Low Serum Phosphorus Correlates with Cerebral Aβ Deposition in Cognitively Impaired Subjects: Results from the KBASE Study

Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid (Aβ) deposition is the major pathological hallmark of AD. Recent studies also have shown that the serum level of phosphorus correlates to...

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Published inFrontiers in aging neuroscience Vol. 9; p. 362
Main Authors Park, Jong-Chan, Han, Sun-Ho, Byun, Min S., Yi, Dahyun, Lee, Jun Ho, Park, Kyua, Lee, Dong Young, Mook-Jung, Inhee
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 06.11.2017
Frontiers Media S.A
Subjects
Age
Aluminum
Alzheimer's disease
Apolipoprotein E
Biomarkers
Brain research
Calcium
Cognitive ability
Dementia
Dementia disorders
Genotypes
Geriatrics
KBASE
Medicine
Memory
mild cognitive impairment
Neurodegeneration
Neurodegenerative diseases
Neuroscience
NMR
Nuclear magnetic resonance
Pathogenesis
Peptides
Phosphorus
PiB-PET
Positron emission tomography
Serum levels
β-Amyloid
United States > US
South Korea
Pittsburgh Pennsylvania
blood-based biomarker
KBASE
mild cognitive impairment
PiB-PET
Alzheimer's disease
phosphorus
β-amyloid
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Abstract Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid (Aβ) deposition is the major pathological hallmark of AD. Recent studies also have shown that the serum level of phosphorus correlates to the risk of incident dementia. To date, the linkage between cerebral Aβ deposition and the serum phosphorus level remains unknown. In this study, we analyzed the levels of serum phosphorus in 109 mild cognitive impairment (MCI) and 73 AD dementia (ADD) subjects. All subjects underwent Pittsburgh compound B positron emission tomography (PiB-PET) imaging to measure cerebral Aβ deposition. The results with Aβ deposition was compared with the serum levels of phosphorus. The subjects with cerebral Aβ deposition showed lower levels of serum phosphorus than those without Aβ deposition. Furthermore, multiple regression analyses showed that a low level of serum phosphorus correlated with cerebral Aβ deposition, even when age, sex, apolipoprotein E ε4 genotype, and MMSE z-score were controlled for. Serum levels of other ions, including calcium, iron, zinc, and copper, showed no such correlation. In conclusion, our results suggest that the serum level of phosphorus may be used as an easily accessible blood biomarker for cerebral Aβ deposition in a cognitively impaired population.
AbstractList Alzheimer’s disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid (Aβ) deposition is the major pathological hallmark of AD. Recent studies also have shown that the serum level of phosphorus correlates to the risk of incident dementia. To date, the linkage between cerebral Aβ deposition and the serum phosphorus level remains unknown. In this study, we analyzed the levels of serum phosphorus in 109 mild cognitive impairment (MCI) and 73 AD dementia (ADD) subjects. All subjects underwent Pittsburgh compound B positron emission tomography (PiB-PET) imaging to measure cerebral Aβ deposition. The results with Aβ deposition was compared with the serum levels of phosphorus. The subjects with cerebral Aβ deposition showed lower levels of serum phosphorus than those without Aβ deposition. Furthermore, multiple regression analyses showed that a low level of serum phosphorus correlated with cerebral Aβ deposition, even when age, sex, apolipoprotein E ε4 genotype, and MMSE z-score were controlled for. Serum levels of other ions, including calcium, iron, zinc, and copper, showed no such correlation. In conclusion, our results suggest that the serum level of phosphorus may be used as an easily accessible blood biomarker for cerebral Aβ deposition in a cognitively impaired population.
Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid (Aβ) deposition is the major pathological hallmark of AD. Recent studies also have shown that the serum level of phosphorus correlates to the risk of incident dementia. To date, the linkage between cerebral Aβ deposition and the serum phosphorus level remains unknown. In this study, we analyzed the levels of serum phosphorus in 109 mild cognitive impairment (MCI) and 73 AD dementia (ADD) subjects. All subjects underwent Pittsburgh compound B positron emission tomography (PiB-PET) imaging to measure cerebral Aβ deposition. The results with Aβ deposition was compared with the serum levels of phosphorus. The subjects with cerebral Aβ deposition showed lower levels of serum phosphorus than those without Aβ deposition. Furthermore, multiple regression analyses showed that a low level of serum phosphorus correlated with cerebral Aβ deposition, even when age, sex, apolipoprotein E ε4 genotype, and MMSE z-score were controlled for. Serum levels of other ions, including calcium, iron, zinc, and copper, showed no such correlation. In conclusion, our results suggest that the serum level of phosphorus may be used as an easily accessible blood biomarker for cerebral Aβ deposition in a cognitively impaired population.Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid (Aβ) deposition is the major pathological hallmark of AD. Recent studies also have shown that the serum level of phosphorus correlates to the risk of incident dementia. To date, the linkage between cerebral Aβ deposition and the serum phosphorus level remains unknown. In this study, we analyzed the levels of serum phosphorus in 109 mild cognitive impairment (MCI) and 73 AD dementia (ADD) subjects. All subjects underwent Pittsburgh compound B positron emission tomography (PiB-PET) imaging to measure cerebral Aβ deposition. The results with Aβ deposition was compared with the serum levels of phosphorus. The subjects with cerebral Aβ deposition showed lower levels of serum phosphorus than those without Aβ deposition. Furthermore, multiple regression analyses showed that a low level of serum phosphorus correlated with cerebral Aβ deposition, even when age, sex, apolipoprotein E ε4 genotype, and MMSE z-score were controlled for. Serum levels of other ions, including calcium, iron, zinc, and copper, showed no such correlation. In conclusion, our results suggest that the serum level of phosphorus may be used as an easily accessible blood biomarker for cerebral Aβ deposition in a cognitively impaired population.
