cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia

• Published in: Frontiers in molecular neuroscience Vol. 11; p. 255
• Main Authors: Wang, Haitao, Xu, Jiangping, Lazarovici, Philip, Quirion, Remi, Zheng, Wenhua
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 30.08.2018; Frontiers Media S.A
• Subjects: Animal models; Antipsychotics; Brain; Brain-derived neurotrophic factor; CREB; Cyclic AMP response element-binding protein; Dopamine; Dopamine receptors; Drug development; Emotional disorders; G protein-coupled receptors; Gene deletion; Genes; Kinases; Memory; Mental disorders; Neurodevelopment; Neurogenesis; Neuroscience; neurotransmitter; Neurotrophic factors; Patients; Phosphorylation; Proteins; Psychiatry; Psychotropic drugs; RNA polymerase; Schizophrenia; Signal transduction; Synaptic plasticity; Transcription factors; China; CREB; schizophrenia; neurodevelopment; neurotransmitter; dopamine

Dopamine is a brain neurotransmitter involved in the pathology of schizophrenia. The dopamine hypothesis states that, in schizophrenia, dopaminergic signal transduction is hyperactive. The cAMP-response element binding protein (CREB) is an intracellular protein that regulates the expression of genes...