Provocation with adenosine 5′-monophosphate, but not methacholine, induces sputum eosinophilia
Summary Introduction Bronchial hyper‐responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5′‐monophosphate (AMP), which acts indirectly via the secondary release of mediators, is another stimulus to measure bronchial hyper‐responsiveness. Aim To i...
Saved in:
| Published in | Clinical and experimental allergy Vol. 34; no. 1; pp. 71 - 76 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Science Ltd
01.01.2004
Blackwell Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0954-7894 1365-2222 |
| DOI | 10.1111/j.1365-2222.2004.01832.x |
Cover
| Abstract | Summary
Introduction
Bronchial hyper‐responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5′‐monophosphate (AMP), which acts indirectly via the secondary release of mediators, is another stimulus to measure bronchial hyper‐responsiveness.
Aim
To investigate whether provocation with inhaled AMP itself initiates an inflammatory response resulting in an influx of eosinophils into the airway lumen.
Methods
We have included 21 non‐smoking atopic asthmatic subjects (mean FEV1 101% predicted, mean age 34 years). Each subject performed three sputum inductions on different days, at least seven days apart: one without previous provocation, one hour after PC20 methacholine, and one hour after PC20 AMP.
Results
After provocation with AMP, but not methacholine, the percentage of sputum eosinophils increased significantly (from 1.9±0.5% to 4.5±1% (P<0.01) and 1.9±0.5% (P=0.89)). No changes in the percentages of neutrophils, lymphocytes, macrophages, or bronchial epithelial cells were found.
Conclusion
A provocation test with AMP leads to an increased percentage of sputum eosinophils. This observation cannot be explained by a non‐specific response of the airways to a vigorous bronchoconstriction, since methacholine had no effect on inflammatory cells. |
|---|---|
| AbstractList | Summary
Introduction
Bronchial hyper‐responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5′‐monophosphate (AMP), which acts indirectly via the secondary release of mediators, is another stimulus to measure bronchial hyper‐responsiveness.
Aim
To investigate whether provocation with inhaled AMP itself initiates an inflammatory response resulting in an influx of eosinophils into the airway lumen.
Methods
We have included 21 non‐smoking atopic asthmatic subjects (mean FEV1 101% predicted, mean age 34 years). Each subject performed three sputum inductions on different days, at least seven days apart: one without previous provocation, one hour after PC20 methacholine, and one hour after PC20 AMP.
Results
After provocation with AMP, but not methacholine, the percentage of sputum eosinophils increased significantly (from 1.9±0.5% to 4.5±1% (P<0.01) and 1.9±0.5% (P=0.89)). No changes in the percentages of neutrophils, lymphocytes, macrophages, or bronchial epithelial cells were found.
Conclusion
A provocation test with AMP leads to an increased percentage of sputum eosinophils. This observation cannot be explained by a non‐specific response of the airways to a vigorous bronchoconstriction, since methacholine had no effect on inflammatory cells. Bronchial hyper-responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5'-monophosphate (AMP), which acts indirectly via the secondary release of mediators, is another stimulus to measure bronchial hyper-responsiveness.INTRODUCTIONBronchial hyper-responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5'-monophosphate (AMP), which acts indirectly via the secondary release of mediators, is another stimulus to measure bronchial hyper-responsiveness.To investigate whether provocation with inhaled AMP itself initiates an inflammatory response resulting in an influx of eosinophils into the airway lumen.AIMTo investigate whether provocation with inhaled AMP itself initiates an inflammatory response resulting in an influx of eosinophils into the airway lumen.We have included 21 non-smoking atopic asthmatic subjects (mean FEV1 101% predicted, mean age 34 years). Each subject performed three sputum inductions on different days, at least seven days apart: one without previous provocation, one hour after PC20 methacholine, and one hour after PC20 AMP.METHODSWe have included 21 non-smoking atopic asthmatic subjects (mean FEV1 101% predicted, mean age 34 years). Each subject performed three sputum inductions on different days, at least seven days apart: one without previous provocation, one hour after PC20 methacholine, and one hour after PC20 AMP.After provocation with AMP, but not methacholine, the percentage of sputum eosinophils increased significantly (from 1.9+/-0.5% to 4.5+/-1% (P<0.01) and 1.9+/-0.5% (P=0.89)). No changes in the percentages of neutrophils, lymphocytes, macrophages, or bronchial epithelial cells were found.RESULTSAfter provocation with AMP, but not methacholine, the percentage of sputum eosinophils increased significantly (from 1.9+/-0.5% to 4.5+/-1% (P<0.01) and 1.9+/-0.5% (P=0.89)). No changes in the percentages of neutrophils, lymphocytes, macrophages, or bronchial epithelial cells were found.A provocation test with AMP leads to an increased percentage of sputum eosinophils. This observation cannot be explained by a non-specific response of the airways to a vigorous bronchoconstriction, since methacholine had no effect on inflammatory cells.CONCLUSIONA provocation test with AMP leads to an increased percentage of sputum eosinophils. This observation cannot be explained by a non-specific response of the airways to a vigorous bronchoconstriction, since methacholine had no effect on inflammatory cells. Bronchial hyper-responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5'-monophosphate (AMP), which acts indirectly via the secondary release of mediators, is another stimulus to measure bronchial hyper-responsiveness. To investigate whether provocation with inhaled AMP itself