Author Mook-Jung, Inhee
Park, Jong-Chan
Park, Kyua
Lee, Jun Ho
Lee, Dong Young
Byun, Min S.
Yi, Dahyun
Han, Sun-Ho
AuthorAffiliation 3 Institute of Human Behavioral Medicine, Medical Research Center Seoul National University , Seoul , South Korea
5 Department of Biology, College of Arts & Sciences, University of Pennsylvania , Pennsylvania, PA , United States
4 Department of Neuropsychiatry, Seoul National University Hospital , Seoul , South Korea
1 Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University , Seoul , South Korea
2 Neuroscience Research Institute, College of Medicine, Seoul National University , Seoul , South Korea
6 Department of Psychiatry, Seoul National University College of Medicine , Seoul , South Korea
AuthorAffiliation_xml – name: 3 Institute of Human Behavioral Medicine, Medical Research Center Seoul National University , Seoul , South Korea
– name: 6 Department of Psychiatry, Seoul National University College of Medicine , Seoul , South Korea
– name: 2 Neuroscience Research Institute, College of Medicine, Seoul National University , Seoul , South Korea
– name: 4 Department of Neuropsychiatry, Seoul National University Hospital , Seoul , South Korea
– name: 1 Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University , Seoul , South Korea
– name: 5 Department of Biology, College of Arts & Sciences, University of Pennsylvania , Pennsylvania, PA , United States
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ContentType Journal Article
Copyright 2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright © 2017 Park, Han, Byun, Yi, Lee, Park, Lee and Mook-Jung for the KBASE Research Group. 2017 Park, Han, Byun, Yi, Lee, Park, Lee and Mook-Jung for the KBASE Research Group
Copyright_xml – notice: 2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: Copyright © 2017 Park, Han, Byun, Yi, Lee, Park, Lee and Mook-Jung for the KBASE Research Group. 2017 Park, Han, Byun, Yi, Lee, Park, Lee and Mook-Jung for the KBASE Research Group
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Keywords blood-based biomarker
KBASE
mild cognitive impairment
PiB-PET
Alzheimer's disease
phosphorus
β-amyloid
Language English
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Edited by: Fatima Nasrallah, The University of Queensland, Australia
Information on the KBASE Research Group is provided in the Appendix (in Supplementary materials).
Reviewed by: Rolf Andreas Heckemann, University of Gothenburg, Sweden; Douglas Watt, Boston University School of Medicine, United States
These authors have contributed equally to this work.
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– reference: 20448202 - Proc Natl Acad Sci U S A. 2010 May 25;107(21):9490-5
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Snippet Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid...
Alzheimer’s disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid...
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StartPage 362
SubjectTerms Age
Aluminum
Alzheimer's disease
Apolipoprotein E
Biomarkers
Brain research
Calcium
Cognitive ability
Dementia
Dementia disorders
Genotypes
Geriatrics
KBASE
Medicine
Memory
mild cognitive impairment
Neurodegeneration
Neurodegenerative diseases
Neuroscience
NMR
Nuclear magnetic resonance
Pathogenesis
Peptides
Phosphorus
PiB-PET
Positron emission tomography
Serum levels
β-Amyloid
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Title Low Serum Phosphorus Correlates with Cerebral Aβ Deposition in Cognitively Impaired Subjects: Results from the KBASE Study
URI https://www.ncbi.nlm.nih.gov/pubmed/29163142
https://www.proquest.com/docview/2300677482
https://www.proquest.com/docview/1967466663
https://pubmed.ncbi.nlm.nih.gov/PMC5681522
https://doaj.org/article/7c08b6a46ef24034824c89fd84527f66
Volume 9
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