New linear polyamine derivatives in spider venoms

Linear free polyamines were characterized in the venom of the spiders Agelenopsis aperta, Hololena curta, and Paracoelotes birulai by RP-HPLC coupled to mass spectrometry. The several linear polyamines found were tetramine, pentamine, and hexamine derivatives. Some of these natural products were ide...

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Bibliographic Details
Published inToxicon (Oxford) Vol. 46; no. 3; pp. 350 - 354
Main Authors Tzouros, Manuel, Chesnov, Sergiy, Bienz, Stefan, Hesse, Manfred, Bigler, Laurent
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.09.2005
Elsevier Science
Subjects
Animal poisons toxicology. Antivenoms
Animals
APCI
Biological and medical sciences
Bridged-Ring Compounds - analysis
Bridged-Ring Compounds - toxicity
Gas Chromatography-Mass Spectrometry
Gas-phase fragmentation
Hololena curta
Medical sciences
Methenamine - analysis
Methenamine - toxicity
MS/MS
Polyamines - analysis
Polyamines - toxicity
Quaternary Ammonium Compounds - analysis
Quaternary Ammonium Compounds - toxicity
Spider toxins
Spider Venoms - chemistry
Toxicology
Triple quadrupole
Spider toxins
Triple quadrupole
Gas-phase fragmentation
APCI
MS/MS
Polyamine
Animal origin
Fragmentation
Toxin
Arachnida
Arthropoda
Venom
Invertebrata
Structural analysis
APCI: MS/MS
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Summary:Linear free polyamines were characterized in the venom of the spiders Agelenopsis aperta, Hololena curta, and Paracoelotes birulai by RP-HPLC coupled to mass spectrometry. The several linear polyamines found were tetramine, pentamine, and hexamine derivatives. Some of these natural products were identified as N-hydroxylated, guanidylated, or acetylated compounds. In addition, the biosynthetical pathway leading to the formation of acylpolyamines in spider venoms is discussed.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2005.04.018