Bidirectional Crosstalk between the Estrogen Receptor and Human Epidermal Growth Factor Receptor 2 Signaling Pathways in Breast Cancer: Molecular Basis and Clinical Implications

• Published in: Breast care (Basel, Switzerland) Vol. 8; no. 4; pp. 256 - 262
• Main Authors: Giuliano, Mario, Trivedi, Meghana V., Schiff, Rachel
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger GmbH 01.01.2013
• Subjects: Review Article · Übersichtsarbeit; Review · Übersichtsarbeit; Resistance; HER2; Estrogen Receptor; Crosstalk

The estrogen receptor (ER) and/or the human epidermal growth factor receptor 2 (HER2) signaling pathways are the dominant drivers of cell proliferation and survival in the majority of human breast cancers. As a result, targeting these pathways provides the most effective therapies in appropriately s...