initiates an inflammatory response resulting in an influx of eosinophils into the airway lumen. We have included 21 non-smoking atopic asthmatic subjects (mean FEV1 101% predicted, mean age 34 years). Each subject performed three sputum inductions on different days, at least seven days apart: one without previous provocation, one hour after PC20 methacholine, and one hour after PC20 AMP. After provocation with AMP, but not methacholine, the percentage of sputum eosinophils increased significantly (from 1.9+/-0.5% to 4.5+/-1% (P<0.01) and 1.9+/-0.5% (P=0.89)). No changes in the percentages of neutrophils, lymphocytes, macrophages, or bronchial epithelial cells were found. A provocation test with AMP leads to an increased percentage of sputum eosinophils. This observation cannot be explained by a non-specific response of the airways to a vigorous bronchoconstriction, since methacholine had no effect on inflammatory cells. Introduction Bronchial hyper-responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5'-monophosphate (AMP), which acts indirectly via the secondary release of mediators, is another stimulus to measure bronchial hyper-responsiveness. Aim To investigate whether provocation with inhaled AMP itself initiates an inflammatory response resulting in an influx of eosinophils into the airway lumen. Methods We have included 21 non-smoking atopic asthmatic subjects (mean FEV sub(1) 101% predicted, mean age 34 years). Each subject performed three sputum inductions on different days, at least seven days apart: one without previous provocation, one hour after PC sub(20) methacholine, and one hour after PC sub(20) AMP. Results After provocation with AMP, but not methacholine, the percentage of sputum eosinophils increased significantly (from 1.9 plus or minus 0.5% to 4.5 plus or minus 1% (P<0.01) and 1.9 plus or minus 0.5% (P=0.89)). No changes in the percentages of neutrophils, lymphocytes, macrophages, or bronchial epithelial cells were found. Conclusion A provocation test with AMP leads to an increased percentage of sputum eosinophils. This observation cannot be explained by a non-specific response of the airways to a vigorous bronchoconstriction, since methacholine had no effect on inflammatory cells. Introduction Bronchial hyper‐responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5′‐monophosphate (AMP), which acts indirectly via the secondary release of mediators, is another stimulus to measure bronchial hyper‐responsiveness. Aim To investigate whether provocation with inhaled AMP itself initiates an inflammatory response resulting in an influx of eosinophils into the airway lumen. Methods We have included 21 non‐smoking atopic asthmatic subjects (mean FEV 1 101% predicted, mean age 34 years). Each subject performed three sputum inductions on different days, at least seven days apart: one without previous provocation, one hour after PC 20 methacholine, and one hour after PC 20 AMP. Results After provocation with AMP, but not methacholine, the percentage of sputum eosinophils increased significantly (from 1.9±0.5% to 4.5±1% ( P <0.01) and 1.9±0.5% ( P =0.89)). No changes in the percentages of neutrophils, lymphocytes, macrophages, or bronchial epithelial cells were found. Conclusion A provocation test with AMP leads to an increased percentage of sputum eosinophils. This observation cannot be explained by a non‐specific response of the airways to a vigorous bronchoconstriction, since methacholine had no effect on inflammatory cells. |
| Author | Koëter, G. H. Kerstjens, H. A. M. Kauffman, H. F. Postma, D. S. De reus, D. M. Van den berge, M. |
| Author_xml | – sequence: 1 givenname: M. surname: Van den berge fullname: Van den berge, M. organization: Departments of Pulmonology, University Hospital Groningen, Groningen, The Netherlands – sequence: 2 givenname: H. A. M. surname: Kerstjens fullname: Kerstjens, H. A. M. organization: Departments of Pulmonology, University Hospital Groningen, Groningen, The Netherlands – sequence: 3 givenname: D. M. surname: De reus fullname: De reus, D. M. organization: Allergology, University Hospital Groningen, Groningen, The Netherlands – sequence: 4 givenname: G. H. surname: Koëter fullname: Koëter, G. H. organization: Departments of Pulmonology, University Hospital Groningen, Groningen, The Netherlands – sequence: 5 givenname: H. F. surname: Kauffman fullname: Kauffman, H. F. organization: Allergology, University Hospital Groningen, Groningen, The Netherlands – sequence: 6 givenname: D. S. surname: Postma fullname: Postma, D. S. organization: Departments of Pulmonology, University Hospital Groningen, Groningen, The Netherlands |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15521186$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/14720265$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkcFuFCEYx4mpsdvqKxhioqfOCMzAwEGTZtNWk1o9aHpElmEyrDMwHRi7vflMPpJPItNd26QX-10g4ff7gO9_APacdwYAiFGOU71d57hgNCOpcoJQmSPMC5JvnoDF3cEeWCBBy6ziotwHByGsEUIFFfwZ2MdlRRBhdAG-fxn9T69VtN7BaxtbqGrjfLDOQPrn1--s984PrQ9Dq6I5gqspQucj7E1slW59l8AjaF09aRNgGKY49dDMfrJsZ9Vz8LRRXTAvdush-HZ68nX5ITv_fPZxeXye6VJgkinKiC4ZLQSrMVsptsKsrLRWqCaCk6ZuSi4qVdSacoQ0LRQilDGlWVUwXrPiELzZ9h1GfzWZEGVvgzZdp5zxU5DJEknF_wWxIJRTTBL46gG49tPo0icSI0SaeMkT9HIHTave1HIYba_GG_lvwgl4vQNU0KprRuW0DfccpQRjPr-fbzk9-hBG09wjSM6hy7Wcs5VztnIOXd6GLjdJff9A1TbeJhpHZbvHNHi3bXBtO3Pz6Ivl8uR43iU_2_o2RLO589X4Q6Z4KiovL87kEp-y6hO7kJfFX3KA1AU |
