Mutations at protein-protein interfaces: Small changes over big surfaces have large impacts on human health

• Published in: Progress in biophysics and molecular biology Vol. 128; pp. 3 - 13
• Main Authors: Jubb, Harry C., Pandurangan, Arun P., Turner, Meghan A., Ochoa-Montaño, Bernardo, Blundell, Tom L., Ascher, David B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2017
• Subjects: Drug development; Genetic Diseases, Inborn - drug therapy; Genetic Diseases, Inborn - genetics; Genetic Diseases, Inborn - metabolism; Health; Humans; Molecular Targeted Therapy; Mutation; Mutations; Protein Binding - genetics; Protein interaction; Protein stability; Protein-protein interfaces; Proteins - chemistry; Proteins - genetics; Proteins - metabolism; Mutations; Protein stability; Drug development; Protein interaction; Protein-protein interfaces

Many essential biological processes including cell regulation and signalling are mediated through the assembly of protein complexes. Changes to protein-protein interaction (PPI) interfaces can affect the formation of multiprotein complexes, and consequently lead to disruptions in interconnected netw...