
  article-title: MyD88-dependent signaling affects the development of meningococcal sepsis by nonlipooligosaccharide ligands
  publication-title: Infect Immun
– volume: 12
  start-page: 1535
  year: 1992
  end-page: 1545
  ident: b1650
  article-title: A collection of mRNA species that are inducible in the RAW 264.7 mouse macrophage cell line by gamma interferon and other agents
  publication-title: Mol Cell Biol
– volume: 17
  year: 2019
  ident: b0480
  article-title: Role of IRF4 in the Protection of Metformin-Mediated Sepsis Myocarditis
  publication-title: Dose Response
– volume: 11
  start-page: 229
  year: 2020
  ident: b0245
  article-title: LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling
  publication-title: Front Immunol
– volume: 123
  start-page: 958
  year: 2013
  end-page: 965
  ident: b0125
  article-title: Causes, consequences, and reversal of immune system aging
  publication-title: The Journal of Clinical Investigation
– volume: 45
  start-page: 314
  year: 2020
  end-page: 321
  ident: b1325
  article-title: Effect of deletion of SUMOylation on dendritic cell function in septic mice and its role in sepsis
  publication-title: Zhong Nan Da Xue Xue Bao Yi Xue Ban
– volume: 410
  start-page: 1103
  year: 2001
  end-page: 1107
  ident: b0555
  article-title: TREM-1 amplifies inflammation and is a crucial mediator of septic shock
  publication-title: Nature
– volume: 287
  start-page: 11002
  year: 2012
  end-page: 11010
  ident: b0925
  article-title: Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation
  publication-title: J Biol Chem
– reference: R.H. Elsherif, H.A.F. Algebaly, D.K. Ismail, B. Meligy, M. Magdy, Aziz, D.M. Ghaith, E. Salah, Toll-like receptors 2 and 9 gene polymorphisms in severe sepsis and septic shock : a single center study in the pediatric intensive care unit, 2019.
– volume: 91
  start-page: 5
  year: 2000
  end-page: 17
  ident: b1185
  article-title: The LIM domain: regulation by association
  publication-title: Mech Dev
– volume: 15
  start-page: 109
  year: 2009
  end-page: 120
  ident: b0780
  article-title: Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo
  publication-title: Innate Immun
– volume: 289
  start-page: 14422
  year: 2014
  end-page: 14433
  ident: b0915
  article-title: Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice
  publication-title: J Biol Chem
– volume: 16
  start-page: 1811
  year: 2005
  end-page: 1822
  ident: b1160
  article-title: Mystique Is a New Insulin-like Growth Factor-I-regulated PDZ-LIM Domain Protein That Promotes Cell Attachment and Migration and Suppresses Anchorage-independent Growth
  publication-title: Molecular Biology of the Cell
– volume: 273
  start-page: 1
  year: 2001
  end-page: 11
  ident: b1640
  article-title: The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis
  publication-title: Gene
– volume: 11
  start-page: 861
  year: 2010
  end-page: 871
  ident: b1305
  article-title: The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
  publication-title: Nature reviews. Molecular cell biology
– volume: 327
  start-page: 1135
  year: 2010
  end-page: 1139
  ident: b0840
  article-title: Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
  publication-title: Science
– volume: 7
  start-page: 155
  year: 2007
  end-page: 161
  ident: b0545
  article-title: Activating and inhibitory functions of DAP12
  publication-title: Nat Rev Immunol
– volume: 87
  start-page: 93
  year: 2010
  end-page: 106
  ident: b0145
  article-title: When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system
  publication-title: J Leukoc Biol
– volume: 50
  start-page: 1412
  year: 2019
  end-page: 1424.e6
  ident: b0465
  article-title: Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
  publication-title: Immunity
– volume: 34
  start-page: 1492
  year: 2014
  end-page: 1504
  ident: b0520
  article-title: Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis
  publication-title: Int J Mol Med
– volume: 87
  start-page: 845
  year: 2010
  end-page: 855
  ident: b0730
  article-title: Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase
  publication-title: J Leukoc Biol
– volume: 9
  year: 2013
  ident: b0950
  article-title: Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes
  publication-title: PLoS Pathog
– volume: 22
  start-page: 729
  year: 2005
  end-page: 736
  ident: b1165
  article-title: SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling
  publication-title: Immunity
– volume: 411
  start-page: 207
  year: 2001
  end-page: 211
  ident: b0630
  article-title: Phagocytosis and clearance of apoptotic cells is mediated by MER
  publication-title: Nature
– volume: 9
  start-page: 1028
  year: 2008
  end-page: 1036
  ident: b1110
  article-title: The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
  publication-title: Nat Immunol
– volume: 3
  start-page: 413
  year: 2004
  end-page: 423
  ident: b1000
  article-title: Nur77 family of nuclear hormone receptors
  publication-title: Curr Drug Targets Inflamm Allergy
– volume: 193
  start-page: 634
  year: 2006
  end-page: 644
  ident: b1755
  article-title: Effective dosing of lipid A analogue E5564 in rats depends on the timing of treatment and the route of Escherichia coli infection
  publication-title: J Infect Dis
– volume: 9
  start-page: 542
  year: 2008
  end-page: 550
  ident: b0715
  article-title: Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
  publication-title: Nat Immunol
– volume: 4
  start-page: 920
  year: 2003
  end-page: 927
  ident: b1530
  article-title: SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
  publication-title: Nat Immunol
– volume: 283
  start-page: 8486
  year: 2008
  end-page: 8495
  ident: b1205
  article-title: Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal
  publication-title: J Biol Chem
– volume: 115
  start-page: 19
  year: 2020
  ident: b1270
  article-title: Triad3A attenuates pathological cardiac hypertrophy involving the augmentation of ubiquitination-mediated degradation of TLR4 and TLR9
  publication-title: Basic Research in Cardiology
– volume: 34
  start-page: 2377
  year: 2006
  end-page: 2385
  ident: b1565
  article-title: Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients
  publication-title: Crit Care Med
– volume: 395
  start-page: 200
  year: 2020
  end-page: 211
  ident: b0010
  article-title: Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
  publication-title: Lancet
– volume: 10
  start-page: 1325
  year: 2010
  end-page: 1334
  ident: b0140
  article-title: Neutrophils: Cinderella of innate immune system
  publication-title: Int Immunopharmacol
– volume: 137
  start-page: 47
  year: 2009
  end-page: 59
  ident: b1040
  article-title: A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
  publication-title: Cell
– volume: 282
  start-page: 11817
  year: 2007
  end-page: 11826
  ident: b1150
  article-title: Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
  publication-title: J Biol Chem
– volume: 53
  start-page: 25
  year: 2020
  end-page: 32
  ident: b0105
  article-title: The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system
  publication-title: Cytokine Growth Factor Rev
– reference: W. Fang, D. Bi, R. Zheng, N. Cai, H. Xu, R. Zhou, J. Lu, M. Wan, X. Xu, Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages, Scientific Reports 7(1) (2017) 1663.
– volume: 315
  start-page: 801
  year: 2016
  end-page: 810
  ident: b0130
  article-title: The third international consensus definitions for sepsis and septic shock (sepsis-3)
  publication-title: JAMA
– volume: 68
  start-page: 7010
  year: 2000
  end-page: 7017
  ident: b0300
  article-title: Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
  publication-title: Infect Immun
– volume: 2019
  start-page: 3737890
  year: 2019
  ident: b0355
  article-title: Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-<i>γ</i> Expression in CD38<sup>−/−</sup> Mice
  publication-title: Journal of Immunology Research
– volume: 123
  start-page: 2460
  year: 2014
  end-page: 2469
  ident: b0600
  article-title: C. van 't Veer, TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis
  publication-title: Blood
– volume: 7
  start-page: 827
  year: 2008
  end-page: 840
  ident: b1450
  article-title: The IL-33/ST2 pathway: therapeutic target and novel biomarker
  publication-title: Nature reviews. Drug discovery
– volume: 274
  start-page: 29242
  year: 1999
  end-page: 29250
  ident: b1170
  article-title: Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation
  publication-title: J Biol Chem
– volume: 9
  year: 2020
  ident: b0400
  article-title: TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury
  publication-title: eLife
– year: 2005
  ident: b0115
  article-title: Human infection by avian influenza A H5N1
  publication-title: Hong Kong Medical Journal
– volume: 381
  start-page: 503
  year: 2004
  end-page: 510
  ident: b1710
  article-title: Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide
  publication-title: Biochem J
– volume: 25
  start-page: 1216
  year: 1993
  end-page: 1217
  ident: b0110
  article-title: Cytokine storm of graft-versus-host disease: a critical effector role for interleukin-1
  publication-title: Transplant Proc
– volume: 318
  start-page: 1628
  year: 2007
  end-page: 1632
  ident: b0985
  article-title: DUBA: a deubiquitinase that regulates type I interferon production
  publication-title: Science
– volume: 34
  start-page: 1612
  year: 2015
  end-page: 1629
  ident: b0970
  article-title: USP18 lack in microglia causes destructive interferonopathy of the mouse brain
  publication-title: The EMBO journal
– volume: 13
  start-page: 4
  year: 2016
  ident: b1020
  article-title: Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
  publication-title: J Inflamm (Lond)
– volume: 38
  start-page: 601
  year: 2011
  end-page: 609
  ident: b1580
  article-title: SIGIRR inhibits toll-like receptor 4, 5, 9-mediated immune responses in human airway epithelial cells
  publication-title: Mol Biol Rep
– volume: 1681
  start-page: 1
  year: 2004
  end-page: 14
  ident: b1480
  article-title: Molecular cloning of the chicken ST2 gene and a novel variant form of the ST2 gene product, ST2LV
  publication-title: Biochim Biophys Acta
– volume: 9
  start-page: 990
  year: 2017
  end-page: 999
  ident: b0785
  article-title: Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy
  publication-title: EMBO Mol Med
– volume: 7
  start-page: 7425
  year: 2017
  ident: b1340
  article-title: Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming
  publication-title: Scientific Reports
– volume: 25
  start-page: 466
  year: 2013
  end-page: 468
  ident: b1695
  article-title: Interleukin-37
  publication-title: Semin Immunol
– volume: 3
  start-page: 799
  issue: 10
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b1230
  article-title: TRIM family proteins: retroviral restriction and antiviral defence
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro1248
– volume: 13
  start-page: 1176
  issue: 5
  year: 1994
  ident: 10.1016/j.intimp.2020.107087_b1470
  article-title: Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor
  publication-title: Embo j
  doi: 10.1002/j.1460-2075.1994.tb06367.x
– volume: 25
  start-page: 1216
  issue: 1 Pt 2
  year: 1993
  ident: 10.1016/j.intimp.2020.107087_b0110
  article-title: Cytokine storm of graft-versus-host disease: a critical effector role for interleukin-1
  publication-title: Transplant Proc
– volume: 166
  start-page: 6633
  issue: 11
  year: 2001
  ident: 10.1016/j.intimp.2020.107087_b1515
  article-title: A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression
  publication-title: J Immunol
  doi: 10.4049/jimmunol.166.11.6633
– volume: 5
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0800
  article-title: Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2014.90
– volume: 93
  start-page: 8241
  issue: 16
  year: 1996
  ident: 10.1016/j.intimp.2020.107087_b1135
  article-title: I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.93.16.8241
– volume: 540
  start-page: 583
  issue: 7634
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1375
  article-title: NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer
  publication-title: Nature
  doi: 10.1038/nature20597
– volume: 33
  start-page: 522
  issue: 10
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1745
  article-title: Targeting of TAK1 in inflammatory disorders and cancer
  publication-title: Trends Pharmacol Sci
  doi: 10.1016/j.tips.2012.06.007
– volume: 18
  start-page: 128
  issue: 1
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1680