| CitedBy_id | crossref_primary_10_1089_jamp_2012_1021 crossref_primary_10_1183_09031936_00169711 crossref_primary_10_1097_01_mcp_0000199002_46038_cb crossref_primary_10_1097_01_all_0000162314_10050_34 crossref_primary_10_1111_j_1398_9995_2009_02187_x crossref_primary_10_1038_sj_bjp_0706272 crossref_primary_10_1183_09031936_00116207 crossref_primary_10_1016_j_bbamem_2010_08_024 crossref_primary_10_1016_S1081_1206_10_61327_0 crossref_primary_10_1111_j_1398_9995_2010_02352_x crossref_primary_10_1152_ajpheart_01224_2007 crossref_primary_10_2165_00126839_200708010_00002 crossref_primary_10_1016_j_jaip_2023_12_013 crossref_primary_10_1016_j_rmed_2010_04_014 crossref_primary_10_1016_S1081_1206_10_61211_2 crossref_primary_10_1111_j_1398_9995_2007_01382_x crossref_primary_10_1152_ajpheart_01090_2009 crossref_primary_10_4049_jimmunol_179_7_4800 crossref_primary_10_1038_bjp_2008_22 crossref_primary_10_1111_j_1440_1843_2010_01712_x crossref_primary_10_1097_MCP_0000000000000009 crossref_primary_10_1378_chest_130_5_1448 crossref_primary_10_17816_rmj37860 crossref_primary_10_1111_j_1398_9995_2010_02414_x crossref_primary_10_1186_1465_9921_11_106 crossref_primary_10_1016_j_ddstr_2006_09_006 crossref_primary_10_1016_j_ejphar_2005_12_056 crossref_primary_10_1111_j_1398_9995_2012_02855_x crossref_primary_10_3109_02770903_2011_565850 crossref_primary_10_1007_s12325_021_01976_4 crossref_primary_10_1007_s11302_006_9033_z crossref_primary_10_1016_j_pupt_2018_01_004 crossref_primary_10_1080_02770900802647540 crossref_primary_10_1183_09031936_00003707 crossref_primary_10_1378_chest_130_4_1157 crossref_primary_10_1016_j_intimp_2005_07_008 crossref_primary_10_1016_j_anai_2010_10_019 crossref_primary_10_1016_j_jaci_2008_06_014 crossref_primary_10_1111_j_1365_2222_2005_0079_x crossref_primary_10_1016_j_pupt_2006_02_001 |
| Cites_doi | 10.1164/ajrccm/147.5.1126 10.1164/ajrccm.159.5.9810095 10.1016/S0091-6749(98)70196-4 10.1164/ajrccm.155.4.9105062 10.1159/000024068 10.1111/j.1476-5381.1983.tb10063.x 10.4049/jimmunol.155.1.333 10.1164/ajrccm.164.8.2102033 10.1164/ajrccm.163.7.2010145 10.1016/0091-6749(93)90023-9 10.4049/jimmunol.151.7.3853 10.1111/j.1749-6632.1996.tb32589.x 10.1136/thx.54.10.894 10.1034/j.1399-3003.2000.15a07.x 10.1034/j.1399-3003.2000.16b10.x 10.1038/sj.bjp.0702223 10.1006/bbrc.1997.8040 10.1165/ajrcmb.18.5.3052 10.1111/j.1365-2222.1996.tb00592.x 10.1159/000237039 10.1016/0006-2952(84)90050-9 10.1183/09041950.005s1693 10.1165/ajrcmb.16.5.9160835 10.1183/09031936.93.06030405 10.1136/thx.46.12.891 10.1183/09031936.95.08111966 10.1136/thx.54.1.37 10.1183/09031936.02.00283202 10.1164/ajrccm.164.7.2102135 |
| ContentType | Journal Article |
| Copyright | 2004 INIST-CNRS Copyright Blackwell Scientific Publications Ltd. Jan 2004 |
| Copyright_xml | – notice: 2004 INIST-CNRS – notice: Copyright Blackwell Scientific Publications Ltd. Jan 2004 |
| DBID | BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 |
| DOI | 10.1111/j.1365-2222.2004.01832.x |
| DatabaseName | Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE AIDS and Cancer Research Abstracts CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1365-2222 |
| EndPage | 76 |
| ExternalDocumentID | 546106761 14720265 15521186 10_1111_j_1365_2222_2004_01832_x CEA1832 ark_67375_WNG_C1F67M6N_W |
| Genre | article Research Support, Non-U.S. Gov't Journal Article Comparative Study General Information |
| GroupedDBID | --- .3N .55 .GA .Y3 05W 0R~ 10A 1OB 1OC 29B 31~ 33P 36B 3O- 3SF 4.4 4P2 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 A8Z AAESR AAEVG AAHHS AAKAS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZCM ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHEFC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOETA ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EAD EAP EAS EBB EBC EBD EBS EBX EDH EJD EMB EMK EMOBN ESTFP ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 Q~Q R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 V8K V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR X7M XG1 YFH YUY ZGI ZXP ZZTAW ~IA ~WT AAHQN AAIPD AAMNL AANHP AAYCA ACRPL ACUHS ACYXJ ADNMO AFWVQ ALVPJ AAYXX AEYWJ AGHNM AGQPQ AGYGG CITATION AAMMB AEFGJ AGXDD AIDQK AIDYY IQODW CGR CUY CVF ECM EIF NPM 7T5 H94 K9. 7X8 |
| ID | FETCH-LOGICAL-c4912-a562c465396d16ba6b1647cca0d2982fdf4897a3dc5800c53a02566ac67368d63 |
| IEDL.DBID | DR2 |
| ISSN | 0954-7894 |
| IngestDate | Mon Sep 08 14:02:15 EDT 2025 Fri Jul 11 02:08:45 EDT 2025 Sun Jul 13 04:01:49 EDT 2025 Wed Feb 19 02:34:17 EST 2025 Mon Jul 21 09:13:51 EDT 2025 Thu Apr 24 23:09:22 EDT 2025 Tue Jul 01 01:20:51 EDT 2025 Wed Jan 22 16:40:56 EST 2025 Wed Oct 30 09:53:46 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Allergy Immunopathology Purine nucleoside Adenosine Immunology hyper-responsiveness inflammation Sputum adenosine 5'-monophosphate Hemopathy Antiarrhythmic agent Eosinophilia |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4912-a562c465396d16ba6b1647cca0d2982fdf4897a3dc5800c53a02566ac67368d63 |
| Notes | ark:/67375/WNG-C1F67M6N-W istex:4A5F3E8E9EDC1613604211F8CB800299994DC5DC ArticleID:CEA1832 SourceType-Scholarly Journals-1 ObjectType-General Information-1 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 |
| PMID | 14720265 |
| PQID | 199918348 |
| PQPubID | 36521 |
| PageCount | 6 |
| ParticipantIDs | proquest_miscellaneous_80095801 proquest_miscellaneous_19258512 proquest_journals_199918348 pubmed_primary_14720265 pascalfrancis_primary_15521186 crossref_primary_10_1111_j_1365_2222_2004_01832_x crossref_citationtrail_10_1111_j_1365_2222_2004_01832_x wiley_primary_10_1111_j_1365_2222_2004_01832_x_CEA1832 istex_primary_ark_67375_WNG_C1F67M6N_W |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2004-01 January 2004 2004-01-00 2004 2004-Jan 20040101 |
| PublicationDateYYYYMMDD | 2004-01-01 |
| PublicationDate_xml | – month: 01 year: 2004 text: 2004-01 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: Oxford – name: England |
| PublicationTitle | Clinical and experimental allergy |
| PublicationTitleAlternate | Clin Exp Allergy |
| PublicationYear | 2004 |
| Publisher | Blackwell Science Ltd Blackwell Wiley Subscription Services, Inc |
| Publisher_xml | – name: Blackwell Science Ltd – name: Blackwell – name: Wiley Subscription Services, Inc |
