Propofol Treatment of Refractory Status Epilepticus : A Study of 31 Episodes

• Published in: Epilepsia (Copenhagen) Vol. 45; no. 7; pp. 757 - 763
• Main Authors: Rossetti, Andrea O., Reichhart, Marc D., Schaller, Marie‐Denise, Despland, Paul‐André, Bogousslavsky, Julien
• Format: Journal Article
• Language: English
• Published: 350 Main Street , Malden , MA 02148 , USA and 9600 Garsington Road , Oxford , OX4 2XG , England Blackwell Science Inc 01.07.2004; Blackwell
• Subjects: Adult; Anesthetics, Intravenous - therapeutic use; Anticonvulsants - therapeutic use; Biological and medical sciences; Clonazepam; Clonazepam - therapeutic use; Coma - chemically induced; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalography - statistics & numerical data; Female; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Humans; Infusions, Intravenous; Male; Medical sciences; Monitoring, Physiologic - statistics & numerical data; Nervous system (semeiology, syndromes); Neurology; Propofol; Propofol - administration & dosage; Propofol - therapeutic use; Refractory status epilepticus; Retrospective Studies; Status Epilepticus - diagnosis; Status Epilepticus - drug therapy; Status Epilepticus - mortality; Thiopental - administration & dosage; Thiopental - therapeutic use; Treatment Outcome; Nervous system diseases; Treatment; Refractory status epilepticus- Clonazepam-Propofol; Epilepsy; Central nervous system disease; Propofol; Status epilepticus; Cerebral disorder

Purpose: Refractory status epilepticus (RSE) is a critical medical condition with high mortality. Although propofol (PRO) is considered an alternative treatment to barbiturates for the management of RSE, only limited data are available. The aim of this study was to assess PRO effectiveness in patien...