Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective

There is a growing interest in using natural medicines to treat stroke as the leading cause of disability worldwide. Especially plant-derived natural medicines have multiple beneficial effects, including antioxidative, anti-inflammatory, antiapoptotic, suggesting their potential for stroke treatment...

Full description

Saved in:
Bibliographic Details
Published inPharmacology & therapeutics (Oxford) Vol. 216; p. 107695
Main Authors Tao, Tao, Liu, Maozhu, Chen, Mengyuan, Luo, Ying, Wang, Cheng, Xu, Tongtong, Jiang, Yixu, Guo, Yiyan, Zhang, John H.
Format Journal Article
LanguageEnglish
Published England Elsevier Inc 01.12.2020
Subjects
Cerebral ischemia
Natural medicine
Neuroprotection
MCAO
pBCCAO
Neuroprotection
Natural medicine
BMECs
OGD
LPS
tBCCAO
BCCAO
ASC
Cerebral ischemia
MCAO/R
t-right MCAO
OGD/R
NALP3
pMCAO
tMCAO
Online AccessGet full text

Cover

Abstract There is a growing interest in using natural medicines to treat stroke as the leading cause of disability worldwide. Especially plant-derived natural medicines have multiple beneficial effects, including antioxidative, anti-inflammatory, antiapoptotic, suggesting their potential for stroke treatment. However, failure in clinical translation has created a substantial challenge for their use as stroke treatment. This review summarises the status of using natural medicinal formulations in stroke treatment, as well as the challenges. Although natural medicines have excellent prospects for ischaemic stroke treatment, several concerns need to be addressed for translating the success in animal research to humans. Specifically, there should be more considerations for investigating the precise mechanisms of natural medicines mediating the neuroprotective effects on stroke. Moreover, to further improve the prospects of clinical translation, further studies should be performed in aged animals rather than young adult animals.
AbstractList There is a growing interest in using natural medicines to treat stroke as the leading cause of disability worldwide. Especially plant-derived natural medicines have multiple beneficial effects, including antioxidative, anti-inflammatory, antiapoptotic, suggesting their potential for stroke treatment. However, failure in clinical translation has created a substantial challenge for their use as stroke treatment. This review summarises the status of using natural medicinal formulations in stroke treatment, as well as the challenges. Although natural medicines have excellent prospects for ischaemic stroke treatment, several concerns need to be addressed for translating the success in animal research to humans. Specifically, there should be more considerations for investigating the precise mechanisms of natural medicines mediating the neuroprotective effects on stroke. Moreover, to further improve the prospects of clinical translation, further studies should be performed in aged animals rather than young adult animals.
There is a growing interest in using natural medicines to treat stroke as the leading cause of disability worldwide. Especially plant-derived natural medicines have multiple beneficial effects, including antioxidative, anti-inflammatory, antiapoptotic, suggesting their potential for stroke treatment. However, failure in clinical translation has created a substantial challenge for their use as stroke treatment. This review summarises the status of using natural medicinal formulations in stroke treatment, as well as the challenges. Although natural medicines have excellent prospects for ischaemic stroke treatment, several concerns need to be addressed for translating the success in animal research to humans. Specifically, there should be more considerations for investigating the precise mechanisms of natural medicines mediating the neuroprotective effects on stroke. Moreover, to further improve the prospects of clinical translation, further studies should be performed in aged animals rather than young adult animals.There is a growing interest in using natural medicines to treat stroke as the leading cause of disability worldwide. Especially plant-derived natural medicines have multiple beneficial effects, including antioxidative, anti-inflammatory, antiapoptotic, suggesting their potential for stroke treatment. However, failure in clinical translation has created a substantial challenge for their use as stroke treatment. This review summarises the status of using natural medicinal formulations in stroke treatment, as well as the challenges. Although natural medicines have excellent prospects for ischaemic stroke treatment, several concerns need to be addressed for translating the success in animal research to humans. Specifically, there should be more considerations for investigating the precise mechanisms of natural medicines mediating the neuroprotective effects on stroke. Moreover, to further improve the prospects of clinical translation, further studies should be performed in aged animals rather than young adult animals.
ArticleNumber 107695
Author Jiang, Yixu
Luo, Ying
Tao, Tao
Xu, Tongtong
Wang, Cheng
Chen, Mengyuan
Zhang, John H.
Guo, Yiyan
Liu, Maozhu
Author_xml – sequence: 1
  givenname: Tao
  surname: Tao
  fullname: Tao, Tao
  email: taotao7819@126.com
  organization: Department of Anesthesiology, Central People's Hospital of Zhanjiang, 236 Yuanzhu Road, Zhanjiang, Guangdong 524045, China
– sequence: 2
  givenname: Maozhu
  surname: Liu
  fullname: Liu, Maozhu
  organization: College of Pharmacy, Chongqing Medical University, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing, 400016, China
– sequence: 3
  givenname: Mengyuan
  surname: Chen
  fullname: Chen, Mengyuan
  organization: College of Pharmacy, Chongqing Medical University, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing, 400016, China
– sequence: 4
  givenname: Ying
  surname: Luo
  fullname: Luo, Ying
  organization: College of Pharmacy, Chongqing Medical University, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing, 400016, China
– sequence: 5
  givenname: Cheng
  surname: Wang
  fullname: Wang, Cheng
  organization: Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
– sequence: 6
  givenname: Tongtong
  surname: Xu
  fullname: Xu, Tongtong
  organization: Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
– sequence: 7
  givenname: Yixu
  surname: Jiang
  fullname: Jiang, Yixu
  organization: Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
– sequence: 8
  givenname: Yiyan
  surname: Guo
  fullname: Guo, Yiyan
  organization: Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
– sequence: 9
  givenname: John H.
  surname: Zhang
  fullname: Zhang, John H.
  email: jhzhang@llu.edu
  organization: Physiology Program Director, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32998014$$D View this record in MEDLINE/PubMed
BookMark eNqNkU9r2zAYh8VIWdJsX6Ho2IszSZZtuYdBG_YPQntoB7sJSX7dKLXlVJIL_faVScJgl_UkEM_7e_V7dI5mbnCAEKZkRQktv-xW-63yfdyCVytG2HRdlXXxAS2oqOosMX9maJGOPKtYIeboPIQdIYRzwj6iec7qWhDKF-j-VsXRqw730FhjHWDrsIPRD3s_RDDRDg63g8c2mC301uAQ_fAEV3i9VV0H7hECVq7BCQ_7iX-BT-isVV2Az8dziX5___aw_plt7n78Wl9vMsNrEjNTa8pAG1oTQcqGt5Voc5PTyggjdKkotE1TNEJzyjgr2iLXFYBONbVu60bnS3R5yE27n0cIUfbpldB1ysEwBsk4rwQnJWMJvTiio05N5d7bXvlXeRKRgK8HwKQewUMrjY1qah-9sp2kRE7m5U7-NS8n8_JgPgWIfwJOO94xenMYhSTrxYKXwVhwJv2IT0ZlM9j_h7wBduCl8g
CitedBy_id crossref_primary_10_1016_j_chroma_2024_465553
crossref_primary_10_1016_j_fmre_2023_09_007
crossref_primary_10_3389_fendo_2023_1124419
crossref_primary_10_1016_j_biopha_2024_117530
crossref_primary_10_1177_1934578X241249069
crossref_primary_10_3390_ijms242216059
crossref_primary_10_1016_j_intimp_2024_112524
crossref_primary_10_3389_fnins_2023_1166010
crossref_primary_10_1039_D3MD00455D
crossref_primary_10_1155_2021_8377362
crossref_primary_10_3389_fnagi_2022_940166
crossref_primary_10_1016_j_brainres_2024_149442
crossref_primary_10_2147_IJN_S439728
crossref_primary_10_1007_s11064_023_03866_3
crossref_primary_10_1111_jcmm_70008
crossref_primary_10_3389_fnmol_2022_848506
crossref_primary_10_3390_molecules27154970
crossref_primary_10_1186_s10020_024_00818_7
crossref_primary_10_1016_j_jstrokecerebrovasdis_2024_107613
crossref_primary_10_1097_JS9_0000000000000922
crossref_primary_10_1016_j_cclet_2025_110956
crossref_primary_10_1007_s12035_022_02944_x
crossref_primary_10_4103_NRR_NRR_D_23_01385
crossref_primary_10_1155_2022_1860925
crossref_primary_10_1049_syb2_12059
crossref_primary_10_1016_j_brainresbull_2024_111032
crossref_primary_10_1016_j_jep_2025_119688
crossref_primary_10_3389_fnins_2023_1265854
crossref_primary_10_1038_s41419_021_03725_5
crossref_primary_10_3389_fphar_2024_1434948
crossref_primary_10_1016_j_brainres_2024_149303
crossref_primary_10_17116_jnevro2023123111111
crossref_primary_10_3389_fphar_2024_1346226
crossref_primary_10_3390_pharmaceutics15122669
crossref_primary_10_1039_D2FO03417D
crossref_primary_10_1016_j_jep_2021_114821
crossref_primary_10_1007_s10787_024_01606_9
crossref_primary_10_1016_j_brainres_2024_149308
crossref_primary_10_1016_j_heliyon_2023_e16622
crossref_primary_10_3390_antiox12040785
crossref_primary_10_1002_adhm_202203132
crossref_primary_10_1016_j_freeradbiomed_2023_06_024
crossref_primary_10_12677_ACM_2023_1351019
crossref_primary_10_1016_j_neuint_2021_105114
crossref_primary_10_3390_gels8120777
crossref_primary_10_1016_j_jep_2023_116269
crossref_primary_10_1016_j_matdes_2022_110943
crossref_primary_10_4103_1673_5374_371366
crossref_primary_10_1111_jcmm_17758
crossref_primary_10_1016_j_carbpol_2024_122505
crossref_primary_10_3390_antiox13111339
crossref_primary_10_1007_s11064_022_03732_8
crossref_primary_10_1016_j_biopha_2022_113744
crossref_primary_10_1016_j_apsb_2023_06_011
crossref_primary_10_3389_fphar_2022_1009169
crossref_primary_10_3390_cells11233726
crossref_primary_10_3389_fphar_2022_990586
crossref_primary_10_1186_s12906_024_04474_6
crossref_primary_10_1038_s41420_024_02067_3
crossref_primary_10_2174_1570159X21666230717144752
crossref_primary_10_4103_1673_5374_380904
crossref_primary_10_1007_s12035_024_04647_x
crossref_primary_10_1097_MD_0000000000034424
crossref_primary_10_1007_s10753_024_02219_8
crossref_primary_10_1007_s12192_023_01372_7
crossref_primary_10_3390_molecules29071665
crossref_primary_10_1038_s41598_024_53127_8
crossref_primary_10_3390_molecules26082347
crossref_primary_10_1016_j_biopha_2021_111796
crossref_primary_10_1021_acsnano_4c03425
crossref_primary_10_3390_molecules28155624
crossref_primary_10_3389_fimmu_2022_930171
crossref_primary_10_1016_j_exger_2024_112448
crossref_primary_10_1016_j_jconrel_2023_09_012
crossref_primary_10_1016_j_bcp_2023_115968
crossref_primary_10_1002_jbt_70076
crossref_primary_10_31083_j_fbl2802038
crossref_primary_10_1016_j_heliyon_2023_e19369
crossref_primary_10_1016_j_ymthe_2024_04_011
crossref_primary_10_1080_13880209_2022_2110599
crossref_primary_10_1016_j_bmc_2021_116522
crossref_primary_10_1016_j_nbd_2025_106885
crossref_primary_10_3389_fphar_2022_940260
crossref_primary_10_1007_s10571_023_01411_y
crossref_primary_10_1016_j_heliyon_2023_e20114
crossref_primary_10_3389_fphar_2024_1373663
crossref_primary_10_1016_j_heliyon_2024_e28597
crossref_primary_10_3389_fimmu_2023_1114596
crossref_primary_10_3389_fchem_2022_975191
crossref_primary_10_3390_ijms232113648
crossref_primary_10_1016_j_jep_2022_115309
crossref_primary_10_3390_biomedicines11123342
crossref_primary_10_1016_j_bioactmat_2025_01_014
crossref_primary_10_1007_s12035_024_04649_9
crossref_primary_10_3390_pharmaceutics17030280
crossref_primary_10_1002_mnfr_202300447
crossref_primary_10_3390_ijms252111620
crossref_primary_10_1016_j_biopha_2023_115543
crossref_primary_10_3389_fimmu_2024_1433590
crossref_primary_10_21926_obm_neurobiol_2204144
crossref_primary_10_1038_s41536_023_00315_1
crossref_primary_10_1002_smll_202309180
crossref_primary_10_1016_j_neulet_2024_137683
crossref_primary_10_1016_j_crad_2024_07_020
crossref_primary_10_1155_2022_3858314
crossref_primary_10_1155_2023_5545205
crossref_primary_10_1080_1028415X_2024_2344141
crossref_primary_10_31612_2616_4868_8_2023_12
crossref_primary_10_3390_cells14020117
crossref_primary_10_1016_j_phymed_2023_155237
crossref_primary_10_1007_s10787_023_01369_9
crossref_primary_10_3390_nu15051207
crossref_primary_10_1080_1028415X_2023_2296165
crossref_primary_10_1002_tox_24036
crossref_primary_10_3389_fphar_2022_948889
crossref_primary_10_1155_2022_8007078
crossref_primary_10_1038_s41598_024_61770_4
crossref_primary_10_1248_bpb_b22_00382
crossref_primary_10_1016_j_cej_2024_154205
crossref_primary_10_1007_s12035_024_04288_0
crossref_primary_10_3390_ijms241814325
crossref_primary_10_1080_15287394_2024_2337365
crossref_primary_10_1002_brb3_70036
crossref_primary_10_3390_ph16081057
crossref_primary_10_1002_jat_4615
crossref_primary_10_1016_S1875_5364_25_60825_9
crossref_primary_10_52711_0974_360X_2024_00164
crossref_primary_10_2147_JIR_S480262
crossref_primary_10_3389_fnmol_2024_1400808
crossref_primary_10_1007_s12035_023_03267_1
crossref_primary_10_3390_toxics11050472
crossref_primary_10_1016_j_biopha_2024_117209
crossref_primary_10_1007_s00210_023_02476_8
crossref_primary_10_1007_s00221_023_06566_0
crossref_primary_10_1038_s41467_023_35895_5
crossref_primary_10_3390_molecules28010331
crossref_primary_10_1002_mef2_58
crossref_primary_10_1016_j_neuropharm_2024_109986
crossref_primary_10_61186_umj_35_10_795
crossref_primary_10_32604_biocell_2023_028866
crossref_primary_10_1177_0271678X241274681
Cites_doi 10.1161/STROKEAHA.117.019687
10.1016/j.cell.2004.09.004
10.3390/molecules17089803
10.1186/1742-2094-8-186
10.1016/j.ejphar.2015.09.042
10.4161/cc.23592
10.1042/CS20060043
10.1016/j.immuni.2017.02.015
10.1016/j.bbi.2017.08.006
10.1016/j.neuint.2012.11.016
10.3389/fncel.2018.00236
10.1016/j.fct.2012.08.047
10.1016/j.nbd.2012.01.006
10.1161/STROKEAHA.114.006864
10.1038/nn.4631
10.1016/j.brainres.2017.12.039
10.1016/j.expneurol.2012.07.017
10.1016/j.jphs.2018.08.002
10.1186/1742-2094-7-97
10.1016/j.jnutbio.2009.08.009
10.1016/S0165-5728(02)00114-5
10.1016/j.jep.2016.04.046
10.1161/CIRCRESAHA.116.308022
10.1016/0006-8993(92)91004-X
10.1007/s10072-011-0828-5
10.1016/j.brainres.2004.04.031
10.1038/nm.2399
10.1016/j.brainres.2003.11.056
10.1016/j.celrep.2016.12.041
10.1186/s12906-015-0678-4
10.1046/j.1440-1681.1999.03037.x
10.1007/s12640-011-9258-7
10.1016/j.jep.2017.02.024
10.1016/j.biopha.2016.11.064
10.1016/j.it.2012.04.006
10.1016/j.cub.2005.11.066
10.1016/j.brainres.2004.05.079
10.3390/ijms130911753
10.1016/j.jep.2020.113164
10.1142/S0192415X08006570
10.1089/ars.2016.6885
10.1161/STROKEAHA.112.656611
10.1093/carcin/19.10.1771
10.1016/j.jchromb.2009.02.013
10.3389/fpsyt.2019.00184
10.1155/2013/951415
10.1016/j.brainres.2012.04.054
10.1007/s12017-009-8074-1
10.1016/j.bbr.2016.01.028
10.1523/JNEUROSCI.4098-14.2015
10.1016/j.jep.2016.04.058
10.1016/j.freeradbiomed.2009.02.027
10.1016/j.neuroscience.2012.06.019
10.1155/2020/6859374
10.1016/S1474-4422(19)30078-X
10.1073/pnas.0606528103
10.1523/JNEUROSCI.17-21-08178.1997
10.1016/j.phymed.2010.03.017
10.1002/ptr.6414
10.1097/00004647-200404000-00011
10.1073/pnas.1619813114
10.1152/ajpheart.00459.2010
10.1016/j.phymed.2013.08.007
10.1159/000346233
10.3233/RNN-140403
10.1016/j.jep.2018.05.011
10.2174/1568010054022051
10.1111/micc.12054
10.1021/acs.jafc.6b04979
10.1186/1742-2094-8-174
10.1039/C5SC00633C
10.1016/j.jocn.2013.04.036
10.1159/000217462
10.1016/j.biopha.2016.11.057
10.1161/STROKEAHA.112.659656
10.1007/s00401-014-1381-0
10.1016/j.jep.2016.02.022
10.1016/j.neuropharm.2013.06.012
10.1016/j.jep.2018.09.018
10.1161/STROKEAHA.113.003226
10.1002/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J
10.1038/aps.2016.156
10.1007/s10753-015-0137-x
10.1016/S0092-8674(00)80483-3
10.1177/0271678X18792372
10.1016/j.jep.2007.05.018
10.1142/S0192415X11008683
10.1016/j.phymed.2010.06.007
10.1016/j.biopha.2017.10.145
10.1111/jphp.13143
10.3389/fneur.2018.00249
10.1016/j.phymed.2016.12.004
10.1002/ptr.2978
10.1016/j.cca.2008.07.016
10.1016/j.bbrc.2009.12.114
10.1089/ars.2010.3576
10.1097/01.WCB.0000087090.01171.E7
10.1093/carcin/bgv079
10.1016/j.jep.2014.05.061
10.1016/j.neuroscience.2019.01.040
10.3390/molecules23092401
10.1016/j.ijdevneu.2009.08.008
10.1016/j.biopha.2016.11.013
10.1016/j.bcp.2006.11.009
10.1016/j.jep.2014.10.020
10.1016/j.jep.2009.04.009
10.1142/S0192415X13500080
10.1038/nrn1106
10.1016/j.pneurobio.2016.01.005
10.1161/STROKEAHA.110.589895
10.1007/s40256-013-0007-6
10.1007/s12035-013-8572-x
10.1016/j.jep.2013.05.018
10.1146/annurev-immunol-051116-052358
10.1142/S0192415X15500639
10.1080/08923973.2017.1344988
10.1016/j.jep.2011.07.031
10.1016/j.jep.2012.01.012
10.1155/2014/370530
10.1142/S0192415X10008020
10.1186/s12974-019-1516-2
10.1038/nrneurol.2010.17
10.2174/1389450118666170427151657
10.1186/s12883-017-1007-y
10.1016/j.jep.2013.10.026
10.1080/21691401.2019.1610413
10.3389/fncel.2015.00018
10.1177/09680519060120040701
10.1186/s12974-018-1124-6
10.1016/j.jep.2012.02.013
10.1016/j.bbrc.2010.03.050
10.1155/2017/1832093
10.1016/j.jstrokecerebrovasdis.2016.09.043
10.1016/j.jep.2011.07.066
10.1002/ptr.2908
10.1038/ni0107-11
10.1186/1750-1326-6-11
10.1016/j.neuropharm.2008.01.005
10.1016/j.taap.2013.05.021
10.1016/j.jep.2011.12.023
10.14336/AD.2016.0207
10.1038/jcbfm.2013.217
10.1142/S0192415X11008658
10.1097/00005072-199903000-00004
10.1016/j.jneuroim.2014.07.009
10.14336/AD.2015.1009
10.1007/s10571-016-0398-4
10.1111/j.2042-7158.2011.01254.x
10.1189/jlb.1109766
10.1196/annals.1341.022
10.1038/s41598-018-36138-0
10.1186/1471-2199-11-18
10.1016/j.jep.2016.04.060
10.1016/j.phymed.2012.06.003
10.1038/cdd.2010.106
10.1016/j.taap.2015.10.001
10.1155/2014/807978
10.1078/09447110260571760
10.1126/science.aad6872
10.1155/2015/134685
10.1152/japplphysiol.01044.2005
10.1016/j.neuropharm.2014.11.020
10.1016/j.jep.2006.05.004
10.3390/molecules16086322
10.1126/science.290.5497.1768
10.1002/ptr.5701
10.1186/s12906-017-1738-8
10.1016/j.neuropharm.2017.11.011
10.1002/ptr.2615
10.1111/jnc.12509
10.1056/NEJMra0910283
10.1142/S0192415X10007786
10.1016/j.jep.2016.01.026
10.1371/journal.pone.0203473
10.1016/j.phymed.2010.03.012
10.5607/en.2016.25.5.241
10.1016/j.ejphar.2016.02.027
10.3389/fphar.2019.00593
10.1080/21691401.2019.1699831
10.1016/S0092-8674(00)00116-1
10.1248/bpb.31.1387
10.1161/01.STR.0000249004.25444.a5
10.1161/STROKEAHA.108.523480
10.1523/JNEUROSCI.2826-07.2007
10.1006/nbdi.2001.0435
10.1159/000492625
10.1111/j.1471-4159.2012.07950.x
10.1038/aps.2017.128
ContentType Journal Article
Copyright 2020 The Authors
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Copyright_xml – notice: 2020 The Authors
– notice: Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
DBID 6I.