| References | Walls AF, He S, Teran LM et al. Granulocyte recruitment by human mast cell tryptase. Int Arch Allergy Immunol 1995; 107: 372-3. Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM. Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. Am J Respir Cell Mol Biol 1997; 17: 519-28. He S, Walls AF. Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo. Br J Pharmacol 1998; 125: 1491-500. Suzuki H, Takei M, Nakahata T, Fukamachi H. Inhibitory effect of adenosine on degranulation of human cultured mast cells upon cross-linking of Fc epsilon RI. Biochem Biophys Res Commun 1998; 242: 697-702. Walker BA, Jacobson MA, Knight DA et al. Adenosine A3 receptor expression and function in eosinophils. Am J Respir Cell Mol Biol 1997; 16: 531-7. Lantero S, Sacco O, Scala C, Morelli MC, Rossi GA. Eosinophil locomotion and the release of IL-3 and IL-5 by allergen-stimulated mononuclear cells are effectively downregulated in vitro by budesonide. Clin Exp Allergy 1996; 26: 656-64. Polosa R, Ciamarra I, Mangano G et al. Bronchial hyperresponsiveness and airway inflammation markers in nonasthmatics with allergic rhinitis. Eur Respir J 2000; 15: 30-5. Bradding P, Holgate ST. The mast cell as a source of cytokines in asthma. Ann N Y Acad Sci 1996; 796: 272-81. Spanevello A, Vignola AM, Bonanno A, Confalonieri M, Crimi E, Brusasco V. Effect of methacholine challenge on cellular composition of sputum induction. Thorax 1999; 54: 37-9. Gauvreau GM, Parameswaran KN, Watson RM, O'Byrne PM. Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma. Am J Respir Crit Care Med 2001; 164: 1495-500. Meijer RJ, Kerstjens HAM, Arends LR, Kauffman HF, Koeter GH, Postma DS. Effects of inhaled fluticasone and oral prednisolone on clinical and inflammatory parameters in patients with asthma. Thorax 1999; 54: 894-9. Blease K, Seybold J, Adcock IM, Hellewell PG, Burke-Gaffney A. Interleukin-4 and lipopolysaccharide synergize to induce vascular cell adhesion molecule-1 expression in human lung microvascular endothelial cells. Am J Respir Cell Mol Biol 1998; 18: 620-30. Kraft M, Bettinger CM, Wenzel SE, Irvin CG, Ackerman SJ, Martin RJ. Methacholine challenge does not affect bronchoalveolar fluid cell number and many indices of cell function in asthma. Eur Respir J 1995; 8: 1966-71. Purokivi M, Randell J, Hirvonen MR, Tukiainen H. Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum. Eur Respir J 2000; 16: 242-6. Compton SJ, Cairns JA, Holgate ST, Walls AF. Interaction of human mast cell tryptase with endothelial cells to stimulate inflammatory cell recruitment. Int Arch Allergy Immunol 1999; 118: 204-5. Van Den Berge M, Kerstjens HAM, Meijer RJ et al. Corticosteroid-induced improvement in the PC(20) of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC(20) of methacholine. Am J Respir Crit Care Med 2001; 164: 1127-32. Fahy JV, Liu JT, Wong H, Boushey HA. Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis 1993; 147: 1126-31. Hirata N, Kohrogi H, Iwagoe H et al. Allergen exposure induces the expression of endothelial adhesion molecules in passively sensitized human bronchus: time course and the role of cytokines. Am J Respir Cell Mol Biol 1998; 18: 12-20. Bradding P, Roberts JA, Britten KM et al. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994; 10: 471-80. Cockcroft DW, Killian DN, Mellon JJ, Hargreave FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 1977; 7: 235-43. Spanevello A, Migliori GB, Sharara A et al. Induced sputum to assess airway inflammation: a study of reproducibility. Clin Exp Allergy 1997; 27: 1138-44. Church MK, Holgate ST, Hughes PJ. Adenosine inhibits and potentiates IgE-dependent histamine release from human basophils by an A2-receptor mediated mechanism. Br J Pharmacol 1983; 80: 719-26. Pizzichini E, Pizzichini MM, Kidney JC et al. Induced sputum, bronchoalveolar lavage and blood from mild asthmatics: inflammatory cells, lymphocyte subsets and soluble markers compared. Eur Respir J 1998; 11: 828-34. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993; 16: 5-40. Nowak D, Grimminger F, Jorres RA et al. Increased LTB4 metabolites and PGD2 in BAL fluid after methacholine challenge in asthmatic subjects. Eur Respir J 1993; 6: 405-12. Bradding P, Feather IH, Wilson SJ et al. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J Immunol 1993; 151: 3853-65. Selroos O, Halme M. Effect of a volumatic spacer and mouth rinsing on systemic absorption of inhaled corticosteroids from a metered dose inhaler and dry powder inhaler. Thorax 1991; 46: 891-4. Cronstein BN, Daguma L, Nichols D, Hutchison AJ, Williams KM. The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively. J Clin Invest 1990; 85: 1150-7. Felsch A, Stocker K, Borchard U. Phorbol ester-stimulated adherence of neutrophils to endothelial cells is reduced by adenosine A2 receptor agonists. J Immunol 1995; 155: 333-8. Polosa R, Ng WH, Crimi N et al. Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. Am J Respir Crit Care Med 1995; 151: 624-9. Barnes PJ. Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids. Eur Respir J 2002; 19: 182-91. Hughes PJ, Holgate ST, Church MK. Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism. Biochem Pharmacol 1984; 33: 3847-52. Diamant Z, Hiltermann TJ, Van Rensen EL et al. The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. Am J Respir Crit Care Med 1997; 155: 1247-53. Miyamasu M, Misaki Y, Izumi S et al. Glucocorticoids inhibit chemokine generation by human eosinophils. J Allergy Clin Immunol 1998; 101: 75-83. Mulder A, Gauvreau GM, Watson RM, O'Byrne PM. Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. Am J Respir Crit Care Med 1999; 159: 1562-7. Oosterhoff Y, Jansen MA, Postma DS, Koeter GH. Airway responsiveness to adenosine 5′-monophosphate in smokers and nonsmokers with atopic asthma. J Allergy Clin Immunol 1993; 92: 773-6. Van Den Berge M, Meijer RJ, Kerstjens HAM et al. PC20 adenosine 5′-monophosphate is more closely associated with airway inflammation in asthma than PC20 methacholine. Am J Respir Crit Care Med 2001; 163: 1546-50. 