Contemporary Outcomes After Repair of Isolated and Complex Complete Atrioventricular Septal Defect
Contemporary outcomes of complete atrioventricular septal defect (CAVSD) repair, particularly for defects with associated abnormalities, is unclear. The goal of this study is to report an all-inclusive experience of CAVSD repair using a consistent surgical approach. All patients undergoing CAVSD rep...
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Published in | The Annals of thoracic surgery Vol. 106; no. 5; pp. 1429 - 1437 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.11.2018
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Abstract | Contemporary outcomes of complete atrioventricular septal defect (CAVSD) repair, particularly for defects with associated abnormalities, is unclear. The goal of this study is to report an all-inclusive experience of CAVSD repair using a consistent surgical approach.
All patients undergoing CAVSD repair between 1995 and 2016 at our institution were included. Patients were divided into 2 groups: isolated and complex (tetralogy of Fallot, aortic arch repair, double outlet right ventricle, and total anomalous pulmonary venous return). Survival and reoperation were analyzed using log-rank test and Gray’s test, respectively. Multivariable analysis was performed with Cox regression.
Overall, 406 patients underwent repair: 350 (86%) isolated and 56 (14%) complex CAVSD (tetralogy of Fallot: 34, double outlet right ventricle: 7, aortic arch repair: 12, total anomalous pulmonary venous return: 3). Median age at repair was 5 months (range, 10 days to 16 years); 339 (84%) had trisomy 21. A 2-patch repair was used in 395 (97%) and the zone of apposition was completely closed in 305 (75%). Perioperative mortality was 2% and 4% in the isolated and complex groups, respectively. Perioperative mortality since 2006 was 0.9%. Median follow-up was 7 years. Overall 10-year survival and incidence of any reoperation were 92% and 11%, respectively. Complex anatomy was not a risk factor for mortality (p = 0.35), but it was for reoperation (hazard ratio [HR]: 2.6; p < 0.01). Risk factors for left atrioventricular valve reoperation were a second bypass run (HR: 2.7) and preoperative moderate or worse regurgitation (HR: 2.3).
Mortality after CAVSD repair is low, yet reoperation remains a significant problem. Repair of complex CAVSD can be performed with similar mortality rates.
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AbstractList | BACKGROUNDContemporary outcomes of complete atrioventricular septal defect (CAVSD) repair, particularly for defects with associated abnormalities, is unclear. The goal of this study is to report an all-inclusive experience of CAVSD repair using a consistent surgical approach. METHODSAll patients undergoing CAVSD repair between 1995 and 2016 at our institution were included. Patients were divided into 2 groups: isolated and complex (tetralogy of Fallot, aortic arch repair, double outlet right ventricle, and total anomalous pulmonary venous return). Survival and reoperation were analyzed using log-rank test and Gray's test, respectively. Multivariable analysis was performed with Cox regression. RESULTSOverall, 406 patients underwent repair: 350 (86%) isolated and 56 (14%) complex CAVSD (tetralogy of Fallot: 34, double outlet right ventricle: 7, aortic arch repair: 12, total anomalous pulmonary venous return: 3). Median age at repair was 5 months (range, 10 days to 16 years); 339 (84%) had trisomy 21. A 2-patch repair was used in 395 (97%) and the zone of apposition was completely closed in 305 (75%). Perioperative mortality was 2% and 4% in the isolated and complex groups, respectively. Perioperative mortality since 2006 was 0.9%. Median follow-up was 7 years. Overall 10-year survival and incidence of any reoperation were 92% and 11%, respectively. Complex anatomy was not a risk factor for mortality (p = 0.35), but it was for reoperation (hazard ratio [HR]: 2.6; p < 0.01). Risk factors for left atrioventricular valve reoperation were a second bypass run (HR: 2.7) and preoperative moderate or worse regurgitation (HR: 2.3). CONCLUSIONSMortality after CAVSD repair is low, yet reoperation remains a significant problem. Repair of complex CAVSD can be performed with similar mortality rates. Contemporary outcomes of complete atrioventricular septal defect (CAVSD) repair, particularly for defects with associated abnormalities, is unclear. The goal of this study is to report an all-inclusive experience of CAVSD repair using a consistent surgical approach. All patients undergoing CAVSD repair between 1995 and 2016 at our institution were included. Patients were divided into 2 groups: isolated and complex (tetralogy of Fallot, aortic arch repair, double outlet right ventricle, and total anomalous pulmonary venous return). Survival and reoperation were analyzed using log-rank test and Gray’s test, respectively. Multivariable analysis was performed with Cox regression. Overall, 406 patients underwent repair: 350 (86%) isolated and 56 (14%) complex CAVSD (tetralogy of Fallot: 34, double outlet right ventricle: 7, aortic arch repair: 12, total anomalous pulmonary venous return: 3). Median age at repair was 5 months (range, 10 days to 16 years); 339 (84%) had trisomy 21. A 2-patch repair was used in 395 (97%) and the zone of apposition was completely closed in 305 (75%). Perioperative mortality was 2% and 4% in the isolated and complex groups, respectively. Perioperative mortality since 2006 was 0.9%. Median follow-up