Combining rTMS With Intensive Language-Action Therapy in Chronic Aphasia: A Randomized Controlled Trial
Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient (ILAT, previously CIAT or CILT), TMS could...
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| Published in | Frontiers in neuroscience Vol. 12; p. 1036 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Frontiers Research Foundation
04.02.2019
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| Abstract | Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient
(ILAT, previously CIAT or CILT), TMS could substantially amplify the beneficial effect of such behavioral therapy alone (Thiel et al., 2013; Martin et al., 2014; Mendoza et al., 2016; Kapoor, 2017). In this randomized study of 17 subjects with post-stroke aphasia in the chronic stage, we studied the combined effect of ILAT and 1-Hz placebo-controlled navigated repetitive TMS (rTMS) to the right-hemispheric inferior frontal cortex-that is, to the anterior part of the non-dominant hemisphere's homolog Broca's area (pars triangularis). Patients were randomized to groups A and B. Patients in group A received a 2-week period of rTMS during naming training where they named pictures displayed on the screen once every 10 s, followed by 2 weeks of rTMS and naming combined with ILAT. Patients in group B received the same behavioral therapy but TMS was replaced by sham stimulation. The primary outcome measures for changes in language performance were the Western Aphasia Battery's aphasia quotient AQ; the secondary outcome measures were the Boston naming test (BNT) and the Action naming test (Action BNT, ANT). All subjects completed the study. At baseline, no statistically significant group differences were discovered for age, post-stroke time or diagnosis. ILAT was associated with significant improvement across groups, as documented by both primary and secondary outcome measures. No significant effect of rTMS could be documented. Our results agree with previous results proving ILAT's ability to improve language in patients with chronic aphasia. In contrast with earlier claims, however, a beneficial effect of rTMS in chronic post-stroke aphasia rehabilitation was not detected in this study.
www.ClinicalTrials.gov, identifier: NCT03629665. |
|---|---|
| AbstractList | Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient Intensive Language-Action Therapy (ILAT, previously CIAT or CILT), TMS could substantially amplify the beneficial effect of such behavioral therapy alone (Thiel et al., 2013; Martin et al., 2014; Mendoza et al., 2016; Kapoor, 2017). In this randomized study of 17 subjects with post-stroke aphasia in the chronic stage, we studied the combined effect of ILAT and 1-Hz placebo-controlled navigated repetitive TMS (rTMS) to the right-hemispheric inferior frontal cortex-that is, to the anterior part of the non-dominant hemisphere's homolog Broca's area (pars triangularis). Patients were randomized to groups A and B. Patients in group A received a 2-week period of rTMS during naming training where they named pictures displayed on the screen once every 10 s, followed by 2 weeks of rTMS and naming combined with ILAT. Patients in group B received the same behavioral therapy but TMS was replaced by sham stimulation. The primary outcome measures for changes in language performance were the Western Aphasia Battery's aphasia quotient AQ; the secondary outcome measures were the Boston naming test (BNT) and the Action naming test (Action BNT, ANT). All subjects completed the study. At baseline, no statistically significant group differences were discovered for age, post-stroke time or diagnosis. ILAT was associated with significant improvement across groups, as documented by both primary and secondary outcome measures. No significant effect of rTMS could be documented. Our results agree with previous results proving ILAT's ability to improve language in patients with chronic aphasia. In contrast with earlier claims, however, a beneficial effect of rTMS in chronic post-stroke aphasia rehabilitation was not detected in this study. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT03629665.Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient Intensive Language-Action Therapy (ILAT, previously CIAT or CILT), TMS could substantially amplify the beneficial effect of such behavioral therapy alone (Thiel et al., 2013; Martin et al., 2014; Mendoza et al., 2016; Kapoor, 2017). In this randomized study of 17 subjects with post-stroke aphasia in the chronic stage, we studied the combined effect of ILAT and 1-Hz placebo-controlled navigated repetitive TMS (rTMS) to the right-hemispheric inferior frontal cortex-that is, to the anterior part of the non-dominant hemisphere's homolog Broca's area (pars triangularis). Patients were randomized to groups A and B. Patients in group A received a 2-week period of rTMS during naming training where they named pictures displayed on the screen once every 10 s, followed by 2 weeks of rTMS and naming combined with ILAT. Patients in group B received the same behavioral therapy but TMS was replaced by sham stimulation. The primary outcome measures for changes in language performance were the Western Aphasia Battery's aphasia quotient AQ; the secondary outcome measures were the Boston naming test (BNT) and the Action naming test (Action BNT, ANT). All subjects completed the study. At baseline, no statistically significant group differences were discovered for age, post-stroke time or diagnosis. ILAT was associated with significant improvement across groups, as documented by both primary and secondary outcome measures. No significant effect of rTMS could be documented. Our results agree with previous results proving ILAT's ability to improve language in patients with chronic aphasia. In contrast with earlier claims, however, a beneficial effect of rTMS in chronic post-stroke aphasia rehabilitation was not detected in this study. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT03629665. New neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included. Combined with behavioral techniques, in particular treatment-efficient Intensive Language-Action Therapy (ILAT, previously CIAT or CILT), TMS could substantially amplify the beneficial effect of such behavioral therapy alone (Thiel et al., 2013; Martin et al., 2014; Mendoza et al., 2016; Kapoor, 2017). In this randomized study of 17 subjects with post-stroke aphasia in the chronic stage, we studied the combined effect of ILAT and 1-Hz placebo-controlled navigated repetitive TMS (rTMS) to the right-hemispheric inferior frontal cortex – that is, to the anterior part of the non-dominant hemisphere’s homologue Broca’s area (pars triangularis). Patients were randomized to groups A and B. Patients in group A received a 2-week period of rTMS during naming training where they named pictures every ten second displayed on the screen, followed by 2-weeks of rTMS and naming combined with ILAT. Those in group B received the same behavioral therapy but TMS was replaced by sham stimulation. The primary outcome measures for changes in language performance were the Western Aphasia Battery’s aphasia quotient AQ; the secondary outcome measures were the Boston naming test (BNT) and the Action naming test (Action BNT, ANT). All subjects completed the study. At baseline, no statistically significant group differences were discovered for age, post-stroke time or diagnosis. ILAT was associated with significant improvement across groups, as documented by both primary (F(1,15)=23.969, p=0.001, η2=0.641) and secondary outcome measures. No significant effect of rTMS could be documented. A ceiling effect for magnetic stimulation was ruled out by numerically lower performance in the TMS group compared with that receiving sham stimulation. Our results agree with previous results proving ILAT’s ability to improve language in patients with chronic aphasia. However, in contrast with earlier claims, a beneficial effect of rTMS in chronic post-stroke aphasia rehabilitation was not detected in this study. Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient (ILAT, previously CIAT or CILT), TMS could substantially amplify the beneficial effect of such behavioral therapy alone (Thiel et al., 2013; Martin et al., 2014; Mendoza et al., 2016; Kapoor, 2017). In this randomized study of 17 subjects with post-stroke aphasia in the chronic stage, we studied the combined effect of ILAT and 1-Hz placebo-controlled navigated repetitive TMS (rTMS) to the right-hemispheric inferior frontal cortex-that is, to the anterior part of the non-dominant hemisphere's homolog Broca's area (pars triangularis). Patients were randomized to groups A and B. Patients in group A received a 2-week period of rTMS during naming training where they named pictures displayed on the screen once every 10 s, followed by 2 weeks of rTMS and naming combined with ILAT. Patients in group B received the same behavioral therapy but TMS was replaced by sham stimulation. The primary outcome measures for changes in language performance were the Western Aphasia Battery's aphasia quotient AQ; the secondary outcome measures were the Boston naming test (BNT) and the Action naming test (Action BNT, ANT). All subjects completed the study. At baseline, no statistically significant group differences were discovered for age, post-stroke time or diagnosis. ILAT was associated with significant improvement across groups, as documented by both primary and secondary outcome measures. No significant effect of rTMS could be documented. Our results agree with previous results proving ILAT's ability to improve language in patients with chronic aphasia. In contrast with earlier claims, however, a beneficial effect of rTMS in chronic post-stroke aphasia rehabilitation was not detected in this study. www.ClinicalTrials.gov, identifier: NCT03629665. Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient Intensive Language-Action Therapy (ILAT, previously CIAT or CILT), TMS could substantially amplify the beneficial effect of such behavioral therapy alone (Thiel et al., 2013; Martin et al., 2014; Mendoza et al., 2016; Kapoor, 2017). In this randomized study of 17 subjects with post-stroke aphasia in the chronic stage, we studied the combined effect of ILAT and 1-Hz placebo-controlled navigated repetitive TMS (rTMS) to the right-hemispheric inferior frontal cortex—that is, to the anterior part of the non-dominant hemisphere's homolog Broca's area (pars triangularis). Patients were randomized to groups A and B. Patients in group A received a 2-week period of rTMS during naming training where they named pictures displayed on the screen once every 10 s, followed by 2 weeks of rTMS and naming combined with ILAT. Patients in group B received the same behavioral therapy but TMS was replaced by sham stimulation. The primary outcome measures for changes in language performance were the Western Aphasia Battery's aphasia quotient AQ; the secondary outcome measures were the Boston naming test (BNT) and the Action naming test (Action BNT, ANT). All subjects completed the study. At baseline, no statistically significant group differences were discovered for age, post-stroke time or diagnosis. ILAT was associated with significant improvement across groups, as documented by both primary and secondary outcome measures. No significant effect of rTMS could be documented. Our results agree with previous results proving ILAT's ability to improve language in patients with chronic aphasia. In contrast with earlier claims, however, a beneficial effect of rTMS in chronic post-stroke aphasia rehabilitation was not detected in this study.Clinical Trial Registration:www.ClinicalTrials.gov, identifier: NCT03629665 Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not yet in common clinical use. Combined with behavioral techniques, in particular treatment-efficient Intensive Language-Action Therapy (ILAT, previously CIAT or CILT), TMS could substantially amplify the beneficial effect of such behavioral therapy alone (Thiel et al., 2013 ; Martin et al., 2014 ; Mendoza et al., 2016 ; Kapoor, 2017 ). In this randomized study of 17 subjects with