AAFTH
AAYXX
CITATION
NPM
7X8
DOI 10.1016/j.pharmthera.2020.107695
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
CrossRef
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1879-016X
ExternalDocumentID 32998014
10_1016_j_pharmthera_2020_107695
S0163725820302254
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
--K
--M
.GJ
.~1
0R~
123
1B1
1RT
1~.
1~5
29O
4.4
457
4G.
53G
5RE
5VS
6I.
7-5
71M
8P~
9JM
AABNK
AACTN
AAEDT
AAEDW
AAFTH
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AATCM
AAXUO
ABFNM
ABMAC
ABXDB
ABYKQ
ABZDS
ACDAQ
ACGFO
ACIUM
ACRLP
ADBBV
ADEZE
ADMUD
AEBSH
AEKER
AENEX
AFFNX
AFKWA
AFTJW
AFXIZ
AGHFR
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
ALCLG
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
C45
CS3
DU5
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HMT
HVGLF
HZ~
IHE
J1W
K-O
KOM
L7B
M34
M41
MO0
N9A
O-L
O9-
OAUVE
OGGZJ
OVD
OZT
P-8
P-9
P2P
PC.
Q38
R2-
RIG
ROL
RPZ
SCC
SDF
SDG
SDP
SES
SEW
SPCBC
SPT
SSP
SSZ
T5K
TEORI
WUQ
Y6R
ZGI
ZXP
~G-
AATTM
AAXKI
AAYWO
AAYXX
ABWVN
ACRPL
ACVFH
ADCNI
ADNMO
AEIPS
AEUPX
AFJKZ
AFPUW
AGCQF
AGQPQ
AGRNS
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
BNPGV
CITATION
SSH
NPM
7X8
ID FETCH-LOGICAL-c490t-c9b12ebc190806d4f78f3c317c8c8b6a1efdd5d8b412425f53b7eeb695bbf9db3
IEDL.DBID .~1
ISSN 0163-7258
1879-016X
IngestDate Fri Jul 11 11:47:45 EDT 2025
Wed Feb 19 02:29:17 EST 2025
Tue Jul 01 03:07:41 EDT 2025
Thu Apr 24 23:08:31 EDT 2025
Fri Feb 23 02:47:12 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords MCAO
pBCCAO
Neuroprotection
Natural medicine
BMECs
OGD
LPS
tBCCAO
BCCAO
ASC
Cerebral ischemia
MCAO/R
t-right MCAO
OGD/R
NALP3
pMCAO
tMCAO
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c490t-c9b12ebc190806d4f78f3c317c8c8b6a1efdd5d8b412425f53b7eeb695bbf9db3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink https://www.sciencedirect.com/science/article/pii/S0163725820302254
PMID 32998014
PQID 2447840622
PQPubID 23479
ParticipantIDs proquest_miscellaneous_2447840622
pubmed_primary_32998014
crossref_citationtrail_10_1016_j_pharmthera_2020_107695
crossref_primary_10_1016_j_pharmthera_2020_107695
elsevier_sciencedirect_doi_10_1016_j_pharmthera_2020_107695
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate December 2020
2020-12-00
20201201
PublicationDateYYYYMMDD 2020-12-01
PublicationDate_xml – month: 12
  year: 2020
  text: December 2020
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Pharmacology & therapeutics (Oxford)
PublicationTitleAlternate Pharmacol Ther
PublicationYear 2020
Publisher Elsevier Inc
Publisher_xml – name: Elsevier Inc
References Wang, He, Wang, Yuan, Guo, Chai, Zhang (bb0725) 2017; 17
Wu, Zhu, Yuan, Chen, Xiong, Zhang, Zhang (bb0805) 2017; 27
Noguchi, Sasaki, Seki, Giddings, Yamamoto (bib947) 1997; 27
Szeto (bb0675) 2006; 8
Tsoi, Chen, Gao, Wang, Yuen, Yang, Shen (bb0700) 2019; 10
Xu, Wang, Wang, Ye, Zhang, Cao, Kou (bb0855) 2017; 2017
Yang, Qian, Wang, Lin, Wang, Wang, Piao (bb0875) 2017; 37
Liu, Tang, Sun, Lin, Wei, Yang, Liu (bb0465) 2013; 148
Ma, Wang, Wang, Yang (bb0485) 2017; 157
Nada, Tulsulkar, Shah (bb0535) 2014; 49
Sun, Bi, Guo, Qi, Zhang, Li, Li (bb0650) 2007; 113
Tsai, Ho, Cheng, Liu, Tsang, Lin, Lin (bb0695) 2017; 200
Doyle, Quach, Solé, Axtell, Nguyen, Soler-Llavina, Buckwalter (bb0185) 2015; 35
Gong, Sun, Li, Zhou, Duan, Duan, Shen (bb0260) 2015; 91
Chu, Kim, Lee, Moore, Chan, Vinh, Sobey (bb0145) 2014; 34
Saleem, Zhuang, Biswal, Christen, Doré (bb0600) 2008; 39
Wang, Li, Du, Hou, Li, Pan, Chen (bb0745) 2012; 141
Forouzanfar, Hosseinzadeh, Ebrahimzadeh Bideskan, Sadeghnia (bb0225) 2016; 30
Choi, Kim, Lee, Kim, Kim (bb0135) 2004; 1019
Mohagheghi, Bigdeli, Rasoulian, Hashemi, Pour (bb0515) 2011; 18
Moumen, Magill, Dry, Jackson (bb0520) 2013; 12
Minnerup, Sutherland, Buchan, Kleinschnitz (bb0510) 2012; 13
Viswanatha, Venkataranganna, Prasad, Shylaja (bb0715) 2019; 228
Zhao, Huang, Fang, Zhao, Shi, Li, Luo (bb0940) 2018; 138
Eltzschig, Carmeliet (bb0205) 2011; 364
Lee, Jung, Lee (bb0415) 2012; 50
Fang, Zhong, Jin, Cui, Yang, Gao, Liu (bb0210) 2019; 10
Deng, Carter, Traystman, Wagner, Herson (bb0170) 2014; 274
Jin, Yang, Li (bb0360) 2010; 87
Lai, Chiang, Lin, Yen, Tu, Chen (bb0410) 2018; 13
Chen, Venketasubramanian, Lee, Wong, Bousser (bb0100) 2013; 44
Ju, Ran, Zhu, Cheng, Gao, Xi, Zhang (bb0365) 2018; 12
Bansal, Sangha, Khatri (bb0025) 2013; 13
Furuichi, Noto, Li, Oku, Ishiye, Moriguchi, Yanagihara (bb0240) 2004; 1014
Xiang, Zhang, Cai, Yang, Zhu, Zhang, Cai (bb0815) 2019; 33
Planas, Solé, Justicia (bb0575) 2001; 8
He, Jiang, Zhao (bb0280) 2020; 48
Hou, Liou, Chern, Wang, Liao, Chang, Shen (bb0300) 2010; 17
Li, Yang, Geng, Jin, Hu, Zhao, Wu (bb0435) 2010; 299
Bu, Kwon, Kim, Kim, Choi, Kim, Kim (bb0070) 2010; 24
Mahmood, Wang, Wu, Wang, Zhou, Yang, Zhao (bb0490) 2017; 25
Kirisattayakul, Wattanathorn, Tong-Un, Muchimapura, Wannanon, Jittiwat (bb0395) 2013; 2013
Xiong, Gu, Zhang, Xu, Zhu, Zhao (bb0835) 2013; 62
Tang, Xue, Bai, Fu, Wu (bb0680) 2010; 17
Gong, Sucher (bb0265) 2002; 9
Gu, Xiong, Zhang, Xu, Steinberg, Zhao (bb0270) 2012; 43
Wang, Gu, Wu, Wang, Xiong, Yang, Chen (bb0750) 2009; 47
Meng, Xie, Xu, Liang, Xu, Sun, Sun (bb0505) 2018; 23
Jiang, Wu, Deng, Ge (bb0340) 2020; 21
Askew, Li, Olmos-Alonso, Garcia-Moreno, Liang, Richardson, Gomez-Nicola (bb0020) 2017; 18
Li, Yu, Ma, Yang, Li, Zheng, Qi (bb0425) 2017; 65
An, Huang, Xu, Zhou, Shang, Huang, Zhou (bb0015) 2010; 11
Li, He, Zhang, Liu, Zhang, Dong, Chen (bb0440) 2012; 1464
Kostandy (bb0405) 2012; 33
Chen, Yoshioka, Kim, Jung, Okami, Sakata, Chan (bb0105) 2011; 14
Marín-Prida, Pavón-Fuentes, Llópiz-Arzuaga, Fernández-Massó, Delgado-Roche, Mendoza-Marí, Pentón-Rol (bb0495) 2013; 272
Dai, Wang, Tang, Liu, Xue (bb0155) 2020; 2020
Davis (bb0165) 2000; 103
Brifault, Gras, Liot, May, Vaudry, Wurtz (bb0055) 2015; 46
Brimson, Tencomnao (bb0060) 2011; 16
Jiang, Zhang, Zhu, Tian (bb0355) 2010; 24
Yang, Li, Lu, Zhang, Zhu, Wan (bb0880) 2012; 140
Neyt, Perros, GeurtsvanKessel, Hammad, Lambrecht (bb0545) 2012; 33
Wang, An, Umanah, Park, Nambiar, Eacker, Dawson (bb0765) 2016; 354
Xie, Li, Hersh, Liu, Yang (bb0820) 2019; 39
Hill, Poddar, Thompson, Rosenberg, Yang (bb0285) 2012; 220
Li, Stetler, Leak, Shi, Li, Yu, Chen (bb0430) 2018; 134
Nagakannan, Shivasharan, Thippeswamy, Veerapur, Bansal (bb0540) 2012; 140
Matzinger (bb0500) 2007; 8
Bhaskar, Stanwell, Cordato, Attia, Levi (bb0035) 2018; 18
Choi, Kim, Choi, Ju, Nam, Hwang, Kim (bb0130) 2011; 63
Dietrich (bb0175) 2002; 128
Furukawa, Fu, Li, Witke, Kwiatkowski, Mattson (bb0245) 1997; 17
Funk, Frye, Davis-Gorman, Spera, Bernas, Witte, Ritter (bb0235) 2013; 20
Xu, Jiang (bb0850) 2014; 2014
Wang, Ruan, Mi, Xu, Wang, Cao, Pang (bb0775) 2018; 67
Noguchi, Sasaki, Seki, Giddings, Yamamoto (bib948) 1999; 26
Hsiao, Lee, Chen, Lin, Shen, Lin, Sheu (bb0305) 2007; 73
Xin, Yang, Li, Li, Dai, Meng, Deng (bb0830) 2013; 21
Elango, Devaraj (bb0195) 2010; 7
Cao, Chen, Zhu, Li, Guo, Gao, Wen (bb0090) 2014; 155
Hur, Lee, Kim, Kim, Cho (bb0325) 2010; 391
Tzeng, Hsiao, Mak (bb0705) 2005; 4
Zhao, Ding, Deng, Lee, Gao, Chen, Yang (bb0935) 2015; 6
Perez-de-Puig, Miró-Mur, Ferrer-Ferrer, Gelpi, Pedragosa, Justicia, Planas (bb0560) 2015; 129
Sun, Xie, Song, Li (bb0655) 2020; 262
Shi, Tian, Li, Ducruet, Lawton, Shi (bb0620) 2019; 18
Loh, Qi, Tan, Liu, Wei, Zhu (bb0475) 2010; 41
Zhou, Qi, Chen (bb0945) 2017; 85
Wang, Yuan, Liu, Liu, Hu, Wang, Zheng (bb0720) 2012; 17
Wang, Wang, Chai, Zhang, Guo, Hu (bb0730) 2018; 39
Chen, Strickland (bb0120) 1997; 91
Salminen, Lehtonen, Paimela, Kaarniranta (bb0605) 2010; 394
Xue, Huang, Ma, Yang, Chang, Liu (bb0860) 2019; 404
Iadecola, Anrather (bb0330) 2011; 17
Smits, Reaper, Jackson (bb0630) 2006; 16
Thippeswamy, Nagakannan, Shivasharan, Mahendran, Veerapur, Badami (bb0690) 2011; 20
Gao, Xu, Chang, Wang, Xu, Ran, Pang (bb0250) 2015; 289
Wang, Zou, Zhou, Ji, Liu (bb0740) 2012; 125
Colonna, Butovsky (bb0150) 2017; 35
Zhang, Li, Huang, Chu, Xu, Zhang, Chen (bb0920) 2014; 158
Zhao, Zou, Zhou (bb0925) 2016; 303
Kim, Park, Chang, Kim, Lee (bb0385) 2016; 25
Suwanwela, Chen, Lee, Young, Tay, Umapathi, Venketasubramanian (bb0670) 2018; 46
Cheng, Ho, Lee, Su, Tang, Hsieh (bb0125) 2008; 36
Honda, Korge, Weiss (bb0295) 2005; 1047
Plesnila, Zhu, Culmsee, Gröger, Moskowitz, Blomgren (bb0580) 2004; 24
Doyle, Simon, Stenzel-Poore (bb0190) 2008; 55
Wang, Zeng, Wang, Chau, Lai, Jia, Li (bb0760) 2011; 18
Füger, Hefendehl, Veeraraghavalu, Wendeln, Schlosser, Obermüller, Jucker (bb0230) 2017; 20
Rabiei, Bigdeli, Rasoulian, Ghassempour, Mirzajani (bb0590) 2012; 19
Yin, Li, Gong, Zhu, Li, Wu (bb0900) 2010; 38
Zhang, Zhang, Liu, Wang, Xue, Yu, Wang (bb0915) 2014; 2014
Woodruff, Thundyil, Tang, Sobey, Taylor, Arumugam (bb0800) 2011; 6
Hoek, Ruuls, Murphy, Wright, Goddard, Zurawski, Sedgwick (bb0290) 2000; 290
Bora, Arora, Shri (bb0050) 2011; 137
Cao, Clark, Pei, Yin, Zhang, Sun, Chen (bb0080) 2003; 23
Chen, Zhong, Zhang, Ji, Zhao, Zhang, Zhang (bb0115) 2009; 124
Hu, Li, Guo, Wang, Leak, Chen, Chen (bb0310) 2012; 43
Huang, McNamara (bb0320) 2004; 118
Wu, Wang, Li, Feng, Zhao, Zhang (bb0810) 2017; 38
Bjørnsen, Hadera, Zhou, Danbolt, Sonnewald (bb0040) 2014; 128
Yu, Andrabi, Wang, Kim, Poirier, Dawson, Dawson (bb0910) 2006; 103
Bazmandegan, Boroushaki, Shamsizadeh, Ayoobi, Hakimizadeh, Allahtavakoli (bb0030) 2017; 85
Qian, Yuanshao, Wensi, Yulei, Xiaoli, Brian, Bei (bb0585) 2016; 7
Petrovic-Djergovic, Goonewardena, Pinsky (bb0570) 2016; 119
Chae, Min, Lee, Song, Lee, Lee, Lee (bb0095) 2017; 39
Murray, Parry-Jones, Allan (bb0525) 2015; 9
Xie, Tang, Song, Long, Zhang, Li (bb0825) 2019; 71
Xiong, Liu, Yang (bb0840) 2018; 9
Yang, Luo, Ren, Peng, Tan, Liu, Peng (bb0885) 2015; 766
Jiang, Wang, Zhou, Li, Wang, Guo (bb0350) 2011; 39
Perego, Fumagalli, De Simoni (bb0555) 2011; 8
Wei, Chen, Yu, Wang, Liu (bb0790) 2018; 1682
Seo, Kang, Kim, Choi, Hong, Choi, Shin (bb0615) 2015; 15
Lo, Dalkara, Moskowitz (bb0470) 2003; 4
Wang, Wang, Zhang, Li, Yu, Kou (bb0735) 2019
Liu, Xing, Gao, Zhou (bb0450) 2014; 21
Zhao, Han, Ji, Luo (bb0930) 2016; 7
Liu, Hua, Lei, Li (bb0460) 2011; 137
Park, Hong, Lee, Kim, Lee, Lee (bb0550) 2010; 21
Suganuma, Okabe, Oniyama, Tada, Ito, Fujiki (bb0645) 1998; 19
Stence, Waite, Dailey (bb0640) 2001; 33
Venketasubramanian, Young, Tay, Chang, Umapathi, Chan, Chen (bb0710) 2013; 35
Faraci (bb0220) 2006; 100
Kim, Chung, Lee, Song, Ku (bb0390) 2016; 188
Yilmaz, Granger (bb0895) 2010; 12
Hao, Li, Feng, Pan (bb0275) 2015; 38
Singh, Krishan, Singh, Kumar, Shri (bb0625) 2017; 85
Cai, Yu, Wang, Song, Zhang, Zhang, Cai (bb0075) 2016; 181
van Leyen, Kim, Lee, Jin, Arai, Lo (bb0420) 2006; 37
Ye, Li, Cao, Chen, Ye, Chen (bb0890) 2016; 188
Kahl, Stepanova, Konrad, Anderson, Manfredi, Zhou, Galkin (bb0375) 2018; 49
Ahn, Kim, Kim, Choi, Kim, Shin, Choi (bb0010) 2016; 188
Wang, Li, Zhang (bb0770) 2019; 47
Perry, Nicoll, Holmes (bb0565) 2010; 6
Jayaraj, Azimullah, Beiram, Jalal, Rosenberg (bb0335) 2019; 16
Chou, Hu, Hsiung, Shen (bb0140) 2015; 36
Gaowa, Bao, Da, Qiburi, Ganbold, Chen, Baigude (bb0255) 2018; 222
Jiang, Liu, Zhang, Wang, Hu, Xu, Xu (bb0345) 2018; 15
Liu, Jin, Liu, Shi, Sun, Zhang, Shi (bb0455) 2017; 46
Elango, Jayachandaran, Niranjali Devaraj (bb0200) 2009; 27
Huang, Zhou, Qin, Liu, Hu, Chang, Han (bb0315) 2012; 237
Fang, Hu, Wang, Yang, Lou, Jin, Chen (bb0215) 2014; 77
Widmann, Gandin, Petit-Paitel, Lazdunski, Heurteaux (bb0795) 2018; 8
Roy-O’Reilly, McCullough (bb0595) 2017; 114
Chen, Chiu, Ko (bb0110) 2008; 31
Schnell, Fearn, Schwab, Perry, Anthony (bb0610) 1999; 58
Tang, Liu, Hsieh, Hsieh (bb0685) 2010; 38
Xu, Yang, Deng, Zhou (bb0845) 2011; 39
Dong, Xu, Yang, Qiao, Wu (bb0180) 2009; 23
Konsman, Drukarch, Van Dam (bb0400) 2007; 112
Luheshi, Kovács, Lopez-Castejon, Brough, Denes (bb0480) 2011; 8
Abdelnaseer, Elfauomy, Esmail, Kamal, Elsawy (bb0005) 2017; 26
Chen, Wang, Chen, Xing, Zhang, Li, Zeng (bib946) 2014; 32
Jung, Kang, Park, Oh, Jung, Kim, Park (bb0370) 2013; 41
Xue, Zhang, Zhang, Kang, Liu, Yu, Wang (bb0865) 2016; 182
Boje, Arora (bb0045) 1992; 587
Kang, Kim, Kim, Lee, Choi, Choi, Shin (bb0380) 2015; 43
Nada, Shah (bb0530) 2012; 46
Yu, Liu, Tang, Jing, Lv, Chen, Li (bb0905) 2016; 775
Wei, Wu, Wen, Shieh (bb0785) 2004; 999
Sowndhararajan, Deepa, Kim, Park, Kim (bb0635) 2018; 97
Cao, Xing, Xiao, Liou, Gao, Yin, Chen (bb0085) 2007; 27
Watcharotayangul, Mao, Xu, Vetri, Baughman, Paisansathan, Pelligrino (bb0780) 2012; 123
Yan, Min, Min, Chao, Ying, Zhi (bb0870) 2014; 151
Lin, Wang, Liu, Yang, Han (bb0445) 2006; 108
Sun, Zhu, Wang, Liu, Bi (bb0660) 2009; 877
Sutterwala, Ogura, Zamboni, Roy, Flavell (bb0665) 2006; 12
Wang, Wang, Wang, Guo, Dong, Chai, Chen (bb0755) 2015; 2015
Dang, Duan, Wang, He, Chen (bb0160) 2017; 18
Brouns, Sheorajpanday, Wauters, De Surgeloose, Mariën, De Deyn (bb0065) 2008; 397
Smits (10.1016/j.pharmthera.2020.107695_bb0630) 2006; 16
Chen (10.1016/j.pharmthera.2020.107695_bb0115) 2009; 124
Perez-de-Puig (10.1016/j.pharmthera.2020.107695_bb0560) 2015; 129
Bu (10.1016/j.pharmthera.2020.107695_bb0070) 2010; 24
Cao (10.1016/j.pharmthera.2020.107695_bb0085) 2007; 27
Chen (10.1016/j.pharmthera.2020.107695_bb0110) 2008; 31
Hao (10.1016/j.pharmthera.2020.107695_bb0275) 2015; 38
Wang (10.1016/j.pharmthera.2020.107695_bb0730) 2018; 39
Xue (10.1016/j.pharmthera.2020.107695_bb0860) 2019; 404
Li (10.1016/j.pharmthera.2020.107695_bb0425) 2017; 65
Wang (10.1016/j.pharmthera.2020.107695_bb0750) 2009; 47
Brouns (10.1016/j.pharmthera.2020.107695_bb0065) 2008; 397
Chu (10.1016/j.pharmthera.2020.107695_bb0145) 2014; 34
Xiang (10.1016/j.pharmthera.2020.107695_bb0815) 2019; 33
Kahl (10.1016/j.pharmthera.2020.107695_bb0375) 2018; 49
Schnell (10.1016/j.pharmthera.2020.107695_bb0610) 1999; 58
Fang (10.1016/j.pharmthera.2020.107695_bb0215) 2014; 77
Tzeng (10.1016/j.pharmthera.2020.107695_bb0705) 2005; 4
Doyle (10.1016/j.pharmthera.2020.107695_bb0185) 2015; 35
Gaowa (10.1016/j.pharmthera.2020.107695_bb0255) 2018; 222
Wu (10.1016/j.pharmthera.2020.107695_bb0810) 2017; 38
Sun (10.1016/j.pharmthera.2020.107695_bb0655) 2020; 262
Sun (10.1016/j.pharmthera.2020.107695_bb0660) 2009; 877
Xie (10.1016/j.pharmthera.2020.107695_bb0825) 2019; 71
Cao (10.1016/j.pharmthera.2020.107695_bb0080) 2003; 23
Doyle (10.1016/j.pharmthera.2020.107695_bb0190) 2008; 55
Konsman (10.1016/j.pharmthera.2020.107695_bb0400) 2007; 112
Zhao (10.1016/j.pharmthera.2020.107695_bb0930) 2016; 7
Stence (10.1016/j.pharmthera.2020.107695_bb0640) 2001; 33
Boje (10.1016/j.pharmthera.2020.107695_bb0045) 1992; 587
Elango (10.1016/j.pharmthera.2020.107695_bb0200) 2009; 27
Xu (10.1016/j.pharmthera.2020.107695_bb0845) 2011; 39
Yu (10.1016/j.pharmthera.2020.107695_bb0910) 2006; 103
Chen (10.1016/j.pharmthera.2020.107695_bb0100) 2013; 44
Gao (10.1016/j.pharmthera.2020.107695_bb0250) 2015; 289
Loh (10.1016/j.pharmthera.2020.107695_bb0475) 2010; 41
Luheshi (10.1016/j.pharmthera.2020.107695_bb0480) 2011; 8
Wang (10.1016/j.pharmthera.2020.107695_bb0745) 2012; 141
He (10.1016/j.pharmthera.2020.107695_bb0280) 2020; 48
An (10.1016/j.pharmthera.2020.107695_bb0015) 2010; 11
Jayaraj (10.1016/j.pharmthera.2020.107695_bb0335) 2019; 16
Zhou (10.1016/j.pharmthera.2020.107695_bb0945) 2017; 85
Chou (10.1016/j.pharmthera.2020.107695_bb0140) 2015; 36
Wang (10.1016/j.pharmthera.2020.107695_bb0725) 2017; 17
Xu (10.1016/j.pharmthera.2020.107695_bb0855) 2017; 2017
Forouzanfar (10.1016/j.pharmthera.2020.107695_bb0225) 2016; 30
Jung (10.1016/j.pharmthera.2020.107695_bb0370) 2013; 41
Meng (10.1016/j.pharmthera.2020.107695_bb0505) 2018; 23
Sowndhararajan (10.1016/j.pharmthera.2020.107695_bb0635) 2018; 97
Petrovic-Djergovic (10.1016/j.pharmthera.2020.107695_bb0570) 2016; 119
Wang (10.1016/j.pharmthera.2020.107695_bb0735) 2019
Widmann (10.1016/j.pharmthera.2020.107695_bb0795) 2018; 8
Li (10.1016/j.pharmthera.2020.107695_bb0430) 2018; 134
Colonna (10.1016/j.pharmthera.2020.107695_bb0150) 2017; 35
Wang (10.1016/j.pharmthera.2020.107695_bb0755) 2015; 2015
Bjørnsen (10.1016/j.pharmthera.2020.107695_bb0040) 2014; 128
Neyt (10.1016/j.pharmthera.2020.107695_bb0545) 2012; 33
Liu (10.1016/j.pharmthera.2020.107695_bb0460) 2011; 137
Xu (10.1016/j.pharmthera.2020.107695_bb0850) 2014; 2014
Wang (10.1016/j.pharmthera.2020.107695_bb0770) 2019; 47
Huang (10.1016/j.pharmthera.2020.107695_bb0320) 2004; 118
Yu (10.1016/j.pharmthera.2020.107695_bb0905) 2016; 775
Xie (10.1016/j.pharmthera.2020.107695_bb0820) 2019; 39
Kim (10.1016/j.pharmthera.2020.107695_bb0390) 2016; 188
Ju (10.1016/j.pharmthera.2020.107695_bb0365) 2018; 12
Brifault (10.1016/j.pharmthera.2020.107695_bb0055) 2015; 46
Brimson (10.1016/j.pharmthera.2020.107695_bb0060) 2011; 16
Mohagheghi (10.1016/j.pharmthera.2020.107695_bb0515) 2011; 18
Kim (10.1016/j.pharmthera.2020.107695_bb0385) 2016; 25
Chen (10.1016/j.pharmthera.2020.107695_bb0105) 2011; 14
Gong (10.1016/j.pharmthera.2020.107695_bb0260) 2015; 91
Jiang (10.1016/j.pharmthera.2020.107695_bb0340) 2020; 21
Yang (10.1016/j.pharmthera.2020.107695_bb0880) 2012; 140
Zhao (10.1016/j.pharmthera.2020.107695_bb0925) 2016; 303
Moumen (10.1016/j.pharmthera.2020.107695_bb0520) 2013; 12