was 7 years. Overall 10-year survival and incidence of any reoperation were 92% and 11%, respectively. Complex anatomy was not a risk factor for mortality (p = 0.35), but it was for reoperation (hazard ratio [HR]: 2.6; p < 0.01). Risk factors for left atrioventricular valve reoperation were a second bypass run (HR: 2.7) and preoperative moderate or worse regurgitation (HR: 2.3). Mortality after CAVSD repair is low, yet reoperation remains a significant problem. Repair of complex CAVSD can be performed with similar mortality rates. [Display omitted] Contemporary outcomes of complete atrioventricular septal defect (CAVSD) repair, particularly for defects with associated abnormalities, is unclear. The goal of this study is to report an all-inclusive experience of CAVSD repair using a consistent surgical approach. All patients undergoing CAVSD repair between 1995 and 2016 at our institution were included. Patients were divided into 2 groups: isolated and complex (tetralogy of Fallot, aortic arch repair, double outlet right ventricle, and total anomalous pulmonary venous return). Survival and reoperation were analyzed using log-rank test and Gray's test, respectively. Multivariable analysis was performed with Cox regression. Overall, 406 patients underwent repair: 350 (86%) isolated and 56 (14%) complex CAVSD (tetralogy of Fallot: 34, double outlet right ventricle: 7, aortic arch repair: 12, total anomalous pulmonary venous return: 3). Median age at repair was 5 months (range, 10 days to 16 years); 339 (84%) had trisomy 21. A 2-patch repair was used in 395 (97%) and the zone of apposition was completely closed in 305 (75%). Perioperative mortality was 2% and 4% in the isolated and complex groups, respectively. Perioperative mortality since 2006 was 0.9%. Median follow-up was 7 years. Overall 10-year survival and incidence of any reoperation were 92% and 11%, respectively. Complex anatomy was not a risk factor for mortality (p = 0.35), but it was for reoperation (hazard ratio [HR]: 2.6; p < 0.01). Risk factors for left atrioventricular valve reoperation were a second bypass run (HR: 2.7) and preoperative moderate or worse regurgitation (HR: 2.3). Mortality after CAVSD repair is low, yet reoperation remains a significant problem. Repair of complex CAVSD can be performed with similar mortality rates. |
Author | Fraser, Charles D. Mery, Carlos M. Adachi, Iki Heinle, Jeffrey S. Kyle, William B. Zhu, Huirong Chacon-Portillo, Martin A. Zea-Vera, Rodrigo |
Author_xml | – sequence: 1 givenname: Carlos M. surname: Mery fullname: Mery, Carlos M. email: cmery@austin.utexas.edu organization: Division of Congenital Heart Surgery, Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas – sequence: 2 givenname: Rodrigo surname: Zea-Vera fullname: Zea-Vera, Rodrigo organization: Division of Congenital Heart Surgery, Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas – sequence: 3 givenname: Martin A. surname: Chacon-Portillo fullname: Chacon-Portillo, Martin A. organization: Division of Congenital Heart Surgery, Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas – sequence: 4 givenname: Huirong surname: Zhu fullname: Zhu, Huirong organization: Outcomes and Impact Service, Texas Children’s Hospital, Houston, Texas – sequence: 5 givenname: William B. surname: Kyle fullname: Kyle, William B. organization: Division of Pediatric Cardiology, Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas – sequence: 6 givenname: Iki surname: Adachi fullname: Adachi, Iki organization: Division of Congenital Heart Surgery, Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas – sequence: 7 givenname: Jeffrey S. surname: Heinle fullname: Heinle, Jeffrey S. organization: Division of Congenital Heart Surgery, Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas – sequence: 8 givenname: Charles D. surname: Fraser fullname: Fraser, Charles D. organization: Division of Congenital Heart Surgery, Texas Children’s Hospital/Baylor College of Medicine, Houston, Texas |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30009807$$D View this record in MEDLINE/PubMed |
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Keywords | ECMO AVV TAPVR CAVSD CI VSD HR TOF LVOT DORV RV-PA ASD LAVV |
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Snippet | Contemporary outcomes of complete atrioventricular septal defect (CAVSD) repair, particularly for defects with associated abnormalities, is unclear. The goal... BACKGROUNDContemporary outcomes of complete atrioventricular septal defect (CAVSD) repair, particularly for defects with associated abnormalities, is unclear.... |
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SubjectTerms | Cardiac Surgical Procedures - methods Cardiac Surgical Procedures - mortality Cardiopulmonary Bypass - methods Cardiopulmonary Bypass - mortality Child, Preschool Databases, Factual Female Follow-Up Studies Heart Septal Defects - diagnostic imaging Heart Septal Defects - mortality Heart Septal Defects - surgery Heart Septal Defects, Ventricular - diagnostic imaging Heart Septal Defects, Ventricular - mortality Heart Septal Defects, Ventricular - surgery Humans Infant Infant, Newborn Male Multivariate Analysis Proportional Hazards Models Reconstructive Surgical Procedures - methods Reconstructive Surgical Procedures - mortality Retrospective Studies Risk Assessment Time Factors Treatment Outcome |
Title | Contemporary Outcomes After Repair of Isolated and Complex Complete Atrioventricular Septal Defect |
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