Interleukin-35 Prevents Development of Autoimmune Diabetes Possibly by Maintaining the Phenotype of Regulatory B Cells

• Published in: International journal of molecular sciences Vol. 22; no. 23; p. 12988
• Main Authors: Luo, Zhengkang, Lundin, Sara, Mejia-Cordova, Mariela, Hassani, Imane, Blixt, Martin, Hjelmqvist, Daisy, Lau, Joey, Espes, Daniel, Carlsson, Per-Ola, Sandler, Stellan, Singh, Kailash
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.11.2021; MDPI
• Subjects: Adult; Animals; Anti-Inflammatory Agents - blood; Anti-Inflammatory Agents - pharmacology; Autoimmune diseases; B-Lymphocytes, Regulatory - immunology; breg cells; Cells, Cultured; Cytokines; Diabetes; Diabetes Mellitus, Type 1 - prevention & control; Disease; Disease Models, Animal; Female; Genotype & phenotype; Humans; Hyperglycemia; Hyperglycemia - chemically induced; Hyperglycemia - prevention & control; IL-35; Immune system; Interferon-gamma - blood; Interleukins - blood; Interleukins - pharmacology; Lymphocyte Count; Male; Mice; Mice, Inbred NOD; Streptozocin - toxicity; type 1 diabetes; type 1 diabetes; IL-35; breg cells

The anti-inflammatory role of regulatory B cells (Breg cells) has been associated with IL-35 based on studies of experimental autoimmune uveitis and encephalitis. The role of Breg cells and IL-35+ Breg cells for type 1 diabetes (T1D) remains to be investigated. We studied PBMCs from T1D subjects and...