Antioxidant Treatment with N-acetyl Cysteine Prevents the Development of Cognitive and Social Behavioral Deficits that Result from Perinatal Ketamine Treatment

• Published in: Frontiers in behavioral neuroscience Vol. 11; p. 106
• Main Authors: Phensy, Aarron, Duzdabanian, Hasmik E., Brewer, Samantha, Panjabi, Anurag, Driskill, Christopher, Berz, Annuska, Peng, George, Kroener, Sven
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 06.06.2017; Frontiers Media S.A
• Subjects: Acetylcysteine; Amphetamines; Animal cognition; Antioxidants; Brain research; Channel gating; Cognitive ability; cognitive flexibility; Cysteine; Etiology; Glutamic acid receptors (ionotropic); Glutathione; Ketamine; Memory; Mental disorders; N-Methyl-D-aspartic acid receptors; Neuroscience; novel object recognition; Oxidative stress; Pattern recognition; Problem solving; Redox properties; Schizophrenia; Sensorimotor gating; Social interaction; Social interactions; Spontaneous alternation; Startle response; Stereotyped behavior; United States > US; ketamine; novel object recognition; social interaction; spontaneous alternation; prepulse inhibition; cognitive flexibility; amphetamine-induced hyperlocomotion; oxidative stress

Alterations of the normal redox state can be found in all stages of schizophrenia, suggesting a key role for oxidative stress in the etiology and maintenance of the disease. Pharmacological blockade of N-methyl-D-aspartic acid (NMDA) receptors can disrupt natural antioxidant defense systems and indu...