Perego (10.1016/j.pharmthera.2020.107695_bb0555) 2011; 8
Tang (10.1016/j.pharmthera.2020.107695_bb0685) 2010; 38
Liu (10.1016/j.pharmthera.2020.107695_bb0450) 2014; 21
Liu (10.1016/j.pharmthera.2020.107695_bb0465) 2013; 148
Sutterwala (10.1016/j.pharmthera.2020.107695_bb0665) 2006; 12
Deng (10.1016/j.pharmthera.2020.107695_bb0170) 2014; 274
Roy-O’Reilly (10.1016/j.pharmthera.2020.107695_bb0595) 2017; 114
Hu (10.1016/j.pharmthera.2020.107695_bb0310) 2012; 43
Shi (10.1016/j.pharmthera.2020.107695_bb0620) 2019; 18
Eltzschig (10.1016/j.pharmthera.2020.107695_bb0205) 2011; 364
Huang (10.1016/j.pharmthera.2020.107695_bb0315) 2012; 237
Yang (10.1016/j.pharmthera.2020.107695_bb0875) 2017; 37
Planas (10.1016/j.pharmthera.2020.107695_bb0575) 2001; 8
Bhaskar (10.1016/j.pharmthera.2020.107695_bb0035) 2018; 18
Fang (10.1016/j.pharmthera.2020.107695_bb0210) 2019; 10
Singh (10.1016/j.pharmthera.2020.107695_bb0625) 2017; 85
Cheng (10.1016/j.pharmthera.2020.107695_bb0125) 2008; 36
Hoek (10.1016/j.pharmthera.2020.107695_bb0290) 2000; 290
Noguchi (10.1016/j.pharmthera.2020.107695_bib947) 1997; 27
Ma (10.1016/j.pharmthera.2020.107695_bb0485) 2017; 157
Xiong (10.1016/j.pharmthera.2020.107695_bb0840) 2018; 9
Perry (10.1016/j.pharmthera.2020.107695_bb0565) 2010; 6
Sun (10.1016/j.pharmthera.2020.107695_bb0650) 2007; 113
Liu (10.1016/j.pharmthera.2020.107695_bb0455) 2017; 46
Wu (10.1016/j.pharmthera.2020.107695_bb0805) 2017; 27
Zhao (10.1016/j.pharmthera.2020.107695_bb0940) 2018; 138
Chen (10.1016/j.pharmthera.2020.107695_bib946) 2014; 32
Kirisattayakul (10.1016/j.pharmthera.2020.107695_bb0395) 2013; 2013
Dang (10.1016/j.pharmthera.2020.107695_bb0160) 2017; 18
Lin (10.1016/j.pharmthera.2020.107695_bb0445) 2006; 108
Zhang (10.1016/j.pharmthera.2020.107695_bb0920) 2014; 158
Lo (10.1016/j.pharmthera.2020.107695_bb0470) 2003; 4
Nada (10.1016/j.pharmthera.2020.107695_bb0535) 2014; 49
Li (10.1016/j.pharmthera.2020.107695_bb0440) 2012; 1464
Salminen (10.1016/j.pharmthera.2020.107695_bb0605) 2010; 394
Thippeswamy (10.1016/j.pharmthera.2020.107695_bb0690) 2011; 20
Park (10.1016/j.pharmthera.2020.107695_bb0550) 2010; 21
Gong (10.1016/j.pharmthera.2020.107695_bb0265) 2002; 9
Murray (10.1016/j.pharmthera.2020.107695_bb0525) 2015; 9
Hou (10.1016/j.pharmthera.2020.107695_bb0300) 2010; 17
Kostandy (10.1016/j.pharmthera.2020.107695_bb0405) 2012; 33
Gu (10.1016/j.pharmthera.2020.107695_bb0270) 2012; 43
Li (10.1016/j.pharmthera.2020.107695_bb0435) 2010; 299
Ahn (10.1016/j.pharmthera.2020.107695_bb0010) 2016; 188
Choi (10.1016/j.pharmthera.2020.107695_bb0135) 2004; 1019
Seo (10.1016/j.pharmthera.2020.107695_bb0615) 2015; 15
Wei (10.1016/j.pharmthera.2020.107695_bb0785) 2004; 999
Hur (10.1016/j.pharmthera.2020.107695_bb0325) 2010; 391
Nagakannan (10.1016/j.pharmthera.2020.107695_bb0540) 2012; 140
Chen (10.1016/j.pharmthera.2020.107695_bb0120) 1997; 91
Suganuma (10.1016/j.pharmthera.2020.107695_bb0645) 1998; 19
Mahmood (10.1016/j.pharmthera.2020.107695_bb0490) 2017; 25
Iadecola (10.1016/j.pharmthera.2020.107695_bb0330) 2011; 17
Woodruff (10.1016/j.pharmthera.2020.107695_bb0800) 2011; 6
Yilmaz (10.1016/j.pharmthera.2020.107695_bb0895) 2010; 12
Watcharotayangul (10.1016/j.pharmthera.2020.107695_bb0780) 2012; 123
Honda (10.1016/j.pharmthera.2020.107695_bb0295) 2005; 1047
Xue (10.1016/j.pharmthera.2020.107695_bb0865) 2016; 182
Jiang (10.1016/j.pharmthera.2020.107695_bb0350) 2011; 39
Wang (10.1016/j.pharmthera.2020.107695_bb0760) 2011; 18
Lai (10.1016/j.pharmthera.2020.107695_bb0410) 2018; 13
Faraci (10.1016/j.pharmthera.2020.107695_bb0220) 2006; 100
Wang (10.1016/j.pharmthera.2020.107695_bb0720) 2012; 17
Wang (10.1016/j.pharmthera.2020.107695_bb0765) 2016; 354
Yang (10.1016/j.pharmthera.2020.107695_bb0885) 2015; 766
Noguchi (10.1016/j.pharmthera.2020.107695_bib948) 1999; 26
Wang (10.1016/j.pharmthera.2020.107695_bb0775) 2018; 67
Jiang (10.1016/j.pharmthera.2020.107695_bb0355) 2010; 24
Szeto (10.1016/j.pharmthera.2020.107695_bb0675) 2006; 8
Hsiao (10.1016/j.pharmthera.2020.107695_bb0305) 2007; 73
Chae (10.1016/j.pharmthera.2020.107695_bb0095) 2017; 39
Füger (10.1016/j.pharmthera.2020.107695_bb0230) 2017; 20
Dong (10.1016/j.pharmthera.2020.107695_bb0180) 2009; 23
Choi (10.1016/j.pharmthera.2020.107695_bb0130) 2011; 63
Wang (10.1016/j.pharmthera.2020.107695_bb0740) 2012; 125
Askew (10.1016/j.pharmthera.2020.107695_bb0020) 2017; 18
Marín-Prida (10.1016/j.pharmthera.2020.107695_bb0495) 2013; 272
Matzinger (10.1016/j.pharmthera.2020.107695_bb0500) 2007; 8
Ye (10.1016/j.pharmthera.2020.107695_bb0890) 2016; 188
Cai (10.1016/j.pharmthera.2020.107695_bb0075) 2016; 181
Wei (10.1016/j.pharmthera.2020.107695_bb0790) 2018; 1682
Tang (10.1016/j.pharmthera.2020.107695_bb0680) 2010; 17
Nada (10.1016/j.pharmthera.2020.107695_bb0530) 2012; 46
Cao (10.1016/j.pharmthera.2020.107695_bb0090) 2014; 155
Qian (10.1016/j.pharmthera.2020.107695_bb0585) 2016; 7
Xiong (10.1016/j.pharmthera.2020.107695_bb0835) 2013; 62
Abdelnaseer (10.1016/j.pharmthera.2020.107695_bb0005) 2017; 26
Bansal (10.1016/j.pharmthera.2020.107695_bb0025) 2013; 13
Lee (10.1016/j.pharmthera.2020.107695_bb0415) 2012; 50
Jiang (10.1016/j.pharmthera.2020.107695_bb0345) 2018; 15
Bazmandegan (10.1016/j.pharmthera.2020.107695_bb0030) 2017; 85
van Leyen (10.1016/j.pharmthera.2020.107695_bb0420) 2006; 37
Venketasubramanian (10.1016/j.pharmthera.2020.107695_bb0710) 2013; 35
Yan (10.1016/j.pharmthera.2020.107695_bb0870) 2014; 151
Yin (10.1016/j.pharmthera.2020.107695_bb0900) 2010; 38
Zhao (10.1016/j.pharmthera.2020.107695_bb0935) 2015; 6
Bora (10.1016/j.pharmthera.2020.107695_bb0050) 2011; 137
Dai (10.1016/j.pharmthera.2020.107695_bb0155) 2020; 2020
Dietrich (10.1016/j.pharmthera.2020.107695_bb0175) 2002; 128
Furuichi (10.1016/j.pharmthera.2020.107695_bb0240) 2004; 1014
Jin (10.1016/j.pharmthera.2020.107695_bb0360) 2010; 87
Furukawa (10.1016/j.pharmthera.2020.107695_bb0245) 1997; 17
Saleem (10.1016/j.pharmthera
References_xml – volume: 16
  start-page: 6322
  year: 2011
  end-page: 6338
  ident: bb0060
  article-title: Rhinacanthus nasutus protects cultured neuronal cells against hypoxia induced cell death
  publication-title: Molecules
– volume: 6
  start-page: 4124
  year: 2015
  end-page: 4130
  ident: bb0935
  article-title: Natural products triptolide, celastrol, and withaferin a inhibit the chaperone activity of peroxiredoxin I
  publication-title: Chemical Science
– volume: 25
  start-page: 8
  year: 2017
  end-page: 14
  ident: bb0490
  article-title: Salvianolic acid a inhibits calpain activation and eNOS uncoupling during focal cerebral ischemia in mice
  publication-title: Phytomedicine
– volume: 113
  start-page: 199
  year: 2007
  end-page: 203
  ident: bb0650
  article-title: Buyang Huanwu decoction promotes growth and differentiation of neural progenitor cells: Using a serum pharmacological method
  publication-title: Journal of Ethnopharmacology
– volume: 237
  start-page: 453
  year: 2012
  end-page: 463
  ident: bb0315
  article-title: Cerebralcare granule® attenuates blood-brain barrier disruption after middle cerebral artery occlusion in rats
  publication-title: Experimental Neurology
– volume: 25
  start-page: 241
  year: 2016
  end-page: 251
  ident: bb0385
  article-title: Inflammation after ischemic stroke: The role of leukocytes and glial cells
  publication-title: Exp Neurobiol
– volume: 58
  start-page: 245
  year: 1999
  end-page: 254
  ident: bb0610
  article-title: Cytokine-induced acute inflammation in the brain and spinal cord
  publication-title: Journal of Neuropathology and Experimental Neurology
– volume: 7
  start-page: 97
  year: 2010
  ident: bb0195
  article-title: Immunomodulatory effect of hawthorn extract in an experimental stroke model
  publication-title: Journal of Neuroinflammation
– volume: 10
  start-page: 184
  year: 2019
  ident: bb0210
  article-title: Effect of inflammation on the process of stroke rehabilitation and Poststroke depression
  publication-title: Frontiers in Psychiatry
– volume: 30
  start-page: 1954
  year: 2016
  end-page: 1967
  ident: bb0225
  article-title: Aqueous and Ethanolic extracts of Boswellia serrata protect against focal cerebral ischemia and reperfusion injury in rats
  publication-title: Phytotherapy Research
– volume: 46
  start-page: 474
  year: 2017
  end-page: 487
  ident: bb0455
  article-title: Brain ischemia suppresses immunity in the periphery and brain via different neurogenic innervations
  publication-title: Immunity
– volume: 97
  start-page: 958
  year: 2018
  end-page: 968
  ident: bb0635
  article-title: An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis
  publication-title: Biomedicine & Pharmacotherapy
– volume: 17
  start-page: 9803
  year: 2012
  end-page: 9817
  ident: bb0720
  article-title: Neuroprotective activity of lavender oil on transient focal cerebral ischemia in mice
  publication-title: Molecules
– volume: 8
  start-page: 18062
  year: 2018
  ident: bb0795
  article-title: The traditional Chinese medicine MLC901 inhibits inflammation processes after focal cerebral ischemia
  publication-title: Scientific Reports
– volume: 228
  start-page: 58
  year: 2019
  end-page: 69
  ident: bb0715
  article-title: Achyranthes aspera Linn. Alleviates cerebral ischemia-reperfusion-induced neurocognitive, biochemical, morphological and histological alterations in Wistar rats
  publication-title: Journal of Ethnopharmacology
– volume: 91
  start-page: 917
  year: 1997
  end-page: 925
  ident: bb0120
  article-title: Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin
  publication-title: Cell
– volume: 17
  start-page: 8178
  year: 1997
  end-page: 8186
  ident: bb0245
  article-title: The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons
  publication-title: The Journal of Neuroscience
– volume: 290
  start-page: 1768
  year: 2000
  end-page: 1771
  ident: bb0290
  article-title: Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
  publication-title: Science
– volume: 20
  start-page: 1371
  year: 2017
  end-page: 1376
  ident: bb0230
  article-title: Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging
  publication-title: Nature Neuroscience
– volume: 48
  start-page: 252
  year: 2020
  end-page: 258
  ident: bb0280
  article-title: Taraxasterol protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activation of Nrf2 signalling pathway
  publication-title: Artif Cells Nanomed Biotechnol
– volume: 55
  start-page: 310
  year: 2008
  end-page: 318
  ident: bb0190
  article-title: Mechanisms of ischemic brain damage
  publication-title: Neuropharmacology
– volume: 19
  start-page: 1771
  year: 1998
  end-page: 1776
  ident: bb0645
  article-title: Wide distribution of [3H](−)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue
  publication-title: Carcinogenesis
– volume: 46
  start-page: 180
  year: 2012
  end-page: 189
  ident: bb0530
  article-title: Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection through HO1 and CRMP2
  publication-title: Neurobiology of Disease
– volume: 6
  start-page: 11
  year: 2011
  ident: bb0800
  article-title: Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
  publication-title: Molecular Neurodegeneration
– volume: 43
  start-page: 3063
  year: 2012
  end-page: 3070
  ident: bb0310
  article-title: Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
  publication-title: Stroke
– volume: 33
  start-page: 297
  year: 2012
  end-page: 305
  ident: bb0545
  article-title: Tertiary lymphoid organs in infection and autoimmunity
  publication-title: Trends in Immunology
– volume: 188
  start-page: 123
  year: 2016
  end-page: 133
  ident: bb0390
  article-title: Neuroprotective effects of Danggui-Jakyak-san on rat stroke model through antioxidant/antiapoptotic pathway
  publication-title: Journal of Ethnopharmacology
– volume: 34
  start-page: 450
  year: 2014
  end-page: 459
  ident: bb0145
  article-title: Immune cell infiltration in malignant middle cerebral artery infarction: Comparison with transient cerebral ischemia
  publication-title: Journal of Cerebral Blood Flow and Metabolism
– volume: 67
  start-page: 101
  year: 2018
  end-page: 117
  ident: bb0775
  article-title: Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions
  publication-title: Brain, Behavior, and Immunity
– volume: 26
  start-page: 330
  year: 1999
  end-page: 335
  ident: bib948
  article-title: Effects of voluntary exercise and L-arginine on thrombogenesis and microcirculation in stroke-prone spontaneously hypertensive rats
  publication-title: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
– volume: 18
  start-page: 1358
  year: 2017
  end-page: 1366
  ident: bb0160
  article-title: A therapeutic target of cerebral Hemorrhagic stroke: Matrix metalloproteinase- 9
  publication-title: Current Drug Targets
– volume: 274
  start-page: 132
  year: 2014
  end-page: 140
  ident: bb0170
  article-title: Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation
  publication-title: Journal of Neuroimmunology
– volume: 20
  start-page: 379
  year: 2011
  end-page: 386
  ident: bb0690
  article-title: Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats
  publication-title: Neurotoxicity Research
– volume: 32
  start-page: 533
  year: 2014
  end-page: 546
  ident: bib946
  article-title: Tongxinluo attenuates neuronal loss and enhances neurogenesis and angiogenesis in the ipsilateral thalamus and improves neurological outcome after focal cortical infarction in hypertensive rats
  publication-title: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
– volume: 13
  start-page: 57
  year: 2013
  end-page: 69
  ident: bb0025
  article-title: Drug treatment of acute ischemic stroke
  publication-title: American Journal of Cardiovascular Drugs
– volume: 148
  start-page: 632
  year: 2013
  end-page: 639
  ident: bb0465
  article-title: The protective role of Tongxinluo on blood-brain barrier after ischemia-reperfusion brain injury
  publication-title: Journal of Ethnopharmacology
– volume: 38
  start-page: 459
  year: 2017
  end-page: 468
  ident: bb0810
  article-title: Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation
  publication-title: Acta Pharmacologica Sinica
– volume: 364
  start-page: 656
  year: 2011
  end-page: 665
  ident: bb0205
  article-title: Hypoxia and inflammation
  publication-title: The New England Journal of Medicine
– volume: 188
  start-page: 259
  year: 2016
  end-page: 265
  ident: bb0890
  article-title: Protective effect of n-butyl alcohol extracts from Rhizoma Pinelliae Pedatisectae against cerebral ischemia-reperfusion injury in rats
  publication-title: Journal of Ethnopharmacology
– volume: 12
  start-page: 236
  year: 2018
  ident: bb0365
  article-title: Increased BBB permeability enhances activation of microglia and exacerbates loss of dendritic spines after transient global cerebral ischemia
  publication-title: Frontiers in Cellular Neuroscience
– volume: 775
  start-page: 113
  year: 2016
  end-page: 119
  ident: bb0905
  article-title: Oleuropein, a natural extract from plants, offers neuroprotection in focal cerebral ischemia/reperfusion injury in mice
  publication-title: European Journal of Pharmacology
– volume: 46
  start-page: 520
  year: 2015
  end-page: 528
  ident: bb0055
  article-title: Delayed pituitary adenylate cyclase-activating polypeptide delivery after brain stroke improves functional recovery by inducing m2 microglia/macrophage polarization
  publication-title: Stroke
– volume: 27
  start-page: 799
  year: 2009
  end-page: 803
  ident: bb0200
  article-title: Hawthorn extract reduces infarct volume and improves neurological score by reducing oxidative stress in rat brain following middle cerebral artery occlusion
  publication-title: International Journal of Developmental Neuroscience
– volume: 10
  start-page: 593
  year: 2019
  ident: bb0700
  article-title: Neuroprotective effects and Hepatorenal toxicity of Angong Niuhuang Wan against ischemia-reperfusion brain injury in rats
  publication-title: Frontiers in Pharmacology
– volume: 7
  start-page: 614
  year: 2016
  end-page: 622
  ident: bb0585
  article-title: Serum IL-33 is a novel diagnostic and prognostic biomarker in acute ischemic stroke
  publication-title: Aging and Disease
– volume: 63
  start-page: 695
  year: 2011
  end-page: 706
  ident: bb0130
  article-title: Amelioration of cerebral infarction and improvement of neurological deficit by a Korean herbal medicine, modified Bo-Yang-Hwan-O-Tang
  publication-title: The Journal of Pharmacy and Pharmacology
– volume: 8
  start-page: 186
  year: 2011
  ident: bb0480
  article-title: Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
  publication-title: Journal of Neuroinflammation
– volume: 24
  start-page: 547
  year: 2010
  end-page: 552
  ident: bb0355
  article-title: Cornin ameliorates cerebral infarction in rats by antioxidant action and stabilization of mitochondrial function
  publication-title: Phytotherapy Research
– volume: 8
  start-page: 174
  year: 2011
  ident: bb0555
