Circulating Conventional and Plasmacytoid Dendritic Cell Subsets Display Distinct Kinetics during In Vivo Repeated Allergen Skin Challenges in Atopic Subjects

• Published in: BioMed research international Vol. 2014; no. 2014; pp. 1 - 14
• Main Authors: Xanthou, Georgina, Gaga, Mina, Vittorakis, Stelios, Panoutsakopoulou, Vily, Semitekolou, Maria, Aggelakopoulou, Maria, Samitas, Konstantinos, Tousa, Sofia, Zervas, Eleftherios
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc
• Subjects: Activins - blood; Activins - immunology; Adolescent; Adult; Allergens - toxicity; Allergies; Aqueous solutions; Asthma; Atopic dermatitis; Biomedical research; Chemokines; Clinical Study; Cytokines; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dendritic Cells - pathology; Dermatitis, Atopic - blood; Dermatitis, Atopic - immunology; Dermatitis, Atopic - pathology; Female; Gene Expression Regulation - drug effects; Gene Expression Regulation - immunology; Genetic aspects; Health aspects; Humans; Immune system; Inflammation - blood; Inflammation - immunology; Inflammation - pathology; Lymphocytes; Male; Middle Aged; Migration; Plasma Cells - immunology; Plasma Cells - metabolism; Plasma Cells - pathology; Receptors, CCR10 - blood; Receptors, CCR10 - immunology; Receptors, CCR4 - blood; Receptors, CCR4 - immunology; Risk factors; Skin - immunology; Skin - metabolism; Skin - pathology; Skin Tests; Studies; Greece

Upon allergen challenge, DC subsets are recruited to target sites under the influence of chemotactic agents; however, details pertinent to their trafficking remain largely unknown. We investigated the kinetic profiles of blood and skin-infiltrating DC subsets in twelve atopic subjects receiving six...