Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells

• Published in: Frontiers in cellular neuroscience Vol. 14; p. 51
• Main Authors: Belov Kirdajova, Denisa, Kriska, Jan, Tureckova, Jana, Anderova, Miroslava
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 19.03.2020; Frontiers Media S.A
• Subjects: Amino acids; Apoptosis; Astrocytes; Calcium (extracellular); Calcium (intracellular); Cell death; Cell membranes; Cellular Neuroscience; Central nervous system; Cerebral blood flow; Depolarization; Edema; Excitotoxicity; Free radicals; Gene expression; Glial cells; glutamate excitotoxicity; glutamate uptake/release; Glutamic acid receptors; Ischemia; ischemic pathway; Membrane potential; Metabolism; Metabolites; Microglia; Mortality; Neurological diseases; Neuronal-glial interactions; Oligodendrocytes; Oxidative phosphorylation; Parenchyma; Phosphorylation; Physiology; glutamate excitotoxicity; ischemic pathway; cell death; glutamate uptake/release; oligodendrocytes; astrocytes; NG2 glia; glutamate receptors and transporters

A plethora of neurological disorders shares a final common deadly pathway known as excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and disability worldwide. Brain ischemia stems from cardiac arrest or stroke, both responsible for insufficient blood supply to the...