Thrombelastography‐guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: A randomized, controlled trial
Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides a more comprehens...
Saved in:
| Published in | Hepatology (Baltimore, Md.) Vol. 63; no. 2; pp. 566 - 573 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wolters Kluwer Health, Inc
01.02.2016
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides a more comprehensive global coagulation assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in patients with cirrhosis and significant coagulopathy (defined in this study as INR >1.8 and/or platelet count <50 × 109/L) who will be undergoing an invasive procedure. Sixty patients were randomly allocated to TEG‐guided transfusion strategy or standard of care (SOC; 1:1 TEG:SOC). The TEG group would receive FFP if the reaction time (r) was >40 min and/or PLT if maximum amplitude (MA) was <30 mm. All SOC patients received FFP and/or PLT per hospital guidelines. Endpoints were blood product use and bleeding complications. Baseline characteristics of the two groups were similar. Per protocol, all subjects in the SOC group received blood product transfusions versus 5 in the TEG group (100% vs. 16.7%; P < 0.0001). Sixteen SOC (53.3%) received FFP, 10 (33.3%) PLT, and 4 (13.3%) both FFP and PLT. In the TEG group, none received FFP alone (P < 0.0001 vs. SOC), 2 received PLT (6.7%; P = 0.009 vs. SOC), and 3 both FFP and PLT (not significant). Postprocedure bleeding occurred in only 1 patient (SOC group) after large‐volume paracentesis. Conclusions: In patients with cirrhosis and significant coagulopathy before invasive procedures, TEG‐guided transfusion strategy leads to a significantly lower use of blood products compared to SOC (transfusion guided by INR and platelet count), without an increase in bleeding complications. Remarkably, even in patients with significant coagulopathy, postprocedure bleeding was rare, indicating that TEG thresholds should be reevaluated. (Hepatology 2016;63:566–573) |
|---|---|
| AbstractList | Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides a more comprehensive global coagulation assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in patients with cirrhosis and significant coagulopathy (defined in this study as INR >1.8 and/or platelet count <50 10 super(9)/L) who will be undergoing an invasive procedure. Sixty patients were randomly allocated to TEG-guided transfusion strategy or standard of care (SOC; 1:1 TEG:SOC). The TEG group would receive FFP if the reaction time (r) was >40 min and/or PLT if maximum amplitude (MA) was <30 mm. All SOC patients received FFP and/or PLT per hospital guidelines. Endpoints were blood product use and bleeding complications. Baseline characteristics of the two groups were similar. Per protocol, all subjects in the SOC group received blood product transfusions versus 5 in the TEG group (100% vs. 16.7%; P<0.0001). Sixteen SOC (53.3%) received FFP, 10 (33.3%) PLT, and 4 (13.3%) both FFP and PLT. In the TEG group, none received FFP alone (P<0.0001 vs. SOC), 2 received PLT (6.7%; P=0.009 vs. SOC), and 3 both FFP and PLT (not significant). Postprocedure bleeding occurred in only 1 patient (SOC group) after large-volume paracentesis. Conclusions: In patients with cirrhosis and significant coagulopathy before invasive procedures, TEG-guided transfusion strategy leads to a significantly lower use of blood products compared to SOC (transfusion guided by INR and platelet count), without an increase in bleeding complications. Remarkably, even in patients with significant coagulopathy, postprocedure bleeding was rare, indicating that TEG thresholds should be reevaluated. (Hepatology 2016; 63:566-573) Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides a more comprehensive global coagulation assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in patients with cirrhosis and significant coagulopathy (defined in this study as INR >1.8 and/or platelet count <50 × 10(9) /L) who will be undergoing an invasive procedure. Sixty patients were randomly allocated to TEG-guided transfusion strategy or standard of care (SOC; 1:1 TEG:SOC). The TEG group would receive FFP if the reaction time (r) was >40 min and/or PLT if maximum amplitude (MA) was <30 mm. All SOC patients received FFP and/or PLT per hospital guidelines. Endpoints were blood product use and bleeding complications. Baseline characteristics of the two groups were similar. Per protocol, all subjects in the SOC group received blood product transfusions versus 5 in the TEG group (100% vs. 16.7%; P < 0.0001). Sixteen SOC (53.3%) received FFP, 10 (33.3%) PLT, and 4 (13.3%) both FFP and PLT. In the TEG group, none received FFP alone (P < 0.0001 vs. SOC), 2 received PLT (6.7%; P = 0.009 vs. SOC), and 3 both FFP and PLT (not significant). Postprocedure bleeding occurred in only 1 patient (SOC group) after large-volume paracentesis. In patients with cirrhosis and significant coagulopathy before invasive procedures, TEG-guided transfusion strategy leads to a significantly lower use of blood products compared to SOC (transfusion guided by INR and platelet count), without an increase in bleeding complications. Remarkably, even in patients with significant coagulopathy, postprocedure bleeding was rare, indicating that TEG thresholds should be reevaluated. Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides a more comprehensive global coagulation assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in patients with cirrhosis and significant coagulopathy (defined in this study as INR >1.8 and/or platelet count <50 × 109/L) who will be undergoing an invasive procedure. Sixty patients were randomly allocated to TEG‐guided transfusion strategy or standard of care (SOC; 1:1 TEG:SOC). The TEG group would receive FFP if the reaction time (r) was >40 min and/or PLT if maximum amplitude (MA) was <30 mm. All SOC patients received FFP and/or PLT per hospital guidelines. Endpoints were blood product use and bleeding complications. Baseline characteristics of the two groups were similar. Per protocol, all subjects in the SOC group received blood product transfusions versus 5 in the TEG group (100% vs. 16.7%; P < 0.0001). Sixteen SOC (53.3%) received FFP, 10 (33.3%) PLT, and 4 (13.3%) both FFP and PLT. In the TEG group, none received FFP alone (P < 0.0001 vs. SOC), 2 received PLT (6.7%; P = 0.009 vs. SOC), and 3 both FFP and PLT (not significant). Postprocedure bleeding occurred in only 1 patient (SOC group) after large‐volume paracentesis. Conclusions: In patients with cirrhosis and significant coagulopathy before invasive procedures, TEG‐guided transfusion strategy leads to a significantly lower use of blood products compared to SOC (transfusion guided by INR and platelet count), without an increase in bleeding complications. Remarkably, even in patients with significant coagulopathy, postprocedure bleeding was rare, indicating that TEG thresholds should be reevaluated. (Hepatology 2016;63:566–573) Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides a more comprehensive global coagulation assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in patients with cirrhosis and significant coagulopathy (defined in this study as INR >1.8 and/or platelet count <50 × 10 9 /L) who will be undergoing an invasive procedure. Sixty patients were randomly allocated to TEG‐guided transfusion strategy or standard of care (SOC; 1:1 TEG:SOC). The TEG group would receive FFP if the reaction time (r) was >40 min and/or PLT if maximum amplitude (MA) was <30 mm. All SOC patients received FFP and/or PLT per hospital guidelines. Endpoints were blood product use and bleeding complications. Baseline characteristics of the two groups were similar. Per protocol, all subjects in the SOC group received blood product transfusions versus 5 in the TEG group (100% vs. 16.7%; P < 0.0001). Sixteen SOC (53.3%) received FFP, 10 (33.3%) PLT, and 4 (13.3%) both FFP and PLT. In the TEG group, none received FFP alone ( P < 0.0001 vs. SOC), 2 received PLT (6.7%; P = 0.009 vs. SOC), and 3 both FFP and PLT (not significant). Postprocedure bleeding occurred in only 1 patient (SOC group) after large‐volume paracentesis. Conclusions : In patients with cirrhosis and significant coagulopathy before invasive procedures, TEG‐guided transfusion strategy leads to a significantly lower use of blood products compared to SOC (transfusion guided by INR and platelet count), without an increase in bleeding complications. Remarkably, even in patients with significant coagulopathy, postprocedure bleeding was rare, indicating that TEG thresholds should be reevaluated. (H epatology 2016;63:566–573) Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides a more comprehensive global coagulation assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in patients with cirrhosis and significant coagulopathy (defined in this study as INR >1.8 and/or platelet count <50 × 10(9) /L) who will be undergoing an invasive procedure. Sixty patients were randomly allocated to TEG-guided transfusion strategy or standard of care (SOC; 1:1 TEG:SOC). The TEG group would receive FFP if the reaction time (r) was >40 min and/or PLT if maximum amplitude (MA) was <30 mm. All SOC patients received FFP and/or PLT per hospital guidelines. Endpoints were blood product use and bleeding complications. Baseline characteristics of the two groups were similar. Per protocol, all subjects in the SOC group received blood product transfusions versus 5 in the TEG group (100% vs. 16.7%; P < 0.0001). Sixteen SOC (53.3%) received FFP, 10 (33.3%) PLT, and 4 (13.3%) both FFP and PLT. In the TEG group, none received FFP alone (P < 0.0001 vs. SOC), 2 received PLT (6.7%; P = 0.009 vs. SOC), and 3 both FFP and PLT (not significant). Postprocedure bleeding occurred in only 1 patient (SOC group) after large-volume paracentesis.UNLABELLEDBleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides a more comprehensive global coagulation assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in patients with cirrhosis and significant coagulopathy (defined in this study as INR >1.8 and/or platelet count <50 × 10(9) /L) who will be undergoing an invasive procedure. Sixty patients were randomly allocated to TEG-guided transfusion strategy or standard of care (SOC; 1:1 TEG:SOC). The TEG group would receive FFP if the reaction time (r) was >40 min and/or PLT if maximum amplitude (MA) was <30 mm. All SOC patients received FFP and/or PLT per hospital guidelines. Endpoints were blood product use and bleeding complications. Baseline characteristics of the two groups were similar. Per protocol, all subjects in the SOC group received blood product transfusions versus 5 in the TEG group (100% vs. 16.7%; P < 0.0001). Sixteen SOC (53.3%) received FFP, 10 (33.3%) PLT, and 4 (13.3%) both FFP and PLT. In the TEG group, none received FFP alone (P < 0.0001 vs. SOC), 2 received PLT (6.7%; P = 0.009 vs. SOC), and 3 both FFP and PLT (not significant). Postprocedure bleeding occurred in only 1 patient (SOC group) after large-volume paracentesis.In patients with cirrhosis and significant coagulopathy before invasive procedures, TEG-guided transfusion strategy leads to a significantly lower use of blood products compared to SOC (transfusion guided by INR and platelet count), without an increase in bleeding complications. Remarkably, even in patients with significant coagulopathy, postprocedure bleeding was rare, indicating that TEG thresholds should be reevaluated.CONCLUSIONSIn patients with cirrhosis and significant coagulopathy before invasive procedures, TEG-guided transfusion strategy leads to a significantly lower use of blood products compared to SOC (transfusion guided by INR and platelet count), without an increase in bleeding complications. Remarkably, even in patients with significant coagulopathy, postprocedure bleeding was rare, indicating that TEG thresholds should be reevaluated. |
| Author | Di Maira, Tommaso Begliomini, Bruno De Maria, Nicola Garcia‐Tsao, Guadalupe di Benedetto, Fabrizio Montalti, Roberto De Pietri, Lesley Gerunda, Giorgio Enrico Bianchini, Marcello Villa, Erica |