  article-title: Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice
  publication-title: Journal of Neuroinflammation
– volume: 123
  start-page: 116
  year: 2012
  end-page: 124
  ident: bb0780
  article-title: Post-ischemic vascular adhesion protein-1 inhibition provides neuroprotection in a rat temporary middle cerebral artery occlusion model
  publication-title: Journal of Neurochemistry
– volume: 1464
  start-page: 8
  year: 2012
  end-page: 13
  ident: bb0440
  article-title: Protective effect of celastrol in rat cerebral ischemia model: Down-regulating p-JNK, p-c-Jun and NF-κB
  publication-title: Brain Research
– volume: 1682
  start-page: 61
  year: 2018
  end-page: 70
  ident: bb0790
  article-title: Patchouli alcohol protects against ischemia/reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice
  publication-title: Brain Research
– volume: 9
  start-page: 249
  year: 2018
  ident: bb0840
  article-title: Refocusing neuroprotection in cerebral reperfusion era: New challenges and strategies
  publication-title: Frontiers in Neurology
– volume: 128
  start-page: 58
  year: 2002
  end-page: 68
  ident: bb0175
  article-title: The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier
  publication-title: Journal of Neuroimmunology
– volume: 49
  start-page: 945
  year: 2014
  end-page: 956
  ident: bb0535
  article-title: Heme oxygenase 1-mediated neurogenesis is enhanced by Ginkgo biloba (EGb 761®) after permanent ischemic stroke in mice
  publication-title: Molecular Neurobiology
– volume: 35
  start-page: 18
  year: 2013
  end-page: 22
  ident: bb0710
  article-title: Chinese medicine NeuroAiD efficacy stroke recovery-extension study (CHIMES-E study): An observational multicenter study to investigate the longer-term efficacy of NeuroAiD in stroke recovery
  publication-title: Cerebrovascular Diseases
– volume: 299
  start-page: H1255
  year: 2010
  end-page: H1261
  ident: bb0435
  article-title: Tongxinluo reduces myocardial no-reflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway
  publication-title: American Journal of Physiology. Heart and Circulatory Physiology
– volume: 100
  start-page: 739
  year: 2006
  end-page: 743
  ident: bb0220
  article-title: Reactive oxygen species: Influence on cerebral vascular tone
  publication-title: Journal of Applied Physiology
– volume: 4
  start-page: 399
  year: 2003
  end-page: 415
  ident: bb0470
  article-title: Mechanisms, challenges and opportunities in stroke
  publication-title: Nature Reviews. Neuroscience
– volume: 36
  start-page: 1105
  year: 2008
  end-page: 1119
  ident: bb0125
  article-title: Ferulic acid reduces cerebral infarct through its antioxidative and anti-inflammatory effects following transient focal cerebral ischemia in rats
  publication-title: The American Journal of Chinese Medicine
– volume: 17
  start-page: 796
  year: 2011
  end-page: 808
  ident: bb0330
  article-title: The immunology of stroke: From mechanisms to translation
  publication-title: Nature Medicine
– volume: 39
  start-page: 111
  year: 2011
  end-page: 120
  ident: bb0350
  article-title: Cerebral protection of salvianolic acid a by the inhibition of granulocyte adherence
  publication-title: The American Journal of Chinese Medicine
– volume: 15
  start-page: 157
  year: 2015
  ident: bb0615
  article-title: Partially purified components of Uncaria sinensis attenuate blood brain barrier disruption after ischemic brain injury in mice
  publication-title: BMC Complementary and Alternative Medicine
– volume: 103
  start-page: 239
  year: 2000
  end-page: 252
  ident: bb0165
  article-title: Signal transduction by the JNK group of MAP kinases
  publication-title: Cell
– volume: 27
  start-page: 754
  year: 2017
  end-page: 768
  ident: bb0805
  article-title: Britanin ameliorates cerebral ischemia-reperfusion injury by inducing the Nrf2 protective pathway
  publication-title: Antioxidants & Redox Signaling
– volume: 91
  start-page: 123
  year: 2015
  end-page: 134
  ident: bb0260
  article-title: Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway
  publication-title: Neuropharmacology
– volume: 21
  start-page: 2006
  year: 2020
  end-page: 2018
  ident: bb0340
  article-title: Modulators of microglia activation and polarization in ischemic stroke (review)
  publication-title: Molecular Medicine Reports
– volume: 124
  start-page: 103
  year: 2009
  end-page: 110
  ident: bb0115
  article-title: Chinese medicine tongxinluo significantly lowers serum lipid levels and stabilizes vulnerable plaques in a rabbit model
  publication-title: Journal of Ethnopharmacology
– volume: 134
  start-page: 208
  year: 2018
  end-page: 217
  ident: bb0430
  article-title: Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery
  publication-title: Neuropharmacology
– volume: 73
  start-page: 682
  year: 2007
  end-page: 693
  ident: bb0305
  article-title: Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: Reduced neutrophil activation and anti-oxidant actions
  publication-title: Biochemical Pharmacology
– volume: 9
  start-page: 18
  year: 2015
  ident: bb0525
  article-title: Interleukin-1 and acute brain injury
  publication-title: Frontiers in Cellular Neuroscience
– volume: 41
  start-page: 99
  year: 2013
  end-page: 117
  ident: bb0370
  article-title: Effect of the semen extract of Thuja orientalis on inflammatory responses in transient focal cerebral ischemia rat model and LPS-stimulated BV-2 microglia
  publication-title: The American Journal of Chinese Medicine
– volume: 65
  start-page: 1533
  year: 2017
  end-page: 1542
  ident: bb0425
  article-title: Intranasal Pretreatment with Z-Ligustilide, the Main volatile component of Rhizoma chuanxiong, confers prophylaxis against cerebral ischemia via Nrf2 and HSP70 Signaling pathways
  publication-title: Journal of Agricultural and Food Chemistry
– volume: 85
  start-page: 503
  year: 2017
  end-page: 510
  ident: bb0030
  article-title: Brown propolis attenuates cerebral ischemia-induced oxidative damage via affecting antioxidant enzyme system in mice
  publication-title: Biomedicine & Pharmacotherapy
– volume: 877
  start-page: 733
  year: 2009
  end-page: 737
  ident: bb0660
  article-title: Isolation and purification of salvianolic acid a and salvianolic acid B from Salvia miltiorrhiza by high-speed counter-current chromatography and comparison of their antioxidant activity
  publication-title: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
– volume: 220
  start-page: 277
  year: 2012
  end-page: 290
  ident: bb0285
  article-title: Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons
  publication-title: Neuroscience
– volume: 303
  start-page: 53
  year: 2016
  end-page: 60
  ident: bb0925
  article-title: Delayed administration IL-1β neutralizing antibody improves cognitive function after transient global ischemia in rats
  publication-title: Behavioural Brain Research
– volume: 44
  start-page: 3580
  year: 2013
  end-page: 3583
  ident: bb0100
  article-title: Effects of MLC601 on early vascular events in patients after stroke: The CHIMES study
  publication-title: Stroke
– volume: 112
  start-page: 1
  year: 2007
  end-page: 25
  ident: bb0400
  article-title: (Peri)vascular production and action of pro-inflammatory cytokines in brain pathology
  publication-title: Clinical Science (London, England : 1979)
– volume: 33
  start-page: 223
  year: 2012
  end-page: 237
  ident: bb0405
  article-title: The role of glutamate in neuronal ischemic injury: The role of spark in fire
  publication-title: Neurological Sciences
– volume: 188
  start-page: 13
  year: 2016
  end-page: 20
  ident: bb0010
  article-title: Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia
  publication-title: Journal of Ethnopharmacology
– volume: 11
  start-page: 18
  year: 2010
  ident: bb0015
  article-title: DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression
  publication-title: BMC Molecular Biology
– volume: 140
  start-page: 64
  year: 2012
  end-page: 72
  ident: bb0880
  article-title: Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia
  publication-title: Journal of Ethnopharmacology
– volume: 9
  start-page: 478
  year: 2002
  end-page: 484
  ident: bb0265
  article-title: Stroke therapy in traditional Chinese medicine (TCM): Prospects for drug discovery and development
  publication-title: Phytomedicine
– volume: 37
  start-page: 619
  year: 2017
  end-page: 633
  ident: bb0875
  article-title: Tetramethylpyrazine protects against oxygen-glucose deprivation-induced brain microvascular endothelial cells injury via rho/rho-kinase Signaling pathway
  publication-title: Cellular and Molecular Neurobiology
– volume: 181
  start-page: 136
  year: 2016
  end-page: 145
  ident: bb0075
  article-title: Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats
  publication-title: Journal of Ethnopharmacology
– volume: 2013
  start-page: 951415
  year: 2013
  ident: bb0395
  article-title: Cerebroprotective effect of Moringa oleifera against focal ischemic stroke induced by middle cerebral artery occlusion
  publication-title: Oxidative Medicine and Cellular Longevity
– volume: 262
  start-page: 113164
  year: 2020
  ident: bb0655
  article-title: Evodiamine: A review of its pharmacology, toxicity, pharmacokinetics and preparation researches
  publication-title: Journal of Ethnopharmacology
– volume: 2014
  start-page: 370530
  year: 2014
  ident: bb0915
  article-title: Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice
  publication-title: Mediators of Inflammation
– volume: 6
  start-page: 193
  year: 2010
  end-page: 201
  ident: bb0565
  article-title: Microglia in neurodegenerative disease
  publication-title: Nature Reviews. Neurology
– volume: 49
  start-page: 1223
  year: 2018
  end-page: 1231
  ident: bb0375
  article-title: Critical role of Flavin and glutathione in complex I-mediated bioenergetic failure in brain ischemia/reperfusion injury
  publication-title: Stroke
– volume: 137
  start-page: 1360
  year: 2011
  end-page: 1365
  ident: bb0050
  article-title: Role of Ocimum basilicum L. in prevention of ischemia and reperfusion-induced cerebral damage, and motor dysfunctions in mice brain
  publication-title: Journal of Ethnopharmacology
– volume: 36
  start-page: 832
  year: 2015
  end-page: 840
  ident: bb0140
  article-title: Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway
  publication-title: Carcinogenesis
– volume: 37
  start-page: 3014
  year: 2006
  end-page: 3018
  ident: bb0420
  article-title: Baicalein and 12/15-lipoxygenase in the ischemic brain
  publication-title: Stroke
– volume: 17
  start-page: 963
  year: 2010
  end-page: 973
  ident: bb0300
  article-title: Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation
  publication-title: Phytomedicine
– volume: 33
  start-page: 256
  year: 2001
  end-page: 266
  ident: bb0640
  article-title: Dynamics of microglial activation: A confocal time-lapse analysis in hippocampal slices
  publication-title: Glia
– start-page: 24
  year: 2019
  ident: bb0735
  article-title: Schizandrin protects against OGD/R-Induced neuronal injury by suppressing autophagy: Involvement of the AMPK/mTOR Pathway
  publication-title: Molecules
– volume: 999
  start-page: 73
  year: 2004
  end-page: 80
  ident: bb0785
  article-title: Green tea polyphenol (−)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats
  publication-title: Brain Research
– volume: 12
  start-page: 251
  year: 2006
  end-page: 256
  ident: bb0665
  article-title: NALP3: A key player in caspase-1 activation
  publication-title: Journal of Endotoxin Research
– volume: 272
  start-page: 49
  year: 2013
  end-page: 60
  ident: bb0495
  article-title: Phycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats
  publication-title: Toxicology and Applied Pharmacology
– volume: 140
  start-page: 247
  year: 2012
  end-page: 254
  ident: bb0540
  article-title: Protective effect of hydroalcoholic extract of Mimusops elengi Linn. Flowers against middle cerebral artery occlusion induced brain injury in rats
  publication-title: Journal of Ethnopharmacology
– volume: 200
  start-page: 31
  year: 2017
  end-page: 44
  ident: bb0695
  article-title: Effect of Chinese herbal medicine on stroke patients with type 2 diabetes
  publication-title: Journal of Ethnopharmacology
– volume: 397
  start-page: 27
  year: 2008
  end-page: 31
  ident: bb0065
  article-title: Evaluation of lactate as a marker of metabolic stress and cause of secondary damage in acute ischemic stroke or TIA
  publication-title: Clinica Chimica Acta
– volume: 85
  start-page: 556
  year: 2017
  end-page: 563
  ident: bb0625
  article-title: Amelioration of ischemia-reperfusion induced functional and biochemical deficit in mice by Ocimum kilimandscharicum leaf extract
  publication-title: Biomedicine & Pharmacotherapy
– volume: 18
  start-page: 8
  year: 2018
  ident: bb0035
  article-title: Reperfusion therapy in acute ischemic stroke: Dawn of a new era?
  publication-title: BMC Neurology
– volume: 8
  start-page: 11
  year: 2007
  end-page: 13
  ident: bb0500
  article-title: Friendly and dangerous signals: Is the tissue in control?
  publication-title: Nature Immunology
– volume: 103
  start-page: 18314
  year: 2006
  end-page: 18319
  ident: bb0910
  article-title: Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
– volume: 13
  start-page: 11753
  year: 2012
  end-page: 11772
  ident: bb0510
  article-title: Neuroprotection for stroke: Current status and future perspectives
  publication-title: International Journal of Molecular Sciences
– volume: 26
  start-page: 733
  year: 2017
  end-page: 740
  ident: bb0005
  article-title: Matrix Metalloproteinase-9 and recovery of acute ischemic stroke
  publication-title: Journal of Stroke and Cerebrovascular Diseases
– volume: 43
  start-page: 1941
  year: 2012
  end-page: 1946
  ident: bb0270
  article-title: Distinctive effects of T cell subsets in neuronal injury induced by cocultured splenocytes in vitro and by in vivo stroke in mice
  publication-title: Stroke
– volume: 41
  start-page: 2661
  year: 2010
  end-page: 2668
  ident: bb0475
  article-title: Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function
  publication-title: Stroke
– volume: 87
  start-page: 779
  year: 2010
  end-page: 789
  ident: bb0360
  article-title: Inflammatory mechanisms in ischemic stroke: Role of inflammatory cells
  publication-title: Journal of Leukocyte Biology
– volume: 62
  start-page: 265
  year: 2013
  end-page: 270
  ident: bb0835
  article-title: The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats
  publication-title: Neurochemistry International
– volume: 151
  start-page: 176
  year: 2014
  end-page: 182
  ident: bb0870
  article-title: N-butanol soluble fraction of the water extract of Chinese toon fruit ameliorated focal brain ischemic insult in rats via inhibition of oxidative stress and inflammation
  publication-title: Journal of Ethnopharmacology
– volume: 18
  start-page: 5
  year: 2011
  end-page: 15
  ident: bb0760
  article-title: A positive role for c-Abl in Atm and Atr activation in DNA damage response
  publication-title: Cell Death and Differentiation
– volume: 2020
  start-page: 6859374
  year: 2020
  ident: bb0155
  article-title: A 90-day Oral toxicity study of the ethanol extract from Eupatorium japonicum Thunb and Foeniculum vulgare in rats
  publication-title: BioMed Research International
– volume: 24
  start-page: 1207
  year: 2010
  end-page: 1212
  ident: bb0070
  article-title: Neuroprotective effect of HT008-1, a prescription of traditional Korean medicine, on transient focal cerebral ischemia model in rats
  publication-title: Phytotherapy Research
– volume: 39
  start-page: 2268
  year: 2019
  end-page: 2276
  ident: bb0820
  article-title: Experimental ischemic stroke induces long-term T cell activation in the brain
  publication-title: Journal of Cerebral Blood Flow and Metabolism
– volume: 394
  start-page: 439
  year: 2010
  end-page: 442
  ident: bb0605
  article-title: Celastrol: Molecular targets of thunder god vine
  publication-title: Biochemical and Biophysical Research Communications
– volume: 125
  start-page: 3675
  year: 2012
  end-page: 3680
  ident: bb0740
  article-title: Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats
  publication-title: Chinese Medical Journal
– volume: 2014
  start-page: 807978
  year: 2014
  ident: bb0850
  article-title: The Yin and Yang of innate immunity in stroke
  publication-title: BioMed Research International
– volume: 2015
  start-page: 134685
  year: 2015
  ident: bb0755
  article-title: Neuroprotective effect of Xueshuantong for injection (lyophilized) in transient and permanent rat cerebral ischemia model
  publication-title: Evidence-based Complementary and Alternative Medicine
– volume: 47
  start-page: 1797
  year: 2019
  end-page: 1807
  ident: bb0770
  article-title: Scutellaria barbata D. Don (SBD) protects oxygen glucose deprivation/reperfusion-induced injuries of PC12 cells by up-regulating Nrf2