  article-title: ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression
  publication-title: Nature Medicine
  doi: 10.1038/nm.2557
– volume: 1
  start-page: 440
  issue: 5
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0175
  article-title: Antimicrobial peptides: the ancient arm of the human immune system
  publication-title: Virulence
  doi: 10.4161/viru.1.5.12983
– volume: 10
  start-page: 131
  issue: 2
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0295
  article-title: Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2707
– volume: 3
  start-page: 413
  issue: 4
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b1000
  article-title: Nur77 family of nuclear hormone receptors
  publication-title: Curr Drug Targets Inflamm Allergy
  doi: 10.2174/1568010042634523
– volume: 39
  start-page: 1556
  issue: 9
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0615
  article-title: Increased MerTK expression in circulating innate immune cells of patients with septic shock
  publication-title: Intensive Care Med
  doi: 10.1007/s00134-013-3006-9
– volume: 7
  start-page: 454
  issue: 6
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b0595
  article-title: SOCS proteins, cytokine signalling and immune regulation
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2093
– volume: 22
  start-page: 2788
  issue: 11
  year: 2003
  ident: 10.1016/j.intimp.2020.107087_b1085
  article-title: MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
  publication-title: Embo j
  doi: 10.1093/emboj/cdg273
– volume: 43
  start-page: 1779
  issue: 8
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b0035
  article-title: HIV-infection and severe sepsis: a bitter pill to swallow
  publication-title: Critical care medicine
  doi: 10.1097/CCM.0000000000001053
– volume: 16
  start-page: 1228
  issue: 12
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1030
  article-title: Transcription factor Nr4a1 couples sympathetic and inflammatory cues in CNS-recruited macrophages to limit neuroinflammation
  publication-title: Nat Immunol
  doi: 10.1038/ni.3321
– volume: 104
  start-page: 114
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b1820
  article-title: DAMP-TLR-cytokine axis dictates the fate of tumor
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2017.10.004
– volume: 9
  issue: 6
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1315
  article-title: Negative regulation of TLR inflammatory signaling by the SUMO-deconjugating enzyme SENP6
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1003480
– volume: 14
  start-page: 857
  issue: 12
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b0165
  article-title: Complement, a target for therapy in inflammatory and degenerative diseases
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd4657
– volume: 103
  start-page: 12487
  issue: 33
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b0375
  article-title: Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0605200103
– volume: 179
  start-page: 3622
  issue: 6
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1660
  article-title: Negative regulation of TLR-signaling pathways by activating transcription factor-3
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.6.3622
– volume: 11
  issue: 2
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0395
  article-title: Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0148987
– volume: 131
  start-page: 6
  issue: 6-131
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0265
  article-title: Dendritic cell-intrinsic TLR signaling regulates polymicrobial sepsis
  publication-title: The Journal of Immunology 198(1 Supplement)
– year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0740
  article-title: SHP-1 suppresses the antiviral innate immune response by targeting TRAF3
  publication-title: Faseb j
  doi: 10.1096/fj.202000600RR
– volume: 43
  start-page: 222
  issue: 3
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b0440
  article-title: Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury: A Clinical Study
  publication-title: Shock
  doi: 10.1097/SHK.0000000000000294
– volume: 102
  start-page: 15989
  issue: 44
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0475
  article-title: Negative regulation of Toll-like-receptor signaling by IRF-4
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0508327102
– volume: 16
  start-page: 876
  issue: 8
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b1050
  article-title: PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
  publication-title: Nat Chem Biol
  doi: 10.1038/s41589-020-0553-6
– volume: 22
  start-page: 836
  issue: 5
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1420
  article-title: NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens
  publication-title: Cell Res
  doi: 10.1038/cr.2012.56
– volume: 11
  start-page: 457
  issue: 7
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b0980
  article-title: Expanding TRAF function: TRAF3 as a tri-faced immune regulator
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2998
– volume: 111
  start-page: 173
  issue: 2
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b0230
  publication-title: Immunology
  doi: 10.1111/j.0019-2805.2003.01803.x
– volume: 157
  start-page: 48
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1005
  article-title: Nuclear receptor 4A (NR4A) family - orphans no more
  publication-title: J Steroid Biochem Mol Biol
  doi: 10.1016/j.jsbmb.2015.04.016
– volume: 13
  issue: 2
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b0280
  article-title: Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0193003
– volume: 98
  start-page: 8774
  issue: 15
  year: 2001
  ident: 10.1016/j.intimp.2020.107087_b0910
  article-title: Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.151236098
– volume: 287
  start-page: 11002
  issue: 14
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b0925
  article-title: Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.328187
– volume: 129
  start-page: 1432
  issue: 6
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b0030
  article-title: The epidemiology of sepsis in patients with malignancy
  publication-title: Chest
  doi: 10.1378/chest.129.6.1432
– volume: 424
  start-page: 793
  issue: 6950
  year: 2003
  ident: 10.1016/j.intimp.2020.107087_b0885
  article-title: CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
  publication-title: Nature
  doi: 10.1038/nature01803
– volume: 7
  issue: 5
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b0360
  article-title: TLR2, TLR4 and the MYD88 Signaling Pathway Are Crucial for Neutrophil Migration in Acute Kidney Injury Induced by Sepsis
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0037584
– volume: 398
  start-page: 80
  issue: 6722
  year: 1999
  ident: 10.1016/j.intimp.2020.107087_b0865
  article-title: DREAM is a Ca2+-regulated transcriptional repressor
  publication-title: Nature
  doi: 10.1038/18044
– volume: 18
  start-page: 10
  issue: 1
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1670
  article-title: Urinary exosomal activating transcriptional factor 3 as the early diagnostic biomarker for sepsis-induced acute kidney injury
  publication-title: BMC Nephrol
  doi: 10.1186/s12882-016-0415-3
– volume: 6
  start-page: ra72
  issue: 289
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0540
  article-title: A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages
  publication-title: Sci Signal
  doi: 10.1126/scisignal.2003801
– volume: 410
  start-page: 1103
  issue: 6832
  year: 2001
  ident: 10.1016/j.intimp.2020.107087_b0555
  article-title: TREM-1 amplifies inflammation and is a crucial mediator of septic shock
  publication-title: Nature
  doi: 10.1038/35074114
– volume: 6
  start-page: 579
  issue: 6
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0530
  article-title: Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
  publication-title: Nat Immunol
  doi: 10.1038/ni1204
– volume: 10
  start-page: 10755
  issue: 1
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b1045
  article-title: Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation
  publication-title: Sci Rep
  doi: 10.1038/s41598-020-67549-7
– volume: 9
  start-page: 369
  issue: 4
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b1240
  article-title: TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation
  publication-title: Nat Immunol
  doi: 10.1038/ni1577
– volume: 41
  start-page: 1012
  issue: 12
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1070
  article-title: Mechanism and Regulation of NLRP3 Inflammasome Activation
  publication-title: Trends in Biochemical Sciences
  doi: 10.1016/j.tibs.2016.09.002
– volume: 191
  start-page: 4818
  issue: 9
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1860
  article-title: Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1301301
– volume: 118
  start-page: 153
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b1780
  article-title: TLR4 induced Wnt3a-Dvl3 restrains the intensity of inflammation and protects against endotoxin-driven organ failure through GSK3β/β-catenin signaling
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2019.12.013
– volume: 87
  start-page: 845
  issue: 5
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0730
  article-title: Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0409289
– volume: 33
  start-page: 1456
  issue: 7
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1120
  article-title: MSK1 and MSK2 inhibit lipopolysaccharide-induced prostaglandin production via an interleukin-10 feedback loop
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.01690-12
– volume: 411
  start-page: 207
  issue: 6834
  year: 2001
  ident: 10.1016/j.intimp.2020.107087_b0630
  article-title: Phagocytosis and clearance of apoptotic cells is mediated by MER
  publication-title: Nature
  doi: 10.1038/35075603
– volume: 395
  start-page: 200
  issue: 10219
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0010
  article-title: Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)32989-7
– volume: 2019
  start-page: 3737890
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b0355
  article-title: Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice
  publication-title: Journal of Immunology Research
  doi: 10.1155/2019/3737890
– volume: 101
  start-page: 11707
  issue: 32
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b1080
  article-title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0306880101
– volume: 11
  issue: 1446
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0095
  article-title: The COVID-19 Cytokine Storm; What We Know So Far
  publication-title: Frontiers in Immunology
– ident: 10.1016/j.intimp.2020.107087_b0065
– volume: 39
  start-page: 517
  issue: 5
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0080
  article-title: Cytokine storm and sepsis disease pathogenesis
  publication-title: Semin Immunopathol
  doi: 10.1007/s00281-017-0639-8
– volume: 20
  start-page: 672
  issue: 6
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0185
  article-title: Innate immunity in sepsis pathogenesis and its modulation: new immunomodulatory targets revealed
  publication-title: J Chemother
  doi: 10.1179/joc.2008.20.6.672
– volume: 280
  start-page: 25233
  issue: 26
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b1570
  article-title: SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M501363200
– volume: 13
  start-page: 4
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1020
  article-title: Nur77-mediated TRAF6 signalling protects against LPS-induced sepsis in mice
  publication-title: J Inflamm (Lond)
  doi: 10.1186/s12950-016-0112-9
– volume: 72
  start-page: 113
  issue: 1
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1700
  article-title: IL-37: a new player in immune tolerance
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2014.11.025
– volume: 318
  start-page: E1004
  issue: 6
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0275
  article-title: GRP94 regulates M1 macrophage polarization and insulin resistance
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00542.2019
– volume: 7
  start-page: 7425
  issue: 1
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1340
  article-title: Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming
  publication-title: Scientific Reports
  doi: 10.1038/s41598-017-07631-9
– volume: 15
  start-page: 45
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0195
  article-title: Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands
  publication-title: Contrib Microbiol
  doi: 10.1159/000135685
– volume: 13
  start-page: 711
  issue: 6
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0205
  article-title: Cellular and molecular regulation of innate inflammatory responses
  publication-title: Cell Mol Immunol
  doi: 10.1038/cmi.2016.58
– volume: 16
  start-page: 378
  issue: 6
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0160
  article-title: Neutrophil migration in infection and wound repair: going forward in reverse
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri.2016.49
– ident: 10.1016/j.intimp.2020.107087_b0215
– volume: 315
  start-page: 801
  issue: 8
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0130
  article-title: The third international consensus definitions for sepsis and septic shock (sepsis-3)
  publication-title: JAMA
  doi: 10.1001/jama.2016.0287
– volume: 9
  start-page: 2481
  issue: 13
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0845
  article-title: A20 inhibition of NFkappaB and inflammation: targeting E2:E3 ubiquitin enzyme complexes
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.13.12269
– year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1635
  article-title: TLR10 suppresses the activation and differentiation of monocytes with effects on DC-mediated adaptive immune responses
  publication-title: Journal of Leukocyte Biology
  doi: 10.1189/jlb.3A1116-492R
– volume: 32
  start-page: 305
  issue: 3
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1825
  article-title: Intracellular Toll-like Receptors
  publication-title: Immunity
  doi: 10.1016/j.immuni.2010.03.012
– volume: 9
  start-page: 1019
  issue: 9
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b1115
  article-title: The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
  publication-title: Nat Immunol
  doi: 10.1038/ni.1640
– year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0735
  article-title: SHP-1 ameliorates nonalcoholic steatohepatitis by inhibiting proinflammatory cytokine production
  publication-title: FEBS Lett
  doi: 10.1002/1873-3468.13879
– volume: 23
  start-page: 479
  issue: 5
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b1465
  article-title: IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
  publication-title: Immunity
  doi: 10.1016/j.immuni.2005.09.015
– volume: 36
  start-page: 630
  issue: 4
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1520
  article-title: Soluble ST2 plasma concentrations predict mortality in severe sepsis
  publication-title: Intensive Care Medicine
  doi: 10.1007/s00134-010-1773-0
– volume: 434
  start-page: 772
  issue: 7034
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0450
  article-title: IRF-7 is the master regulator of type-I interferon-dependent immune responses
  publication-title: Nature
  doi: 10.1038/nature03464
– volume: 19
  start-page: 6665
  issue: 10
  year: 1999
  ident: 10.1016/j.intimp.2020.107087_b1140
  article-title: TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.19.10.6665
– volume: 18
  start-page: 622
  issue: 6
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1795
  article-title: S100-alarmin-induced innate immune programming protects newborn infants from sepsis
  publication-title: Nat Immunol
  doi: 10.1038/ni.3745
– volume: 14
  start-page: 52
  issue: 1
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1625
  article-title: Variation in the TLR10/TLR1/TLR6 Locus is the Major Genetic Determinant of Inter-Individual Difference in TLR1/2-Mediated Responses
  publication-title: Genes and immunity
  doi: 10.1038/gene.2012.53
– volume: 7
  start-page: 6807
  issue: 1
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0755
  article-title: Reciprocal regulation of TLR2-mediated IFN-β production by SHP2 and Gsk3β
  publication-title: Scientific Reports
  doi: 10.1038/s41598-017-07316-3
– volume: 188
  start-page: 2847
  issue: 6
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1380
  article-title: TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1102157
– ident: 10.1016/j.intimp.2020.107087_b0855
  doi: 10.1097/CCM.0000000000002294
– volume: 34
  start-page: 843
  issue: 6
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1360
  article-title: NLRX1 negatively regulates TLR-induced NF-kappaB signaling by targeting TRAF6 and IKK
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.02.022
– volume: 193
  start-page: 634
  issue: 5
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b1755
  article-title: Effective dosing of lipid A analogue E5564 in rats depends on the timing of treatment and the route of Escherichia coli infection
  publication-title: J Infect Dis
  doi: 10.1086/500147
– volume: 10
  start-page: 579
  issue: 6
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b0425
  article-title: TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway
  publication-title: Nat Immunol
  doi: 10.1038/ni.1727
– volume: 10
  start-page: 482
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b1850
  article-title: TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2019.00482
– volume: 111
  start-page: 3793
  issue: 10
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b1600
  article-title: Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1324266111
– volume: 13
  start-page: 415
  issue: 3
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b1355
  article-title: Drugging SUMOylation for neuroprotection and oncotherapy
  publication-title: Neural Regen Res
  doi: 10.4103/1673-5374.228718
– volume: 8
  start-page: 511
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0700
  article-title: Toll-Interacting Protein in Resolving and Non-Resolving Inflammation
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2017.00511
– ident: 10.1016/j.intimp.2020.107087_b1455
– volume: 112
  start-page: 2497
  issue: 8
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1740
  article-title: Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1424626112
– volume: 27
  start-page: 7451
  issue: 21
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b0850
  article-title: IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.01101-07
– volume: 34
  start-page: 1612
  issue: 12
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b0970
  article-title: USP18 lack in microglia causes destructive interferonopathy of the mouse brain
  publication-title: The EMBO journal
  doi: 10.15252/embj.201490791
– volume: 78
  start-page: 399
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b1215
  article-title: RING domain E3 ubiquitin ligases
  publication-title: Annu Rev Biochem
  doi: 10.1146/annurev.biochem.78.101807.093809
– volume: 287
  start-page: 4883
  issue: 7
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b0960
  article-title: Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.255570
– volume: 10
  start-page: 782
  issue: 10
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b0225
  article-title: Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis
  publication-title: Cell Death & Disease
  doi: 10.1038/s41419-019-2015-1
– year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1435
  article-title: A feedforward loop of NLRC5 (de)ubiquitination keeps IKK–NF-κB in check
  publication-title: The Journal of Cell Biology
  doi: 10.1083/jcb.201511039
– volume: 13
  start-page: 823
  issue: 9
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1370
  article-title: The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-[kappa]B
  publication-title: Nat Immunol
  doi: 10.1038/ni.2378
– volume: 11
  issue: 1722
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0345
  article-title: Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury
  publication-title: Frontiers in Immunology
– volume: 157
  start-page: 23
  issue: 1–2
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0135
  article-title: Innate lymphoid cells: new paradigm in immunology of inflammation
  publication-title: Immunol Lett
  doi: 10.1016/j.imlet.2013.11.003
– ident: 10.1016/j.intimp.2020.107087_b1385
  doi: 10.1038/s41598-017-01868-0
– volume: 22
  start-page: 1313
  issue: 6
  year: 2003
  ident: 10.1016/j.intimp.2020.107087_b1090
  article-title: Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
  publication-title: Embo j
  doi: 10.1093/emboj/cdg139
– volume: 93
  start-page: 1033
  issue: 9
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b0505
  article-title: TIPE2 acts as a negative regulator linking NOD2 and inflammatory responses in myocardial ischemia/reperfusion injury
  publication-title: J Mol Med (Berl)
  doi: 10.1007/s00109-015-1288-9
– volume: 199
  start-page: 1440
  issue: 4
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0650
  article-title: Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1601982
– volume: 13
  start-page: 971
  issue: 5
  year: 1996
  ident: 10.1016/j.intimp.2020.107087_b1285
  article-title: PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia
  publication-title: Oncogene
– volume: 30
  start-page: 639
  issue: 5
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0335
  article-title: Analysis of Toll-like Receptor 9 Gene Polymorphisms in Sepsis
  publication-title: Vivo
– volume: 10
  start-page: 1703
  issue: 12
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b1690
  article-title: Immunobiology of Interleukin-37: Mechanism of Action and Clinical Perspectives
  publication-title: Expert review of clinical immunology
  doi: 10.1586/1744666X.2014.971014
– volume: 8
  start-page: 584
  issue: 6
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1190
  article-title: PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit
  publication-title: Nat Immunol
  doi: 10.1038/ni1464
– volume: 7
  start-page: 155
  issue: 2
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b0545
  article-title: Activating and inhibitory functions of DAP12
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2014
– volume: 8
  start-page: 487
  issue: 5
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1845
  article-title: Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
  publication-title: Nat Immunol
  doi: 10.1038/ni1457
– volume: 88
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0055
  article-title: Understanding the complexities of SARS-CoV2 infection and its immunology: A road to immune-based therapeutics
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2020.106980
– volume: 186
  start-page: 1234
  issue: 5
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0805
  article-title: Protein Tyrosine Phosphatase-1B Negatively Impacts Host Defense against Pseudomonas aeruginosa Infection
  publication-title: Am J Pathol
  doi: 10.1016/j.ajpath.2016.01.005
– volume: 36
  start-page: 1087
  issue: 5
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0660
  article-title: Association Between Gene Polymorphisms of IRAK-M and the Susceptibility of Sepsis
  publication-title: Inflammation
  doi: 10.1007/s10753-013-9641-z
– volume: 277
  start-page: 7059
  issue: 9
  year: 2002
  ident: 10.1016/j.intimp.2020.107087_b0670
  article-title: Negative regulation of toll-like receptor-mediated signaling by Tollip
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109537200
– volume: 17
  start-page: 397
  issue: 4
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0745
  article-title: The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3
  publication-title: Nat Immunol
  doi: 10.1038/ni.3395
– volume: 34
  start-page: 2377
  issue: 9
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b1565
  article-title: Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients
  publication-title: Crit Care Med
  doi: 10.1097/01.CCM.0000233875.93866.88
– volume: 12
  issue: 11
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0290
  article-title: Expression of Toll-like receptors (TLRs) in the lungs of an experimental sepsis mouse model
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0188050
– volume: 4
  start-page: 56
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1105
  article-title: Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2
  publication-title: Frontiers in Cell and Developmental Biology
  doi: 10.3389/fcell.2016.00056
– volume: 121
  start-page: 1270
  issue: 6
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0285
  article-title: Toll-like Receptor 4 Is Essential to Preserving Cardiac Function and Survival in Low-grade Polymicrobial Sepsis
  publication-title: Anesthesiology: The Journal of the American Society of Anesthesiologists
