Reduced Expression of Cerebral Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome - Brašić, James R.; Nandi, Ayon; Russell, David S.; Jennings, Danna; Barret, Olivier; Mathur, Anil; Slifer, Keith; Sedlak, Thomas; Martin, Samuel D.; Brinson, Zabecca; Vyas, Pankhuri; Seibyl, John P.; et al. (Brain sciences, 2020)
Keywords: Age; Allosteric properties; Animal models; Autism; binding potential; Brain; caudate nucleus; Clinical trials; FMR1 gene; FMR1 protein; Fragile X Mental Retardation Protein (FMRP); Fragile X syndrome; genetic mutation; Glutamatergic transmission; Glutamic acid receptors; Glutamic acid receptors (metabotropic); Intellectual disabilities; Kinases; Magnetic resonance imaging; magnetic resonance imaging (MRI); Positron emission tomography; Protein synthesis; Proteins; Standard scores; United States--US; Maryland; Baltimore Maryland; caudate nucleus; magnetic resonance imaging (MRI); neuropsychological testing; positron emission tomography (PET); mosaicism; genetic mutation; 3-[18F]fluoro-5-(2-pyridinylethynyl)benzonitrile ([18F]FPEB); binding potential; FMR1 gene; Fragile X Mental Retardation Protein (FMRP)