  publication-title: Artif Cells Nanomed Biotechnol
– volume: 71
  start-page: 1475
  year: 2019
  end-page: 1487
  ident: bb0825
  article-title: Chrysophanol: A review of its pharmacology, toxicity and pharmacokinetics
  publication-title: The Journal of Pharmacy and Pharmacology
– volume: 23
  start-page: 1137
  year: 2003
  end-page: 1150
  ident: bb0080
  article-title: Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation
  publication-title: Journal of Cerebral Blood Flow and Metabolism
– volume: 39
  start-page: 268
  year: 2017
  end-page: 275
  ident: bb0095
  article-title: Chrysophanol suppresses pro-inflammatory response in microglia via regulation of Drp1-dependent mitochondrial fission
  publication-title: Immunopharmacology and Immunotoxicology
– volume: 18
  start-page: 1058
  year: 2019
  end-page: 1066
  ident: bb0620
  article-title: Global brain inflammation in stroke
  publication-title: Lancet Neurology
– volume: 766
  start-page: 91
  year: 2015
  end-page: 98
  ident: bb0885
  article-title: Beneficial effect of magnesium lithospermate B on cerebral ischemia-reperfusion injury in rats involves the regulation of miR-107/glutamate transporter 1 pathway
  publication-title: European Journal of Pharmacology
– volume: 158
  start-page: 76
  year: 2014
  end-page: 84
  ident: bb0920
  article-title: Neuroprotective effects of Gualou Guizhi decoction in vivo and in vitro
  publication-title: J Ethnopharmacol
– volume: 14
  start-page: 1505
  year: 2011
  end-page: 1517
  ident: bb0105
  article-title: Oxidative stress in ischemic brain damage: Mechanisms of cell death and potential molecular targets for neuroprotection
  publication-title: Antioxidants & Redox Signaling
– volume: 38
  start-page: 517
  year: 2010
  end-page: 527
  ident: bb0900
  article-title: Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats
  publication-title: The American Journal of Chinese Medicine
– volume: 17
  start-page: 1145
  year: 2010
  end-page: 1149
  ident: bb0680
  article-title: The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats
  publication-title: Phytomedicine
– volume: 155
  start-page: 1053
  year: 2014
  end-page: 1060
  ident: bb0090
  article-title: Huangqi-Honghua combination and its main components ameliorate cerebral infarction with Qi deficiency and blood stasis syndrome by antioxidant action in rats
  publication-title: Journal of Ethnopharmacology
– volume: 1019
  start-page: 47
  year: 2004
  end-page: 54
  ident: bb0135
  article-title: Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats
  publication-title: Brain Research
– volume: 108
  start-page: 217
  year: 2006
  end-page: 222
  ident: bb0445
  article-title: Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism
  publication-title: Journal of Ethnopharmacology
– volume: 119
  start-page: 142
  year: 2016
  end-page: 158
  ident: bb0570
  article-title: Inflammatory disequilibrium in stroke
  publication-title: Circulation Research
– volume: 39
  start-page: 65
  year: 2011
  end-page: 81
  ident: bb0845
  article-title: Antioxidant activities of Dracocephalum tanguticum maxim extract and its up-regulation on the expression of neurotrophic factors in a rat model of permanent focal cerebral ischemia
  publication-title: The American Journal of Chinese Medicine
– volume: 8
  year: 2006
  ident: bb0675
  article-title: Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents
  publication-title: The AAPS Journal
– volume: 39
  start-page: 998
  year: 2018
  end-page: 1011
  ident: bb0730
  article-title: Xueshuantong injection (lyophilized) combined with salvianolate lyophilized injection protects against focal cerebral ischemia/reperfusion injury in rats through attenuation of oxidative stress
  publication-title: Acta Pharmacologica Sinica
– volume: 12
  start-page: 193
  year: 2010
  end-page: 204
  ident: bb0895
  article-title: Leukocyte recruitment and ischemic brain injury
  publication-title: Neuromolecular Medicine
– volume: 114
  start-page: 425
  year: 2017
  end-page: 427
  ident: bb0595
  article-title: Astrocytes fuel the fire of lymphocyte toxicity after stroke
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
– volume: 138
  start-page: 16
  year: 2018
  end-page: 22
  ident: bb0940
  article-title: Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion
  publication-title: Journal of Pharmacological Sciences
– volume: 354
  year: 2016
  ident: bb0765
  article-title: A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
  publication-title: Science
– volume: 1047
  start-page: 248
  year: 2005
  end-page: 258
  ident: bb0295
  article-title: Mitochondria and ischemia/reperfusion injury
  publication-title: Annals of the New York Academy of Sciences
– volume: 141
  start-page: 151
  year: 2012
  end-page: 157
  ident: bb0745
  article-title: Tong Luo Jiu Nao injection, a traditional Chinese medicinal preparation, inhibits MIP-1β expression in brain microvascular endothelial cells injured by oxygen-glucose deprivation
  publication-title: Journal of Ethnopharmacology
– volume: 21
  start-page: 298
  year: 2014
  end-page: 300
  ident: bb0450
  article-title: Changes in serum interleukin-33 levels in patients with acute cerebral infarction
  publication-title: Journal of Clinical Neuroscience
– volume: 17
  start-page: 258
  year: 2017
  ident: bb0725
  article-title: Neuroprotective effect of salvianolate lyophilized injection against cerebral ischemia in type 1 diabetic rats
  publication-title: BMC Complementary and Alternative Medicine
– volume: 50
  start-page: 4239
  year: 2012
  end-page: 4245
  ident: bb0415
  article-title: Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats
  publication-title: Food and Chemical Toxicology
– volume: 24
  start-page: 458
  year: 2004
  end-page: 466
  ident: bb0580
  article-title: Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia
  publication-title: Journal of Cerebral Blood Flow and Metabolism
– volume: 404
  start-page: 326
  year: 2019
  end-page: 337
  ident: bb0860
  article-title: Astragaloside IV protects primary cerebral cortical neurons from oxygen and glucose deprivation/Reoxygenation by activating the PKA/CREB pathway
  publication-title: Neuroscience
– volume: 39
  start-page: 3389
  year: 2008
  end-page: 3396
  ident: bb0600
  article-title: Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury
  publication-title: Stroke
– volume: 19
  start-page: 940
  year: 2012
  end-page: 946
  ident: bb0590
  article-title: The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model
  publication-title: Phytomedicine
– volume: 33
  start-page: 2329
  year: 2019
  end-page: 2336
  ident: bb0815
  article-title: Bilobalide protects astrocytes from oxygen and glucose deprivation-induced oxidative injury by upregulating manganese superoxide dismutase
  publication-title: Phytotherapy Research
– volume: 391
  start-page: 1526
  year: 2010
  end-page: 1530
  ident: bb0325
  article-title: Ischemia-activated microglia induces neuronal injury via activation of gp91phox NADPH oxidase
  publication-title: Biochemical and Biophysical Research Communications
– volume: 4
  start-page: 335
  year: 2005
  end-page: 340
  ident: bb0705
  article-title: Prostaglandins and cyclooxygenases in glial cells during brain inflammation
  publication-title: Current Drug Targets. Inflammation and Allergy
– volume: 47
  start-page: 229
  year: 2009
  end-page: 240
  ident: bb0750
  article-title: Protection by tetrahydroxystilbene glucoside against cerebral ischemia: Involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation
  publication-title: Free Radical Biology & Medicine
– volume: 8
  start-page: 834
  year: 2001
  end-page: 846
  ident: bb0575
  article-title: Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia
  publication-title: Neurobiology of Disease
– volume: 128
  start-page: 641
  year: 2014
  end-page: 649
  ident: bb0040
  article-title: The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse
  publication-title: Journal of Neurochemistry
– volume: 27
  start-page: 9278
  year: 2007
  end-page: 9293
  ident: bb0085
  article-title: Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury
  publication-title: The Journal of Neuroscience
– volume: 18
  start-page: 170
  year: 2011
  end-page: 175
  ident: bb0515
  article-title: The neuroprotective effect of olive leaf extract is related to improved blood-brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia
  publication-title: Phytomedicine
– volume: 137
  start-page: 1035
  year: 2011
  end-page: 1046
  ident: bb0460
  article-title: Effect of Tong Luo Jiu Nao on Aβ-degrading enzymes in AD rat brains
  publication-title: Journal of Ethnopharmacology
– volume: 2017
  start-page: 1832093
  year: 2017
  ident: bb0855
  article-title: YiQiFuMai powder injection protects against ischemic stroke via inhibiting neuronal apoptosis and PKCδ/Drp1-mediated excessive mitochondrial fission
  publication-title: Oxidative Medicine and Cellular Longevity
– volume: 157
  start-page: 247
  year: 2017
  end-page: 272
  ident: bb0485
  article-title: The biphasic function of microglia in ischemic stroke
  publication-title: Progress in Neurobiology
– volume: 31
  start-page: 1387
  year: 2008
  end-page: 1391
  ident: bb0110
  article-title: Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats
  publication-title: Biological & Pharmaceutical Bulletin
– volume: 20
  start-page: 544
  year: 2013
  end-page: 554
  ident: bb0235
  article-title: Curcuminoids limit neutrophil-mediated reperfusion injury in experimental stroke by targeting the endothelium
  publication-title: Microcirculation
– volume: 289
  start-page: 142
  year: 2015
  end-page: 154
  ident: bb0250
  article-title: Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction
  publication-title: Toxicology and Applied Pharmacology
– volume: 13
  year: 2018
  ident: bb0410
  article-title: Chinese herbal medicine reduced the risk of stroke in patients with Parkinson’s disease: A population-based retrospective cohort study from Taiwan
  publication-title: PLoS One
– volume: 35
  start-page: 2133
  year: 2015
  end-page: 2145
  ident: bb0185
  article-title: B-lymphocyte-mediated delayed cognitive impairment following stroke
  publication-title: The Journal of Neuroscience
– volume: 21
  start-page: 68
  year: 2013
  end-page: 74
  ident: bb0830
  article-title: Dragon’s blood dropping pills have protective effects on focal cerebral ischemia rats model
  publication-title: Phytomedicine
– volume: 23
  start-page: 608
  year: 2009
  end-page: 613
  ident: bb0180
  article-title: Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice
  publication-title: Phytotherapy Research
– volume: 118
  start-page: 665
  year: 2004
  end-page: 666
  ident: bb0320
  article-title: Ischemic stroke: “acidotoxicity” is a perpetrator
  publication-title: Cell
– volume: 222
  start-page: 249
  year: 2018
  end-page: 260
  ident: bb0255
  article-title: Traditional Mongolian medicine Eerdun Wurile improves stroke recovery through regulation of gene expression in rat brain
  publication-title: Journal of Ethnopharmacology
– volume: 43
  start-page: 1099
  year: 2015
  end-page: 1115
  ident: bb0380
  article-title: Anti-Neuroinflammatory effects of Uncaria sinensis in LPS-stimulated BV2 microglia cells and focal cerebral ischemic mice
  publication-title: The American Journal of Chinese Medicine
– volume: 16
  start-page: 150
  year: 2006
  end-page: 159
  ident: bb0630
  article-title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
  publication-title: Current Biology
– volume: 12
  start-page: 698
  year: 2013
  end-page: 704
  ident: bb0520
  article-title: ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage
  publication-title: Cell Cycle
– volume: 182
  start-page: 181
  year: 2016
  end-page: 189
  ident: bb0865
  article-title: Protective effect of Naoxintong against cerebral ischemia reperfusion injury in mice
  publication-title: Journal of Ethnopharmacology
– volume: 21
  start-page: 1038
  year: 2010
  end-page: 1044
  ident: bb0550
  article-title: Green tea polyphenol (−)-epigallocatechin gallate reduces matrix metalloproteinase-9 activity following transient focal cerebral ischemia
  publication-title: The Journal of Nutritional Biochemistry
– volume: 38
  start-page: 1617
  year: 2015
  end-page: 1623
  ident: bb0275
  article-title: Triptolide protects against ischemic stroke in rats
  publication-title: Inflammation
– volume: 35
  start-page: 441
  year: 2017
  end-page: 468
  ident: bb0150
  article-title: Microglia function in the central nervous system during health and neurodegeneration
  publication-title: Annual Review of Immunology
– volume: 1014
  start-page: 120
  year: 2004
  end-page: 130
  ident: bb0240
  article-title: Multiple modes of action of tacrolimus (FK506) for neuroprotective action on ischemic damage after transient focal cerebral ischemia in rats
  publication-title: Brain Research
– volume: 27
  start-page: 237
  year: 1997
  end-page: 245
  ident: bib947
  article-title: Enhanced Thrombogenicity and Altered Hemodynamics in the Cerebral Mïcrovasculature of Stroke-Prone Spontaneously Hypertensive Rats
  publication-title: Pathophysiology of Haemostasis and Thrombosis
– volume: 23
  year: 2018
  ident: bb0505
  article-title: Neuroprotective effects of Radix Scrophulariae on cerebral ischemia and reperfusion injury via MAPK pathways
  publication-title: Molecules
– volume: 129
  start-page: 239
  year: 2015
  end-page: 257
  ident: bb0560
  article-title: Neutrophil recruitment to the brain in mouse and human ischemic stroke
  publication-title: Acta Neuropathologica
– volume: 7
  start-page: 295
  year: 2016
  end-page: 306
  ident: bb0930
  article-title: Epigenetic regulation of oxidative stress in ischemic stroke
  publication-title: Aging and Disease
– volume: 77
  start-page: 156
  year: 2014
  end-page: 166
  ident: bb0215
  article-title: Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury
  publication-title: Neuropharmacology
– volume: 46
  start-page: 82
  year: 2018
  end-page: 88
  ident: bb0670
  article-title: Effect of combined treatment with MLC601 (NeuroAiDTM) and rehabilitation on post-stroke recovery: The CHIMES and CHIMES-E studies
  publication-title: Cerebrovascular Diseases
– volume: 18
  start-page: 391
  year: 2017
  end-page: 405
  ident: bb0020
  article-title: Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain
  publication-title: Cell Reports
– volume: 85
  start-page: 256
  year: 2017
  end-page: 263
  ident: bb0945
  article-title: Long-term pre-treatment of antioxidant Ginkgo biloba extract EGb-761 attenuates cerebral-ischemia-induced neuronal damage in aged mice
  publication-title: Biomedicine & Pharmacotherapy
– volume: 16
  start-page: 142
  year: 2019
  ident: bb0335
  article-title: Neuroinflammation: Friend and foe for ischemic stroke
  publication-title: Journal of Neuroinflammation
– volume: 38
  start-page: 51
  year: 2010
  end-page: 64
  ident: bb0685
  article-title: The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats
  publication-title: The American Journal of Chinese Medicine
– volume: 587
  start-page: 250
  year: 1992
  end-page: 256
  ident: bb0045
  article-title: Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
  publication-title: Brain Research
– volume: 15
  start-page: 78
  year: 2018
  ident: bb0345
  article-title: Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization
  publication-title: Journal of Neuroinflammation
– volume: 49
  start-page: 1223
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0375
  article-title: Critical role of Flavin and glutathione in complex I-mediated bioenergetic failure in brain ischemia/reperfusion injury
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.117.019687
– volume: 118
  start-page: 665
  year: 2004
  ident: 10.1016/j.pharmthera.2020.107695_bb0320
  article-title: Ischemic stroke: “acidotoxicity” is a perpetrator
  publication-title: Cell
  doi: 10.1016/j.cell.2004.09.004
– volume: 17
  start-page: 9803
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0720
  article-title: Neuroprotective activity of lavender oil on transient focal cerebral ischemia in mice
  publication-title: Molecules
  doi: 10.3390/molecules17089803
– volume: 8
  start-page: 186
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0480
  article-title: Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
  publication-title: Journal of Neuroinflammation
  doi: 10.1186/1742-2094-8-186
– volume: 766
  start-page: 91
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0885
  article-title: Beneficial effect of magnesium lithospermate B on cerebral ischemia-reperfusion injury in rats involves the regulation of miR-107/glutamate transporter 1 pathway
  publication-title: European Journal of Pharmacology
  doi: 10.1016/j.ejphar.2015.09.042
