Frequent promoter hypermethylation of BRCA2, CDH13, MSH6, PAX5, PAX6 and WT1 in ductal carcinoma in situ and invasive breast cancer

• Published in: The Journal of pathology Vol. 225; no. 2; pp. 222 - 231
• Main Authors: Moelans, Cathy B, Verschuur-Maes, Anoek HJ, van Diest, Paul J
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.10.2011; Wiley
• Subjects: Biological and medical sciences; BRCA2 protein; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cadherins - genetics; Carcinoma; Carcinoma in Situ - genetics; Carcinoma in Situ - pathology; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - pathology; Cell cycle; CpG islands; DCIS; Development; DNA methylation; DNA Methylation - genetics; DNA repair; DNA-Binding Proteins - genetics; epigenetics; Eye Proteins - genetics; Female; Genes, BRCA2; Genes, Wilms Tumor; Glutathione transferase; Gynecology. Andrology. Obstetrics; Homeodomain Proteins - genetics; Humans; Invasiveness; Investigative techniques, diagnostic techniques (general aspects); Mammary gland diseases; Medical sciences; methylation; Microdissection; MS-MLPA; MSH6 protein; Paired Box Transcription Factors - genetics; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Pax5 protein; PAX5 Transcription Factor - genetics; Pax6 protein; PAX6 Transcription Factor; Promoter Regions, Genetic - genetics; Promoters; Repressor Proteins - genetics; Transcription factors; Tumor suppressor genes; Tumors; H Cadherin; Ductal carcinoma; Breast disease; Carcinoma in situ; Transcription promoter; In situ; Breast cancer; Wilms tumor gene; Malignant tumor; Repair gene; Mammary gland diseases; Anatomic pathology; Multiplex ligation dependent probe amplification; BRCA2 gene; DCIS; MS-MLPA; Frequency; Invasive cancer; Methylation; Cancer; Tumor suppressor gene

Epigenetic changes are considered to be a frequent event during tumour development. Hypermethylation of promoter CpG islands represents an alternative mechanism to inactivate tumour suppressor genes, DNA repair genes, cell cycle regulators and transcription factors. In search of epigenetic events re...