The Mammalian Brain rsec6/8 Complex

• Published in: Neuron (Cambridge, Mass.) Vol. 17; no. 6; pp. 1209 - 1219
• Main Authors: Hsu, Shu-Chan, Ting, Anthony E, Hazuka, Christopher D, Davanger, Svend, Kenny, James W, Kee, Yun, Scheller, Richard H
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.1996
• Subjects: Animals; Brain - metabolism; Carrier Proteins; Cells, Cultured; Hippocampus - cytology; Hippocampus - metabolism; Mammalia; Membrane Proteins - metabolism; Neurons - metabolism; Peptide Mapping; Precipitin Tests; Proteins - genetics; Proteins - isolation & purification; Proteins - metabolism; Qa-SNARE Proteins; Rats; Subcellular Fractions - metabolism; Tissue Distribution

rsec6 and rsec8 are two components of a 17S complex in mammalian brain that is homologous to the yeast 834 kDa Sec6/8/15 complex which is essential for exocytosis. Purification and partial amino acid sequencing of the mammalian rsec6/8 complex reveals that it is composed of eight novel proteins with...