  doi: 10.1097/ALN.0000000000000337
– volume: 2
  start-page: 202
  issue: 3
  year: 2001
  ident: 10.1016/j.intimp.2020.107087_b1275
  article-title: SUMO, ubiquitin's mysterious cousin
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/35056591
– volume: 5
  start-page: 12738
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b0965
  article-title: USP18 negatively regulates NF-kappaB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms
  publication-title: Sci Rep
  doi: 10.1038/srep12738
– volume: 186
  start-page: 994
  issue: 2
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1425
  article-title: NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1002094
– volume: 6
  start-page: 754
  issue: 6
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0775
  article-title: The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis
  publication-title: J Innate Immun
  doi: 10.1159/000362647
– volume: 9
  issue: 10
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0950
  article-title: Usp18 driven enforced viral replication in dendritic cells contributes to break of immunological tolerance in autoimmune diabetes
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1003650
– volume: 28
  start-page: 34
  issue: 1
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b1095
  article-title: A coordinated phosphorylation cascade initiated by p38MAPK/MSK1 directs RARalpha to target promoters
  publication-title: Embo j
  doi: 10.1038/emboj.2008.256
– volume: 31
  start-page: 17
  issue: 1
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1065
  article-title: Small Heterodimer Partner and Innate Immune Regulation
  publication-title: Endocrinology and Metabolism
  doi: 10.3803/EnM.2016.31.1.17
– volume: 11
  start-page: 389
  issue: 6
  year: 1999
  ident: 10.1016/j.intimp.2020.107087_b1540
  article-title: Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily
  publication-title: Cytokine
  doi: 10.1006/cyto.1998.0452
– volume: 26
  start-page: 461
  issue: 4
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1550
  article-title: The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis
  publication-title: Immunity
  doi: 10.1016/j.immuni.2007.02.012
– volume: 12
  start-page: 1035
  issue: 11
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b0150
  article-title: Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
  publication-title: Nat Immunol
  doi: 10.1038/ni.2109
– volume: 14
  start-page: 477
  issue: 6
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1400
  article-title: NLRC5: a newly discovered MHC class I transactivator (CITA)
  publication-title: Microbes and Infection / Institut Pasteur
  doi: 10.1016/j.micinf.2011.12.007
– volume: 7
  start-page: 479
  issue: 4
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1765
  article-title: Eritoran tetrasodium (E5564) Treatment for Sepsis: Review of Preclinical and Clinical Studies
  publication-title: Expert opinion on drug metabolism & toxicology
  doi: 10.1517/17425255.2011.558190
– start-page: 1
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0050
  article-title: Emerging Human Coronavirus Infections (SARS, MERS, and COVID-19): Where They Are Leading Us
  publication-title: International Reviews of Immunology
  doi: 10.1080/08830185.2019.1707479
– year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1595
  article-title: A protective role of IL-37 in cancer: a new hope for cancer patients
  publication-title: Journal of leukocyte biology
– volume: 285
  start-page: 4291
  issue: 7
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0995
  article-title: Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6
  publication-title: The Journal of biological chemistry
  doi: 10.1074/jbc.M109.074971
– ident: 10.1016/j.intimp.2020.107087_b0070
– volume: 38
  start-page: 1419
  issue: 5
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0515
  article-title: Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2016.2749
– volume: 9
  start-page: 990
  issue: 8
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0785
  article-title: Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy
  publication-title: EMBO Mol Med
  doi: 10.15252/emmm.201707698
– volume: 1
  start-page: 135
  issue: 2
  year: 1989
  ident: 10.1016/j.intimp.2020.107087_b1445
  article-title: Establishment of IL-5-dependent early B cell lines by long-term bone marrow cultures
  publication-title: Growth Factors
  doi: 10.3109/08977198909029123
– volume: 38
  start-page: 601
  issue: 1
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1580
  article-title: SIGIRR inhibits toll-like receptor 4, 5, 9-mediated immune responses in human airway epithelial cells
  publication-title: Mol Biol Rep
  doi: 10.1007/s11033-010-0146-7
– volume: 53
  start-page: 25
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0105
  article-title: The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2020.05.003
– volume: 35
  start-page: 1670
  issue: 6
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0535
  article-title: KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions
  publication-title: Eur J Immunol
  doi: 10.1002/eji.200425932
– volume: 5
  start-page: 495
  issue: 5
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b1255
  article-title: Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
  publication-title: Nat Immunol
  doi: 10.1038/ni1066
– volume: 17
  start-page: 726
  issue: 6
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1300
  article-title: Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways
  publication-title: Curr Opin Struct Biol
  doi: 10.1016/j.sbi.2007.08.018
– volume: 10
  start-page: 773
  issue: 10
  year: 1998
  ident: 10.1016/j.intimp.2020.107087_b1505
  article-title: Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo
  publication-title: Cytokine
  doi: 10.1006/cyto.1998.0359
– volume: 179
  start-page: 3119
  issue: 5
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1590
  article-title: Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.5.3119
– volume: 210
  start-page: 239
  issue: 2
  year: 1998
  ident: 10.1016/j.intimp.2020.107087_b1175
  article-title: The human RIL gene: mapping to human chromosome 5q31.1, genomic organization and alternative transcripts
  publication-title: Gene
  doi: 10.1016/S0378-1119(98)00080-8
– volume: 33
  start-page: 449
  issue: 9
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b0430
  article-title: Dissecting negative regulation of Toll-like receptor signaling
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2012.05.002
– volume: 279
  start-page: 36171
  issue: 35
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b0900
  article-title: NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M406638200
– volume: 141
  start-page: 483
  issue: 3
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1410
  article-title: NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
  publication-title: Cell
  doi: 10.1016/j.cell.2010.03.040
– volume: 273
  start-page: 11349
  issue: 18
  year: 1998
  ident: 10.1016/j.intimp.2020.107087_b1280
  article-title: Characterization of a second member of the sentrin family of ubiquitin-like proteins
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.18.11349
– volume: 13
  start-page: 159
  issue: 3
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0155
  article-title: Neutrophil recruitment and function in health and inflammation
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3399
– volume: 7
  start-page: 1074
  issue: 10
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b0445
  article-title: The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
  publication-title: Nat Immunol
  doi: 10.1038/ni1382
– volume: 207
  start-page: 2799
  issue: 13
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0990
  article-title: Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9–driven antiinflammatory cytokine production
  publication-title: The Journal of Experimental Medicine
  doi: 10.1084/jem.20101326
– volume: 90
  start-page: 62
  issue: 1
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b1125
  article-title: Lysophosphatidic acid-induced IL-8 secretion involves MSK1 and MSK2 mediated activation of CREB1 in human fibroblast-like synoviocytes
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2014.04.012
– volume: 20
  issue: 3
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b1855
  article-title: TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics
  publication-title: Immune Netw
  doi: 10.4110/in.2020.20.e21
– volume: 41
  start-page: 85
  issue: 1
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b0680
  article-title: Characterization of Tollip protein upon Lipopolysaccharide challenge
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2004.03.009
– volume: 5
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0675
  article-title: Negative regulation of toll-like receptor-mediated immune responses
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri1630
– volume: 1518
  start-page: 157
  issue: 1–2
  year: 2001
  ident: 10.1016/j.intimp.2020.107087_b1615
  article-title: Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells
  publication-title: Biochim Biophys Acta
  doi: 10.1016/S0167-4781(00)00289-X
– ident: 10.1016/j.intimp.2020.107087_b0930
  doi: 10.1371/journal.pone.0022200
– volume: 11
  start-page: 229
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0245
  article-title: LPS Induces Active HMGB1 Release From Hepatocytes Into Exosomes Through the Coordinated Activities of TLR4 and Caspase-11/GSDMD Signaling
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.00229
– volume: 275
  start-page: 11100
  issue: 15
  year: 2000
  ident: 10.1016/j.intimp.2020.107087_b1225
  article-title: CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.15.11100
– volume: 177
  start-page: 548
  issue: 1
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b1585
  article-title: SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling
  publication-title: J Immunol
  doi: 10.4049/jimmunol.177.1.548
– volume: 12
  start-page: 11
  issue: 1
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0410
  article-title: Innate Lymphoid Cells: Immunoregulatory Cells of Mucosal Inflammation
  publication-title: European Journal of Inflammation
  doi: 10.1177/1721727X1401200102
– volume: 13
  start-page: 51
  issue: 1
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b0945
  article-title: Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus
  publication-title: Nat Immunol
  doi: 10.1038/ni.2169
– volume: 337
  start-page: 1111
  issue: 6098
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1870
  article-title: TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
  publication-title: Science
  doi: 10.1126/science.1220363
– volume: 303
  start-page: 2495
  issue: 24
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0060
  article-title: Infection rate and acute organ dysfunction risk as explanations for racial differences in severe sepsis
  publication-title: Jama
  doi: 10.1001/jama.2010.851
– volume: 327
  start-page: 1135
  issue: 5969
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0840
  article-title: Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
  publication-title: Science
  doi: 10.1126/science.1182364
– volume: 201
  start-page: 333
  issue: 3
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0560
  article-title: Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling
  publication-title: J Exp Med
  doi: 10.1084/jem.20041817
– volume: 2013
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1675
  article-title: ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression
  publication-title: Evid Based Complement Alternat Med
  doi: 10.1155/2013/716481
– volume: 17
  start-page: 140
  issue: 2
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1320
  article-title: Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing
  publication-title: Nat Immunol
  doi: 10.1038/ni.3342
– volume: 13
  start-page: 1042
  issue: 9
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1785
  article-title: Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
  publication-title: Nat Med
  doi: 10.1038/nm1638
– volume: 87
  start-page: 93
  issue: 1
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0145
  article-title: When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0809549
– volume: 39
  start-page: 688
  issue: 2
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1015
  article-title: Inflammation: a role for NR4A orphan nuclear receptors?