2001; 164 2001; 163 2002; 19 1997; 155 1997; 27 1995; 155 1993; 147 1995; 151 1995; 8 1993; 6 1990; 85 1998; 18 2000; 16 1993; 16 2000; 15 1991; 46 1993; 92 1984; 33 1995; 107 1997; 17 1993; 151 1999; 54 1997; 16 1998; 125 1983; 80 1996; 796 1999; 118 1998; 242 1999; 159 1998; 101 1996; 26 1977; 7 1998; 11 1994; 10 Polosa R (e_1_2_6_7_2) 1995; 151 Pizzichini E (e_1_2_6_22_2) 1998; 11 Bradding P (e_1_2_6_9_2) 1994; 10 e_1_2_6_19_2 Cockcroft DW (e_1_2_6_18_2) 1977; 7 e_1_2_6_12_2 Nowak D (e_1_2_6_34_2) 1993; 6 e_1_2_6_35_2 e_1_2_6_13_2 e_1_2_6_33_2 e_1_2_6_11_2 e_1_2_6_32_2 e_1_2_6_16_2 e_1_2_6_17_2 e_1_2_6_38_2 e_1_2_6_14_2 e_1_2_6_37_2 e_1_2_6_15_2 e_1_2_6_20_2 Bradding P (e_1_2_6_10_2) 1993; 151 Cronstein BN (e_1_2_6_30_2) 1990; 85 Hirata N (e_1_2_6_28_2) 1998; 18 Felsch A (e_1_2_6_31_2) 1995; 155 e_1_2_6_8_2 e_1_2_6_29_2 e_1_2_6_4_2 e_1_2_6_3_2 e_1_2_6_6_2 Spanevello A (e_1_2_6_36_2) 1997; 27 e_1_2_6_5_2 e_1_2_6_24_2 e_1_2_6_23_2 e_1_2_6_2_2 Okada S (e_1_2_6_21_2) 1997; 17 e_1_2_6_27_2 e_1_2_6_26_2 e_1_2_6_25_2 |
| References_xml | – reference: Hughes PJ, Holgate ST, Church MK. Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism. Biochem Pharmacol 1984; 33: 3847-52. – reference: Spanevello A, Migliori GB, Sharara A et al. Induced sputum to assess airway inflammation: a study of reproducibility. Clin Exp Allergy 1997; 27: 1138-44. – reference: Walls AF, He S, Teran LM et al. Granulocyte recruitment by human mast cell tryptase. Int Arch Allergy Immunol 1995; 107: 372-3. – reference: Suzuki H, Takei M, Nakahata T, Fukamachi H. Inhibitory effect of adenosine on degranulation of human cultured mast cells upon cross-linking of Fc epsilon RI. Biochem Biophys Res Commun 1998; 242: 697-702. – reference: Blease K, Seybold J, Adcock IM, Hellewell PG, Burke-Gaffney A. Interleukin-4 and lipopolysaccharide synergize to induce vascular cell adhesion molecule-1 expression in human lung microvascular endothelial cells. Am J Respir Cell Mol Biol 1998; 18: 620-30. – reference: Cronstein BN, Daguma L, Nichols D, Hutchison AJ, Williams KM. The adenosine/neutrophil paradox resolved: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively. J Clin Invest 1990; 85: 1150-7. – reference: Polosa R, Ciamarra I, Mangano G et al. Bronchial hyperresponsiveness and airway inflammation markers in nonasthmatics with allergic rhinitis. Eur Respir J 2000; 15: 30-5. – reference: He S, Walls AF. Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells in vivo. Br J Pharmacol 1998; 125: 1491-500. – reference: Mulder A, Gauvreau GM, Watson RM, O'Byrne PM. Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects. Am J Respir Crit Care Med 1999; 159: 1562-7. – reference: Selroos O, Halme M. Effect of a volumatic spacer and mouth rinsing on systemic absorption of inhaled corticosteroids from a metered dose inhaler and dry powder inhaler. Thorax 1991; 46: 891-4. – reference: Miyamasu M, Misaki Y, Izumi S et al. Glucocorticoids inhibit chemokine generation by human eosinophils. J Allergy Clin Immunol 1998; 101: 75-83. – reference: Felsch A, Stocker K, Borchard U. Phorbol ester-stimulated adherence of neutrophils to endothelial cells is reduced by adenosine A2 receptor agonists. J Immunol 1995; 155: 333-8. – reference: Kraft M, Bettinger CM, Wenzel SE, Irvin CG, Ackerman SJ, Martin RJ. Methacholine challenge does not affect bronchoalveolar fluid cell number and many indices of cell function in asthma. Eur Respir J 1995; 8: 1966-71. – reference: Barnes PJ. Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids. Eur Respir J 2002; 19: 182-91. – reference: Van Den Berge M, Meijer RJ, Kerstjens HAM et al. PC20 adenosine 5′-monophosphate is more closely associated with airway inflammation in asthma than PC20 methacholine. Am J Respir Crit Care Med 2001; 163: 1546-50. – reference: Spanevello A, Vignola AM, Bonanno A, Confalonieri M, Crimi E, Brusasco V. Effect of methacholine challenge on cellular composition of sputum induction. Thorax 1999; 54: 37-9. – reference: Lantero S, Sacco O, Scala C, Morelli MC, Rossi GA. Eosinophil locomotion and the release of IL-3 and IL-5 by allergen-stimulated mononuclear cells are effectively downregulated in vitro by budesonide. Clin Exp Allergy 1996; 26: 656-64. – reference: Bradding P, Roberts JA, Britten KM et al. Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 1994; 10: 471-80. – reference: Van Den Berge M, Kerstjens HAM, Meijer RJ et al. Corticosteroid-induced improvement in the PC(20) of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC(20) of methacholine. Am J Respir Crit Care Med 2001; 164: 1127-32. – reference: Pizzichini E, Pizzichini MM, Kidney JC et al. Induced sputum, bronchoalveolar lavage and blood from mild asthmatics: inflammatory cells, lymphocyte subsets and soluble markers compared. Eur Respir J 1998; 11: 828-34. – reference: Church MK, Holgate ST, Hughes PJ. Adenosine inhibits and potentiates IgE-dependent histamine release from human basophils by an A2-receptor mediated mechanism. Br J Pharmacol 1983; 80: 719-26. – reference: Cockcroft DW, Killian DN, Mellon JJ, Hargreave FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 1977; 7: 235-43. – reference: Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM. Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. Am J Respir Cell Mol Biol 1997; 17: 519-28. – reference: Hirata N, Kohrogi H, Iwagoe H et al. Allergen exposure induces the expression of endothelial adhesion molecules in passively sensitized human bronchus: time course and the role of cytokines. Am J Respir Cell Mol Biol 1998; 18: 12-20. – reference: Oosterhoff Y, Jansen MA, Postma DS, Koeter GH. Airway responsiveness to adenosine 5′-monophosphate in smokers and nonsmokers with atopic asthma. J Allergy Clin Immunol 1993; 92: 773-6. – reference: Fahy JV, Liu JT, Wong H, Boushey HA. Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects. Am Rev Respir Dis 1993; 147: 1126-31. – reference: Walker BA, Jacobson MA, Knight DA et al. Adenosine A3 receptor expression and function in eosinophils. Am J Respir Cell Mol Biol 1997; 16: 531-7. – reference: Diamant Z, Hiltermann TJ, Van Rensen EL et al. The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. Am J Respir Crit Care Med 1997; 155: 1247-53. – reference: Meijer RJ, Kerstjens HAM, Arends LR, Kauffman HF, Koeter GH, Postma DS. Effects of inhaled fluticasone and oral prednisolone on clinical and inflammatory parameters in patients with asthma. Thorax 1999; 54: 894-9. – reference: Bradding P, Feather IH, Wilson SJ et al. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J Immunol 1993; 151: 3853-65. – reference: Nowak D, Grimminger F, Jorres RA et al. Increased LTB4 metabolites and PGD2 in BAL fluid after methacholine challenge in asthmatic subjects. Eur Respir J 1993; 6: 405-12. – reference: Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993; 16: 5-40. – reference: Compton SJ, Cairns JA, Holgate ST, Walls AF. Interaction of human mast cell tryptase with endothelial cells to stimulate inflammatory cell recruitment. Int Arch Allergy Immunol 1999; 118: 204-5. – reference: Purokivi M, Randell J, Hirvonen MR, Tukiainen H. Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum. Eur Respir J 2000; 16: 242-6. – reference: Bradding P, Holgate ST. The mast cell as a source of cytokines in asthma. Ann N Y Acad Sci 1996; 796: 272-81. – reference: Polosa R, Ng WH, Crimi N et al. Release of mast-cell-derived mediators after endobronchial adenosine challenge in asthma. Am J Respir Crit Care Med 1995; 151: 624-9. – reference: Gauvreau GM, Parameswaran KN, Watson RM, O'Byrne PM. Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma. Am J Respir Crit Care Med 2001; 164: 1495-500. – volume: 18 start-page: 620 year: 1998 end-page: 30 article-title: Interleukin‐4 and lipopolysaccharide synergize to induce vascular cell adhesion molecule‐1 expression in human lung microvascular endothelial cells publication-title: Am J Respir Cell Mol Biol – volume: 16 start-page: 242 year: 2000 end-page: 6 article-title: Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum publication-title: Eur Respir J – volume: 26 start-page: 656 year: 1996 end-page: 64 article-title: Eosinophil locomotion and the release of IL‐3 and IL‐5 by allergen‐stimulated mononuclear cells are effectively downregulated by budesonide publication-title: Clin Exp Allergy – volume: 33 start-page: 3847 year: 1984 end-page: 52 article-title: Adenosine inhibits and potentiates IgE‐dependent histamine release from human lung mast cells by an A ‐purinoceptor mediated mechanism publication-title: Biochem Pharmacol – volume: 125 start-page: 1491 year: 1998 end-page: 500 article-title: Human mast cell chymase induces the accumulation of neutrophils, eosinophils and other inflammatory cells publication-title: Br J Pharmacol – volume: 155 start-page: 1247 year: 1997 end-page: 53 article-title: The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma publication-title: Am J Respir Crit Care Med – volume: 107 start-page: 372 year: 1995 end-page: 3 article-title: Granulocyte recruitment by human mast cell tryptase publication-title: Int Arch Allergy Immunol – volume: 163 start-page: 1546 year: 2001 end-page: 50 article-title: PC adenosine 5′‐monophosphate is more closely associated with airway inflammation in asthma than PC methacholine publication-title: Am J Respir Crit Care Med – volume: 46 start-page: 891 year: 1991 end-page: 4 article-title: Effect of a volumatic spacer and mouth rinsing on systemic absorption of inhaled corticosteroids from a metered dose inhaler and dry powder inhaler publication-title: Thorax – volume: 147 start-page: 1126 year: 1993 end-page: 31 article-title: Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects publication-title: Am Rev Respir Dis – volume: 151 start-page: 3853 year: 1993 end-page: 65 article-title: Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL‐4, IL‐5, and IL‐6 in human allergic mucosal inflammation publication-title: J Immunol – volume: 164 start-page: 1495 year: 2001 end-page: 500 article-title: Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma publication-title: Am J Respir Crit Care Med – volume: 7 start-page: 235 year: 1977 end-page: 43 article-title: Bronchial reactivity to inhaled histamine publication-title: a method and clinical survey – volume: 796 start-page: 272 year: 1996 end-page: 81 article-title: The mast cell as a source of cytokines in asthma publication-title: Ann N Y Acad Sci – volume: 92 start-page: 773 year: 1993 end-page: 6 article-title: Airway responsiveness to adenosine 5′‐monophosphate in smokers and nonsmokers with atopic asthma publication-title: J Allergy Clin Immunol – volume: 17 start-page: 519 year: 1997 end-page: 28 article-title: Migration of eosinophils through basement membrane components publication-title: role of matrix metalloproteinase-9 – volume: 85 start-page: 1150 year: 1990 end-page: 7 article-title: The adenosine/neutrophil paradox resolved publication-title: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively – volume: 16 start-page: 531 year: 1997 end-page: 7 article-title: Adenosine A3 receptor expression and function in eosinophils publication-title: Am J Respir Cell Mol Biol – volume: 54 start-page: 894 year: 1999 end-page: 9 article-title: Effects of inhaled fluticasone and oral prednisolone on clinical and inflammatory parameters in patients with asthma publication-title: Thorax – volume: 155 start-page: 333 year: 1995 end-page: 8 article-title: Phorbol ester‐stimulated adherence of neutrophils to endothelial cells is reduced by adenosine A receptor agonists publication-title: J Immunol – volume: 54 start-page: 37 year: 1999 end-page: 9 article-title: Effect of methacholine challenge on cellular composition of sputum induction publication-title: Thorax – volume: 11 start-page: 828 year: 1998 end-page: 34 article-title: Induced sputum, bronchoalveolar lavage and blood from mild asthmatics publication-title: inflammatory cells, lymphocyte subsets and soluble markers compared – volume: 80 start-page: 719 year: 