Probiotics Alleviate the Progressive Deterioration of Motor Functions in a Mouse Model of Parkinson’s Disease

• Published in: Brain sciences Vol. 10; no. 4; p. 206
• Main Authors: Hsieh, Tsung-Hsun, Kuo, Chi-Wei, Hsieh, Kai-Hsuan, Shieh, Meng-Jyh, Peng, Chih-Wei, Chen, Yen-Chien, Chang, Ying-Ling, Huang, Ying-Zu, Chen, Chih-Chung, Chang, Pi-Kai, Chen, Kai-Yun, Chen, Hsin-Yung
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2020; MDPI
• Subjects: Animal models; Brain; Constipation; Coordination; Disease; Dopamine; Dopamine receptors; Dysbacteriosis; Gait; Hydroxylase; Investigations; Laboratory animals; mice; Microbiota; MitoPark; Motor ability; motor function; Motor systems; Movement disorders; Neurodegeneration; Neurodegenerative diseases; Neurons; Neuroprotection; Parkinson's disease; Probiotics; Software; Substantia nigra; Transgenic mice; Tyrosine 3-monooxygenase; Walking; United States > US; Taiwan; motor function; MitoPark; mice; neuroprotection; Parkinson’s disease; probiotics

Parkinson’s disease (PD) is one of the common long-term degenerative disorders that primarily affect motor systems. Gastrointestinal (GI) symptoms are common in individuals with PD and often present before motor symptoms. It has been found that gut dysbiosis to PD pathology is related to the severit...