  publication-title: Biochemical Society transactions
  doi: 10.1042/BST0390688
– volume: 9
  start-page: 4010
  issue: 1
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b0350
  article-title: Increased expression of Toll-like receptors 2, 3, 4 and 7 mRNA in the kidney and intestine of a septic mouse model
  publication-title: Scientific Reports
  doi: 10.1038/s41598-019-40537-2
– volume: 174
  start-page: 2942
  issue: 5
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b1620
  article-title: Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88
  publication-title: J Immunol
  doi: 10.4049/jimmunol.174.5.2942
– volume: 145
  start-page: 1471
  issue: 7
  year: 1999
  ident: 10.1016/j.intimp.2020.107087_b0820
  article-title: The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN
  publication-title: The Journal of cell biology
  doi: 10.1083/jcb.145.7.1471
– volume: 15
  start-page: 239
  issue: 3
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0860
  article-title: The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation
  publication-title: Nature immunology
  doi: 10.1038/ni.2823
– volume: 116
  start-page: 2532
  issue: 9
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b0645
  article-title: Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M
  publication-title: The Journal of Clinical Investigation
– volume: 15
  start-page: 109
  issue: 2
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b0780
  article-title: Calcineurin inactivation leads to decreased responsiveness to LPS in macrophages and dendritic cells and protects against LPS-induced toxicity in vivo
  publication-title: Innate Immun
  doi: 10.1177/1753425908100928
– volume: 10
  issue: 11
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b1730
  article-title: IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1004462
– volume: 10
  start-page: 365
  issue: 5
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1330
  article-title: Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2748
– volume: 274
  start-page: 29242
  issue: 41
  year: 1999
  ident: 10.1016/j.intimp.2020.107087_b1170
  article-title: Purification and characterization of an alpha-actinin-binding PDZ-LIM protein that is up-regulated during muscle differentiation
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.41.29242
– volume: 303
  start-page: 1522
  issue: 5663
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b0390
  article-title: A toll-like receptor that prevents infection by uropathogenic bacteria
  publication-title: Science
  doi: 10.1126/science.1094351
– volume: 9
  start-page: 1028
  issue: 9
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b1110
  article-title: The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
  publication-title: Nat Immunol
  doi: 10.1038/ni.1644
– ident: 10.1016/j.intimp.2020.107087_b0085
  doi: 10.1126/scitranslmed.3000678
– volume: 4
  start-page: 499
  issue: 7
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b0380
  article-title: Toll-like receptor signalling
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri1391
– volume: 110
  start-page: 191
  issue: 2
  year: 2002
  ident: 10.1016/j.intimp.2020.107087_b0635
  article-title: IRAK-M is a negative regulator of Toll-like receptor signaling
  publication-title: Cell
  doi: 10.1016/S0092-8674(02)00827-9
– volume: 22
  start-page: 1099
  issue: 7
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1395
  article-title: NLRC5: a NOD-like receptor protein with many faces in immune regulation
  publication-title: Cell Research
  doi: 10.1038/cr.2012.83
– volume: 193
  start-page: 259
  issue: 3
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0005
  article-title: Assessment of Global Incidence and Mortality of Hospital-treated Sepsis
  publication-title: Current Estimates and Limitations, Am J Respir Crit Care Med
  doi: 10.1164/rccm.201504-0781OC
– volume: 232
  start-page: 273
  issue: 1
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b0565
  article-title: The roles of Dok family adapters in immunoreceptor signaling
  publication-title: Immunol Rev
  doi: 10.1111/j.1600-065X.2009.00844.x
– volume: 18
  issue: 3
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0485
  article-title: Protective Effect of Metformin on Sepsis Myocarditis in Zebrafish
  publication-title: Dose-Response
  doi: 10.1177/1559325820938543
– volume: 2
  issue: 12
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0720
  article-title: Leishmania-Induced IRAK-1 Inactivation Is Mediated by SHP-1 Interacting with an Evolutionarily Conserved KTIM Motif
  publication-title: PLOS Neglected Tropical Diseases
  doi: 10.1371/journal.pntd.0000305
– volume: 35
  start-page: 22
  issue: 1
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0815
  article-title: A20 in inflammation and autoimmunity
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2013.10.005
– volume: 16
  start-page: 73
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1535
  article-title: SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells
  publication-title: BMC Immunol
  doi: 10.1186/s12865-015-0137-5
– volume: 190
  start-page: 5152
  issue: 10
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0235
  article-title: Lipopolysaccharide clearance, bacterial clearance, and systemic inflammatory responses are regulated by cell type-specific functions of TLR4 during sepsis
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1300496
– ident: 10.1016/j.intimp.2020.107087_b0240
  doi: 10.1097/SHK.0b013e318181af2a
– volume: 434
  start-page: 243
  issue: 7030
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0470
  article-title: Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
  publication-title: Nature
  doi: 10.1038/nature03308
– volume: 179
  start-page: 4598
  issue: 7
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b0770
  article-title: Calcineurin negatively regulates TLR-mediated activation pathways
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.7.4598
– volume: 10
  start-page: 2247
  issue: 11
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0895
  article-title: CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia
  publication-title: Cell Microbiol
  doi: 10.1111/j.1462-5822.2008.01204.x
– volume: 5
  start-page: 446
  issue: 6
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0420
  article-title: Negative regulation of toll-like receptor-mediated immune responses
  publication-title: Nature reviews. Immunology
  doi: 10.1038/nri1630
– volume: 50
  start-page: 1412
  issue: 6
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b0465
  article-title: Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.04.005
– volume: 7
  start-page: 827
  issue: 10
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b1450
  article-title: The IL-33/ST2 pathway: therapeutic target and novel biomarker
  publication-title: Nature reviews. Drug discovery
  doi: 10.1038/nrd2660
– volume: 5
  start-page: 18327
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1220
  article-title: PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm
  publication-title: Scientific Reports
  doi: 10.1038/srep18327
– volume: 279
  start-page: 6629
  issue: 8
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b0640
  article-title: Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M308620200
– volume: 25
  start-page: 919
  issue: 6
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b0750
  article-title: SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.10.014
– volume: 15
  issue: 1
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b0685
  article-title: Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population
  publication-title: Critical Care
  doi: 10.1186/cc9413
– volume: 21
  start-page: 291
  issue: 3
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1010
  article-title: The NR4A subfamily of nuclear receptors: potential new therapeutic targets for the treatment of inflammatory diseases
  publication-title: Expert Opin Ther Targets
  doi: 10.1080/14728222.2017.1279146
– volume: 289
  start-page: 2350
  issue: 5488
  year: 2000
  ident: 10.1016/j.intimp.2020.107087_b0825
  article-title: Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
  publication-title: Science
  doi: 10.1126/science.289.5488.2350
– volume: 108
  start-page: 17093
  issue: 41
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1155
  article-title: The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1114194108
– volume: 101
  start-page: 3522
  issue: 10
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b1555
  article-title: Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0308680101
– volume: 26
  start-page: 42
  issue: 1
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0255
  article-title: Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?
  publication-title: Mol Med
  doi: 10.1186/s10020-020-00172-4
– volume: 10
  start-page: 963
  issue: 8
  year: 1996
  ident: 10.1016/j.intimp.2020.107087_b1130
  article-title: TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation
  publication-title: Genes Dev
  doi: 10.1101/gad.10.8.963
– year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0115
  article-title: Human infection by avian influenza A H5N1
  publication-title: Hong Kong Medical Journal
– volume: 36
  start-page: 57
  issue: 2
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1830
  article-title: Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells
  publication-title: International Reviews of Immunology
  doi: 10.1080/08830185.2016.1261318
– volume: 45
  start-page: 3545
  issue: 13
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0795
  article-title: Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2008.05.006
– volume: 309
  start-page: 1154
  issue: 11
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1760
  article-title: Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial
  publication-title: Jama
  doi: 10.1001/jama.2013.2194
– volume: 277
  start-page: 9976
  issue: 12
  year: 2002
  ident: 10.1016/j.intimp.2020.107087_b0940
  article-title: UBP43 (USP18) specifically removes ISG15 from conjugated proteins
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109078200
– volume: 497
  start-page: 498
  issue: 7450
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1770
  article-title: The TLR4 antagonist Eritoran protects mice from lethal influenza infection
  publication-title: Nature
  doi: 10.1038/nature12118
– volume: 2
  start-page: 233
  issue: 2
  year: 1998
  ident: 10.1016/j.intimp.2020.107087_b1310
  article-title: SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation
  publication-title: Mol Cell
  doi: 10.1016/S1097-2765(00)80133-1
– volume: 7
  start-page: 46097
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1210
  article-title: MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-kappaB and negatively regulates inflammatory responses
  publication-title: Sci Rep
  doi: 10.1038/srep46097
– volume: 6
  start-page: 7229
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1335
  article-title: Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure
  publication-title: Nat Commun
  doi: 10.1038/ncomms8229
– volume: 46
  start-page: 1067
  issue: 5
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1735
  article-title: Suppression of innate inflammation and immunity by interleukin-37
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201545828
– volume: 25
  start-page: 466
  issue: 6
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1695
  article-title: Interleukin-37
  publication-title: Semin Immunol
  doi: 10.1016/j.smim.2013.10.004
– volume: 184
  start-page: 5802
  issue: 10
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1495
  article-title: ST2 negatively regulates TLR2 signaling, but is not required for bacterial lipoprotein-induced tolerance
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0904127
– volume: 137
  start-page: 47
  issue: 1
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b1040
  article-title: A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
  publication-title: Cell
  doi: 10.1016/j.cell.2009.01.038
– volume: 12
  start-page: 742
  issue: 8
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1060
  article-title: The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors
  publication-title: Nat Immunol
  doi: 10.1038/ni.2064
– volume: 424
  start-page: 801
  issue: 6950
  year: 2003
  ident: 10.1016/j.intimp.2020.107087_b0880
  article-title: The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
  publication-title: Nature
  doi: 10.1038/nature01802
– volume: 4
  start-page: 920
  issue: 9
  year: 2003
  ident: 10.1016/j.intimp.2020.107087_b1530
  article-title: SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
  publication-title: Nat Immunol
