Identification and characterization of spontaneous AA amyloidosis in CD-1 mice used in toxicity studies: implications of SAA1 and SAA2 copy number variations

• Published in: Journal of Toxicologic Pathology Vol. 38; no. 1; pp. 69 - 82
• Main Authors: Mizukawa, Mao, Tanaka, Kohei, Kashimura, Akane, Uchida, Yu, Shiga, Takanori, Aihara, Naoyuki, Kamiie, Junichi
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY 01.01.2025; The Japanese Society of Toxicologic Pathology; Japan Science and Technology Agency; Japanese Society of Toxicologic Pathology
• Subjects: AA amyloidosis; Amyloid; Amyloidosis; CD-1 mice; Chromatography; Copy number; copy number variation (CNVs); Deposition; Fibrils; Genetic factors; Immunohistochemistry; Liquid chromatography; Mass spectrometry; Mass spectroscopy; Organs; Original; Pathogenesis; Precursors; Proteins; serum amyloid A (SAA); Toxicity testing; Variation; AA amyloidosis; amyloidosis; copy number variation (CNVs); serum amyloid A (SAA); CD-1 mice

Amyloidosis is characterized by the extracellular deposition of insoluble protein fibrils that cause cellular damage and dysfunction in organs and tissues. Multiple types of amyloidosis and their causative precursor proteins have been identified in humans and animals. In toxicological studies, a hig...