Increased Vascular Endothelial Growth Factor Serum Level and the Role of +936C/T Gene Polymorphism in Chronic Obstructive Pulmonary Disease

• Published in: Medicina (Kaunas, Lithuania) Vol. 57; no. 12; p. 1351
• Main Authors: Chis, Ana Florica, Râjnoveanu, Ruxandra-Mioara, Man, Milena Adina, Todea, Doina Adina, Chis, Bogdan Augustin, Stancu, Bogdan, Arghir, Ioan Anton, Alexescu, Teodora Gabriela, Pop, Carmen Monica
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.12.2021; MDPI
• Subjects: Alleles; Asthma; Blood gas analysis; Body mass index; Case-Control Studies; Chronic obstructive pulmonary disease; ELISA; Enzymes; Genetic Predisposition to Disease; Genomes; Genotype & phenotype; Humans; Injuries; Outdoor air quality; Pathogenesis; PCR RFLP; Permeability; Polymorphism; Polymorphism, Single Nucleotide; Pulmonary Disease, Chronic Obstructive - genetics; Romania; rs3025039; Smoking; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - blood; Vascular Endothelial Growth Factor A - genetics; VEGF; Romania; United States > US; rs3025039; VEGF; ELISA; PCR RFLP; chronic obstructive pulmonary disease

Background and Objectives: Chronic obstructive pulmonary disease (COPD) represents a debilitating disease, with rising morbidity and mortality. Vascular endothelial growth factor (VEGF) plays a major role in angiogenesis, vascular permeability, and airway remodeling. The purpose of this study was to...