  doi: 10.1038/ni968
– volume: 283
  start-page: 8486
  issue: 13
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b1205
  article-title: Makorin-2 is a neurogenesis inhibitor downstream of phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signal
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M704768200
– volume: 283
  start-page: 3618
  issue: 6
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0625
  article-title: Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M706906200
– volume: 10
  start-page: 203
  issue: 2
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b0315
  article-title: Toll-Like Receptors: Regulators of the Immune Response in the Human Gut
  publication-title: Nutrients
  doi: 10.3390/nu10020203
– volume: 90
  start-page: 472
  issue: 5
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0320
  article-title: TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis
  publication-title: Jornal de Pediatria
  doi: 10.1016/j.jped.2013.12.012
– volume: 198
  start-page: 1563
  issue: 10
  year: 2003
  ident: 10.1016/j.intimp.2020.107087_b0405
  article-title: A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease
  publication-title: J Exp Med
  doi: 10.1084/jem.20031220
– volume: 19
  start-page: 5114
  issue: 19
  year: 2000
  ident: 10.1016/j.intimp.2020.107087_b0570
  article-title: p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction
  publication-title: Embo j
  doi: 10.1093/emboj/19.19.5114
– volume: 9
  start-page: 43
  issue: 1
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0180
  article-title: Therapeutic potential of complement modulation
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/nrd3011
– volume: 67
  start-page: 318
  issue: 1
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1055
  article-title: Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-06-2164
– year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1250
  article-title: TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1601647
– ident: 10.1016/j.intimp.2020.107087_b0325
– volume: 11
  start-page: 861
  issue: 12
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1305
  article-title: The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
  publication-title: Nature reviews. Molecular cell biology
  doi: 10.1038/nrm3011
– volume: 30
  start-page: 383
  issue: 8
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b1800
  article-title: The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2009.05.007
– volume: 17
  start-page: 1128
  issue: 4
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1835
  article-title: HMGB1 Activates Proinflammatory Signaling via TLR5 Leading to Allodynia
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2016.09.076
– volume: 29
  start-page: 12
  issue: 1
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0610
  article-title: When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.06.004
– volume: 16
  issue: 7
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b1815
  article-title: TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes
  publication-title: PLOS Pathogens
  doi: 10.1371/journal.ppat.1008622
– volume: 12
  start-page: 8
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0765
  article-title: Calcineurin/NFAT signaling and innate host defence: a role for NOD1-mediated phagocytic functions
  publication-title: Cell Commun Signal
  doi: 10.1186/1478-811X-12-8
– volume: 83
  start-page: 258
  issue: 4
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b1460
  article-title: Modulation of Toll-interleukin 1 receptor mediated signaling
  publication-title: J Mol Med (Berl)
  doi: 10.1007/s00109-004-0622-4
– volume: 43
  start-page: 359
  issue: 3
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0975
  article-title: Roles of ubiquitination in pattern-recognition receptors and type I interferon receptor signaling
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2008.07.012
– volume: 9
  start-page: 542
  issue: 5
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0715
  article-title: Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
  publication-title: Nat Immunol
  doi: 10.1038/ni.1604
– volume: 22
  start-page: 159
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b1295
  article-title: Modification of proteins by ubiquitin and ubiquitin-like proteins
  publication-title: Annu Rev Cell Dev Biol
  doi: 10.1146/annurev.cellbio.22.010605.093503
– volume: 79
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0525
  article-title: Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2019.106044
– volume: 9
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0400
  article-title: TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury
  publication-title: eLife
  doi: 10.7554/eLife.50458
– volume: 91
  start-page: 5
  issue: 1–2
  year: 2000
  ident: 10.1016/j.intimp.2020.107087_b1185
  article-title: The LIM domain: regulation by association
  publication-title: Mech Dev
  doi: 10.1016/S0925-4773(99)00314-7
– volume: 113
  start-page: E165
  issue: 2
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0905
  article-title: Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88
  publication-title: Proceedings of the National Academy of Sciences
  doi: 10.1073/pnas.1518615113
– volume: 85
  start-page: 481
  issue: 3
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b1200
  article-title: Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0408238
– volume: 9
  start-page: 2112
  issue: 6
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b1790
  article-title: Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2014.11.020
– volume: 6
  start-page: 34672
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0690
  article-title: Deficiency in Toll-interacting protein (Tollip) skews inflamed yet incompetent innate leukocytes in vivo during DSS-induced septic colitis
  publication-title: Scientific Reports
  doi: 10.1038/srep34672
– volume: 10
  start-page: 586
  issue: 8
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b1265
  article-title: Inhibition of transmembrane TNF-α shedding by a specific antibody protects against septic shock
  publication-title: Cell Death & Disease
  doi: 10.1038/s41419-019-1808-6
– volume: 18
  start-page: 839
  issue: 8
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1840
  article-title: Autophagosome-lysosome fusion triggers a lysosomal response mediated by TLR9 and controlled by OCRL
  publication-title: Nat Cell Biol
  doi: 10.1038/ncb3386
– volume: 12
  start-page: 774
  issue: 11
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b0810
  article-title: A20: linking a complex regulator of ubiquitylation to immunity and human disease
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri3313
– volume: 195
  start-page: 3515
  issue: 8
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1025
  article-title: Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8+ T Cell Expansion and Effector Function through Direct Repression of Irf4
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1403027
– volume: 45
  start-page: 314
  issue: 3
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b1325
  article-title: Effect of deletion of SUMOylation on dendritic cell function in septic mice and its role in sepsis
  publication-title: Zhong Nan Da Xue Xue Bao Yi Xue Ban
– volume: 15
  start-page: 1586
  issue: 2
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b0655
  article-title: Interleukin-1 receptor-associated kinase 3 downregulation in peripheral blood mononuclear cells attenuates immunosuppression in sepsis
  publication-title: Exp Ther Med
– volume: 211
  start-page: 1025
  issue: 5
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1430
  article-title: Reversible ubiquitination shapes NLRC5 function and modulates NF-kappaB activation switch
  publication-title: J Cell Biol
  doi: 10.1083/jcb.201505091
– volume: 140
  start-page: 918
  issue: 6
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1035
  article-title: Mechanisms underlying inflammation in neurodegeneration
  publication-title: Cell
  doi: 10.1016/j.cell.2010.02.016
– volume: 98
  issue: 10
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b1715
  article-title: Elevated serum IL-37 concentrations in patients with sepsis
  publication-title: Medicine (Baltimore)
  doi: 10.1097/MD.0000000000014756
– volume: 39
  start-page: 2217
  issue: 12
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0620
  article-title: A Janus role for MerTK in the outcome of septic shock
  publication-title: Intensive Care Medicine
  doi: 10.1007/s00134-013-3106-6
– volume: 123
  start-page: 2460
  issue: 16
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0600
  article-title: C. van 't Veer, TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis
  publication-title: Blood
  doi: 10.1182/blood-2013-09-528752
– volume: 32
  start-page: 1653
  issue: 6
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b0340
  article-title: The Relationship Between Sepsis-induced Immunosuppression and Serum Toll-like Receptor 9 Level
  publication-title: Vivo
  doi: 10.21873/invivo.11428
– volume: 74
  start-page: 3538
  issue: 6
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b0370
  article-title: MyD88-dependent signaling affects the development of meningococcal sepsis by nonlipooligosaccharide ligands
  publication-title: Infect Immun
  doi: 10.1128/IAI.00128-06
– volume: 9
  start-page: 360
  issue: 5
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0090
  article-title: Calming the cytokine storm
  publication-title: Nature Reviews Drug Discovery
  doi: 10.1038/nrd3162
– volume: 32
  start-page: 143
  issue: 2
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b0170
  article-title: Antimicrobial peptides: key components of the innate immune system
  publication-title: Crit Rev Biotechnol
  doi: 10.3109/07388551.2011.594423
– year: 2018
  ident: 10.1016/j.intimp.2020.107087_b1345
  article-title: Small molecular inhibitors targeting protein SUMOylation as novel anticancer compounds
  publication-title: Molecular Pharmacology
  doi: 10.1124/mol.118.112300
– volume: 40
  start-page: 1738
  issue: 6
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0455
  article-title: SARM inhibits both TRIF- and MyD88-mediated AP-1 activation
  publication-title: Eur J Immunol
  doi: 10.1002/eji.200940034
– volume: 17
  issue: 1
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b0480
  article-title: Role of IRF4 in the Protection of Metformin-Mediated Sepsis Myocarditis
  publication-title: Dose Response
  doi: 10.1177/1559325819827436
– volume: 17
  start-page: 205
  issue: 4
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1525
  article-title: Soluble ST2 levels in patients with cardiogenic and septic shock are not predictors of mortality
  publication-title: Experimental & Clinical Cardiology
– volume: 17
  start-page: 25
  issue: 1
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0890
  article-title: CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes
  publication-title: Cell Death Differ
  doi: 10.1038/cdd.2009.43
– volume: 131
  start-page: 1124
  issue: 6
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b0590
  article-title: TAM receptors are pleiotropic inhibitors of the innate immune response
  publication-title: Cell
  doi: 10.1016/j.cell.2007.10.034
– volume: 2
  issue: 1
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b0045
  article-title: Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality
  publication-title: Journal of Global Health
  doi: 10.7189/jogh.01.010404
– volume: 39
  start-page: 1930
  issue: 6
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0460
  article-title: Reduced Expression of SARM in Mouse Spleen during Polymicrobial Sepsis
  publication-title: Inflammation
  doi: 10.1007/s10753-016-0428-x
– volume: 102
  start-page: 657
  issue: 3
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0710
  article-title: Shp1 function in myeloid cells
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.2MR0317-105R
– volume: 10
  start-page: 965
  issue: 9
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b1145
  article-title: TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis
  publication-title: Nat Immunol
  doi: 10.1038/ni.1771
– volume: 12
  start-page: 1535
  issue: 4
  year: 1992
  ident: 10.1016/j.intimp.2020.107087_b1650
  article-title: A collection of mRNA species that are inducible in the RAW 264.7 mouse macrophage cell line by gamma interferon and other agents
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.12.4.1535
– volume: 43
  start-page: 187
  issue: 1
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b0415
  article-title: Toll-like receptors activation, signaling, and targeting: an overview
  publication-title: Bulletin of the National Research Centre