| Author_xml | – sequence: 1 givenname: Lesley surname: De Pietri fullname: De Pietri, Lesley organization: AOU Policlinico di Modena – sequence: 2 givenname: Marcello surname: Bianchini fullname: Bianchini, Marcello organization: AOU Policlinico di Modena – sequence: 3 givenname: Roberto surname: Montalti fullname: Montalti, Roberto organization: Polytechnic University of Marche – sequence: 4 givenname: Nicola surname: De Maria fullname: De Maria, Nicola organization: AOU Policlinico di Modena – sequence: 5 givenname: Tommaso surname: Di Maira fullname: Di Maira, Tommaso organization: AOU Policlinico di Modena – sequence: 6 givenname: Bruno surname: Begliomini fullname: Begliomini, Bruno organization: AOU Policlinico di Modena – sequence: 7 givenname: Giorgio Enrico surname: Gerunda fullname: Gerunda, Giorgio Enrico organization: AOU Policlinico di Modena – sequence: 8 givenname: Fabrizio surname: di Benedetto fullname: di Benedetto, Fabrizio organization: AOU Policlinico di Modena – sequence: 9 givenname: Guadalupe surname: Garcia‐Tsao fullname: Garcia‐Tsao, Guadalupe organization: Section of Digestive Diseases – sequence: 10 givenname: Erica surname: Villa fullname: Villa, Erica organization: AOU Policlinico di Modena |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26340411$$D View this record in MEDLINE/PubMed |
| BookMark | eNqN0c1u1DAQB3ALFdFt4cALIEtcQCKtHSd23FtVFYpUCQ7lHPljsnHlxMFOtlpOPAHiGXkSvGzhUAnEyZLnN2ON_0foYAwjIPSckhNKSHnaw3RSNrRqHqEVrUtRMFaTA7QipSCFpEweoqOUbgkhsiqbJ-iw5KwiFaUr9O2mj2HQ4FWawzqqqd_--Pp9vTgLFmsfgsVTDHYxM14SYA1diIDduFHJbWBXM2CXCCnfYeNi7ENyCd-5uccJNpCxCWq9-DCpud-e4XMc1WjD4L6AfZNr4xyD9_mxOTrln6LHnfIJnt2fx-jT28ubi6vi-sO79xfn14WpJG0KVXHBdU1IxYklnHSaEV2CAGulpdQwrYEBKGkbLRtdlrWxuuqYkox1YAw7Rq_2c_MCnxdIczu4ZMB7NUJYUkuF4JwzJpr_oJxIQni1oy8f0NuwxDEvklUtpOCyEVm9uFeLHsC2U3SDitv2dygZvN4DE0NKEbo_hJJ2F3ibA29_BZ7t6QNr3Kxmt_tX5fy_Ou6ch-3fR7dXlx_3HT8Bd8G_7g |
| CODEN | HPTLD9 |
| CitedBy_id | crossref_primary_10_1111_aas_14558 crossref_primary_10_1016_j_cgh_2023_04_016 crossref_primary_10_1055_s_0040_1702918 crossref_primary_10_1007_s10049_016_0242_x crossref_primary_10_1007_s11239_021_02621_1 crossref_primary_10_1016_j_jvir_2019_04_016 crossref_primary_10_1002_lt_25198 crossref_primary_10_1111_liv_13056 crossref_primary_10_1016_j_tmrv_2017_06_002 crossref_primary_10_1111_ejh_13342 crossref_primary_10_1111_hae_14548 crossref_primary_10_1055_s_0043_1773773 crossref_primary_10_1016_j_jclinane_2020_110154 crossref_primary_10_1111_apt_17080 crossref_primary_10_1080_00325481_2024_2320080 crossref_primary_10_1007_s00134_023_07149_x crossref_primary_10_1016_j_rgmx_2023_08_007 crossref_primary_10_1111_jvim_15467 crossref_primary_10_3390_jcm11144036 crossref_primary_10_3390_diagnostics12123172 crossref_primary_10_3390_jcm11205994 crossref_primary_10_3390_membranes11030189 crossref_primary_10_1002_hep_28833 crossref_primary_10_1002_hep_28830 crossref_primary_10_1111_liv_14034 crossref_primary_10_3390_jcm13123612 crossref_primary_10_1111_jth_15562 crossref_primary_10_1161_CIRCULATIONAHA_120_043561 crossref_primary_10_1038_ajg_2016_498 crossref_primary_10_1055_s_0040_1714205 crossref_primary_10_1093_labmed_lmx041 crossref_primary_10_4103_ijciis_ijciis_65_23 crossref_primary_10_1186_s13049_017_0378_9 crossref_primary_10_1002_pbc_26955 crossref_primary_10_1053_j_gastro_2021_08_015 crossref_primary_10_1055_s_0040_1715774 crossref_primary_10_1055_s_0040_1714203 crossref_primary_10_1097_MCG_0000000000001285 crossref_primary_10_1111_liv_13712 crossref_primary_10_1007_s11695_018_3437_z crossref_primary_10_1016_j_cld_2021_02_001 crossref_primary_10_1177_1751143720978849 crossref_primary_10_1007_s11938_018_0182_2 crossref_primary_10_1016_j_jhep_2024_07_032 crossref_primary_10_1111_jth_14447 crossref_primary_10_1016_j_ajem_2022_04_049 crossref_primary_10_1016_j_cgh_2018_09_043 crossref_primary_10_1016_j_jceh_2022_03_004 crossref_primary_10_7759_cureus_32818 crossref_primary_10_1007_s11894_017_0585_6 crossref_primary_10_1007_s12072_018_9886_6 crossref_primary_10_1016_j_jss_2018_09_052 crossref_primary_10_1016_j_jclinane_2020_109809 crossref_primary_10_14309_ajg_0000000000001595 crossref_primary_10_3390_medicina59020346 crossref_primary_10_1002_hep_31443 crossref_primary_10_1186_s13017_018_0194_1 crossref_primary_10_1002_hep_28291 crossref_primary_10_14218_JCTH_2019_00055 crossref_primary_10_14309_ajg_0000000000000486 crossref_primary_10_1016_j_tmrv_2024_150823 crossref_primary_10_1007_s10620_019_05939_2 crossref_primary_10_1002_hep_28855 crossref_primary_10_1002_jgh3_70013 crossref_primary_10_1515_sjpain_2018_0041 crossref_primary_10_1055_s_0042_1758081 crossref_primary_10_1016_j_annemergmed_2020_07_026 crossref_primary_10_1080_17474086_2022_2144217 crossref_primary_10_1055_a_1242_3827 crossref_primary_10_5811_westjem_2018_7_37893 crossref_primary_10_1097_MEG_0000000000001588 crossref_primary_10_1093_gastro_goae071 crossref_primary_10_1055_a_1355_3716 crossref_primary_10_1111_hae_14995 crossref_primary_10_1177_1098612X20939828 crossref_primary_10_1055_s_0040_1715475 crossref_primary_10_21320_1818_474X_2024_4_7_39 crossref_primary_10_1016_j_jceh_2018_10_002 crossref_primary_10_1080_20009666_2018_1466600 crossref_primary_10_1111_liv_15398 crossref_primary_10_1111_apt_14331 crossref_primary_10_1111_apt_18016 crossref_primary_10_1016_j_jhepr_2021_100363 crossref_primary_10_12968_hmed_2021_0111 crossref_primary_10_1053_j_gastro_2021_09_004 crossref_primary_10_1136_flgastro_2023_102432 crossref_primary_10_1016_j_cgh_2021_07_018 crossref_primary_10_52784_27112330_145 crossref_primary_10_3350_cmh_2024_0928 crossref_primary_10_1016_j_transproceed_2021_10_012 crossref_primary_10_1080_17843286_2025_2469906 crossref_primary_10_1213_ANE_0000000000003301 crossref_primary_10_1002_rth2_12037 crossref_primary_10_1111_eci_13508 crossref_primary_10_1016_j_jhep_2021_11_004 crossref_primary_10_7759_cureus_41401 crossref_primary_10_3748_wjg_v27_i23_3290 crossref_primary_10_1177_17511437241290154 crossref_primary_10_1002_cld_906 crossref_primary_10_1097_EJA_0000000000000630 crossref_primary_10_1159_000501229 crossref_primary_10_1016_j_tige_2021_09_002 crossref_primary_10_1097_EJA_0000000000000513 crossref_primary_10_7861_clinmedicine_18_4_320 crossref_primary_10_1097_EJA_0000000000000514 crossref_primary_10_1038_s41598_024_54379_0 crossref_primary_10_1111_jth_15888 crossref_primary_10_1055_a_1246_3423 crossref_primary_10_1016_j_jhep_2020_10_024 crossref_primary_10_1055_s_0042_1753530 crossref_primary_10_1111_jth_14672 