Mast cell degranulation via MRGPRX2 by isolated human albumin fragments

• Published in: Biochimica et Biophysica Acta (BBA) - General Subjects Vol. 1861; no. 11; pp. 2530 - 2534
• Main Authors: Karhu, T., Akiyama, K., Vuolteenaho, O., Bergmann, U., Naito, T., Tatemoto, K., Herzig, K.-H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017; Elsevier BV
• Subjects: Albumin; albumins; beta-N-acetylhexosaminidase; beta-N-Acetylhexosaminidases; beta-N-Acetylhexosaminidases - metabolism; Cell Degranulation; Cell Degranulation - genetics; Cell Degranulation - immunology; cell lines; dose response; G-protein coupled receptors; GPCR; HEK293 Cells; high performance liquid chromatography; Humans; Immunoglobulin E; Immunoglobulin E - immunology; Immunoglobulin E - metabolism; immunoglobulins; Inflammation; Ligands; Mast cell; Mast Cells; Mast Cells - immunology; Mast Cells - metabolism; MRGPRX2; Nerve Tissue Proteins; Nerve Tissue Proteins - immunology; Nerve Tissue Proteins - metabolism; Peptide Library; Peptides; Peptides - blood; Peptides - immunology; proteinases; Receptors, G-Protein-Coupled; Receptors, G-Protein-Coupled - immunology; Receptors, G-Protein-Coupled - metabolism; Receptors, Neuropeptide; Receptors, Neuropeptide - immunology; Receptors, Neuropeptide - metabolism; Serum Albumin, Human; Serum Albumin, Human - immunology; Serum Albumin, Human - metabolism; Signal Transduction; synthetic peptides; Albumin; GPCR; Inflammation; Mast cell; MRGPRX2

Mast cells are important modulators of the human immune system via their release of several inflammatory mediators and proteases. The release can be activated by different pathways: the classical immunoglobulin E-dependent pathway and by the non-immunological immunoglobulin E-independent pathway. MA...