Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction

• Published in: Nature chemistry Vol. 6; no. 6; pp. 484 - 491
• Main Authors: Woerly, Eric M., Roy, Jahnabi, Burke, Martin D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2014; Nature Publishing Group
• Subjects: 140/131; 639/638/549/977; Algorithms; Amino acids; Analytical Chemistry; Automation; Biochemistry; Biological Products - chemical synthesis; Carotenoids - chemical synthesis; Chemistry; Chemistry/Food Science; Glucosides - chemical synthesis; Inorganic Chemistry; Modularity; Molecular Structure; Natural products; Organic Chemistry; Physical Chemistry; Polyenes - chemistry; Polypeptides; Stereoisomerism; United States > US; Illinois

The inherent modularity of polypeptides, oligonucleotides and oligosaccharides has been harnessed to achieve generalized synthesis platforms. Importantly, like these other targets, most small-molecule natural products are biosynthesized via iterative coupling of bifunctional building blocks. This su...