crossref_primary_10_1055_s_0042_1757135 crossref_primary_10_1053_j_gastro_2023_05_046 crossref_primary_10_7759_cureus_11124 crossref_primary_10_1055_s_0040_1715451 crossref_primary_10_1007_s11901_018_0406_x crossref_primary_10_1097_HEP_0000000000000671 crossref_primary_10_1111_ejh_13688 crossref_primary_10_1177_1076029617731624 crossref_primary_10_1080_02656736_2017_1390787 crossref_primary_10_3748_wjg_v29_i9_1460 crossref_primary_10_3390_jcm12175759 crossref_primary_10_1016_j_thromres_2019_04_033 crossref_primary_10_1016_j_jhep_2015_09_018 crossref_primary_10_1016_j_jss_2017_05_115 crossref_primary_10_1177_1089253217739121 crossref_primary_10_17352_2455_3476_000042 crossref_primary_10_1155_2021_8218042 crossref_primary_10_1007_s12072_017_9826_x crossref_primary_10_1016_j_jhepr_2023_100986 crossref_primary_10_1055_s_0040_1715449 crossref_primary_10_4330_wjc_v13_i11_599 crossref_primary_10_1097_HC9_0000000000000147 crossref_primary_10_1111_anae_13480 crossref_primary_10_1016_j_thromres_2019_03_021 crossref_primary_10_5500_wjt_v6_i3_583 crossref_primary_10_1016_j_transci_2021_103247 crossref_primary_10_1016_j_transci_2021_103125 crossref_primary_10_1055_a_1214_5355 crossref_primary_10_1016_j_suc_2023_05_011 crossref_primary_10_1111_vec_13034 crossref_primary_10_3350_cmh_2016_0110 crossref_primary_10_1055_a_2448_0664 crossref_primary_10_1007_s12325_022_02235_w crossref_primary_10_1007_s00261_022_03539_9 crossref_primary_10_1016_j_jceh_2024_102409 crossref_primary_10_1016_j_jhep_2021_09_003 crossref_primary_10_14218_JCTH_2020_00067 crossref_primary_10_3390_jcm13020506 crossref_primary_10_1016_j_liver_2023_100152 crossref_primary_10_1097_CCM_0000000000004193 crossref_primary_10_1002_14651858_CD011756_pub2 crossref_primary_10_1111_ctr_13191 crossref_primary_10_1111_hae_14033 crossref_primary_10_1111_jth_15185 crossref_primary_10_1016_j_aohep_2023_101140 crossref_primary_10_1016_j_dld_2018_06_003 crossref_primary_10_1097_CCM_0000000000004192 crossref_primary_10_1136_bcr_2016_218294 crossref_primary_10_1159_000491106 crossref_primary_10_1177_0885066620903027 crossref_primary_10_1016_j_bbmt_2017_01_074 crossref_primary_10_1016_j_dld_2016_08_119 crossref_primary_10_1097_MEG_0000000000001526 crossref_primary_10_1097_MOT_0000000000000391 crossref_primary_10_1186_s13613_020_00703_6 crossref_primary_10_1111_apt_14654 crossref_primary_10_1182_hematology_2023000479 crossref_primary_10_1016_j_emc_2019_03_008 crossref_primary_10_1097_MOT_0000000000000275 crossref_primary_10_1007_s00261_021_03075_y crossref_primary_10_1097_MCC_0000000000000591 crossref_primary_10_1159_000486453 crossref_primary_10_1136_gutjnl_2020_321299 crossref_primary_10_1001_jama_2021_12742 crossref_primary_10_1007_s12072_024_10720_3 crossref_primary_10_3390_diagnostics15060751 crossref_primary_10_1016_j_xcrm_2022_100765 crossref_primary_10_15406_jaccoa_2016_06_00215 crossref_primary_10_30841_2307_5112_5_6_2020_225448 crossref_primary_10_1111_vox_13225 crossref_primary_10_1053_j_gastro_2019_03_070 crossref_primary_10_1007_s40140_018_0270_9 crossref_primary_10_1055_a_1886_5909 crossref_primary_10_1007_s15036_020_1371_0 crossref_primary_10_1055_a_1667_7293 crossref_primary_10_1002_cld_947 crossref_primary_10_1097_EJA_0000000000001803 crossref_primary_10_1016_j_jcrc_2017_07_053 crossref_primary_10_28982_josam_7694 crossref_primary_10_1093_bja_aex122 crossref_primary_10_1016_j_jceh_2024_102452 crossref_primary_10_1007_s11894_019_0700_y crossref_primary_10_1097_HEP_0000000000000756 crossref_primary_10_1007_s00101_025_01518_5 crossref_primary_10_14309_ajg_0000000000003129 crossref_primary_10_1159_000446304 crossref_primary_10_1186_s13063_023_07552_1 crossref_primary_10_14309_ctg_0000000000000062 crossref_primary_10_1016_j_gtc_2017_01_005 crossref_primary_10_1097_MCG_0000000000001568 crossref_primary_10_4240_wjgs_v15_i2_127 crossref_primary_10_16931_1995_5464_20211107_114 crossref_primary_10_3390_ijms21093294 crossref_primary_10_1097_ALN_0000000000003670 crossref_primary_10_3892_etm_2019_7333 crossref_primary_10_1016_j_jss_2023_02_004 crossref_primary_10_5604_01_3001_0010_8635 crossref_primary_10_1097_CNQ_0000000000000398 crossref_primary_10_1097_MOG_0000000000000635 crossref_primary_10_3748_wjg_v29_i46_6092 crossref_primary_10_1016_j_rpth_2022_100031 crossref_primary_10_1097_MCC_0000000000000698 crossref_primary_10_23736_S0375_9393_18_12875_6 crossref_primary_10_1097_HC9_0000000000000292 crossref_primary_10_1002_14651858_CD012779_pub2 crossref_primary_10_1097_MCG_0000000000001214 crossref_primary_10_1111_liv_15621 crossref_primary_10_1002_jac5_1828 crossref_primary_10_1016_j_cvsm_2016_11_009 crossref_primary_10_1002_hep_28336 crossref_primary_10_1177_1178632917691270 crossref_primary_10_17085_apm_2019_14_4_371 crossref_primary_10_1097_MPG_0000000000003555 crossref_primary_10_5604_01_3001_0012_7205 crossref_primary_10_1007_s11239_018_1756_5 crossref_primary_10_1111_jth_14737 crossref_primary_10_1186_s13063_017_1835_5 crossref_primary_10_1080_09537104_2021_1961709 crossref_primary_10_1177_29768675231208426 crossref_primary_10_1007_s00063_015_0138_4 crossref_primary_10_1111_jvim_14639 crossref_primary_10_1016_j_amjms_2016_02_022 crossref_primary_10_1016_j_amjsurg_2023_09_001 crossref_primary_10_1016_j_cld_2021_08_002 crossref_primary_10_14309_ctg_0000000000000288 crossref_primary_10_1002_cld_976 crossref_primary_10_1007_s10620_021_07376_6 crossref_primary_10_1080_0886022X_2019_1700805 crossref_primary_10_1111_trf_16073 crossref_primary_10_1097_MPG_0000000000001721 crossref_primary_10_1016_j_tmrv_2017_05_008 crossref_primary_10_1007_s12072_024_10644_y crossref_primary_10_1097_CCE_0000000000000287 crossref_primary_10_1055_s_0042_1758058 crossref_primary_10_1111_jth_14265 crossref_primary_10_1111_ctr_13819 crossref_primary_10_3390_jcm13216614 crossref_primary_10_1111_apt_14600 crossref_primary_10_3389_fcvm_2020_00009 crossref_primary_10_1016_j_tmrv_2016_11_006 crossref_primary_10_3748_wjg_v25_i28_3738 crossref_primary_10_1007_s11239_023_02941_4 crossref_primary_10_1016_j_bja_2019_09_017 crossref_primary_10_1016_j_jvir_2024_06_014 crossref_primary_10_3390_jpm13050764 crossref_primary_10_1097_EJA_0000000000001200 crossref_primary_10_33590_emjhepatol_10313853 crossref_primary_10_1002_cld_749 