post-stroke aphasia in the chronic stage, we studied the combined effect of ILAT and 1-Hz placebo-controlled navigated repetitive TMS (rTMS) to the right-hemispheric inferior frontal cortex—that is, to the anterior part of the non-dominant hemisphere's homolog Broca's area (pars triangularis). Patients were randomized to groups A and B. Patients in group A received a 2-week period of rTMS during naming training where they named pictures displayed on the screen once every 10 s, followed by 2 weeks of rTMS and naming combined with ILAT. Patients in group B received the same behavioral therapy but TMS was replaced by sham stimulation. The primary outcome measures for changes in language performance were the Western Aphasia Battery's aphasia quotient AQ; the secondary outcome measures were the Boston naming test (BNT) and the Action naming test (Action BNT, ANT). All subjects completed the study. At baseline, no statistically significant group differences were discovered for age, post-stroke time or diagnosis. ILAT was associated with significant improvement across groups, as documented by both primary and secondary outcome measures. No significant effect of rTMS could be documented. Our results agree with previous results proving ILAT's ability to improve language in patients with chronic aphasia. In contrast with earlier claims, however, a beneficial effect of rTMS in chronic post-stroke aphasia rehabilitation was not detected in this study. Clinical Trial Registration: www.ClinicalTrials.gov , identifier: NCT03629665 |
| Author | Pulvermüller, Friedemann Klippi, Anu Kujala, Teija Heikkinen, Paula H. Lioumis, Pantelis Ahvenainen, Antti Ilmoniemi, Risto J. Mäkelä, Jyrki P. Manninen, Riitta-Leena |
| AuthorAffiliation | 6 Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki , Helsinki , Finland 4 Department of Neuroscience and Biomedical Engineering, Aalto University School of Science , Espoo , Finland 2 Brain Language Laboratory, Department of Philosophy and Humanities, WE4, Freie Universität Berlin , Berlin , Germany 3 BioMag Laboratory, HUS Medical Imaging Center University of Helsinki and Helsinki University Hospital , Helsinki , Finland 5 Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto , Toronto, ON , Canada 1 Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki , Helsinki , Finland |
| AuthorAffiliation_xml | – name: 3 BioMag Laboratory, HUS Medical Imaging Center University of Helsinki and Helsinki University Hospital , Helsinki , Finland – name: 6 Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki , Helsinki , Finland – name: 5 Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto , Toronto, ON , Canada – name: 1 Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki , Helsinki , Finland – name: 4 Department of Neuroscience and Biomedical Engineering, Aalto University School of Science , Espoo , Finland – name: 2 Brain Language Laboratory, Department of Philosophy and Humanities, WE4, Freie Universität Berlin , Berlin , Germany |
| Author_xml | – sequence: 1 givenname: Paula H. surname: Heikkinen fullname: Heikkinen, Paula H. – sequence: 2 givenname: Friedemann surname: Pulvermüller fullname: Pulvermüller, Friedemann – sequence: 3 givenname: Jyrki P. surname: Mäkelä fullname: Mäkelä, Jyrki P. – sequence: 4 givenname: Risto J. surname: Ilmoniemi fullname: Ilmoniemi, Risto J. – sequence: 5 givenname: Pantelis surname: Lioumis fullname: Lioumis, Pantelis – sequence: 6 givenname: Teija surname: Kujala fullname: Kujala, Teija – sequence: 7 givenname: Riitta-Leena surname: Manninen fullname: Manninen, Riitta-Leena – sequence: 8 givenname: Antti surname: Ahvenainen fullname: Ahvenainen, Antti – sequence: 9 givenname: Anu surname: Klippi fullname: Klippi, Anu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30778280$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0140-6736(17)30067-3 10.1080/02687038.2012.710316 10.3233/RNN-2010-0570 10.1073/pnas.1310190110 10.1016/j.apmr.2011.06.040 10.1093/brain/awv022 10.3389/fpsyg.2011.00230 10.1177/1545968314521009 10.1016/j.cortex.2016.09.021 