1983 end-page: 26 article-title: Adenosine inhibits and potentiates IgE‐dependent histamine release from human basophils by an A ‐receptor mediated mechanism publication-title: Br J Pharmacol – volume: 10 start-page: 471 year: 1994 end-page: 80 article-title: Interleukin‐4, ‐5, and ‐6 and tumor necrosis factor‐alpha in normal and asthmatic airways publication-title: evidence for the human mast cell as a source of these cytokines – volume: 8 start-page: 1966 year: 1995 end-page: 71 article-title: Methacholine challenge does not affect bronchoalveolar fluid cell number and many indices of cell function in asthma publication-title: Eur Respir J – volume: 18 start-page: 12 year: 1998 end-page: 20 article-title: Allergen exposure induces the expression of endothelial adhesion molecules in passively sensitized human bronchus publication-title: time course and the role of cytokines – volume: 27 start-page: 1138 year: 1997 end-page: 44 article-title: Induced sputum to assess airway inflammation publication-title: a study of reproducibility – volume: 15 start-page: 30 year: 2000 end-page: 5 article-title: Bronchial hyperresponsiveness and airway inflammation markers in nonasthmatics with allergic rhinitis publication-title: Eur Respir J – volume: 164 start-page: 1127 year: 2001 end-page: 32 article-title: Corticosteroid‐induced improvement in the PC(20) of adenosine monophosphate is more closely associated with reduction in airway inflammation than improvement in the PC(20) of methacholine publication-title: Am J Respir Crit Care Med – volume: 6 start-page: 405 year: 1993 end-page: 12 article-title: Increased LTB4 metabolites and PGD2 in BAL fluid after methacholine challenge in asthmatic subjects publication-title: Eur Respir J – volume: 19 start-page: 182 year: 2002 end-page: 91 article-title: Scientific rationale for inhaled combination therapy with long‐acting beta2‐agonists and corticosteroids publication-title: Eur Respir J – volume: 118 start-page: 204 year: 1999 end-page: 5 article-title: Interaction of human mast cell tryptase with endothelial cells to stimulate inflammatory cell recruitment publication-title: Int Arch Allergy Immunol – volume: 16 start-page: 5 year: 1993 end-page: 40 article-title: Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society publication-title: Eur Respir J Suppl – volume: 159 start-page: 1562 year: 1999 end-page: 7 article-title: Effect of inhaled leukotriene D4 on airway eosinophilia and airway hyperresponsiveness in asthmatic subjects publication-title: Am J Respir Crit Care Med – volume: 242 start-page: 697 year: 1998 end-page: 702 article-title: Inhibitory effect of adenosine on degranulation of human cultured mast cells upon cross‐linking of Fc epsilon RI publication-title: Biochem Biophys Res Commun – volume: 101 start-page: 75 year: 1998 end-page: 83 article-title: Glucocorticoids inhibit chemokine generation by human eosinophils publication-title: J Allergy Clin Immunol – volume: 151 start-page: 624 year: 1995 end-page: 9 article-title: Release of mast‐cell‐derived mediators after endobronchial adenosine challenge in asthma publication-title: Am J Respir Crit Care Med – volume: 11 start-page: 828 year: 1998 ident: e_1_2_6_22_2 article-title: Induced sputum, bronchoalveolar lavage and blood from mild asthmatics publication-title: inflammatory cells, lymphocyte subsets and soluble markers compared – volume: 7 start-page: 235 year: 1977 ident: e_1_2_6_18_2 article-title: Bronchial reactivity to inhaled histamine publication-title: a method and clinical survey – ident: e_1_2_6_20_2 doi: 10.1164/ajrccm/147.5.1126 – volume: 85 start-page: 1150 year: 1990 ident: e_1_2_6_30_2 article-title: The adenosine/neutrophil paradox resolved publication-title: human neutrophils possess both A1 and A2 receptors that promote chemotaxis and inhibit O2 generation, respectively – ident: e_1_2_6_14_2 doi: 10.1164/ajrccm.159.5.9810095 – ident: e_1_2_6_37_2 doi: 10.1016/S0091-6749(98)70196-4 – ident: e_1_2_6_13_2 doi: 10.1164/ajrccm.155.4.9105062 – ident: e_1_2_6_26_2 doi: 10.1159/000024068 – ident: e_1_2_6_5_2 doi: 10.1111/j.1476-5381.1983.tb10063.x – volume: 155 start-page: 333 year: 1995 ident: e_1_2_6_31_2 article-title: Phorbol ester‐stimulated adherence of neutrophils to endothelial cells is reduced by adenosine A2 receptor agonists publication-title: J Immunol doi: 10.4049/jimmunol.155.1.333 – ident: e_1_2_6_27_2 doi: 10.1164/ajrccm.164.8.2102033 – ident: e_1_2_6_2_2 doi: 10.1164/ajrccm.163.7.2010145 – ident: e_1_2_6_19_2 doi: 10.1016/0091-6749(93)90023-9 – volume: 151 start-page: 3853 year: 1993 ident: e_1_2_6_10_2 article-title: Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL‐4, IL‐5, and IL‐6 in human allergic mucosal inflammation publication-title: J Immunol doi: 10.4049/jimmunol.151.7.3853 – volume: 17 start-page: 519 year: 1997 ident: e_1_2_6_21_2 article-title: Migration of eosinophils through basement membrane components in vitro publication-title: role of matrix metalloproteinase-9 – ident: e_1_2_6_8_2 doi: 10.1111/j.1749-6632.1996.tb32589.x – ident: e_1_2_6_17_2 doi: 10.1136/thx.54.10.894 – ident: e_1_2_6_4_2 doi: 10.1034/j.1399-3003.2000.15a07.x – ident: e_1_2_6_35_2 doi: 10.1034/j.1399-3003.2000.16b10.x – volume: 18 start-page: 12 year: 1998 ident: e_1_2_6_28_2 article-title: Allergen exposure induces the expression of endothelial adhesion molecules in passively sensitized human bronchus publication-title: time course and the role of cytokines – ident: e_1_2_6_25_2 doi: 10.1038/sj.bjp.0702223 – ident: e_1_2_6_32_2 doi: 10.1006/bbrc.1997.8040 – volume: 10 start-page: 471 year: 1994 ident: e_1_2_6_9_2 article-title: Interleukin‐4, ‐5, and ‐6 and tumor necrosis factor‐alpha in normal and asthmatic airways publication-title: evidence for the human mast cell as a source of these cytokines – ident: e_1_2_6_29_2 doi: 10.1165/ajrcmb.18.5.3052 – ident: e_1_2_6_38_2 doi: 10.1111/j.1365-2222.1996.tb00592.x – ident: e_1_2_6_24_2 