Bridging the treatment gap in infant medulloblastoma: molecularly informed outcomes of a globally feasible regimen

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 22; no. 12; pp. 1873 - 1881
• Main Authors: Baroni, Lorena V, Sampor, Claudia, Gonzalez, Adriana, Lubieniecki, Fabiana, Lamas, Gabriela, Rugilo, Carlos, Bartels, Ute, Heled, Ayala, Smith, Kyle S, Northcott, Paul A, Bouffet, Eric, Alderete, Daniel, Ramaswamy, Vijay
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 18.12.2020
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Argentina; Cerebellar Neoplasms - drug therapy; Child, Preschool; Cranial Irradiation; Female; Hedgehog Proteins - genetics; Humans; Infant; Male; Medulloblastoma - drug therapy; Pediatric Neuro-Oncology; Retrospective Studies; Argentina; brain tumor; SHH; infant; medulloblastoma; radiation

Abstract Background Infant medulloblastoma represents an enormous challenge in neuro-oncology, due to their simultaneous high-risk of recurrence and high risk of severe neurodevelopmental sequelae with craniospinal irradiation. Currently infant medulloblastoma are treated with intensified protocols,...