  doi: 10.1186/s42269-019-0227-2
– volume: 186
  start-page: 5443
  issue: 9
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b0725
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1003551
– volume: 14
  start-page: 211
  issue: 4
  year: 2003
  ident: 10.1016/j.intimp.2020.107087_b1560
  article-title: Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR
  publication-title: Eur Cytokine Netw
– year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0075
  article-title: Recognizing Sepsis as a Global Health Priority - A WHO Resolution
  publication-title: N Engl J Med
  doi: 10.1056/NEJMp1707170
– volume: 5
  start-page: 373
  issue: 4
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b1485
  article-title: ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
  publication-title: Nat Immunol
  doi: 10.1038/ni1050
– volume: 29
  start-page: 1303
  issue: 7
  year: 2001
  ident: 10.1016/j.intimp.2020.107087_b0040
  article-title: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
  publication-title: Crit Care Med
  doi: 10.1097/00003246-200107000-00002
– year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0100
  article-title: Is a “Cytokine Storm” Relevant to COVID-19?, JAMA
  publication-title: Internal Medicine
– volume: 12
  issue: 12
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b1100
  article-title: Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.1002026
– volume: 20
  start-page: 5479
  issue: 15
  year: 2000
  ident: 10.1016/j.intimp.2020.107087_b0790
  article-title: Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.20.15.5479-5489.2000
– volume: 108
  start-page: 19341
  issue: 48
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1245
  article-title: Tripartite motif 8 (TRIM8) modulates TNFalpha- and IL-1beta-triggered NF-kappaB activation by targeting TAK1 for K63-linked polyubiquitination
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1110946108
– volume: 16
  start-page: 17344
  issue: 1
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0025
  article-title: Sepsis in AIDS patients: clinical, etiological and inflammatory characteristics
  publication-title: Journal of the International AIDS Society
  doi: 10.7448/IAS.16.1.17344
– volume: 5
  start-page: 1052
  issue: 10
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b0835
  article-title: The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
  publication-title: Nat Immunol
  doi: 10.1038/ni1110
– volume: 289
  start-page: 14422
  issue: 20
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0915
  article-title: Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M114.547547
– volume: 2
  start-page: 346
  issue: 6
  year: 2000
  ident: 10.1016/j.intimp.2020.107087_b0665
  article-title: Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
  publication-title: Nat Cell Biol
  doi: 10.1038/35014038
– volume: 22
  start-page: 822
  issue: 5
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b1415
  article-title: Enhanced TLR-induced NF-kappaB signaling and type I interferon responses in NLRC5 deficient mice
  publication-title: Cell Res
  doi: 10.1038/cr.2012.53
– volume: 11
  start-page: 1014
  issue: 11
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1705
  article-title: IL-37 is a fundamental inhibitor of innate immunity
  publication-title: Nat Immunol
  doi: 10.1038/ni.1944
– volume: 49
  start-page: 219
  issue: 1–2
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b0510
  article-title: Expression of tumor necrosis factor-α induced protein 8 like-2 contributes to the immunosuppressive property of CD4(+)CD25(+) regulatory T cells in mice
  publication-title: Mol Immunol
  doi: 10.1016/j.molimm.2011.08.016
– volume: 157
  start-page: 4277
  issue: 10
  year: 1996
  ident: 10.1016/j.intimp.2020.107087_b1290
  article-title: Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin
  publication-title: J Immunol
  doi: 10.4049/jimmunol.157.10.4277
– volume: 26
  start-page: 215
  issue: 2
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b0270
  article-title: Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.12.005
– volume: 441
  start-page: 173
  issue: 7090
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b1655
  article-title: Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4
  publication-title: Nature
  doi: 10.1038/nature04768
– volume: 11
  start-page: 275
  issue: 4
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b0190
  article-title: Immunity to fungal infections
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2939
– volume: 442
  start-page: 147
  issue: 2–3
  year: 1999
  ident: 10.1016/j.intimp.2020.107087_b0830
  article-title: The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6
  publication-title: FEBS Lett
  doi: 10.1016/S0014-5793(98)01645-7
– volume: 29
  start-page: 565
  issue: 4
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b1390
  article-title: The TSC-mTOR signaling pathway regulates the innate inflammatory response
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.08.012
– volume: 19
  start-page: 515
  issue: 4
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1365
  article-title: NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.03.001
– volume: 67
  start-page: 139
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1440
  article-title: ST2 from rainbow trout quenches TLR signalling, localises at the nuclear membrane and allows the nuclear translocation of MYD88
  publication-title: Developmental & Comparative Immunology
  doi: 10.1016/j.dci.2016.10.009
– ident: 10.1016/j.intimp.2020.107087_b0260
  doi: 10.1080/09537104.2018.1445841
– volume: 133
  start-page: 415
  issue: 3
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0490
  article-title: TIPE2, a novel negative regulator of innate and adaptive immunity that maintains immune homeostasis
  publication-title: Cell
  doi: 10.1016/j.cell.2008.03.026
– volume: 9
  issue: 8
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0365
  article-title: MyD88-, but not Nod1- and/or Nod2-deficient mice, show increased susceptibility to polymicrobial sepsis due to impaired local inflammatory response
  publication-title: PloS one
  doi: 10.1371/journal.pone.0103734
– volume: 72
  start-page: 182
  issue: 2
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1545
  article-title: Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells
  publication-title: Kidney Int
  doi: 10.1038/sj.ki.5002293
– volume: 5
  issue: 11
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b1260
  article-title: The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1000650
– volume: 381
  start-page: 503
  issue: Pt 2
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b1710
  article-title: Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide
  publication-title: Biochem J
  doi: 10.1042/BJ20040217
– volume: 273
  start-page: 1
  issue: 1
  year: 2001
  ident: 10.1016/j.intimp.2020.107087_b1640
  article-title: The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis
  publication-title: Gene
  doi: 10.1016/S0378-1119(01)00551-0
– volume: 10
  issue: 5
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b0435
  article-title: Interleukin-8 for Diagnosis of Neonatal Sepsis: A Meta-Analysis
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0127170
– volume: 318
  start-page: 1628
  issue: 5856
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b0985
  article-title: DUBA: a deubiquitinase that regulates type I interferon production
  publication-title: Science
  doi: 10.1126/science.1145918
– year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1685
  article-title: The emerging role of interleukin-37 in cardiovascular diseases
  publication-title: Immun Inflamm Dis
  doi: 10.1002/iid3.159
– volume: 38
  start-page: 119
  issue: 1
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1865
  article-title: Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.09.016
– volume: 5
  issue: 11
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0575
  article-title: Biology of the TAM receptors
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a009076
– volume: 32
  start-page: 1677
  issue: 3
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b1350
  article-title: Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2
  publication-title: Faseb j
  doi: 10.1096/fj.201700711R
– volume: 277
  start-page: 49205
  issue: 51
  year: 2002
  ident: 10.1016/j.intimp.2020.107087_b1490
  article-title: Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M209685200
– volume: 1681
  start-page: 1
  issue: 1
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b1480
  article-title: Molecular cloning of the chicken ST2 gene and a novel variant form of the ST2 gene product, ST2LV
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbaexp.2004.08.013
– volume: 33
  start-page: 989
  issue: 11–12
  year: 1996
  ident: 10.1016/j.intimp.2020.107087_b1645
  article-title: Identification of a lipopolysaccharide inducible transcription factor in murine macrophages
  publication-title: Mol Immunol
  doi: 10.1016/S0161-5890(96)00043-0
– volume: 220
  start-page: 1008
  issue: 6
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b0500
  article-title: TIPE2 Suppresses Pseudomonas aeruginosa Keratitis by Inhibiting NF-κB Signaling and the Infiltration of Inflammatory Cells
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jiz246
– volume: 115
  start-page: 19
  issue: 2
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b1270
  article-title: Triad3A attenuates pathological cardiac hypertrophy involving the augmentation of ubiquitination-mediated degradation of TLR4 and TLR9
  publication-title: Basic Research in Cardiology
  doi: 10.1007/s00395-020-0779-1
– volume: 10
  start-page: 1325
  issue: 11
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0140
  article-title: Neutrophils: Cinderella of innate immune system
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2010.08.012
– volume: 4
  issue: 56
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1075
  article-title: Emerging Roles of the Mitogen and Stress Activated Kinases MSK1 and MSK2
  publication-title: Frontiers in Cell and Developmental Biology
– volume: 33
  start-page: 355
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b0585
  article-title: TAM receptor signaling in immune homeostasis
  publication-title: Annu Rev Immunol
  doi: 10.1146/annurev-immunol-032414-112103
– volume: 279
  start-page: 17278
  issue: 17
  year: 2004
  ident: 10.1016/j.intimp.2020.107087_b0875
  article-title: TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis
  publication-title: J Biol Chem
  doi: 10.1074/jbc.C400063200
– volume: 7
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0955
  article-title: Multiple functions of USP18
  publication-title: Cell Death Dis
  doi: 10.1038/cddis.2016.326
– volume: 372
  start-page: 1
  issue: 1
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b0310
  article-title: Recognizing conserved non-canonical localization patterns of toll-like receptors in tissues and across species
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-017-2767-9
– volume: 16
  start-page: 1811
  issue: 4
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b1160
  article-title: Mystique Is a New Insulin-like Growth Factor-I-regulated PDZ-LIM Domain Protein That Promotes Cell Attachment and Migration and Suppresses Anchorage-independent Growth
  publication-title: Molecular Biology of the Cell
  doi: 10.1091/mbc.e04-12-1052
– volume: 123
  start-page: 958
  issue: 3
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b0125
  article-title: Causes, consequences, and reversal of immune system aging
  publication-title: The Journal of Clinical Investigation
  doi: 10.1172/JCI64096
– volume: 76
  start-page: 16
  issue: 1
  year: 2012
  ident: 10.1016/j.intimp.2020.107087_b0120
  article-title: Into the eye of the cytokine storm
  publication-title: Microbiol Mol Biol Rev
  doi: 10.1128/MMBR.05015-11
– volume: 7
  start-page: ra119
  issue: 356
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b1195
  article-title: HSP70 mediates degradation of the p65 subunit of nuclear factor kappaB to inhibit inflammatory signaling
  publication-title: Sci Signal
  doi: 10.1126/scisignal.2005533
– volume: 30
  start-page: 439
  issue: 9
  year: 2009
  ident: 10.1016/j.intimp.2020.107087_b1575
  article-title: TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2009.06.001
– volume: 80
  start-page: 1483
  issue: 4
  year: 2000
  ident: 10.1016/j.intimp.2020.107087_b0760
  article-title: Calcineurin: form and function
  publication-title: Physiol Rev
  doi: 10.1152/physrev.2000.80.4.1483
– volume: 235
  start-page: 474
  issue: 3
  year: 1997
  ident: 10.1016/j.intimp.2020.107087_b1510
  article-title: Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli
  publication-title: Biochem Biophys Res Commun
  doi: 10.1006/bbrc.1997.6810
– volume: 34
  start-page: 1492
  issue: 6
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0520
  article-title: Xuebijing exerts protective effects on lung permeability leakage and lung injury by upregulating Toll-interacting protein expression in rats with sepsis
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2014.1943
– volume: 196
  start-page: 3834
  issue: 9
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b1610
  article-title: TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1502599
– volume: 57
  start-page: 1203
  issue: 3
  year: 2013
  ident: 10.1016/j.intimp.2020.107087_b1775
  article-title: beta-catenin regulates innate and adaptive immunity in mouse liver ischemia-reperfusion injury
  publication-title: Hepatology
  doi: 10.1002/hep.26100
– volume: 280
  start-page: 41111
  issue: 49
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0870
  article-title: The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M509526200
– volume: 318
  start-page: 83
  issue: 1
  year: 1993
  ident: 10.1016/j.intimp.2020.107087_b1475
  article-title: Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1
  publication-title: FEBS Lett
  doi: 10.1016/0014-5793(93)81333-U
– volume: 291
  start-page: 22650
  issue: 43
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0495
  article-title: TIPE2 (Tumor Necrosis Factor alpha-induced Protein 8-like 2) Is a Novel Negative Regulator of TAK1 Signal
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M116.733451
– volume: 49
  start-page: 740
  issue: 4
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b0250
  article-title: The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.08.016
– volume: 39
  start-page: 1086
  issue: 4
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1805
  article-title: Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST0391086
– volume: 72
  start-page: 3343
  issue: 17
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b0305
  article-title: Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-015-1931-1
– volume: 203
  start-page: 1891
  issue: 8
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b0605
  article-title: Twist mediates suppression of inflammation by type I IFNs and Axl
  publication-title: J Exp Med
  doi: 10.1084/jem.20051725
– volume: 42
  start-page: 942
  issue: 9
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b0020
  article-title: International Nosocomial Infection Control Consortium (INICC) report, data summary of 43 countries for 2007–2012
  publication-title: Device-associated module, Am J Infect Control
  doi: 10.1016/j.ajic.2014.05.029
– volume: 304
  start-page: 1093
  issue: 3
  year: 2003
  ident: 10.1016/j.intimp.2020.107087_b1750
  article-title: Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist
  publication-title: J Pharmacol Exp Ther
  doi: 10.1124/jpet.102.044487
– volume: 184
  start-page: 5094
  issue: 9
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1605
  article-title: Human TLRs 10 and 1 Share Common Mechanisms of Innate Immune Sensing but Not Signaling
  publication-title: The Journal of Immunology
  doi: 10.4049/jimmunol.0901888
– volume: 202
  start-page: 363
  issue: 3
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b0550
  article-title: DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
  publication-title: J Exp Med
  doi: 10.1084/jem.20050986
– volume: 100
  start-page: 35
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b0580
  article-title: TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer
  publication-title: Adv Cancer Res
  doi: 10.1016/S0065-230X(08)00002-X
– volume: 186
  start-page: 4467
  issue: 7
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b0695
  article-title: Low-dose endotoxin induces inflammation by selectively removing nuclear receptors and activating CCAAT/enhancer-binding protein delta
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1003300
– volume: 274
  start-page: 330
  issue: 1
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0220
  article-title: The immune system's role in sepsis progression, resolution, and long-term outcome
  publication-title: Immunol Rev
  doi: 10.1111/imr.12499
– volume: 140
  start-page: 805
  issue: 6
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b0200
  article-title: Pattern recognition receptors and inflammation
  publication-title: Cell
  doi: 10.1016/j.cell.2010.01.022
– ident: 10.1016/j.intimp.2020.107087_b0330
– volume: 19
  start-page: 3029
  issue: 4
  year: 1999
  ident: 10.1016/j.intimp.2020.107087_b0935
  article-title: A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation
  publication-title: Mol Cell Biol
  doi: 10.1128/MCB.19.4.3029
– volume: 6
  issue: 8
  year: 2011
  ident: 10.1016/j.intimp.2020.107087_b1500
  article-title: In Silico Approach to Inhibition of Signaling Pathways of Toll-Like Receptors 2 and 4 by ST2L
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0023989
– volume: 92
  start-page: 145
  issue: 3
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1810
  article-title: Innate immunity: toll-like receptors and some more
  publication-title: A brief history, basic organization and relevance for the human newborn, Neonatology
– volume: 68
  start-page: 7010
  issue: 12
  year: 2000
  ident: 10.1016/j.intimp.2020.107087_b0300
  article-title: Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
  publication-title: Infect Immun
  doi: 10.1128/IAI.68.12.7010-7017.2000
– volume: 185
  start-page: 1681
  issue: 3
  year: 2010
  ident: 10.1016/j.intimp.2020.107087_b1405
  article-title: NLRC5 limits the activation of inflammatory pathways
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0903900
– volume: 332
  start-page: 16
  year: 2019
  ident: 10.1016/j.intimp.2020.107087_b0210
  article-title: Toll-like receptors in the pathogenesis of neuroinflammation
  publication-title: Journal of Neuroimmunology
  doi: 10.1016/j.jneuroim.2019.03.012
– volume: 124
  start-page: 783
  issue: 4
  year: 2006
  ident: 10.1016/j.intimp.2020.107087_b0385
  article-title: Pathogen recognition and innate immunity
  publication-title: Cell
  doi: 10.1016/j.cell.2006.02.015
– volume: 111
  start-page: E4478
  issue: 42
  year: 2014
  ident: 10.1016/j.intimp.2020.107087_b1630
  article-title: Human TLR10 is an anti-inflammatory pattern-recognition receptor
  publication-title: Proceedings of the National Academy of Sciences
  doi: 10.1073/pnas.1410293111
– volume: 8
  start-page: 849
  issue: 11
  year: 2008
  ident: 10.1016/j.intimp.2020.107087_b1235
  article-title: TRIM family proteins and their emerging roles in innate immunity
  publication-title: Nature reviews. Immunology
  doi: 10.1038/nri2413
– volume: 23
  start-page: 83
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b1725
  article-title: IL-37 Suppresses MyD88-mediated Inflammatory Responses in Human Aortic Valve Interstitial Cells
  publication-title: Molecular Medicine
  doi: 10.2119/molmed.2017.00022
– volume: 6
  issue: 4
  year: 2017
  ident: 10.1016/j.intimp.2020.107087_b0705
  article-title: Tollip Deficiency Alters Atherosclerosis and Steatosis by Disrupting Lipophagy
  publication-title: J Am Heart Assoc
  doi: 10.1161/JAHA.116.004078
– volume: 193
  start-page: 228
  issue: 3
  year: 2016
  ident: 10.1016/j.intimp.2020.107087_b0015
  article-title: The Global Epidemiology of Sepsis. Does It Matter That We Know So Little?
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201510-1976ED
– volume: 19
  start-page: 469
  issue: 6
  year: 1997
  ident: 10.1016/j.intimp.2020.107087_b1180
  article-title: PDZ domains: targeting signalling molecules to sub-membranous sites
  publication-title: Bioessays
  doi: 10.1002/bies.950190606
– volume: 27
  start-page: 161
  issue: 1
  year: 2020
  ident: 10.1016/j.intimp.2020.107087_b0920
  article-title: RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
  publication-title: Cell Death & Differentiation
  doi: 10.1038/s41418-019-0347-0
– volume: 282
  start-page: 11817
  issue: 16
  year: 2007
  ident: 10.1016/j.intimp.2020.107087_b1150
  article-title: Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M700017200
– volume: 9
  issue: 1954
  year: 2018
  ident: 10.1016/j.intimp.2020.107087_b1665
  article-title: ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1β Activation During Streptococcus pneumoniae Infection
  publication-title: Frontiers in Immunology
– volume: 16
  start-page: 354
  issue: 4
  year: 2015
  ident: 10.1016/j.intimp.2020.107087_b1720
  article-title: IL-37 requires the receptors IL-18Ralpha and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
  publication-title: Nat Immunol
  doi: 10.1038/ni.3103
– volume: 22
  start-page: 729
  issue: 6
  year: 2005
  ident: 10.1016/j.intimp.2020.107087_b1165
  article-title: SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling
  publication-title: Immunity
  doi: 10.1016/j.immuni.2005.04.008
SSID ssj0017041
Score 2.629213
SecondaryResourceType review_article
Snippet [Display omitted] •Sepsis infects more than 48.9 million people world-wide, with 19.7 million deaths.•Cytokine storm plays a significant role in sepsis, along...
Cytokine storm generates during various systemic acute infections, including sepsis and current pandemic called COVID-19 (severe) causing devastating...
• Sepsis infects more than 48.9 million people world-wide, with 19.7 million deaths. • Cytokine storm plays a significant role in sepsis, along with severe...
SourceID pubmedcentral
proquest
pubmed
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 107087
SubjectTerms Animals
Chemokines
Coronaviruses
COVID-19
COVID-19 - immunology
Cytokine Release Syndrome - etiology
Cytokine storm
Cytokines
Damage patterns
Down-regulation
Feedback
Homeostasis
Humans
Immune system
Immunomodulation
Immunosuppressive agents
Inflammation
Inflammatory diseases
Inflammatory response
Innate Immunity
Interferon
Mice
Microorganisms
Negative feedback
PAMPs
Pandemics
Pathogens
Pattern recognition
Pattern recognition receptors
Proteins
Reactive nitrogen species
Reactive oxygen species
Receptors
Regulators
SARS-CoV-2
Sepsis
Sepsis - immunology
Signal transduction
Signal Transduction - physiology
Signaling
State-of-the-art reviews
Storm damage
TLRs
Toll-like receptors
Toll-Like Receptors - physiology
Ubiquitination
Title Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
URI https://dx.doi.org/10.1016/j.intimp.2020.107087
https://www.ncbi.nlm.nih.gov/pubmed/33075714
https://www.proquest.com/docview/2477270816
https://www.proquest.com/docview/2452496709
https://pubmed.ncbi.nlm.nih.gov/PMC7550173
Volume 89
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBYhpdBLadPXtmlQoeQUd62HrfUxhIZNCyHQDeQmtLLcOsnKS-0efOklfzwzlu1020CgRz1sZM9oNIO--YaQj0spTOxSFnHrZCSTXEZZnEOUAn1xajjWPUK0xWk6P5dfLpKLLXI05MIgrLK3_cGmd9a675n2f3O6LsvpN4g8FHjLGdYAh6ADk_ikVKjln36PMA-mYhk4U8Eg4Owhfa7DeJW-KVfIWsmxS8UIrLv_ePrX_fwbRfnHsXT8jDzt_Ul6GJb8nGw5v0MehwqT7Q7ZPwvU1O0BXdxlWtUHdJ-e3ZFWty_IzQIUIrourxyF_-HWWISHlp7Wbl2XdWR6Kbqc2raprsA3pYirXFHjc9rdNlDn8ypQvlLvvneE4vCurtQ9vszUNBCY0BJzUqpVlYehlgY4ev2SnB9_XhzNo75AQ2RlxpqI8ZxLy4wTSzzpl8IlRVIYUzDnIPA0YEhTbhNwOoSw3PACmqkyygnwQsUsFq_Itq-8e0OoNW7GlIHwxkgpIAqUeTZD2twit7Eo0gkRg1y07dnLsYjGtR5gapc6SFOjNHWQ5oRE41PrwN7xwHw1iFxvaKGGA-aBJ3cHDdG9Fag1lxC7KCxtMiEfxmHYv3gpY7wDgWi8-ZYZsuhNyOugUONSBRjgRDEJy9pQtXECcoNvjvjyR8cRriDyZEq8_e8PekeeYCsgd3bJdvPzl3sP_lez3Os22B55dHjydX56C9fbM34
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VrRC9ICivhQJGQj012iR24s2xqqi2tKwqsZV6s7yJU0K7zqoJh5z548zEScoCUiWO8UuOZzyekT9_A_BxKbj2TRx4YWqEJ6JMeImfYZSCZX6sQ8p7RGiLeTy7EJ8vo8stOOrfwhCssrP9zqa31rormXSrOVkXxeQrRh4SveWEcoBj0JE8gG1ip4pGsH14cjqbD5cJ0heONhVtAnXoX9C1MK_C1sWKiCtDKpI-Yev-fUL97YH-CaT87WQ6fgKPO5eSHbpZP4UtY3fhoUsy2ezC_rljp24O2OLusVV1wPbZ-R1vdfMMfi5QJ7yb4towXBKzpjw8rLCsMuuqqDzdCdJkLG3q8hrdU0bQyhXTNmPthQMzNisd6yuz5qrlFMex2mz3NJiumOMwYQU9SylXZeaqGuYQ6dVzuDj-tDiaeV2OBi8VSVB7QZiFIg204Us67JfcRHmUa50HxmDsqdGWxmEaod_BeRrqMMfPWGppODqifOrzFzCypTWvgKXaTAOpMcLRQnAMBEWWTIk5N89Sn-fxGHgvF5V2BOaUR-NG9Ui178pJU5E0lZPmGLyh19oReNzTXvYiVxuKqPCMuafnXq8hqjMElQoFhi-SspuM4cNQjVuY7mW0NSgQRZffIiEivTG8dAo1TJWjDY5kIHBaG6o2NCB68M0aW3xracIlBp-B5K__-4few6PZ4suZOjuZn76BHapxQJ49GNW3P8xbdMfq5btuu_0COXw2Lw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Toll-like+receptors+in+sepsis-associated+cytokine+storm+and+their+endogenous+negative+regulators+as+future+immunomodulatory+targets&rft.jtitle=International+immunopharmacology&rft.au=Kumar%2C+V&rft.date=2020-12-01&rft.pub=Elsevier+BV&rft.issn=1567-5769&rft.eissn=1878-1705&rft.volume=89&rft.spage=1&rft_id=info:doi/10.1016%2Fj.intimp.2020.107087&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1567-5769&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1567-5769&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1567-5769&client=summon