– volume: 12
  start-page: 698
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0520
  article-title: ATM-dependent phosphorylation of heterogeneous nuclear ribonucleoprotein K promotes p53 transcriptional activation in response to DNA damage
  publication-title: Cell Cycle
  doi: 10.4161/cc.23592
– volume: 112
  start-page: 1
  year: 2007
  ident: 10.1016/j.pharmthera.2020.107695_bb0400
  article-title: (Peri)vascular production and action of pro-inflammatory cytokines in brain pathology
  publication-title: Clinical Science (London, England : 1979)
  doi: 10.1042/CS20060043
– volume: 46
  start-page: 474
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0455
  article-title: Brain ischemia suppresses immunity in the periphery and brain via different neurogenic innervations
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.02.015
– volume: 67
  start-page: 101
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0775
  article-title: Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions
  publication-title: Brain, Behavior, and Immunity
  doi: 10.1016/j.bbi.2017.08.006
– volume: 62
  start-page: 265
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0835
  article-title: The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats
  publication-title: Neurochemistry International
  doi: 10.1016/j.neuint.2012.11.016
– volume: 12
  start-page: 236
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0365
  article-title: Increased BBB permeability enhances activation of microglia and exacerbates loss of dendritic spines after transient global cerebral ischemia
  publication-title: Frontiers in Cellular Neuroscience
  doi: 10.3389/fncel.2018.00236
– volume: 50
  start-page: 4239
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0415
  article-title: Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats
  publication-title: Food and Chemical Toxicology
  doi: 10.1016/j.fct.2012.08.047
– volume: 46
  start-page: 180
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0530
  article-title: Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection through HO1 and CRMP2
  publication-title: Neurobiology of Disease
  doi: 10.1016/j.nbd.2012.01.006
– volume: 46
  start-page: 520
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0055
  article-title: Delayed pituitary adenylate cyclase-activating polypeptide delivery after brain stroke improves functional recovery by inducing m2 microglia/macrophage polarization
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.114.006864
– volume: 20
  start-page: 1371
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0230
  article-title: Microglia turnover with aging and in an Alzheimer’s model via long-term in vivo single-cell imaging
  publication-title: Nature Neuroscience
  doi: 10.1038/nn.4631
– volume: 1682
  start-page: 61
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0790
  article-title: Patchouli alcohol protects against ischemia/reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice
  publication-title: Brain Research
  doi: 10.1016/j.brainres.2017.12.039
– volume: 237
  start-page: 453
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0315
  article-title: Cerebralcare granule® attenuates blood-brain barrier disruption after middle cerebral artery occlusion in rats
  publication-title: Experimental Neurology
  doi: 10.1016/j.expneurol.2012.07.017
– volume: 138
  start-page: 16
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0940
  article-title: Chrysophanol attenuates nitrosative/oxidative stress injury in a mouse model of focal cerebral ischemia/reperfusion
  publication-title: Journal of Pharmacological Sciences
  doi: 10.1016/j.jphs.2018.08.002
– volume: 7
  start-page: 97
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0195
  article-title: Immunomodulatory effect of hawthorn extract in an experimental stroke model
  publication-title: Journal of Neuroinflammation
  doi: 10.1186/1742-2094-7-97
– volume: 21
  start-page: 1038
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0550
  article-title: Green tea polyphenol (−)-epigallocatechin gallate reduces matrix metalloproteinase-9 activity following transient focal cerebral ischemia
  publication-title: The Journal of Nutritional Biochemistry
  doi: 10.1016/j.jnutbio.2009.08.009
– volume: 128
  start-page: 58
  year: 2002
  ident: 10.1016/j.pharmthera.2020.107695_bb0175
  article-title: The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier
  publication-title: Journal of Neuroimmunology
  doi: 10.1016/S0165-5728(02)00114-5
– volume: 188
  start-page: 259
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0890
  article-title: Protective effect of n-butyl alcohol extracts from Rhizoma Pinelliae Pedatisectae against cerebral ischemia-reperfusion injury in rats
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2016.04.046
– volume: 119
  start-page: 142
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0570
  article-title: Inflammatory disequilibrium in stroke
  publication-title: Circulation Research
  doi: 10.1161/CIRCRESAHA.116.308022
– volume: 587
  start-page: 250
  year: 1992
  ident: 10.1016/j.pharmthera.2020.107695_bb0045
  article-title: Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death
  publication-title: Brain Research
  doi: 10.1016/0006-8993(92)91004-X
– volume: 33
  start-page: 223
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0405
  article-title: The role of glutamate in neuronal ischemic injury: The role of spark in fire
  publication-title: Neurological Sciences
  doi: 10.1007/s10072-011-0828-5
– volume: 1014
  start-page: 120
  year: 2004
  ident: 10.1016/j.pharmthera.2020.107695_bb0240
  article-title: Multiple modes of action of tacrolimus (FK506) for neuroprotective action on ischemic damage after transient focal cerebral ischemia in rats
  publication-title: Brain Research
  doi: 10.1016/j.brainres.2004.04.031
– volume: 17
  start-page: 796
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0330
  article-title: The immunology of stroke: From mechanisms to translation
  publication-title: Nature Medicine
  doi: 10.1038/nm.2399
– volume: 999
  start-page: 73
  year: 2004
  ident: 10.1016/j.pharmthera.2020.107695_bb0785
  article-title: Green tea polyphenol (−)-epigallocatechin gallate attenuates the neuronal NADPH-d/nNOS expression in the nodose ganglion of acute hypoxic rats
  publication-title: Brain Research
  doi: 10.1016/j.brainres.2003.11.056
– volume: 18
  start-page: 391
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0020
  article-title: Coupled proliferation and apoptosis maintain the rapid turnover of microglia in the adult brain
  publication-title: Cell Reports
  doi: 10.1016/j.celrep.2016.12.041
– volume: 15
  start-page: 157
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0615
  article-title: Partially purified components of Uncaria sinensis attenuate blood brain barrier disruption after ischemic brain injury in mice
  publication-title: BMC Complementary and Alternative Medicine
  doi: 10.1186/s12906-015-0678-4
– volume: 26
  start-page: 330
  year: 1999
  ident: 10.1016/j.pharmthera.2020.107695_bib948
  article-title: Effects of voluntary exercise and L-arginine on thrombogenesis and microcirculation in stroke-prone spontaneously hypertensive rats
  publication-title: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  doi: 10.1046/j.1440-1681.1999.03037.x
– volume: 20
  start-page: 379
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0690
  article-title: Protective effect of embelin from Embelia ribes Burm. against transient global ischemia-induced brain damage in rats
  publication-title: Neurotoxicity Research
  doi: 10.1007/s12640-011-9258-7
– volume: 200
  start-page: 31
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0695
  article-title: Effect of Chinese herbal medicine on stroke patients with type 2 diabetes
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2017.02.024
– volume: 85
  start-page: 556
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0625
  article-title: Amelioration of ischemia-reperfusion induced functional and biochemical deficit in mice by Ocimum kilimandscharicum leaf extract
  publication-title: Biomedicine & Pharmacotherapy
  doi: 10.1016/j.biopha.2016.11.064
– volume: 125
  start-page: 3675
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0740
  article-title: Effects of Chinese medicine Tongxinluo on hyperglycemia and beta-cell damage in streptozotocin-induced diabetic rats
  publication-title: Chinese Medical Journal
– volume: 33
  start-page: 297
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0545
  article-title: Tertiary lymphoid organs in infection and autoimmunity
  publication-title: Trends in Immunology
  doi: 10.1016/j.it.2012.04.006
– volume: 21
  start-page: 2006
  year: 2020
  ident: 10.1016/j.pharmthera.2020.107695_bb0340
  article-title: Modulators of microglia activation and polarization in ischemic stroke (review)
  publication-title: Molecular Medicine Reports
– volume: 16
  start-page: 150
  year: 2006
  ident: 10.1016/j.pharmthera.2020.107695_bb0630
  article-title: Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
  publication-title: Current Biology
  doi: 10.1016/j.cub.2005.11.066
– volume: 1019
  start-page: 47
  year: 2004
  ident: 10.1016/j.pharmthera.2020.107695_bb0135
  article-title: Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats
  publication-title: Brain Research
  doi: 10.1016/j.brainres.2004.05.079
– volume: 13
  start-page: 11753
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0510
  article-title: Neuroprotection for stroke: Current status and future perspectives
  publication-title: International Journal of Molecular Sciences
  doi: 10.3390/ijms130911753
– volume: 262
  start-page: 113164
  year: 2020
  ident: 10.1016/j.pharmthera.2020.107695_bb0655
  article-title: Evodiamine: A review of its pharmacology, toxicity, pharmacokinetics and preparation researches
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2020.113164
– volume: 36
  start-page: 1105
  year: 2008
  ident: 10.1016/j.pharmthera.2020.107695_bb0125
  article-title: Ferulic acid reduces cerebral infarct through its antioxidative and anti-inflammatory effects following transient focal cerebral ischemia in rats
  publication-title: The American Journal of Chinese Medicine
  doi: 10.1142/S0192415X08006570
– volume: 27
  start-page: 754
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0805
  article-title: Britanin ameliorates cerebral ischemia-reperfusion injury by inducing the Nrf2 protective pathway
  publication-title: Antioxidants & Redox Signaling
  doi: 10.1089/ars.2016.6885
– volume: 43
  start-page: 1941
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0270
  article-title: Distinctive effects of T cell subsets in neuronal injury induced by cocultured splenocytes in vitro and by in vivo stroke in mice
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.112.656611
– volume: 19
  start-page: 1771
  year: 1998
  ident: 10.1016/j.pharmthera.2020.107695_bb0645
  article-title: Wide distribution of [3H](−)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/19.10.1771
– volume: 877
  start-page: 733
  year: 2009
  ident: 10.1016/j.pharmthera.2020.107695_bb0660
  article-title: Isolation and purification of salvianolic acid a and salvianolic acid B from Salvia miltiorrhiza by high-speed counter-current chromatography and comparison of their antioxidant activity
  publication-title: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
  doi: 10.1016/j.jchromb.2009.02.013
– volume: 10
  start-page: 184
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0210
  article-title: Effect of inflammation on the process of stroke rehabilitation and Poststroke depression
  publication-title: Frontiers in Psychiatry
  doi: 10.3389/fpsyt.2019.00184
– volume: 2013
  start-page: 951415
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0395
  article-title: Cerebroprotective effect of Moringa oleifera against focal ischemic stroke induced by middle cerebral artery occlusion
  publication-title: Oxidative Medicine and Cellular Longevity
  doi: 10.1155/2013/951415
– volume: 1464
  start-page: 8
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0440
  article-title: Protective effect of celastrol in rat cerebral ischemia model: Down-regulating p-JNK, p-c-Jun and NF-κB
  publication-title: Brain Research
  doi: 10.1016/j.brainres.2012.04.054
– volume: 12
  start-page: 193
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0895
  article-title: Leukocyte recruitment and ischemic brain injury
  publication-title: Neuromolecular Medicine
  doi: 10.1007/s12017-009-8074-1
– volume: 303
  start-page: 53
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0925
  article-title: Delayed administration IL-1β neutralizing antibody improves cognitive function after transient global ischemia in rats
  publication-title: Behavioural Brain Research
  doi: 10.1016/j.bbr.2016.01.028
– volume: 35
  start-page: 2133
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0185
  article-title: B-lymphocyte-mediated delayed cognitive impairment following stroke
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.4098-14.2015
– volume: 188
  start-page: 13
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0010
  article-title: Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2016.04.058
– volume: 47
  start-page: 229
  year: 2009
  ident: 10.1016/j.pharmthera.2020.107695_bb0750
  article-title: Protection by tetrahydroxystilbene glucoside against cerebral ischemia: Involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation
  publication-title: Free Radical Biology & Medicine
  doi: 10.1016/j.freeradbiomed.2009.02.027
– volume: 220
  start-page: 277
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0285
  article-title: Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2012.06.019
– volume: 2020
  start-page: 6859374
  year: 2020
  ident: 10.1016/j.pharmthera.2020.107695_bb0155
  article-title: A 90-day Oral toxicity study of the ethanol extract from Eupatorium japonicum Thunb and Foeniculum vulgare in rats
  publication-title: BioMed Research International
  doi: 10.1155/2020/6859374
– volume: 18
  start-page: 1058
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0620
  article-title: Global brain inflammation in stroke
  publication-title: Lancet Neurology
  doi: 10.1016/S1474-4422(19)30078-X
– volume: 103
  start-page: 18314
  year: 2006
  ident: 10.1016/j.pharmthera.2020.107695_bb0910
  article-title: Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
  doi: 10.1073/pnas.0606528103
– volume: 17
  start-page: 8178
  year: 1997
  ident: 10.1016/j.pharmthera.2020.107695_bb0245
  article-title: The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.17-21-08178.1997
– volume: 17
  start-page: 1145
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0680
  article-title: The effects of Tanshinone IIA on blood-brain barrier and brain edema after transient middle cerebral artery occlusion in rats
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2010.03.017
– volume: 33
  start-page: 2329
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0815
  article-title: Bilobalide protects astrocytes from oxygen and glucose deprivation-induced oxidative injury by upregulating manganese superoxide dismutase
  publication-title: Phytotherapy Research
  doi: 10.1002/ptr.6414
– volume: 24
  start-page: 458
  year: 2004
  ident: 10.1016/j.pharmthera.2020.107695_bb0580
  article-title: Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia
  publication-title: Journal of Cerebral Blood Flow and Metabolism
  doi: 10.1097/00004647-200404000-00011
– volume: 114
  start-page: 425
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0595
  article-title: Astrocytes fuel the fire of lymphocyte toxicity after stroke
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
  doi: 10.1073/pnas.1619813114
– volume: 299
  start-page: H1255
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0435
  article-title: Tongxinluo reduces myocardial no-reflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway
  publication-title: American Journal of Physiology. Heart and Circulatory Physiology
  doi: 10.1152/ajpheart.00459.2010
– volume: 21
  start-page: 68
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0830
  article-title: Dragon’s blood dropping pills have protective effects on focal cerebral ischemia rats model
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2013.08.007
– volume: 35
  start-page: 18
  issue: Suppl. 1
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0710
  article-title: Chinese medicine NeuroAiD efficacy stroke recovery-extension study (CHIMES-E study): An observational multicenter study to investigate the longer-term efficacy of NeuroAiD in stroke recovery
  publication-title: Cerebrovascular Diseases
  doi: 10.1159/000346233
– volume: 32
  start-page: 533
  issue: 4