doi: 10.1159/000237039 – ident: e_1_2_6_6_2 doi: 10.1016/0006-2952(84)90050-9 – ident: e_1_2_6_16_2 doi: 10.1183/09041950.005s1693 – volume: 27 start-page: 1138 year: 1997 ident: e_1_2_6_36_2 article-title: Induced sputum to assess airway inflammation publication-title: a study of reproducibility – ident: e_1_2_6_33_2 doi: 10.1165/ajrcmb.16.5.9160835 – volume: 6 start-page: 405 year: 1993 ident: e_1_2_6_34_2 article-title: Increased LTB4 metabolites and PGD2 in BAL fluid after methacholine challenge in asthmatic subjects publication-title: Eur Respir J doi: 10.1183/09031936.93.06030405 – ident: e_1_2_6_23_2 doi: 10.1136/thx.46.12.891 – ident: e_1_2_6_15_2 doi: 10.1183/09031936.95.08111966 – ident: e_1_2_6_12_2 doi: 10.1136/thx.54.1.37 – volume: 151 start-page: 624 year: 1995 ident: e_1_2_6_7_2 article-title: Release of mast‐cell‐derived mediators after endobronchial adenosine challenge in asthma publication-title: Am J Respir Crit Care Med – ident: e_1_2_6_11_2 doi: 10.1183/09031936.02.00283202 – ident: e_1_2_6_3_2 doi: 10.1164/ajrccm.164.7.2102135 |
| SSID | ssj0003598 |
| Score | 1.9153521 |
| Snippet | Summary
Introduction
Bronchial hyper‐responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5′‐monophosphate... Introduction Bronchial hyper‐responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5′‐monophosphate (AMP),... Bronchial hyper-responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5'-monophosphate (AMP), which acts... Introduction Bronchial hyper-responsiveness is usually measured with direct stimuli such as methacholine (MCh) or histamine. Adenosine 5'-monophosphate (AMP),... |
| SourceID | proquest pubmed pascalfrancis crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 71 |
| SubjectTerms | adenosine adenosine 5′-monophosphate Adenosine Monophosphate Administration, Inhalation Adult Allergic diseases Asthma - drug therapy Asthma - immunology Biological and medical sciences Bronchial Hyperreactivity - diagnosis Bronchial Provocation Tests Bronchoconstrictor Agents Cross-Over Studies Eosinophilia - chemically induced Female Fundamental and applied biological sciences. Psychology Fundamental immunology Glucocorticoids - therapeutic use Humans hyper-responsiveness Immunopathology inflammation Male Medical sciences Methacholine Chloride sputum Sputum - immunology Statistics, Nonparametric |
| Title | Provocation with adenosine 5′-monophosphate, but not methacholine, induces sputum eosinophilia |
| URI | https://api.istex.fr/ark:/67375/WNG-C1F67M6N-W/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2222.2004.01832.x https://www.ncbi.nlm.nih.gov/pubmed/14720265 https://www.proquest.com/docview/199918348 https://www.proquest.com/docview/19258512 https://www.proquest.com/docview/80095801 |
| Volume | 34 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3dbtMwFD5CQyBu-Bl_YTB8gbhaqiaxHedyKisT0iqEmLY7yz-JVnUkVZOgwdUegWfhkfYk-MRpS9GQJkSvKjknTk6-43y2T74D8CZlMVPMqtDwYRHSVCeh4MYFnhDUqIIiCjDbYsIPj-mHU3ba5z_htzBeH2K14IaR0Y3XGOBK15tB3mVouV83zRsMEZ0D5JOuAWX0331aK0mhUJ2X3aNhKjK6mdRz7Yk23lS30ekXmDmpaue8wle9uI6WbrLc7jU1fgCz5Q367JTZoG30wHz_Q_vx_3jgIdzv2SzZ9_B7BLfychvu-PqW37bh7lG_c_8Y9MdF9bXy64MEF3-JsqhT7hoJu7r8eXX5wwVENT-r6vmZ4797RLcNKauGYI1rLOmC17tHpqV1YKxJPW-b9gvJ8QzOano-VU_geHzweXQY9vUdQkOzKA6V414G9d0ybiOuFdcobuYgNbRxJuLCFlRkqUqsYY7WGpYoJGhcGcxFE5YnT2GrrMr8ORAUOC0yLYRROS0iqkwitLbDwkS5FVQHkC6fpTS9-DnW4DiXv02CnDMlOhNLc1LZOVNeBBCtLOdeAOQGNm87uKwM1GKGCXQpkyeT93IUjXl6xCfyJIDdDTyte2COVkWCB7CzBJjsB5daonKE64iKAF6vWt2ogFs9qsyrFg-Jcb83_vsRAsm1oycBPPO4XfdN09jNzFkAvEPfjW9bjg728d-LfzXcgXs-MQpXuF7CVrNo81eO8zV6t4vmX1X1Rsw |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3bbtNAEB2hVlxeuJSbKbT7gHiqo9her9ePVWgI0EQItWrfVnux1ajBjmIbFZ76CXwLn9QvYcd2EoyKVCHyFMkerz05sz47OzkD8DoK_VCGRrqa9VOXRipwOdM28DinWqYUUYDVFhM2OqYfTsPTth0Q_hem0YdYJdwwMur5GgMcE9LdKK9LtOynXuf1-gjPniWUm9TyDlyJvf281pJCqbpGeI-6EY9pt6zn2it13lWb6PYLrJ2UhXVf2vS9uI6Ydnlu_aIaPoDZ8hGb-pTzXlWqnv7-h_rjf_LBQ7jfElqy3yDwEdxKsi243bS4_LYFd8bt5v1jUJ8W-de8SRESzP8SaVCq3B4k4dXlz6vLHzYm8vlZXszPLAXeI6oqSZaXBNtcY1cXvOE9Ms2MxWNBinlVVl9IglewVtPZVD6B4-HB0WDkti0eXE1jz3elpV8aJd5iZjymJFOob2ZR1Td-zP3UpJTHkQyMDi2z1WEgkaMxqbEcjRsWPIWNLM-S50BQ4zSNFedaJjT1qNQBV8r0U-0lhlPlQLT8MYVu9c-xDcdM_LYOss4U6EzszklF7Uxx4YC3spw3GiA3sHlT42VlIBfnWEMXheJk8k4MvCGLxmwiThzY6QBqPUJomZXHmQPbS4SJdn4pBIpH2IEod2B3ddRODLjbI7Mkr_AUH7d8_b-fwZFfW4biwLMGuOuxaeTbxXnoAKvhd-PHFoODffz24l8Nd-Hu6Gh8KA7fTz5uw72mTgoTXi9ho1xUyStLAUu1U4f2L8NJSus |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3dbpRAFD4xbWy88adqxWo7F8arsllgGIbLZu1af7ppjE17N5kfSDdbgSxgqld9BJ_FR-qTOAfYXTE1aYxckcBh4PCd4ZuZw3cAXkWhH8rQSFezYerSSAUuZ9oGHudUy5QiCjDbYsIOT-j7s_Csy3_Cf2FafYjlhBtGRtNfY4AXJu0HeZOhZbdmmDcYIjoHlk-uU2aJBRKkTyspKVSqa3X3qBvxmPazem68Uu9TtY5ev8TUSVla76Vt2YubeGmf5jbfqfEDmC2esE1PmQ3qSg309z_EH_-PCx7C_Y7Okv0Wf4_gTpJtwt22wOW3Tdg46pbuH4M6nudf83aCkODsL5EGhcrtQRJeX_28vvphIyIvzvOyOLcEeI-ouiJZXhEsco01XfB-98g0MxaNJSmLuqq_kASvYK2mF1P5BE7GB59Hh25X4MHVNPZ8V1rypVHgLWbGY0oyhepmFlND48fcT01KeRzJwOjQ8lodBhIZGpMak9G4YcFTWMvyLHkGBBVO01hxrmVCU49KHXClzDDVXmI4VQ5Ei3cpdKd-jkU4LsRvoyDrTIHOxNqcVDTOFJcOeEvLolUAuYXN6wYuSwM5n2EGXRSK08lbMfLGLDpiE3HqwE4PT6sWQsurPM4c2F4ATHS9SylQOsI2RLkDu8ujtlvAtR6ZJXmNp_i44Ov__QyO7NryEwe2Wtyu2qaRb4fmoQOsQd-tH1uMDvZx7_m_Gu7CxvGbsfj4bvJhG-61SVI42_UC1qp5nby0_K9SO01g_wKTiEma |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Provocation+with+adenosine+5%27-monophosphate%2C+but+not+methacholine%2C+induces+sputum+eosinophilia&rft.jtitle=Clinical+and+experimental+allergy&rft.au=VAN+DEN+BERGE%2C+M&rft.au=KERSTJENS%2C+H.+A.+M&rft.au=DE+REUS%2C+D.+M&rft.au=KO%C3%8BTER%2C+G.+H&rft.date=2004&rft.pub=Blackwell&rft.issn=0954-7894&rft.volume=34&rft.issue=1&rft.spage=71&rft.epage=76&rft_id=info:doi/10.1111%2Fj.1365-2222.2004.01832.x&rft.externalDBID=n%2Fa&rft.externalDocID=15521186 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0954-7894&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0954-7894&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0954-7894&client=summon |