Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of β-catenin

• Published in: Current biology Vol. 8; no. 4; pp. 181 - 190
• Main Authors: Fagotto, François, Glück, Ursula, Gumbiner, Barry M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 12.02.1998
• Subjects: alpha Karyopherins; Animals; beta Catenin; Binding, Competitive; Biological Transport; Cell Nucleus - metabolism; Cytoskeletal Proteins - metabolism; Cytosol - metabolism; Karyopherins; Nuclear Localization Signals; Nuclear Proteins - metabolism; Recombinant Proteins - metabolism; Trans-Activators; Xenopus; Xenopus Proteins

Background: Control of the nuclear localization of specific proteins is an important mechanism for regulating many signal transduction pathways. Upon activation of the Wnt signaling pathway, β-catenin localizes into the nucleus and interacts with TCF/LEF-1 (T-cell factor/lymphocyte enhancer factor-1...