10.1080/02687038.2012.705815 10.1016/0010-0277(93)90028-T 10.1016/j.clinph.2009.08.016 10.1016/j.bandl.2015.03.006 10.3389/fnhum.2017.00332 10.1016/j.apmr.2011.03.036 10.1007/s11910-015-0593-6 10.1161/STROKEAHA.111.000574 10.1177/1545968314522710 10.1002/14651858.CD000425.pub4 10.1016/0013-4694(94)90029-9 10.3389/fnhum.2016.00482 10.1161/01.STR.0000169941.29831.2a 10.1161/01.STR.0000062343.64383.D0 10.1007/s11910-009-0067-9 10.1016/j.bandl.2010.01.001 10.1136/jnnp-2017-315962 10.12659/MSM.894291 10.1080/02687030902732745 10.1080/10749357.2017.1331417 10.3233/NRE-130915 10.1002/ana.21597 10.1177/1545968317744275 10.1002/ana.410380416 10.1016/j.neuroimage.2009.09.026 10.1016/S0168-5597(97)00096-8 10.1080/02687030701612213 10.1161/01.STR.32.7.1621 10.1044/2016 10.1016/j.bandl.2004.08.004 10.1177/1545968308328730 10.3389/fpsyg.2014.00037 10.1038/nrneurol.2010.201 10.3233/RNN-130365 10.1044/1092-4388(2008/020) 10.1111/j.1468-1331.2010.03284.x 10.1016/j.bandl.2011.02.005 10.1016/j.jcomdis.2011.04.006 10.1016/j.jneumeth.2011.10.004 10.1093/brain/awg044 10.3389/fnhum.2014.00919 10.1016/j.bandl.2009.07.007 10.1093/brain/awl090 |
| ContentType | Journal Article |
| Copyright | 2019. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2019 Heikkinen, Pulvermüller, Mäkelä, Ilmoniemi, Lioumis, Kujala, Manninen, Ahvenainen and Klippi. 2019 Heikkinen, Pulvermüller, Mäkelä, Ilmoniemi, Lioumis, Kujala, Manninen, Ahvenainen and Klippi |
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| Keywords | language rehabilitation ILAT rTMS randomized controlled trial (RCT) efficacy chronic aphasia |
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| References | Raymer (B46) 2008; 51 Berthier (B6) 2011; 7 Meinzer (B32) 2012; 93 Stahl (B52) 2018; 89 Al-Janabi (B2) 2014; 4 Stahl (B53) 2016; 85 Martin (B29) 2014; 32 Kaplan (B20) 1983 Difrancesco (B15) 2012; 26 Saur (B50) 2006; 129 Wassermann (B59) 1998; 108 Barwood (B4) 2011; 18 Davis (B14) 1985 Pietilä (B41) 2005 Wisenburn (B60) 2009; 23 Platz (B42) 2010; 28 Pulvermüller (B43) 2008; 22 B38 Thiel (B55) 2013; 44 Bhogal (B7) 2003; 34 Vines (B58) 2011; 6 Casali (B12) 2010; 49 Brady (B9) 2016; 6 Hamilton (B16) 2011; 118 Jochumsen (B19) 2016; 10 Pedersen (B40) 1995; 38 Saur (B49) 2012; 93 Mohr (B35) 2014; 8 Mohr (B36) 2017; 31 Breitenstein (B10) 2017; 389 Hartwigsen (B18) 2013; 110 Mohr (B34) 2017; 11 Obler (B39) 1986 Szaflarski (B54) 2015; 21 Blicher (B8) 2009; 23 Naeser (B37) 2005; 93 Turkeltaub (B57) 2015; 15 Rossi (B47) 2009; 120 Kertez (B23) 1982 Martin (B28); 9 Rossini (B48) 1994; 91 Meinzer (B31) 2005; 36 Abel (B1) 2015; 138 Kleim (B25) 2011; 44 Bütefisch (B11) 2003; 126 Danner (B13) 2012; 203 Khedr (B24) 2014; 28 Martin (B27); 111 Barwood (B3) 2013; 32 Somers (B51) 2015; 144 Berthier (B5) 2009; 65 Mendoza (B33) 2016; 4 Kurland (B26) 2016; 25 Pulvermüller (B44) 2001; 32 Medina (B30) 2012; 26 Hamilton (B17) 2010; 113 Kapoor (B21) 2017; 24 Tsai (B56) 2014; 28 Kertesz (B22) 1985 Pulvermüller (B45) 1993; 48 |
| References_xml | – volume: 389 start-page: 1528 year: 2017 ident: B10 article-title: Intensive speech and language therapy in patients with chronic aphasia after stroke: a randomised, open-label, blindedendpoint, controlled trial in a health-care setting publication-title: Lancet doi: 10.1016/S0140-6736(17)30067-3 – volume: 26 start-page: 1153 year: 2012 ident: B30 article-title: Finding the right words: transcranial magnetic stimulation improves discourse productivity in non-fluent aphasia after stroke publication-title: Aphasiology doi: 10.1080/02687038.2012.710316 – volume: 4 start-page: 2333 year: 2016 ident: B33 article-title: Repetitive transcranial magnetic stimulation in aphasia and communication impairment in post-stroke: systematic review of literature publication-title: J. Neurol. Transl. Neurosci. – volume: 28 start-page: 387 year: 2010 ident: B42 article-title: Brain stimulation and brain repair–rTMS: from animal experiment to clinical trials-what do we know? publication-title: Restor. Neurol. Neurosci. doi: 10.3233/RNN-2010-0570 – volume: 110 start-page: 