Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

• Published in: Drug design, development and therapy Vol. 12; pp. 1855 - 1863
• Main Authors: Choi, Bo Ram, Kim, Hye Kyung, Soni, Kiran Kumar, Karna, Keshab Kumar, Lee, Sung Won, So, Insuk, Park, Jong Kwan
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 2018; Taylor & Francis Ltd; Dove Medical Press
• Subjects: 17β-Estradiol; 5α-reductase inhibitors; Abdomen; Administration, Oral; Adrenergic receptors; Anesthesia; Animals; Aprotinin; Benign; Benzofurans - administration & dosage; benzofuroindole; Biomedical research; Bladder; Carboxylic acids; Castration; Combination drug therapy; Disease Models, Animal; Drug Therapy, Combination; EDTA; Estradiol; Estrogens; Finasteride; Finasteride - administration & dosage; Gene expression; Histochemistry; Histopathology; Hormones; Hyperplasia; Indoles; Indoles - administration & dosage; intraurethral pressure; Ketamine; Laboratory animals; Male; Messenger RNA; mRNA; Original Research; Phenols (Class of compounds); Physiology; Polyethylene; Pressure transducers; Propionic acid; Prostate; Prostatic hyperplasia; Prostatic Hyperplasia - blood; Prostatic Hyperplasia - drug therapy; Rats; Rats, Sprague-Dawley; Receptors (physiology); Receptors, Adrenergic, alpha-1 - analysis; Receptors, Adrenergic, alpha-1 - genetics; Retirement benefits; RNA; Rodents; Serum; Sex hormones; Smooth muscle; Sulfonamides - administration & dosage; Surgery; Tamsulosin; Testosterone; Testosterone - blood; Testosterone propionate; Urogenital system; Urology; α1-adrenergic receptor antagonists; α1-adrenoceptors; United States > US; South Korea; Japan; 5α-reductase inhibitors; α1-adrenergic receptor antagonists; intraurethral pressure; benzofuroindole; α1-adrenoceptors

We investigated the benefits of the BK agonist 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid (LDD175) combined with tamsulosin and finasteride, in a benign prostatic hyperplasia (BPH) rat model. Castration was performed by bilateral orchiectomy under ketamine anesthesi...