N-Acyl Taurines are Anti-Proliferative in Prostate Cancer Cells

• Published in: Lipids Vol. 47; no. 4; pp. 355 - 361
• Main Authors: Chatzakos, Vicky, Slätis, Katharina, Djureinovic, Tatjana, Helleday, Thomas, Hunt, Mary C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.04.2012; Springer‐Verlag; Springer Nature B.V
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - pathology; Amides; Amino acids; Apoptosis - drug effects; Arachidonic Acids - chemistry; Arachidonic Acids - pharmacology; Biomedical and Life Sciences; Cannabinoid Receptor Modulators - chemistry; Cannabinoid Receptor Modulators - pharmacology; Cell Count; Cell Cycle - drug effects; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Dose-Response Relationship, Drug; Fatty acid amide hydrolase; Fatty acids; Flow Cytometry; Humans; Life Sciences; Lipidology; Lipids; Male; Medical Biochemistry; Medicinal Chemistry; Microbial Genetics and Genomics; Molecular Genetics; molekylärgenetik; N-Acyl amino acids; N-Arachidonoyl taurine; N-Oleoyl taurine; Neurochemistry; Nutrition; Original Article; Oxazines; PC-3 cells; Prostate - drug effects; Prostate - pathology; Prostate cancer; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; Taurine - analogs & derivatives; Taurine - chemistry; Taurine - pharmacology; Xanthenes; Cell proliferation; Fatty acid amide hydrolase; Oleoyl taurine; Arachidonoyl taurine; PC-3 cells; Acyl amino acids

Endocannabinoids have been implicated in cancer development and cause heterogenous effects in tumor cells, by inducing apoptosis, reducing migration, causing anti-angiogenic activity and alterations in the cell cycle resulting in growth arrest. Recently, several novel amides of fatty acids that are...