16402 year: 2013 ident: B18 article-title: Perturbation of the left inferior frontal gyrus triggers adaptive plasticity in the right homologous area during speech production publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1310190110 – volume: 93 start-page: 35 year: 2012 ident: B32 article-title: First decade of research on constrained-induced treatment approaches for aphasia rehabilitation publication-title: Arch. Phys. Med. Rehabil. doi: 10.1016/j.apmr.2011.06.040 – volume: 138 start-page: 1097 year: 2015 ident: B1 article-title: Therapy-induced brain reorganization patterns in aphasia publication-title: Brain doi: 10.1093/brain/awv022 – volume-title: Boston Naming Test year: 1983 ident: B20 – start-page: 287 volume-title: Handbook of Clinical Neurology, Vol. 45, Clinical Neuropsychology year: 1985 ident: B22 article-title: Aphasia – volume: 6 start-page: 230 year: 2011 ident: B58 article-title: Non-invasive brain stimulation enhances the effects of melodic intonation therapy publication-title: Front. Psychol doi: 10.3389/fpsyg.2011.00230 – volume: 28 start-page: 740 year: 2014 ident: B24 article-title: Dual-hemisphere repetitive transcranial magnetic stimulation for rehabilitation of poststroke aphasia: a randomized, double-blind clinical trial publication-title: Neurorehabil. Neural Repair doi: 10.1177/1545968314521009 – volume: 85 start-page: 90 year: 2016 ident: B53 article-title: Using language for social interaction: communication mechanisms promote recovery from chronic non-fluent aphasia publication-title: Cortex doi: 10.1016/j.cortex.2016.09.021 – volume: 26 start-page: 1317 year: 2012 ident: B15 article-title: Intensive language-action therapy (ILAT): the methods publication-title: Aphasiology doi: 10.1080/02687038.2012.705815 – volume: 48 start-page: 139 year: 1993 ident: B45 article-title: Behavioral and neuronal changes during treatment of mixed-transcortical aphasia: a case study publication-title: Cognition doi: 10.1016/0010-0277(93)90028-T – volume: 120 start-page: 2008 year: 2009 ident: B47 article-title: Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research publication-title: Clin. Neurophysiol. doi: 10.1016/j.clinph.2009.08.016 – volume: 144 start-page: 10 year: 2015 ident: B51 article-title: On the relationship between degree of hand-preference and degree of language lateralization publication-title: Brain Lang. doi: 10.1016/j.bandl.2015.03.006 – volume: 11 start-page: 332 year: 2017 ident: B34 article-title: Neuroplasticity and functional recovery after intensive language therapy in chronic post stroke aphasia: which factors are relevant? publication-title: Front. Hum. Neurosci. doi: 10.3389/fnhum.2017.00332 – volume: 93 start-page: S15 year: 2012 ident: B49 article-title: Neurobiology of language recovery after stroke: lessons from neuroimaging studies publication-title: Arch. Phys. Med. Rehabil. doi: 10.1016/j.apmr.2011.03.036 – volume: 15 start-page: 72 year: 2015 ident: B57 article-title: Brain stimulation and the role of the right hemisphere in aphasia recovery publication-title: Curr. Neurol. Neurosci. Reports doi: 10.1007/s11910-015-0593-6 – volume: 44 start-page: 2240 year: 2013 ident: B55 article-title: Effects of noninvasive brain stimulation on language networks and recovery in early poststroke aphasia publication-title: Stroke doi: 10.1161/STROKEAHA.111.000574 – volume: 28 start-page: 779 year: 2014 ident: B56 article-title: The persistent and broadly modulating effect of inhibitory rTMS in nonfluent aphasic patients: a sham-controlled, double-blind study publication-title: Neurorehabilit. Neural Repair doi: 10.1177/1545968314522710 – volume: 6 start-page: CD000425 year: 2016 ident: B9 article-title: Speech and language therapy for aphasia following stroke (Review) publication-title: Cochr. Lib. doi: 10.1002/14651858.CD000425.pub4 – volume: 91 start-page: 79 year: 1994 ident: B48 article-title: Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN committee publication-title: Electroencephalogr. Clin. Neurophysiol. doi: 10.1016/0013-4694(94)90029-9 – volume: 