Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice

• Published in: Journal of controlled release Vol. 127; no. 1; pp. 41 - 49
• Main Authors: Kim, Jong-Ho, Kim, Yoo-Shin, Park, Kyeongsoon, Lee, Seulki, Nam, Hae Yun, Min, Kyung Hyun, Jo, Hyung Gon, Park, Jae Hyung, Choi, Kuiwon, Jeong, Seo Young, Park, Rang-Woon, Kim, In-San, Kim, Kwangmeyung, Kwon, Ick Chan
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 07.04.2008; Elsevier
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - therapeutic use; Apoptosis - drug effects; Biological and medical sciences; Cell Survival - drug effects; Chitosan - chemistry; Chitosan - pharmacokinetics; Cisplatin; Cisplatin - administration & dosage; Cisplatin - chemistry; Cisplatin - pharmacokinetics; Cisplatin - therapeutic use; Drug Carriers - chemistry; Drug Carriers - pharmacokinetics; Drug delivery system; General pharmacology; Humans; Hydrophobically modified glycol chitosan; In vivo antitumor efficacy; Male; Medical sciences; Mice; Nanoparticles - chemistry; Particle Size; Passive tumor targeting; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Self-assembled nanoparticles; Solubility; Tissue Distribution; Xenograft Model Antitumor Assays; Hydrophobically modified glycol chitosan; In vivo antitumor efficacy; Self-assembled nanoparticles; Drug delivery system; Cisplatin; Passive tumor targeting; Antineoplastic agent; Targeting; Nanoparticle; Drug carrier; Target; Efficiency; Microparticle; Platinum II Complexes; Pharmaceutical technology; Rodentia; Polymer; Malignant tumor; In vivo; Alkylating agent; Vertebrata; Mammalia; Mouse; Animal; Chitosan; Glycol; Cancer

To make a tumor targeting nano-sized drug delivery system, biocompatible and biodegradable glycol chitosan ( M w = 250 kDa) was modified with hydrophobic cholanic acid. The resulting hydrophobically modified glycol chitosans (HGCs) that formed nano-sized self-aggregates in an aqueous medium were inv...