Concomitant knockdown resistance allele, L982W + F1534C, in Aedes aegypti has the potential to impose fitness costs without selection pressure

• Published in: Pesticide Biochemistry and Physiology Vol. 193; p. 105422
• Main Authors: Uemura, Nozomi, Furutani, Shogo, Tomita, Takashi, Itokawa, Kentaro, Komagata, Osamu, Kasai, Shinji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2023; Elsevier BV
• Subjects: Aedes; Aedes - genetics; Aedes aegypti; Allele frequency; Alleles; amino acids; Animals; arboviruses; dengue; Eprobe; Fitness cost; fluorescent dyes; genotyping; heterozygosity; homozygosity; Insecticide Resistance; Insecticide Resistance - genetics; Insecticides; Insecticides - pharmacology; Kdr; Mosquito Vectors; Mosquito Vectors - genetics; mutants; Mutation; pesticide resistance; pesticides; physiology; Pyrethrins; Pyrethrins - pharmacology; selection pressure; sodium channels; viability; Voltage-Gated Sodium Channels; Voltage-Gated Sodium Channels - genetics; yellow fever; Zika Virus; Zika Virus Infection; Zika Virus Infection - genetics; Kdr; Aedes aegypti; Allele frequency; Fitness cost; Eprobe

The Aedes aegypti mosquito, is an arbovirus vector that can spread dengue, chikungunya, Zika, and yellow fever. Pyrethroids are widely used to control mosquitoes. The voltage-gated sodium channel (Vgsc) is the target of pyrethroids, and amino acid substitutions in this channel attenuate the effects...