10 start-page: 482 year: 2016 ident: B19 article-title: Voluntary movement and muscle-located electrical stimulation increases cortical excitability publication-title: Front. Hum. Neurosci. doi: 10.3389/fnhum.2016.00482 – volume: 36 start-page: 1462 year: 2005 ident: B31 article-title: Long-term stability of improved language functions in chronic aphasia after constraint-induced aphasia therapy publication-title: Stroke doi: 10.1161/01.STR.0000169941.29831.2a – volume: 34 start-page: 987 year: 2003 ident: B7 article-title: Intensity of aphasia therapy, impact on recovery publication-title: Stroke doi: 10.1161/01.STR.0000062343.64383.D0 – volume: 9 start-page: 451 ident: B28 article-title: Research with transcranial magnetic stimulation in the treatment of aphasia publication-title: Curr. Neurol. Neurosci. Rep. doi: 10.1007/s11910-009-0067-9 – volume: 113 start-page: 45 year: 2010 ident: B17 article-title: Stimulating conversation: Enhancement of elicited propositional speech in a patient with chronic non-fluent aphasia following transcranial magnetic stimulation publication-title: Brain Lang. doi: 10.1016/j.bandl.2010.01.001 – volume: 89 start-page: 586 year: 2018 ident: B52 article-title: Efficacy of intensive aphasia therapy in patients with chronic stroke: a randomised controlled trial publication-title: J. Neurol Neurosurg. Psychiatry doi: 10.1136/jnnp-2017-315962 – ident: B38 – volume-title: Action Naming Test year: 1986 ident: B39 – volume: 21 start-page: 2861 year: 2015 ident: B54 article-title: Constraint-induced aphasia therapy for treatment of chronic post-stroke aphasia: a randomized, blinded, controlled pilot trial publication-title: Med. Sci. Monit. doi: 10.12659/MSM.894291 – volume: 23 start-page: 1338 year: 2009 ident: B60 article-title: A meta-analysis of word-finding treatments for aphasia publication-title: Aphasiology doi: 10.1080/02687030902732745 – volume: 24 start-page: 547 year: 2017 ident: B21 article-title: Repetitive transcranial magnetic stimulation therapy for post-stroke non-fluent aphasia: a critical review publication-title: Top. Stroke Rehabilit. doi: 10.1080/10749357.2017.1331417 – volume: 32 start-page: 915 year: 2013 ident: B3 article-title: Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia publication-title: NeuroRehabilitation doi: 10.3233/NRE-130915 – volume: 65 start-page: 577 year: 2009 ident: B5 article-title: Memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia publication-title: Ann. Neurol. doi: 10.1002/ana.21597 – volume: 31 start-page: 1053 year: 2017 ident: B36 article-title: Intensive communicative therapy reduces symptoms of depression in chronic nonfluent aphasia publication-title: Neurorehabilit. Neural Repair doi: 10.1177/1545968317744275 – volume: 38 start-page: 659 year: 1995 ident: B40 article-title: Aphasia inacute stroke: incidence, determinants, and recovery publication-title: Ann. Neurol. doi: 10.1002/ana.410380416 – volume: 49 start-page: 1459 year: 2010 ident: B12 article-title: General indices to characterize the electrical response of the cerebral cortex to TMS publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.09.026 – volume: 108 start-page: 1 year: 1998 ident: B59 article-title: Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5–7, 1996 publication-title: Electroenceph. Clin. Neurophysiol. doi: 10.1016/S0168-5597(97)00096-8 – volume-title: Adult Aphasia Rehabilitation: Applied Pragmatics year: 1985 ident: B14 – volume: 22 start-page: 563 year: 2008 ident: B43 article-title: Aphasia therapy on a neuroscience basis publication-title: Aphasiology doi: 10.1080/02687030701612213 – volume: 32 start-page: 1621 year: 2001 ident: B44 article-title: Constraint-induced therapy of chronic aphasia after stroke publication-title: Stroke doi: 10.1161/01.STR.32.7.1621 – volume: 25 start-page: S798 year: 2016 ident: B26 article-title: Intensive language action therapy in chronic aphasia: a randomized clinical trial examining guidance by constraint publication-title: Am. J. Speech Lang. Pathol. doi: 10.1044/2016 – volume: 93 start-page: 