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bib946
  article-title: Tongxinluo attenuates neuronal loss and enhances neurogenesis and angiogenesis in the ipsilateral thalamus and improves neurological outcome after focal cortical infarction in hypertensive rats
  publication-title: RESTORATIVE NEUROLOGY AND NEUROSCIENCE
  doi: 10.3233/RNN-140403
– volume: 222
  start-page: 249
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0255
  article-title: Traditional Mongolian medicine Eerdun Wurile improves stroke recovery through regulation of gene expression in rat brain
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2018.05.011
– volume: 4
  start-page: 335
  year: 2005
  ident: 10.1016/j.pharmthera.2020.107695_bb0705
  article-title: Prostaglandins and cyclooxygenases in glial cells during brain inflammation
  publication-title: Current Drug Targets. Inflammation and Allergy
  doi: 10.2174/1568010054022051
– volume: 20
  start-page: 544
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0235
  article-title: Curcuminoids limit neutrophil-mediated reperfusion injury in experimental stroke by targeting the endothelium
  publication-title: Microcirculation
  doi: 10.1111/micc.12054
– volume: 65
  start-page: 1533
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0425
  article-title: Intranasal Pretreatment with Z-Ligustilide, the Main volatile component of Rhizoma chuanxiong, confers prophylaxis against cerebral ischemia via Nrf2 and HSP70 Signaling pathways
  publication-title: Journal of Agricultural and Food Chemistry
  doi: 10.1021/acs.jafc.6b04979
– volume: 8
  start-page: 174
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0555
  article-title: Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice
  publication-title: Journal of Neuroinflammation
  doi: 10.1186/1742-2094-8-174
– volume: 6
  start-page: 4124
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0935
  article-title: Natural products triptolide, celastrol, and withaferin a inhibit the chaperone activity of peroxiredoxin I
  publication-title: Chemical Science
  doi: 10.1039/C5SC00633C
– volume: 21
  start-page: 298
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0450
  article-title: Changes in serum interleukin-33 levels in patients with acute cerebral infarction
  publication-title: Journal of Clinical Neuroscience
  doi: 10.1016/j.jocn.2013.04.036
– volume: 27
  start-page: 237
  year: 1997
  ident: 10.1016/j.pharmthera.2020.107695_bib947
  article-title: Enhanced Thrombogenicity and Altered Hemodynamics in the Cerebral Mïcrovasculature of Stroke-Prone Spontaneously Hypertensive Rats
  publication-title: Pathophysiology of Haemostasis and Thrombosis
  doi: 10.1159/000217462
– volume: 85
  start-page: 503
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0030
  article-title: Brown propolis attenuates cerebral ischemia-induced oxidative damage via affecting antioxidant enzyme system in mice
  publication-title: Biomedicine & Pharmacotherapy
  doi: 10.1016/j.biopha.2016.11.057
– volume: 43
  start-page: 3063
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0310
  article-title: Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.112.659656
– volume: 129
  start-page: 239
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0560
  article-title: Neutrophil recruitment to the brain in mouse and human ischemic stroke
  publication-title: Acta Neuropathologica
  doi: 10.1007/s00401-014-1381-0
– volume: 182
  start-page: 181
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0865
  article-title: Protective effect of Naoxintong against cerebral ischemia reperfusion injury in mice
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2016.02.022
– volume: 77
  start-page: 156
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0215
  article-title: Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2013.06.012
– volume: 228
  start-page: 58
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0715
  article-title: Achyranthes aspera Linn. Alleviates cerebral ischemia-reperfusion-induced neurocognitive, biochemical, morphological and histological alterations in Wistar rats
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2018.09.018
– volume: 44
  start-page: 3580
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0100
  article-title: Effects of MLC601 on early vascular events in patients after stroke: The CHIMES study
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.113.003226
– volume: 33
  start-page: 256
  year: 2001
  ident: 10.1016/j.pharmthera.2020.107695_bb0640
  article-title: Dynamics of microglial activation: A confocal time-lapse analysis in hippocampal slices
  publication-title: Glia
  doi: 10.1002/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J
– volume: 38
  start-page: 459
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0810
  article-title: Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation
  publication-title: Acta Pharmacologica Sinica
  doi: 10.1038/aps.2016.156
– volume: 38
  start-page: 1617
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0275
  article-title: Triptolide protects against ischemic stroke in rats
  publication-title: Inflammation
  doi: 10.1007/s10753-015-0137-x
– volume: 91
  start-page: 917
  year: 1997
  ident: 10.1016/j.pharmthera.2020.107695_bb0120
  article-title: Neuronal death in the hippocampus is promoted by plasmin-catalyzed degradation of laminin
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80483-3
– volume: 8
  year: 2006
  ident: 10.1016/j.pharmthera.2020.107695_bb0675
  article-title: Mitochondria-targeted peptide antioxidants: Novel neuroprotective agents
  publication-title: The AAPS Journal
– volume: 39
  start-page: 2268
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0820
  article-title: Experimental ischemic stroke induces long-term T cell activation in the brain
  publication-title: Journal of Cerebral Blood Flow and Metabolism
  doi: 10.1177/0271678X18792372
– volume: 113
  start-page: 199
  year: 2007
  ident: 10.1016/j.pharmthera.2020.107695_bb0650
  article-title: Buyang Huanwu decoction promotes growth and differentiation of neural progenitor cells: Using a serum pharmacological method
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2007.05.018
– volume: 39
  start-page: 111
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0350
  article-title: Cerebral protection of salvianolic acid a by the inhibition of granulocyte adherence
  publication-title: The American Journal of Chinese Medicine
  doi: 10.1142/S0192415X11008683
– volume: 18
  start-page: 170
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0515
  article-title: The neuroprotective effect of olive leaf extract is related to improved blood-brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2010.06.007
– volume: 97
  start-page: 958
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0635
  article-title: An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis
  publication-title: Biomedicine & Pharmacotherapy
  doi: 10.1016/j.biopha.2017.10.145
– volume: 71
  start-page: 1475
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0825
  article-title: Chrysophanol: A review of its pharmacology, toxicity and pharmacokinetics
  publication-title: The Journal of Pharmacy and Pharmacology
  doi: 10.1111/jphp.13143
– volume: 9
  start-page: 249
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0840
  article-title: Refocusing neuroprotection in cerebral reperfusion era: New challenges and strategies
  publication-title: Frontiers in Neurology
  doi: 10.3389/fneur.2018.00249
– volume: 25
  start-page: 8
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0490
  article-title: Salvianolic acid a inhibits calpain activation and eNOS uncoupling during focal cerebral ischemia in mice
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2016.12.004
– volume: 24
  start-page: 547
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0355
  article-title: Cornin ameliorates cerebral infarction in rats by antioxidant action and stabilization of mitochondrial function
  publication-title: Phytotherapy Research
  doi: 10.1002/ptr.2978
– volume: 397
  start-page: 27
  year: 2008
  ident: 10.1016/j.pharmthera.2020.107695_bb0065
  article-title: Evaluation of lactate as a marker of metabolic stress and cause of secondary damage in acute ischemic stroke or TIA
  publication-title: Clinica Chimica Acta
  doi: 10.1016/j.cca.2008.07.016
– volume: 391
  start-page: 1526
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0325
  article-title: Ischemia-activated microglia induces neuronal injury via activation of gp91phox NADPH oxidase
  publication-title: Biochemical and Biophysical Research Communications
  doi: 10.1016/j.bbrc.2009.12.114
– volume: 14
  start-page: 1505
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0105
  article-title: Oxidative stress in ischemic brain damage: Mechanisms of cell death and potential molecular targets for neuroprotection
  publication-title: Antioxidants & Redox Signaling
  doi: 10.1089/ars.2010.3576
– volume: 23
  start-page: 1137
  year: 2003
  ident: 10.1016/j.pharmthera.2020.107695_bb0080
  article-title: Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation
  publication-title: Journal of Cerebral Blood Flow and Metabolism
  doi: 10.1097/01.WCB.0000087090.01171.E7
– volume: 36
  start-page: 832
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0140
  article-title: Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgv079
– volume: 155
  start-page: 1053
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0090
  article-title: Huangqi-Honghua combination and its main components ameliorate cerebral infarction with Qi deficiency and blood stasis syndrome by antioxidant action in rats
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2014.05.061
– start-page: 24
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0735
  article-title: Schizandrin protects against OGD/R-Induced neuronal injury by suppressing autophagy: Involvement of the AMPK/mTOR Pathway
  publication-title: Molecules
– volume: 404
  start-page: 326
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0860
  article-title: Astragaloside IV protects primary cerebral cortical neurons from oxygen and glucose deprivation/Reoxygenation by activating the PKA/CREB pathway
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2019.01.040
– volume: 23
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0505
  article-title: Neuroprotective effects of Radix Scrophulariae on cerebral ischemia and reperfusion injury via MAPK pathways
  publication-title: Molecules
  doi: 10.3390/molecules23092401
– volume: 27
  start-page: 799
  year: 2009
  ident: 10.1016/j.pharmthera.2020.107695_bb0200
  article-title: Hawthorn extract reduces infarct volume and improves neurological score by reducing oxidative stress in rat brain following middle cerebral artery occlusion
  publication-title: International Journal of Developmental Neuroscience
  doi: 10.1016/j.ijdevneu.2009.08.008
– volume: 85
  start-page: 256
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0945
  article-title: Long-term pre-treatment of antioxidant Ginkgo biloba extract EGb-761 attenuates cerebral-ischemia-induced neuronal damage in aged mice
  publication-title: Biomedicine & Pharmacotherapy
  doi: 10.1016/j.biopha.2016.11.013
– volume: 73
  start-page: 682
  year: 2007
  ident: 10.1016/j.pharmthera.2020.107695_bb0305
  article-title: Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: Reduced neutrophil activation and anti-oxidant actions
  publication-title: Biochemical Pharmacology
  doi: 10.1016/j.bcp.2006.11.009
– volume: 158
  start-page: 76
  issue: Pt A
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0920
  article-title: Neuroprotective effects of Gualou Guizhi decoction in vivo and in vitro
  publication-title: J Ethnopharmacol
  doi: 10.1016/j.jep.2014.10.020
– volume: 124
  start-page: 103
  year: 2009
  ident: 10.1016/j.pharmthera.2020.107695_bb0115
  article-title: Chinese medicine tongxinluo significantly lowers serum lipid levels and stabilizes vulnerable plaques in a rabbit model
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2009.04.009
– volume: 41
  start-page: 99
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0370
  article-title: Effect of the semen extract of Thuja orientalis on inflammatory responses in transient focal cerebral ischemia rat model and LPS-stimulated BV-2 microglia
  publication-title: The American Journal of Chinese Medicine
  doi: 10.1142/S0192415X13500080
– volume: 4
  start-page: 399
  year: 2003
  ident: 10.1016/j.pharmthera.2020.107695_bb0470
  article-title: Mechanisms, challenges and opportunities in stroke
  publication-title: Nature Reviews. Neuroscience
  doi: 10.1038/nrn1106
– volume: 157
  start-page: 247
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0485
  article-title: The biphasic function of microglia in ischemic stroke
  publication-title: Progress in Neurobiology
  doi: 10.1016/j.pneurobio.2016.01.005
– volume: 41
  start-page: 2661
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0475
  article-title: Leonurine protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.110.589895
– volume: 13
  start-page: 57
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0025
  article-title: Drug treatment of acute ischemic stroke
  publication-title: American Journal of Cardiovascular Drugs
  doi: 10.1007/s40256-013-0007-6
– volume: 49
  start-page: 945
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0535
  article-title: Heme oxygenase 1-mediated neurogenesis is enhanced by Ginkgo biloba (EGb 761®) after permanent ischemic stroke in mice
  publication-title: Molecular Neurobiology
  doi: 10.1007/s12035-013-8572-x
– volume: 148
  start-page: 632
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0465
  article-title: The protective role of Tongxinluo on blood-brain barrier after ischemia-reperfusion brain injury
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2013.05.018
– volume: 35
  start-page: 441
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0150
  article-title: Microglia function in the central nervous system during health and neurodegeneration
  publication-title: Annual Review of Immunology
  doi: 10.1146/annurev-immunol-051116-052358
– volume: 43
  start-page: 1099
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0380
  article-title: Anti-Neuroinflammatory effects of Uncaria sinensis in LPS-stimulated BV2 microglia cells and focal cerebral ischemic mice
  publication-title: The American Journal of Chinese Medicine
  doi: 10.1142/S0192415X15500639
– volume: 39
  start-page: 268
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0095
  article-title: Chrysophanol suppresses pro-inflammatory response in microglia via regulation of Drp1-dependent mitochondrial fission
  publication-title: Immunopharmacology and Immunotoxicology
  doi: 10.1080/08923973.2017.1344988
– volume: 137
  start-page: 1035
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0460
  article-title: Effect of Tong Luo Jiu Nao on Aβ-degrading enzymes in AD rat brains
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2011.07.031
– volume: 140
  start-page: 247
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0540
  article-title: Protective effect of hydroalcoholic extract of Mimusops elengi Linn. Flowers against middle cerebral artery occlusion induced brain injury in rats
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2012.01.012
– volume: 2014
  start-page: 370530
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0915
  article-title: Chrysophanol inhibits NALP3 inflammasome activation and ameliorates cerebral ischemia/reperfusion in mice
  publication-title: Mediators of Inflammation
  doi: 10.1155/2014/370530
– volume: 38
  start-page: 517
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0900
  article-title: Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats
  publication-title: The American Journal of Chinese Medicine
  doi: 10.1142/S0192415X10008020
– volume: 16
  start-page: 142
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0335
  article-title: Neuroinflammation: Friend and foe for ischemic stroke
  publication-title: Journal of Neuroinflammation
  doi: 10.1186/s12974-019-1516-2
– volume: 6
  start-page: 193
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0565
  article-title: Microglia in neurodegenerative disease
  publication-title: Nature Reviews. Neurology
  doi: 10.1038/nrneurol.2010.17
– volume: 18
  start-page: 1358
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0160
  article-title: A therapeutic target of cerebral Hemorrhagic stroke: Matrix metalloproteinase- 9
  publication-title: Current Drug Targets
  doi: 10.2174/1389450118666170427151657
– volume: 18
  start-page: 8
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0035
  article-title: Reperfusion therapy in acute ischemic stroke: Dawn of a new era?
