Chronic Intermittent Ethanol Exposure Alters Stress Effects on (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP) Immunolabeling of Amygdala Neurons in C57BL/6J Mice

• Published in: Frontiers in cellular neuroscience Vol. 10; p. 40
• Main Authors: Maldonado-Devincci, Antoniette M, Kampov-Polevoi, Alexander, McKinley, Raechel E, Morrow, Danielle H, O'Buckley, Todd K, Morrow, A Leslie
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 04.03.2016; Frontiers Media S.A
• Subjects: alcohol; Alcoholism; Allopregnanolone; Amygdala; Animal behavior; Binding sites; Corticosterone; Drinking behavior; Drug abuse; Drug dependence; Drug dosages; Enzymes; Ethanol; Hypothalamus; Menopause; Mouse; Neuroscience; Nucleus accumbens; Paraventricular nucleus; Pregnanolone; Psychopharmacology; Rodents; Stress; Stress response; Swimming behavior; withdrawal; γ-Aminobutyric acid; North Carolina; United States > US; 5α-THP; alcohol; mouse; stress; allopregnanolone; withdrawal; 3α; neuroactive steroid

The GABAergic neuroactive steroid (3α,5α)-3-hydroxy-pregnan-20-one (3α,5α-THP, allopregnanolone) is decreased in various brain regions of C57BL/6J mice following exposure to an acute stressor or chronic intermittent ethanol (CIE) exposure and withdrawal. It is well established that there are complex...