Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1

• Published in: Journal of dermatology Vol. 46; no. 3; pp. 177 - 185
• Main Authors: Xie, Bo, Li, Xin‐Yu
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2019; John Wiley and Sons Inc
• Subjects: Animals; Ankyrins; Atopic dermatitis; Calcium - metabolism; chronic cutaneous itch; Chronic Disease; Cytokines; Cytokines - metabolism; Dermatitis; Diabetes mellitus; dorsal root ganglion neurons; Ganglia, Spinal - cytology; Ganglia, Spinal - metabolism; Humans; Inflammation; inflammatory mediators; Jaundice; Neurons - metabolism; Osmosis; Phosphorylation; Pruritus; Pruritus - pathology; Psoriasis; Review; Skin; Skin - cytology; Skin - metabolism; Skin diseases; transient receptor potential channel ankyrin transmembrane protein 1; transient receptor potential channel vanilloid 1; Transient receptor potential proteins; TRPA1 Cation Channel - metabolism; TRPV Cation Channels - metabolism; inflammatory mediators; chronic cutaneous itch; transient receptor potential channel vanilloid 1; dorsal root ganglion neurons; transient receptor potential channel ankyrin transmembrane protein 1

Chronic itch with an itch–scratch vicious circle is a significant problem in a large amount of diseases. Some of these diseases, such as psoriasis, atopic dermatitis, prurigo nodularis, Sézary syndrome, uremic pruritus, diabetes and jaundice, are common. For a very long time, chronic itch has been a...