PHARMACOLOGICAL STUDIES WITH SOME NEWLY SYNTHESIZED PHENOTHIAZINES EXHIBITING LESSER EXTRAPYRAMIDAL REACTIONS

• Published in: Japanese journal of pharmacology Vol. 19; no. 2; pp. 211 - 223
• Main Authors: SHARMA, V.N., MITAL, R.L., BANERJEE, S.P., SHARMA, H.L.
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Pharmacological Society 01.01.1969
• Subjects: Aggression - drug effects; Amphetamine - antagonists & inhibitors; Animals; Behavior, Animal - drug effects; Catalepsy; Central Nervous System - drug effects; Chemical Phenomena; Chemistry; Chlorpromazine - pharmacology; Drug Synergism; Extrapyramidal Tracts - drug effects; Humans; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Mice; Motor Activity - drug effects; Pentobarbital - pharmacology; Perphenazine - pharmacology; Phenothiazines - pharmacology; Rats; Solubility; Tranquilizing Agents - pharmacology; Trifluoperazine - pharmacology

The signs and symptoms due to extrapyramidal tract involvement are amongst the most common side effects in tranquillizer therapy, which is uniformly present in all the six group of drugs used in medicine (1). With many of these drugs, severe extrapyramidal symptoms are uncommon, but with those pheno...