A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions

• Published in: Pharmaceutical research Vol. 21; no. 4; pp. 585 - 591
• Main Authors: Blanquet, Stéphanie, Zeijdner, Evelijn, Beyssac, Erick, Meunier, Jean-Philippe, Denis, Sylvain, Havenaar, Robert, Alric, Monique
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.04.2004
• Subjects: Acetaminophen - administration & dosage; Administration, Oral; Digestive System - drug effects; Dosage Forms; Gastrointestinal Transit - drug effects; Gastrointestinal Transit - physiology; Models, Biological; Predictive Value of Tests

The purpose of this study was to demonstrate the potential of a dynamic, multicompartmental in vitro system simulating the human stomach and small intestine (TIM-1) for studying the behavior of oral drug dosage forms under various physiological gastrointestinal conditions. Two model drug compounds w...