Alteration of neural tissue structure by expression of polysialic acid induced by viral delivery of PST polysialyltransferase

• Published in: Glycobiology (Oxford) Vol. 14; no. 1; pp. 83 - 93
• Main Authors: Canger, Anthony K., Rutishauser, Urs
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2004; Oxford Publishing Limited (England)
• Subjects: Animals; Chick Embryo; Chickens; Chinese hamster ovary; CHO; DMEM; Dulbecco's modified Eagle medium; endo N; endoneuraminidase; FCS; fetal calf serum; Gene Expression Regulation, Developmental - genetics; Gene Expression Regulation, Enzymologic - genetics; GFP; green fluorescent protein; inner plexiform layer; IPL; NCAM; Nervous System - embryology; neural cell adhesion molecule; Neural Cell Adhesion Molecules - genetics; OFL; optic fiber layer; PBS; PCR; phosphate buffered saline; plasticity; polymerase chain reaction; polysialic acid; polysialyltransferase; PSA; PST; RCAS; replication competant avian leukemia virus; Retina; retinal ganglion cell; Retrovirus; RGC; Sialyltransferases - genetics; ST8Sia II; ST8Sia IV; STX

The expression of polysialic acid (PSA) on neural cell adhesion molecule (NCAM) is known to attenuate cell–cell interactions. During neural development the widespread expression of PSA-NCAM creates permissive conditions for the migration of neuronal and glial precursors and the guidance and targetin...