crossref_primary_10_1016_j_cgh_2019_04_057 crossref_primary_10_1111_jth_14712 crossref_primary_10_1097_ALN_0000000000001467 crossref_primary_10_1097_CCE_0000000000001023 crossref_primary_10_1097_MEG_0000000000001948 crossref_primary_10_4103_singaporemedj_SMJ_2021_404 crossref_primary_10_1016_j_rgmx_2022_03_012 crossref_primary_10_1016_j_rgmxen_2023_08_008 crossref_primary_10_1111_liv_15659 crossref_primary_10_1007_s41971_019_0045_2 crossref_primary_10_36290_vnl_2024_064 crossref_primary_10_1097_PG9_0000000000000324 crossref_primary_10_1002_14651858_CD012745_pub2 crossref_primary_10_1097_EJA_0000000000002069 crossref_primary_10_1053_j_jvca_2022_03_003 crossref_primary_10_1055_a_2255_7246 crossref_primary_10_1177_0310057X1704500206 crossref_primary_10_3748_wjg_v27_i42_7285 crossref_primary_10_1016_j_cld_2023_03_010 crossref_primary_10_1016_j_amjmed_2020_04_029 crossref_primary_10_1016_j_transproceed_2018_07_032 crossref_primary_10_1002_hep_31646 crossref_primary_10_1186_s12876_020_01413_w crossref_primary_10_1002_hep_30794 crossref_primary_10_3343_alm_2017_37_3_204 crossref_primary_10_1016_j_transproceed_2021_07_018 crossref_primary_10_1016_j_jvir_2017_04_001 crossref_primary_10_1002_lt_26451 crossref_primary_10_1007_s10620_019_05597_4 crossref_primary_10_4254_wjh_v12_i11_1115 crossref_primary_10_1002_14651858_CD012745 crossref_primary_10_1016_j_jhepr_2019_02_006 crossref_primary_10_22516_25007440_313 crossref_primary_10_1111_bjh_19360 crossref_primary_10_1111_liv_13493 crossref_primary_10_1007_s12325_020_01307_z crossref_primary_10_1055_a_1934_1867 crossref_primary_10_1055_a_2531_4712 crossref_primary_10_5604_16652681_1226811 crossref_primary_10_1002_cld_606 crossref_primary_10_1111_apt_15279 crossref_primary_10_1016_j_dld_2020_07_017 crossref_primary_10_1016_j_jceh_2021_05_001 crossref_primary_10_12788_jhm_3458 crossref_primary_10_1055_s_0042_1756302 crossref_primary_10_1111_anae_16463 crossref_primary_10_1016_j_rgmxen_2022_06_011 |
| Cites_doi | 10.1016/j.jvir.2012.02.012 10.1002/hep.21303 10.1097/00001721-200107000-00001 10.1016/j.ejim.2010.01.005 10.1007/s00464-012-2334-0 10.1186/s12871-015-0033-9 10.1002/hep.20569 10.1016/j.cgh.2009.05.004 10.1016/S1072-7515(00)00261-1 10.1002/hep.21231 10.1053/j.jvca.2006.01.016 10.1097/EJA.0b013e32835f4d5b 10.1111/j.1365-2141.2007.06688.x 10.1056/NEJMra1011170 10.1002/hep.27546 10.1016/j.transproceed.2010.05.144 10.1378/chest.12-2374 10.1053/j.gastro.2012.07.018 10.1378/chest.101.6.1481 10.1111/j.1365-2036.2007.03369.x 10.1136/gut.2004.042796 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6 10.1038/ajg.2008.34 10.1002/hep.22853 10.1053/j.gastro.2009.08.045 10.1111/aas.12295 |
| ContentType | Journal Article |
| Copyright | 2015 by the American Association for the Study of Liver Diseases 2015 by the American Association for the Study of Liver Diseases. 2016 by the American Association for the Study of Liver Diseases |
| Copyright_xml | – notice: 2015 by the American Association for the Study of Liver Diseases – notice: 2015 by the American Association for the Study of Liver Diseases. – notice: 2016 by the American Association for the Study of Liver Diseases |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7T5 7TM 7TO 7U9 H94 K9. 7X8 |
| DOI | 10.1002/hep.28148 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE AIDS and Cancer Research Abstracts CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1527-3350 |
| EndPage | 573 |
| ExternalDocumentID | 3925320061 26340411 10_1002_hep_28148 HEP28148 |
| Genre | article Randomized Controlled Trial Journal Article |
| GroupedDBID | --- --K .3N .55 .GA .GJ .Y3 05W 0R~ 10A 186 1B1 1CY 1L6 1OB 1OC 1ZS 1~5 24P 31~ 33P 3O- 3SF 3WU 4.4 4G. 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5RE 5VS 7-5 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEDT AAESR AAEVG AAHHS AALRI AANHP AAONW AAQFI AAQQT AAQXK AASGY AAXRX AAXUO AAZKR ABCQN ABCUV ABEML ABIJN ABLJU ABMAC ABOCM ABPVW ABWVN ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACLDA ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADEOM ADIZJ ADKYN ADMGS ADMUD ADNMO ADOZA ADXAS ADZMN ADZOD AECAP AEEZP AEIMD AENEX AEQDE AEUQT AFBPY AFFNX AFGKR AFPWT AFUWQ AFZJQ AHMBA AIACR AIURR AIWBW AJAOE AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BAWUL BDRZF BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EBS EJD F00 F01 F04 F5P FD8 FDB FEDTE FGOYB FUBAC G-S G.N GNP GODZA H.X HBH HF~ HHY HHZ HVGLF HZ~ IHE IX1 J0M J5H JPC KBYEO KQQ LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M41 M65 MJL MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N4W N9A NF~ NNB NQ- O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K R2- RGB RIG RIWAO RJQFR ROL RPZ RWI RX1 RYL SEW SSZ SUPJJ TEORI UB1 V2E V9Y W2D W8V W99 WBKPD WH7 WHWMO WIB WIH WIJ WIK WIN WJL WOHZO WQJ WRC WUP WVDHM WXI X7M XG1 XV2 ZGI ZXP ZZTAW ~IA ~WT AAYXX ABJNI ACZKN AFNMH AGQPQ AHQVU CITATION MEWTI WXSBR ACIJW CGR CUY CVF ECM EIF NPM 7T5 7TM 7TO 7U9 AAMMB ADSXY AEFGJ AGXDD AIDQK AIDYY H94 K9. 7X8 |
| ID | FETCH-LOGICAL-c4918-a4676b500460d060fb30b2e7edd9d11c3bbe3eea9d8b98b225cdb4f3a933fecc3 |
| IEDL.DBID | DR2 |
| ISSN | 0270-9139 1527-3350 |
| IngestDate | Fri Jul 11 05:24:57 EDT 2025 Tue Aug 05 11:29:11 EDT 2025 Wed Aug 13 04:34:33 EDT 2025 Thu Apr 03 07:02:55 EDT 2025 Thu Apr 24 23:07:43 EDT 2025 Tue Jul 01 03:33:42 EDT 2025 Wed Jan 22 16:52:15 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | 2015 by the American Association for the Study of Liver Diseases. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4918-a4676b500460d060fb30b2e7edd9d11c3bbe3eea9d8b98b225cdb4f3a933fecc3 |
| Notes | See Editorial on Page 368 These authors contributed equally. Potential conflict of interest: Nothing to report. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://aasldpubs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/hep.28148 |
| PMID | 26340411 |
| PQID | 1757976987 |
| PQPubID | 996352 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1776663378 proquest_miscellaneous_1760900648 proquest_journals_1757976987 pubmed_primary_26340411 crossref_primary_10_1002_hep_28148 crossref_citationtrail_10_1002_hep_28148 wiley_primary_10_1002_hep_28148_HEP28148 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | February 2016 |
