Mechanistic and regulatory aspects of intestinal iron absorption

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 307; no. 4; pp. G397 - G409
• Main Authors: Gulec, Sukru, Anderson, Gregory J., Collins, James F.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 15.08.2014
• Subjects: Anemia, Iron-Deficiency - physiopathology; Animals; Biological Availability; Cation Transport Proteins - genetics; Cation Transport Proteins - metabolism; Cytochromes b - metabolism; Diet; Enterocytes - metabolism; Ferric Compounds - metabolism; Genotype & phenotype; Heme - metabolism; Hemochromatosis - physiopathology; Hepatocytes - metabolism; Hepcidins - physiology; Homeostasis; Homeostasis - physiology; Humans; Intestinal Absorption - physiology; Iron; Iron - metabolism; Metabolism; Microvilli - metabolism; Molecules; Oxygen; Review; Transmitters; ferroportin 1; hepcidin; hephaestin; divalent metal-ion transporter 1; duodenum

Iron is an essential trace mineral that plays a number of important physiological roles in humans, including oxygen transport, energy metabolism, and neurotransmitter synthesis. Iron absorption by the proximal small bowel is a critical checkpoint in the maintenance of whole-body iron levels since, u...