Lamp2a is required for tumor growth and promotes tumor recurrence of hepatocellular carcinoma

• Published in: International journal of oncology Vol. 49; no. 6; pp. 2367 - 2376
• Main Authors: Ding, Zhen-Bin, Fu, Xiu-Tao, Shi, Ying-Hong, Zhou, Jian, Peng, Yuan-Fei, Liu, Wei-Ren, Shi, Guo-Ming, Gao, Qiang, Wang, Xiao-Ying, Song, Kang, Jin, Lei, Tian, Meng-Xin, Shen, Ying-Hao, Fan, Jia
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.12.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Animals; Apoptosis; Apoptosis - genetics; Autophagy; Autophagy - genetics; Carcinoma, Hepatocellular - pathology; Care and treatment; Cell growth; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Cell Survival - genetics; cell viability; chaperone-mediated autophagy; Development and progression; Gene expression; Genetic aspects; Glycoproteins; Health aspects; Hep G2 Cells; hepatocellular carcinoma; Hepatoma; Heterografts - growth & development; Humans; Hypoxia; Lamp2a; Liver cancer; Liver Neoplasms - pathology; Lysosomal-Associated Membrane Protein 2 - genetics; Lysosomal-Associated Membrane Protein 2 - metabolism; Medical prognosis; Mice; Mice, Nude; Neoplasm Recurrence, Local - genetics; Neoplasm Transplantation; Patients; Physiology; Prognosis; Proteins; RNA Interference; RNA, Small Interfering - genetics; Rodents; Studies; Transplantation, Heterologous; tumor recurrence; China

Exploring the function of chaperone-mediated autophagy (CMA) in cancer has promoted progress in cancer treatment through the regulation of CMA pathways. However, CMA status and function in hepatocellular carcinoma (HCC) by focusing on the regulatory role of lysosome-associated membrane protein type...