| PublicationDateYYYYMMDD | 2016-02-01 |
| PublicationDate_xml | – month: 02 year: 2016 text: February 2016 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Hepatology (Baltimore, Md.) |
| PublicationTitleAlternate | Hepatology |
| PublicationYear | 2016 |
| Publisher | Wolters Kluwer Health, Inc |
| Publisher_xml | – name: Wolters Kluwer Health, Inc |
| References | 2015; 15 2012; 143 2009; 20 1992; 101 1981; 47 2005; 41 2013; 144 2005; 43 1985; 64 2009; 49 2009; 137 2000; 191 2011; 9 2010; 21 2010; 42 2009; 13 2006; 20 2007; 138 2006; 44 2015; 61 2013; 30 2015; 21 2014; 58 2005; 54 2009; 7 2012; 26 2001; 12 2012; 23 2011; 365 2009; 104 2007; 26 (hep28148-bib-0012-20241017) 2005; 54 (hep28148-bib-0025-20241017) 2005; 43 (hep28148-bib-0015-20241017) 2010; 42 (hep28148-bib-0029-20241017) 2009; 20 (hep28148-bib-0004-20241017) 2012; 23 (hep28148-bib-0028-20241017) 2009; 49 (hep28148-bib-0024-20241017) 2000; 191 (hep28148-bib-0014-20241017) 2001; 12 (hep28148-bib-0027-20241017) 2012; 26 (hep28148-bib-0018-20241017) 1992; 101 (hep28148-bib-0020-20241017) 1981; 47 (hep28148-bib-0011-20241017) 2015; 61 (hep28148-bib-0016-20241017) 2006; 20 (hep28148-bib-0008-20241017) 2007; 138 (hep28148-bib-0017-20241017) 2013; 30 (hep28148-bib-0023-20241017) 2014; 58 (hep28148-bib-0013-20241017) 2012; 143 (hep28148-bib-0021-20241017) 2009; 7 (hep28148-bib-0007-20241017) 2006; 44 (hep28148-bib-0002-20241017) 2010; 21 (hep28148-bib-0019-20241017) 2015; 15 (hep28148-bib-0001-20241017) 2009; 137 (hep28148-bib-0005-20241017) 2007; 26 (hep28148-bib-0030-20241017) 2006; 44 (hep28148-bib-0006-20241017) 2005; 41 (hep28148-bib-0032-20241017) 2015; 21 (hep28148-bib-0009-20241017) 2011; 365 (hep28148-bib-0010-20241017) 2009; 104 (hep28148-bib-0031-20241017) 1985; 64 (hep28148-bib-0022-20241017) 2013; 144 26547808 - Hepatology. 2016 Aug;64(2):682-3 26547626 - Hepatology. 2016 Aug;64(2):683-4 26474059 - Hepatology. 2016 Feb;63(2):368-70 |
| References_xml | – volume: 44 start-page: 1039 year: 2006 end-page: 1046 article-title: Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management publication-title: Hepatology – volume: 64 start-page: 888 year: 1985 end-page: 896 article-title: Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation publication-title: Anesth Analg – volume: 26 start-page: 3258 year: 2012 end-page: 3263 article-title: The risk of postpolypectomy bleeding during colonoscopy in patients with early liver cirrhosis publication-title: Surg Endosc – volume: 44 start-page: 53 year: 2006 end-page: 61 article-title: Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity publication-title: Hepatology – volume: 54 start-page: 691 year: 2005 end-page: 697 article-title: Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation publication-title: Gut – volume: 191 start-page: 38 year: 2000 end-page: 46 article-title: Seven hundred forty‐seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection publication-title: J Am Coll Surg – volume: 20 start-page: S240 issue: 7 Suppl year: 2009 end-page: S249 article-title: Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image‐guided interventions publication-title: J Vasc Interv Radiol – volume: 7 start-page: 906 year: 2009 end-page: 909 article-title: Risk of complications after abdominal paracentesis in cirrhotic patients: a prospective study publication-title: Clin Gastroenterol Hepatol – volume: 21 start-page: 45 year: 2015 end-page: 51 article-title: Use of viscoelastic haemostatic assay in emergency and elective surgery publication-title: Hong Kong Med J – volume: 144 start-page: 456 year: 2013 end-page: 463 article-title: Safety of ultrasound‐guided thoracentesis in patients with abnormal preprocedural coagulation parameters publication-title: Chest – volume: 49 start-page: 2087 year: 2009 end-page: 2107 article-title: Management of adult patients with ascites due to cirrhosis: an update publication-title: Hepatology – volume: 138 start-page: 534 year: 2007 end-page: 540 article-title: ADAMTS13 activity to antigen ratio in physiological and pathological conditions associated with an increased risk of thrombosis publication-title: Br J Haematol – volume: 365 start-page: 147 year: 2011 end-page: 156 article-title: The coagulopathy of chronic liver disease publication-title: N Engl J Med – volume: 42 start-page: 2590 year: 2010 end-page: 2593 article-title: Thromboelastography‐guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial publication-title: Transplant Proc – volume: 15 start-page: 50 year: 2015 article-title: Time impact on non‐activated and kaolin‐activated blood samples in thromboelastography publication-title: BMC Anesthesiol – volume: 47 start-page: 207 year: 1981 end-page: 214 article-title: Reporting results of cancer treatment publication-title: Cancer – volume: 21 start-page: 62 year: 2010 end-page: 64 article-title: The coagulopathy of chronic liver disease: is there a causal relationship with bleeding? Yes publication-title: Eur J Intern Med – volume: 13 start-page: 343 year: 2009 end-page: 403 article-title: European Hernia Society guidelines on the treatment of inguinal hernia in adult patients. Hernia – volume: 58 start-page: 508 year: 2014 end-page: 524 article-title: Clinical guidelines on central venous catheterisation. Swedish Society of Anaesthesiology and Intensive Care Medicine publication-title: Acta Anaesthesiol Scand – volume: 30 start-page: 270 year: 2013 end-page: 382 article-title: Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology publication-title: Eur J Anaesthesiol – volume: 137 start-page: 2105 year: 2009 end-page: 2111 article-title: An imbalance of pro‐ vs anti‐coagulation factors in plasma from patients with cirrhosis publication-title: Gastroenterology – volume: 23 start-page: 727 year: 2012 end-page: 736 article-title: Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image‐guided interventions publication-title: J Vasc Interv Radiol – volume: 143 start-page: 1253 year: 2012 end-page: 1260 article-title: Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis publication-title: Gastroenterology – volume: 104 start-page: 96 year: 2009 end-page: 101 article-title: Risk of venous thromboembolism in