  publication-title: BMC Neurology
  doi: 10.1186/s12883-017-1007-y
– volume: 151
  start-page: 176
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0870
  article-title: N-butanol soluble fraction of the water extract of Chinese toon fruit ameliorated focal brain ischemic insult in rats via inhibition of oxidative stress and inflammation
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2013.10.026
– volume: 47
  start-page: 1797
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0770
  article-title: Scutellaria barbata D. Don (SBD) protects oxygen glucose deprivation/reperfusion-induced injuries of PC12 cells by up-regulating Nrf2
  publication-title: Artif Cells Nanomed Biotechnol
  doi: 10.1080/21691401.2019.1610413
– volume: 9
  start-page: 18
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0525
  article-title: Interleukin-1 and acute brain injury
  publication-title: Frontiers in Cellular Neuroscience
  doi: 10.3389/fncel.2015.00018
– volume: 12
  start-page: 251
  year: 2006
  ident: 10.1016/j.pharmthera.2020.107695_bb0665
  article-title: NALP3: A key player in caspase-1 activation
  publication-title: Journal of Endotoxin Research
  doi: 10.1177/09680519060120040701
– volume: 15
  start-page: 78
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0345
  article-title: Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization
  publication-title: Journal of Neuroinflammation
  doi: 10.1186/s12974-018-1124-6
– volume: 141
  start-page: 151
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0745
  article-title: Tong Luo Jiu Nao injection, a traditional Chinese medicinal preparation, inhibits MIP-1β expression in brain microvascular endothelial cells injured by oxygen-glucose deprivation
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2012.02.013
– volume: 394
  start-page: 439
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0605
  article-title: Celastrol: Molecular targets of thunder god vine
  publication-title: Biochemical and Biophysical Research Communications
  doi: 10.1016/j.bbrc.2010.03.050
– volume: 2017
  start-page: 1832093
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0855
  article-title: YiQiFuMai powder injection protects against ischemic stroke via inhibiting neuronal apoptosis and PKCδ/Drp1-mediated excessive mitochondrial fission
  publication-title: Oxidative Medicine and Cellular Longevity
  doi: 10.1155/2017/1832093
– volume: 26
  start-page: 733
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0005
  article-title: Matrix Metalloproteinase-9 and recovery of acute ischemic stroke
  publication-title: Journal of Stroke and Cerebrovascular Diseases
  doi: 10.1016/j.jstrokecerebrovasdis.2016.09.043
– volume: 137
  start-page: 1360
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0050
  article-title: Role of Ocimum basilicum L. in prevention of ischemia and reperfusion-induced cerebral damage, and motor dysfunctions in mice brain
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2011.07.066
– volume: 24
  start-page: 1207
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0070
  article-title: Neuroprotective effect of HT008-1, a prescription of traditional Korean medicine, on transient focal cerebral ischemia model in rats
  publication-title: Phytotherapy Research
  doi: 10.1002/ptr.2908
– volume: 8
  start-page: 11
  year: 2007
  ident: 10.1016/j.pharmthera.2020.107695_bb0500
  article-title: Friendly and dangerous signals: Is the tissue in control?
  publication-title: Nature Immunology
  doi: 10.1038/ni0107-11
– volume: 6
  start-page: 11
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0800
  article-title: Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
  publication-title: Molecular Neurodegeneration
  doi: 10.1186/1750-1326-6-11
– volume: 55
  start-page: 310
  year: 2008
  ident: 10.1016/j.pharmthera.2020.107695_bb0190
  article-title: Mechanisms of ischemic brain damage
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2008.01.005
– volume: 272
  start-page: 49
  year: 2013
  ident: 10.1016/j.pharmthera.2020.107695_bb0495
  article-title: Phycocyanobilin promotes PC12 cell survival and modulates immune and inflammatory genes and oxidative stress markers in acute cerebral hypoperfusion in rats
  publication-title: Toxicology and Applied Pharmacology
  doi: 10.1016/j.taap.2013.05.021
– volume: 140
  start-page: 64
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0880
  article-title: Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2011.12.023
– volume: 7
  start-page: 614
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0585
  article-title: Serum IL-33 is a novel diagnostic and prognostic biomarker in acute ischemic stroke
  publication-title: Aging and Disease
  doi: 10.14336/AD.2016.0207
– volume: 34
  start-page: 450
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0145
  article-title: Immune cell infiltration in malignant middle cerebral artery infarction: Comparison with transient cerebral ischemia
  publication-title: Journal of Cerebral Blood Flow and Metabolism
  doi: 10.1038/jcbfm.2013.217
– volume: 39
  start-page: 65
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0845
  article-title: Antioxidant activities of Dracocephalum tanguticum maxim extract and its up-regulation on the expression of neurotrophic factors in a rat model of permanent focal cerebral ischemia
  publication-title: The American Journal of Chinese Medicine
  doi: 10.1142/S0192415X11008658
– volume: 58
  start-page: 245
  year: 1999
  ident: 10.1016/j.pharmthera.2020.107695_bb0610
  article-title: Cytokine-induced acute inflammation in the brain and spinal cord
  publication-title: Journal of Neuropathology and Experimental Neurology
  doi: 10.1097/00005072-199903000-00004
– volume: 274
  start-page: 132
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0170
  article-title: Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation
  publication-title: Journal of Neuroimmunology
  doi: 10.1016/j.jneuroim.2014.07.009
– volume: 7
  start-page: 295
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0930
  article-title: Epigenetic regulation of oxidative stress in ischemic stroke
  publication-title: Aging and Disease
  doi: 10.14336/AD.2015.1009
– volume: 37
  start-page: 619
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0875
  article-title: Tetramethylpyrazine protects against oxygen-glucose deprivation-induced brain microvascular endothelial cells injury via rho/rho-kinase Signaling pathway
  publication-title: Cellular and Molecular Neurobiology
  doi: 10.1007/s10571-016-0398-4
– volume: 63
  start-page: 695
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0130
  article-title: Amelioration of cerebral infarction and improvement of neurological deficit by a Korean herbal medicine, modified Bo-Yang-Hwan-O-Tang
  publication-title: The Journal of Pharmacy and Pharmacology
  doi: 10.1111/j.2042-7158.2011.01254.x
– volume: 87
  start-page: 779
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0360
  article-title: Inflammatory mechanisms in ischemic stroke: Role of inflammatory cells
  publication-title: Journal of Leukocyte Biology
  doi: 10.1189/jlb.1109766
– volume: 1047
  start-page: 248
  year: 2005
  ident: 10.1016/j.pharmthera.2020.107695_bb0295
  article-title: Mitochondria and ischemia/reperfusion injury
  publication-title: Annals of the New York Academy of Sciences
  doi: 10.1196/annals.1341.022
– volume: 8
  start-page: 18062
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0795
  article-title: The traditional Chinese medicine MLC901 inhibits inflammation processes after focal cerebral ischemia
  publication-title: Scientific Reports
  doi: 10.1038/s41598-018-36138-0
– volume: 11
  start-page: 18
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0015
  article-title: DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression
  publication-title: BMC Molecular Biology
  doi: 10.1186/1471-2199-11-18
– volume: 188
  start-page: 123
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0390
  article-title: Neuroprotective effects of Danggui-Jakyak-san on rat stroke model through antioxidant/antiapoptotic pathway
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2016.04.060
– volume: 19
  start-page: 940
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0590
  article-title: The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2012.06.003
– volume: 18
  start-page: 5
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0760
  article-title: A positive role for c-Abl in Atm and Atr activation in DNA damage response
  publication-title: Cell Death and Differentiation
  doi: 10.1038/cdd.2010.106
– volume: 289
  start-page: 142
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0250
  article-title: Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction
  publication-title: Toxicology and Applied Pharmacology
  doi: 10.1016/j.taap.2015.10.001
– volume: 2014
  start-page: 807978
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0850
  article-title: The Yin and Yang of innate immunity in stroke
  publication-title: BioMed Research International
  doi: 10.1155/2014/807978
– volume: 9
  start-page: 478
  year: 2002
  ident: 10.1016/j.pharmthera.2020.107695_bb0265
  article-title: Stroke therapy in traditional Chinese medicine (TCM): Prospects for drug discovery and development
  publication-title: Phytomedicine
  doi: 10.1078/09447110260571760
– volume: 354
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0765
  article-title: A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
  publication-title: Science
  doi: 10.1126/science.aad6872
– volume: 2015
  start-page: 134685
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0755
  article-title: Neuroprotective effect of Xueshuantong for injection (lyophilized) in transient and permanent rat cerebral ischemia model
  publication-title: Evidence-based Complementary and Alternative Medicine
  doi: 10.1155/2015/134685
– volume: 100
  start-page: 739
  issue: 1985
  year: 2006
  ident: 10.1016/j.pharmthera.2020.107695_bb0220
  article-title: Reactive oxygen species: Influence on cerebral vascular tone
  publication-title: Journal of Applied Physiology
  doi: 10.1152/japplphysiol.01044.2005
– volume: 91
  start-page: 123
  year: 2015
  ident: 10.1016/j.pharmthera.2020.107695_bb0260
  article-title: Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2014.11.020
– volume: 108
  start-page: 217
  year: 2006
  ident: 10.1016/j.pharmthera.2020.107695_bb0445
  article-title: Protective effect of tanshinone IIA on human umbilical vein endothelial cell injured by hydrogen peroxide and its mechanism
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2006.05.004
– volume: 16
  start-page: 6322
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0060
  article-title: Rhinacanthus nasutus protects cultured neuronal cells against hypoxia induced cell death
  publication-title: Molecules
  doi: 10.3390/molecules16086322
– volume: 290
  start-page: 1768
  year: 2000
  ident: 10.1016/j.pharmthera.2020.107695_bb0290
  article-title: Down-regulation of the macrophage lineage through interaction with OX2 (CD200)
  publication-title: Science
  doi: 10.1126/science.290.5497.1768
– volume: 30
  start-page: 1954
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0225
  article-title: Aqueous and Ethanolic extracts of Boswellia serrata protect against focal cerebral ischemia and reperfusion injury in rats
  publication-title: Phytotherapy Research
  doi: 10.1002/ptr.5701
– volume: 17
  start-page: 258
  year: 2017
  ident: 10.1016/j.pharmthera.2020.107695_bb0725
  article-title: Neuroprotective effect of salvianolate lyophilized injection against cerebral ischemia in type 1 diabetic rats
  publication-title: BMC Complementary and Alternative Medicine
  doi: 10.1186/s12906-017-1738-8
– volume: 134
  start-page: 208
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0430
  article-title: Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2017.11.011
– volume: 23
  start-page: 608
  year: 2009
  ident: 10.1016/j.pharmthera.2020.107695_bb0180
  article-title: Neuroprotective effects of Tanshinone IIA on permanent focal cerebral ischemia in mice
  publication-title: Phytotherapy Research
  doi: 10.1002/ptr.2615
– volume: 128
  start-page: 641
  year: 2014
  ident: 10.1016/j.pharmthera.2020.107695_bb0040
  article-title: The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse
  publication-title: Journal of Neurochemistry
  doi: 10.1111/jnc.12509
– volume: 364
  start-page: 656
  year: 2011
  ident: 10.1016/j.pharmthera.2020.107695_bb0205
  article-title: Hypoxia and inflammation
  publication-title: The New England Journal of Medicine
  doi: 10.1056/NEJMra0910283
– volume: 38
  start-page: 51
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0685
  article-title: The anti-inflammatory effect of paeoniflorin on cerebral infarction induced by ischemia-reperfusion injury in Sprague-Dawley rats
  publication-title: The American Journal of Chinese Medicine
  doi: 10.1142/S0192415X10007786
– volume: 181
  start-page: 136
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0075
  article-title: Tongxinluo reduces brain edema and inhibits post-ischemic inflammation after middle cerebral artery occlusion in rats
  publication-title: Journal of Ethnopharmacology
  doi: 10.1016/j.jep.2016.01.026
– volume: 13
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0410
  article-title: Chinese herbal medicine reduced the risk of stroke in patients with Parkinson’s disease: A population-based retrospective cohort study from Taiwan
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0203473
– volume: 17
  start-page: 963
  year: 2010
  ident: 10.1016/j.pharmthera.2020.107695_bb0300
  article-title: Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2010.03.012
– volume: 25
  start-page: 241
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0385
  article-title: Inflammation after ischemic stroke: The role of leukocytes and glial cells
  publication-title: Exp Neurobiol
  doi: 10.5607/en.2016.25.5.241
– volume: 775
  start-page: 113
  year: 2016
  ident: 10.1016/j.pharmthera.2020.107695_bb0905
  article-title: Oleuropein, a natural extract from plants, offers neuroprotection in focal cerebral ischemia/reperfusion injury in mice
  publication-title: European Journal of Pharmacology
  doi: 10.1016/j.ejphar.2016.02.027
– volume: 10
  start-page: 593
  year: 2019
  ident: 10.1016/j.pharmthera.2020.107695_bb0700
  article-title: Neuroprotective effects and Hepatorenal toxicity of Angong Niuhuang Wan against ischemia-reperfusion brain injury in rats
  publication-title: Frontiers in Pharmacology
  doi: 10.3389/fphar.2019.00593
– volume: 48
  start-page: 252
  year: 2020
  ident: 10.1016/j.pharmthera.2020.107695_bb0280
  article-title: Taraxasterol protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activation of Nrf2 signalling pathway
  publication-title: Artif Cells Nanomed Biotechnol
  doi: 10.1080/21691401.2019.1699831
– volume: 103
  start-page: 239
  year: 2000
  ident: 10.1016/j.pharmthera.2020.107695_bb0165
  article-title: Signal transduction by the JNK group of MAP kinases
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)00116-1
– volume: 31
  start-page: 1387
  year: 2008
  ident: 10.1016/j.pharmthera.2020.107695_bb0110
  article-title: Schisandrin B enhances cerebral mitochondrial antioxidant status and structural integrity, and protects against cerebral ischemia/reperfusion injury in rats
  publication-title: Biological & Pharmaceutical Bulletin
  doi: 10.1248/bpb.31.1387
– volume: 37
  start-page: 3014
  year: 2006
  ident: 10.1016/j.pharmthera.2020.107695_bb0420
  article-title: Baicalein and 12/15-lipoxygenase in the ischemic brain
  publication-title: Stroke
  doi: 10.1161/01.STR.0000249004.25444.a5
– volume: 39
  start-page: 3389
  year: 2008
  ident: 10.1016/j.pharmthera.2020.107695_bb0600
  article-title: Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.108.523480
– volume: 27
  start-page: 9278
  year: 2007
  ident: 10.1016/j.pharmthera.2020.107695_bb0085
  article-title: Critical role of calpain I in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury
  publication-title: The Journal of Neuroscience
  doi: 10.1523/JNEUROSCI.2826-07.2007
– volume: 8
  start-page: 834
  year: 2001
  ident: 10.1016/j.pharmthera.2020.107695_bb0575
  article-title: Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia
  publication-title: Neurobiology of Disease
  doi: 10.1006/nbdi.2001.0435
– volume: 46
  start-page: 82
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0670
  article-title: Effect of combined treatment with MLC601 (NeuroAiDTM) and rehabilitation on post-stroke recovery: The CHIMES and CHIMES-E studies
  publication-title: Cerebrovascular Diseases
  doi: 10.1159/000492625
– volume: 123
  start-page: 116
  issue: Suppl. 2
  year: 2012
  ident: 10.1016/j.pharmthera.2020.107695_bb0780
  article-title: Post-ischemic vascular adhesion protein-1 inhibition provides neuroprotection in a rat temporary middle cerebral artery occlusion model
  publication-title: Journal of Neurochemistry
  doi: 10.1111/j.1471-4159.2012.07950.x
– volume: 39
  start-page: 998
  year: 2018
  ident: 10.1016/j.pharmthera.2020.107695_bb0730
  article-title: Xueshuantong injection (lyophilized) combined with salvianolate lyophilized injection protects against focal cerebral ischemia/reperfusion injury in rats through attenuation of oxidative stress
  publication-title: Acta Pharmacologica Sinica
  doi: 10.1038/aps.2017.128
SSID ssj0004402
Score 2.6589162
SecondaryResourceType review_article
Snippet There is a growing interest in using natural medicines to treat stroke as the leading cause of disability worldwide. Especially plant-derived natural medicines...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 107695
SubjectTerms Cerebral ischemia
Natural medicine
Neuroprotection
Title Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective
URI https://dx.doi.org/10.1016/j.pharmthera.2020.107695
https://www.ncbi.nlm.nih.gov/pubmed/32998014
https://www.proquest.com/docview/2447840622
Volume 216
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Na8IwFA_iLruMfc99SAbDk51tkzbtdhKZuI2JoIK3kLQpuI0qth687G_fSz8sgw2EHRsSmub3mvcLee_3ELoDiC1pEWqoiNoGeAhigClHBpF-KG0qBaE6wflt6A6m9GXmzGqoV-bC6LDKYu_P9_Rsty5aOsVqdpbzeWcMZIUw2wEXRsAROVoTlFKmrfz-qwrzoDSLO9SdDd27iObJY7yWWh46S3SCk6Ktm5mrK0387qL-oqCZK-ofooOCQ-JuPs0jVFPxMWqNchHqTRtPqpyqpI1beFTJU29O0HgoMq0NXF6r43mMM1nLQrMBkMJAZfEcDr46dB4n6WrxoR5wryy8kmARhxi6l3map2jaf5r0BkZRWsEIqG-mRuBLy1YyADrgmW5II-ZFJAAuEXiBJ11hqSgMndCTuji17UQOkUwpCYsjZQQokjNUjxexukCYSVP4StEwMEOqhOUJyYAzwD4CzEh4bgOxcjV5UOiO6_IXn7wMMHvnFQ5c48BzHBrI2o5c5tobO4x5LAHjP-yIg4vYYfRtiTGH30zfnYhYLdYJhy9icBZ2bbuBznPwt3Mi4NK1CM_lv959hfb1Ux4qc43q6WqtboDwpLKZWXQT7XWfXwfDb6nGAoA
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFD7o9qAv4t15jSA-WbY26WX6JMPRqSuDTfAtJG0KU-nGLg_795606YagMPA1zaFpvjTnCznnOwA3CLEtbcoslTLHQg9BLVzKqUVlM5EOk4IyneDcjbzwjT2_u-8b0CpzYXRYpdn7iz09361NS93MZn08HNb7SFao77jowig6IpdtQlWrU7kVqD52XsJolR7J8tBD3d_SBiagpwjzGmuF6DzXCQ-Ljm72PV1s4ncv9RcLzb1Rexd2DI0kj8VI92BDZftw2yt0qBd3ZLBKq5rekVvSWylULw6gH4lcboOUN-tkmJFc2dLINiBYBNksGeLZV0fPk-lsMvpU96RV1l6ZEpElBLuXqZqH8NZ-GrRCy1RXsGLWbMysuCltR8kYGUHQ8BKW-kFKY6QTcRAH0hO2SpPETQKp61M7bupS6SslcXKkTBFIegSVbJSpEyC-bIimUiyJGwlTwg6E9JE24FaC5EgEXg38cjZ5bKTHdQWML17GmH3wFQ5c48ALHGpgLy3HhfzGGjYPJWD8x1Li6CXWsL4uMeb4p-nrE5Gp0XzK8Yt8PA57jlOD4wL85ZgoenWtw3P6r3dfwVY46L7y1070cgbb-kkROXMOldlkri6Q_8zkpVnf33fCBTE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Natural+medicine+in+neuroprotection+for+ischemic+stroke%3A+Challenges+and+prospective&rft.jtitle=Pharmacology+%26+therapeutics+%28Oxford%29&rft.au=Tao%2C+Tao&rft.au=Liu%2C+Maozhu&rft.au=Chen%2C+Mengyuan&rft.au=Luo%2C+Ying&rft.date=2020-12-01&rft.issn=1879-016X&rft.eissn=1879-016X&rft.volume=216&rft.spage=107695&rft_id=info:doi/10.1016%2Fj.pharmthera.2020.107695&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0163-7258&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0163-7258&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0163-7258&client=summon