95 year: 2005 ident: B37 article-title: Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study publication-title: Brain Lang. doi: 10.1016/j.bandl.2004.08.004 – volume: 23 start-page: 486 year: 2009 ident: B8 article-title: Cortical excitability in chronic stroke and modulation by training: a TMS study publication-title: Neurorehabil. Neural Repair doi: 10.1177/1545968308328730 – year: 2005 ident: B41 publication-title: Kertesz Psykologien Kustannus Oy – volume: 4 start-page: 37 year: 2014 ident: B2 article-title: Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies publication-title: Front. Psychol. doi: 10.3389/fpsyg.2014.00037 – volume: 7 start-page: 86 year: 2011 ident: B6 article-title: Neuroscience insights improve neurorehabilitation of poststroke aphasia publication-title: Nat. Rev. Neurol. doi: 10.1038/nrneurol.2010.201 – volume: 32 start-page: 483 year: 2014 ident: B29 article-title: Language improvements after TMS plus modified CILT: Pilot, open-protocol study with two, chronic nonfluent aphasia cases publication-title: Restor. Neurol Neurosci. doi: 10.3233/RNN-130365 – volume: 51 start-page: 259 year: 2008 ident: B46 article-title: Translational research in aphasia: from neuroscience to neurorehabilitation publication-title: J. Speech Lang. Hear Res doi: 10.1044/1092-4388(2008/020) – volume: 18 start-page: 935 year: 2011 ident: B4 article-title: Improved language performance subsequent to low-frequency rTMS in patients with chronic non-fluent aphasia post-stroke publication-title: Eur. J. Neurol. doi: 10.1111/j.1468-1331.2010.03284.x – volume: 118 start-page: 40 year: 2011 ident: B16 article-title: Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation publication-title: Brain Lang. doi: 10.1016/j.bandl.2011.02.005 – volume-title: Western Aphasia Battery year: 1982 ident: B23 – volume: 44 start-page: 521 year: 2011 ident: B25 article-title: Neural plasticity and neurorehabilitation: teaching the new brain old tricks publication-title: J. Commun. Disord. doi: 10.1016/j.jcomdis.2011.04.006 – volume: 203 start-page: 298 year: 2012 ident: B13 article-title: Effect of individual anatomy on resting motor threshold—computed electric field as a measure of cortical excitability publication-title: J. Neurosci. Methods doi: 10.1016/j.jneumeth.2011.10.004 – volume: 126 start-page: 470 year: 2003 ident: B11 article-title: Remote changes in cortical excitability after stroke publication-title: Brain doi: 10.1093/brain/awg044 – volume: 8 start-page: 919 year: 2014 ident: B35 article-title: Changes of right-hemispheric activation after constraint-induced, intensive language action therapy in chronic aphasia: fMRI evidence from auditory semantic processing publication-title: Front. Hum. Neurosci. doi: 10.3389/fnhum.2014.00919 – volume: 111 start-page: 20 ident: B27 article-title: Overt naming fMRI pre- and post-TMS: Two nonfluent aphasia patients, with and without improved naming post-TMS publication-title: Brain Lang. doi: 10.1016/j.bandl.2009.07.007 – volume: 129 start-page: 1371 year: 2006 ident: B50 article-title: Dynamics of language reorganization after stroke publication-title: Brain doi: 10.1093/brain/awl090 |
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| Snippet | Neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included, but not... New neuromodulation technologies, such as transcranial magnetic stimulation (TMS), are promising tools for neurorehabilitation, aphasia therapy included.... |
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| SubjectTerms | Aphasia chronic aphasia Cortex (frontal) efficacy Hemispheric laterality ILAT Laboratories Language language rehabilitation Magnetic fields Neurology Neuromodulation Neuroscience Neurosciences randomized controlled trial (RCT) Rehabilitation rTMS Statistical analysis Stroke Transcranial magnetic stimulation |
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| Title | Combining rTMS With Intensive Language-Action Therapy in Chronic Aphasia: A Randomized Controlled Trial |
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