Sarcopenia and preserved bone mineral density in paediatric survivors of high‐risk neuroblastoma with growth failure

• Published in: Journal of cachexia, sarcopenia and muscle Vol. 12; no. 4; pp. 1024 - 1033
• Main Authors: Guo, Michelle, Zemel, Babette S., Hawkes, Colin P., Long, Jin, Kelly, Andrea, Leonard, Mary B., Jaramillo, Diego, Mostoufi‐Moab, Sogol
• Format: Journal Article
• Language: English
• Published: Heidelberg John Wiley & Sons, Inc 01.08.2021; John Wiley and Sons Inc; Wiley
• Subjects: Age; Body composition; Bone density; Cancer therapies; Chemotherapy; Children & youth; Growth hormones; High‐risk neuroblastoma; DXA; Sarcopenia; Areal bone mineral density; Autologous stem cell transplantation; cis‐Retinoic acid; Immunotherapy; Medical prognosis; Neuroblastoma; Original; Pediatrics; Questionnaires; Radiation; Sarcopenia; Stem cells; Thyroid gland; Transplants & implants; United Kingdom > UK

Background Survival from paediatric high‐risk neuroblastoma (HR‐NBL) has increased, but cis‐retinoic acid (cis‐RA), the cornerstone of HR‐NBL therapy, can cause osteoporosis and premature physeal closure and is a potential threat to skeletal structure in HR‐NBL survivors. Sarcopenia is associated wi...