Parkin Regulation and Neurodegenerative Disorders

• Published in: Frontiers in aging neuroscience Vol. 7; p. 248
• Main Authors: Zhang, Cheng-Wu, Hang, Liting, Yao, Tso-Pang, Lim, Kah-Leong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 12.01.2016; Frontiers Media S.A
• Subjects: Amyotrophic lateral sclerosis; Autophagy; Basal ganglia; Binding sites; Central nervous system diseases; Enzymes; Homeostasis; Insects; Kinases; Mitochondria; mitophagy; Movement disorders; Mutation; Neurodegenerative Diseases; Neuroscience; Parkin protein; Parkinson Disease; Parkinson's disease; Phosphorylation; Proteins; Quality control; Risk factors; Ubiquitin; Ubiquitin-protein ligase; Singapore; proteasome; mitophagy; autophagy; mitochondria; protein misfolding; neurodegeneration; Parkinson’s disease; ubiquitin

Parkin is a unique, multifunctional ubiquitin ligase whose various roles in the cell, particularly in neurons, are widely thought to be protective. The pivotal role that Parkin plays in maintaining neuronal survival is underscored by our current recognition that Parkin dysfunction represents not onl...