patients with liver disease: a nationwide population‐based case‐control study publication-title: Am J Gastroenterol – volume: 43 start-page: 177 year: 2005 end-page: 188 article-title: Complications of endoscopic variceal therapy publication-title: S Afr J Surg – volume: 12 start-page: 327 year: 2001 end-page: 337 article-title: Thrombelastography publication-title: Blood Coagul Fibrinolysis – volume: 101 start-page: 1481 year: 1992 end-page: 1483 article-title: The ACCP‐SCCM consensus conference on sepsis and organ failure publication-title: Chest – volume: 26 start-page: 141 year: 2007 end-page: 148 article-title: Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease publication-title: Aliment Pharmacol Ther – volume: 61 start-page: 660 year: 2015 end-page: 667 article-title: Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study publication-title: Hepatology – volume: 41 start-page: 553 year: 2005 end-page: 558 article-title: Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests publication-title: Hepatology – volume: 9 start-page: 320 year: 2011 end-page: 335 – volume: 20 start-page: 548 year: 2006 end-page: 553 article-title: Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests publication-title: J Cardiothorac Vasc Anesth – volume: 23 start-page: 727 year: 2012 ident: hep28148-bib-0004-20241017 article-title: Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image‐guided interventions publication-title: J Vasc Interv Radiol doi: 10.1016/j.jvir.2012.02.012 – volume: 44 start-page: 1039 year: 2006 ident: hep28148-bib-0030-20241017 article-title: Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management publication-title: Hepatology doi: 10.1002/hep.21303 – volume: 12 start-page: 327 year: 2001 ident: hep28148-bib-0014-20241017 article-title: Thrombelastography publication-title: Blood Coagul Fibrinolysis doi: 10.1097/00001721-200107000-00001 – volume: 20 start-page: S240 issue: 7 Suppl year: 2009 ident: hep28148-bib-0029-20241017 article-title: Consensus guidelines for periprocedural management of coagulation status and hemostasis risk in percutaneous image‐guided interventions publication-title: J Vasc Interv Radiol – volume: 21 start-page: 62 year: 2010 ident: hep28148-bib-0002-20241017 article-title: The coagulopathy of chronic liver disease: is there a causal relationship with bleeding? Yes publication-title: Eur J Intern Med doi: 10.1016/j.ejim.2010.01.005 – volume: 26 start-page: 3258 year: 2012 ident: hep28148-bib-0027-20241017 article-title: The risk of postpolypectomy bleeding during colonoscopy in patients with early liver cirrhosis publication-title: Surg Endosc doi: 10.1007/s00464-012-2334-0 – volume: 15 start-page: 50 year: 2015 ident: hep28148-bib-0019-20241017 article-title: Time impact on non‐activated and kaolin‐activated blood samples in thromboelastography publication-title: BMC Anesthesiol doi: 10.1186/s12871-015-0033-9 – volume: 41 start-page: 553 year: 2005 ident: hep28148-bib-0006-20241017 article-title: Evidence of normal thrombin generation in cirrhosis despite abnormal conventional coagulation tests publication-title: Hepatology doi: 10.1002/hep.20569 – volume: 7 start-page: 906 year: 2009 ident: hep28148-bib-0021-20241017 article-title: Risk of complications after abdominal paracentesis in cirrhotic patients: a prospective study publication-title: Clin Gastroenterol Hepatol doi: 10.1016/j.cgh.2009.05.004 – volume: 191 start-page: 38 year: 2000 ident: hep28148-bib-0024-20241017 article-title: Seven hundred forty‐seven hepatectomies in the 1990s: an update to evaluate the actual risk of liver resection publication-title: J Am Coll Surg doi: 10.1016/S1072-7515(00)00261-1 – volume: 21 start-page: 45 year: 2015 ident: hep28148-bib-0032-20241017 article-title: Use of viscoelastic haemostatic assay in emergency and elective surgery publication-title: Hong Kong Med J – volume: 44 start-page: 53 year: 2006 ident: hep28148-bib-0007-20241017 article-title: Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity publication-title: Hepatology doi: 10.1002/hep.21231 – volume: 20 start-page: 548 year: 2006 ident: hep28148-bib-0016-20241017 article-title: Transfusion triggers in orthotopic liver transplantation: a comparison of the thromboelastometry analyzer, the thromboelastogram, and conventional coagulation tests publication-title: J Cardiothorac Vasc Anesth doi: 10.1053/j.jvca.2006.01.016 – volume: 30 start-page: 270 year: 2013 ident: hep28148-bib-0017-20241017 article-title: Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology publication-title: Eur J Anaesthesiol doi: 10.1097/EJA.0b013e32835f4d5b – volume: 138 start-page: 534 year: 2007 ident: hep28148-bib-0008-20241017 article-title: ADAMTS13 activity to antigen ratio in physiological and pathological conditions associated with an increased risk of thrombosis publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2007.06688.x – volume: 365 start-page: 147 year: 2011 ident: hep28148-bib-0009-20241017 article-title: The coagulopathy of chronic liver disease publication-title: N Engl J Med doi: 10.1056/NEJMra1011170 – volume: 61 start-page: 660 year: 2015 ident: hep28148-bib-0011-20241017 article-title: Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study publication-title: Hepatology doi: 10.1002/hep.27546 – volume: 42 start-page: 2590 year: 2010 ident: hep28148-bib-0015-20241017 article-title: Thromboelastography‐guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial publication-title: Transplant Proc doi: 10.1016/j.transproceed.2010.05.144 – volume: 144 start-page: 456 year: 2013 ident: hep28148-bib-0022-20241017 article-title: Safety of ultrasound‐guided thoracentesis in patients with abnormal preprocedural coagulation parameters publication-title: Chest doi: 10.1378/chest.12-2374 – volume: 143 start-page: 1253 year: 2012 ident: hep28148-bib-0013-20241017 article-title: Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.07.018 – volume: 101 start-page: 1481 year: 1992 ident: hep28148-bib-0018-20241017 article-title: The ACCP‐SCCM consensus conference on sepsis and organ failure publication-title: Chest doi: 10.1378/chest.101.6.1481 – volume: 26 start-page: 141 year: 2007 ident: hep28148-bib-0005-20241017 article-title: Review article: the prothrombin time test as a measure of bleeding risk and prognosis in liver disease publication-title: Aliment Pharmacol Ther doi: 10.1111/j.1365-2036.2007.03369.x – volume: 64 start-page: 888 year: 1985 ident: hep28148-bib-0031-20241017 article-title: Intraoperative changes in blood coagulation and thrombelastographic monitoring in liver transplantation publication-title: Anesth Analg – volume: 54 start-page: 691 year: 2005 ident: hep28148-bib-0012-20241017 article-title: Splanchnic vein thrombosis in candidates for liver transplantation: usefulness of screening and anticoagulation publication-title: Gut doi: 10.1136/gut.2004.042796 – volume: 43 start-page: 177 year: 2005 ident: hep28148-bib-0025-20241017 article-title: Complications of endoscopic variceal therapy publication-title: S Afr J Surg – volume: 47 start-page: 207 year: 1981 ident: hep28148-bib-0020-20241017 article-title: Reporting results of cancer treatment publication-title: Cancer doi: 10.1002/1097-0142(19810101)47:1<207::AID-CNCR2820470134>3.0.CO;2-6 – volume: 104 start-page: 96 year: 2009 ident: hep28148-bib-0010-20241017 article-title: Risk of venous thromboembolism in patients with liver disease: a nationwide population‐based case‐control study publication-title: Am J Gastroenterol doi: 10.1038/ajg.2008.34 – volume: 49 start-page: 2087 year: 2009 ident: hep28148-bib-0028-20241017 article-title: Management of adult patients with ascites due to cirrhosis: an update publication-title: Hepatology doi: 10.1002/hep.22853 – volume: 137 start-page: 2105 year: 2009 ident: hep28148-bib-0001-20241017 article-title: An imbalance of pro‐ vs anti‐coagulation factors in plasma from patients with cirrhosis publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.08.045 – volume: 58 start-page: 508 year: 2014 ident: hep28148-bib-0023-20241017 article-title: Clinical guidelines on central venous catheterisation. Swedish Society of Anaesthesiology and Intensive Care Medicine publication-title: Acta Anaesthesiol Scand doi: 10.1111/aas.12295 – reference: 26474059 - Hepatology. 2016 Feb;63(2):368-70 – reference: 26547626 - Hepatology. 2016 Aug;64(2):683-4 – reference: 26547808 - Hepatology. 2016 Aug;64(2):682-3 |
| SSID | ssj0009428 |
| Score | 2.6226513 |
| Snippet | Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and... |
| SourceID | proquest pubmed crossref wiley |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 566 |
| SubjectTerms | Adolescent Adult Aged Aged, 80 and over Blood Coagulation Disorders - complications Female Hepatology Humans Liver Cirrhosis - complications Male Middle Aged Plasma Platelet Transfusion Preoperative Care - methods Severity of Illness Index Thrombelastography Young Adult |
| Title | Thrombelastography‐guided blood product use before invasive procedures in cirrhosis with severe coagulopathy: A randomized, controlled trial |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhep.28148 https://www.ncbi.nlm.nih.gov/pubmed/26340411 https://www.proquest.com/docview/1757976987 https://www.proquest.com/docview/1760900648 https://www.proquest.com/docview/1776663378 |
| Volume | 63 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqHhAXKO-lBRnEgQPZxrETx_RUoVYrpCKEWqkHpCi2J92IbbLabJDoiV-A-I38ko6dR1VeQtyiZKLYzozns2f8DSEvQEaAfoMFstA2EAxEoBGFBCmTNkEPHzNwWwNH75LZiXh7Gp9ukL3hLEzHDzFuuDnL8PO1M_BcN7tXpKFzWE6jFNE8zr8uV8sBog9X1FFK-LqquOoKXXRZDaxCYbQ7vnndF_0CMK_jVe9wDm-Tj0NTuzyTT9N2rafm4icWx__syxa51QNRut9pzh2yAdVdcuOoD7XfI9-O56v6XAOi63VPa_3j6_eztrRgqU93p8uOLZa2DVANiH6BltXn3CXEU-8YbYuLebxHTblazeumbKjb96XojQGFTZ2ftYvaFUX-8pruU3Sbtj4vL8C-on0K_QI_5guL3CcnhwfHb2ZBX7whMEKxNMhxBk507A-n2jAJC81DHYEEa5VlzHCtgQPkyqZapRqnFWO1KHiuOC9Qr_gDslnVFTwiNEwLkYdxEevICBnnKk1cVEIZBoXETk_Iy-E3ZqZnNncFNhZZx8kcZTi-mR_fCXk-ii47Oo_fCe0MupD1Ft1kCLMkQjeVygl5Nj5GW3QBlryCunUySagcyEv_JiNxxci5RJmHnZ6NLYkSLkLBGHbIa8ufm5jNDt77i8f_LrpNbiLa61POd8jmetXCE0RUa_3Um84lmNogRg |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKkYAL79KFAgZx4EC2cezEMeJSoVYLdCuEtlIvKIrjSTfqNlntbpDoiV-A-I38EsbOoyovIW5RMlFsZ8bzeTz-hpBnIANAv8E8mWvjCQbC04hCvJhJE6GHDxnY0MD4IBodirdH4dEaedWdhWn4IfqAm7UMN19bA7cB6e1z1tApzIdBjHD-ErlsK3q7BdWHc_IoJVxlVVx3-XZ_WXW8Qn6w3b960Rv9AjEvIlbncvZukI9dY5tMk5NhvdLD7OwnHsf_7c1Ncr3FonSnUZ5bZA3K2-TKuN1tv0O-TqaL6lQDAuxVy2z9_cu347owYKjLeKfzhjCW1kugGhAAAy3KT6nNiafON5oa1_N4j2bFYjGtlsWS2tAvRYcMKJxV6XE9q2xd5M8v6Q5Fz2mq0-IMzAvaZtHP8GOutshdcri3O3k98tr6DV4mFIu9FCfhSIfufKrxIz_X3NcBSDBGGcYyrjVwgFSZWKtY48ySGS1ynirOc1QtvkHWy6qETUL9OBepH-ahDjIhw1TFkd2YUBmDXGKnB-R59x-TrCU3tzU2ZklDyxwkOL6JG98BedqLzhtGj98JbXXKkLRGvUwQaUlEbyqWA_Kkf4zmaPdY0hKq2spEvrI4L_6bjMRFI-cSZe41ita3JIi48AVj2CGnLn9uYjLafe8u7v-76GNydTQZ7yf7bw7ePSDXEPy1GehbZH21qOEhAqyVfuTs6Ad0ICRh |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZKkSouvCkLBQziwIFs7cRJbDhVtKvl0apCrdQDUhTHk27ENlntbpDoiV9Q9TfySxg7j6q8hLhFyUSxnRnPZ8_4G0KeQ-wD-g3uxbk2nuAgPI0oxJM8NhF6-JCD3RrY3YvGh-LdUXi0Ql53Z2Eafoh-w81ahpuvrYHPTL55QRo6gdnQl4jmr5CrImLSqvT2xwvuKCVcYVVcdjEbXlYdrRDzN_tXLzujXxDmZcDqPM7oBvnUtbVJNPk8rJd6mJ3-ROP4n525Sa63SJRuNapzi6xAeZus7bax9jvk7GAyr040ILxetrzW37-dH9eFAUNdvjudNXSxtF4A1YDwF2hRfkltRjx1ntHUuJrHezQr5vNJtSgW1G78UnTHgMJZlR7X08pWRf76im5R9JumOilOwbykbQ79FD_mKovcJYejnYM3Y6-t3uBlQnHppTgFRzp0p1MNi1iuA6Z9iMEYZTjPAq0hAEiVkVpJjfNKZrTIg1QFQY6KFdwjq2VVwn1CmcxFysI81H4m4jBVMrJhCZVxyGPs9IC86H5jkrXU5rbCxjRpSJn9BMc3ceM7IM960VnD5_E7oY1OF5LWpBcJ4qwYsZuS8YA87R-jMdoIS1pCVVuZiCmL8uTfZGJcMgZBjDLrjZ71LfGjQDDBOXbIacufm5iMd_bdxYN_F31C1va3R8mHt3vvH5JriPza9PMNsrqc1_AI0dVSP3ZW9AMXpiMZ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Thrombelastography-guided+blood+product+use+before+invasive+procedures+in+cirrhosis+with+severe+coagulopathy%3A+A+randomized%2C+controlled+trial&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.au=De+Pietri%2C+Lesley&rft.au=Bianchini%2C+Marcello&rft.au=Montalti%2C+Roberto&rft.au=De+Maria%2C+Nicola&rft.date=2016-02-01&rft.pub=Wolters+Kluwer+Health%2C+Inc&rft.issn=0270-9139&rft.eissn=1527-3350&rft.volume=63&rft.issue=2&rft.spage=566&rft_id=info:doi/10.1002%2Fhep.28148&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=3925320061 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-9139&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-9139&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-9139&client=summon |