The Primacy Effect in Amnestic Mild Cognitive Impairment: Associations with Hippocampal Functional Connectivity

• Published in: Frontiers in aging neuroscience Vol. 8; p. 244
• Main Authors: Brueggen, Katharina, Kasper, Elisabeth, Dyrba, Martin, Bruno, Davide, Pomara, Nunzio, Ewers, Michael, Duering, Marco, Bürger, Katharina, Teipel, Stefan J.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 21.10.2016; Frontiers Media S.A
• Subjects: Alzheimer's disease; Alzheimer’s disease (AD); Amygdala; Brain mapping; Brain research; Cognitive ability; Cortex (cingulate); Cortex (frontal); Default Mode Network; Dementia; Education; functional connectivity; Functional magnetic resonance imaging; Hippocampus; Memory; Mental task performance; mild cognitive impairment (MCI); Neural networks; Neuroimaging; Neuroscience; NMR; Nuclear magnetic resonance; Primacy effect; Seeds; Substantia grisea; Temporal cortex; Thalamus; United States > US; Germany; mild cognitive impairment (MCI); Alzheimer's disease (AD); functional connectivity; hippocampus; default mode network; primacy effect
• ISSN: 1663-4365; 1663-4365
• DOI: 10.3389/fnagi.2016.00244

The "primacy effect," i.e., increased memory recall for the first items of a series compared to the following items, is reduced in amnestic mild cognitive impairment (aMCI). Memory task-fMRI studies demonstrated that primacy recall is associated with higher activation of the hippocampus an...