Insights into the HIV Latency and the Role of Cytokines

• Published in: Pathogens (Basel) Vol. 8; no. 3; p. 137
• Main Authors: Hokello, Joseph, Sharma, Adhikarimayum Lakhikumar, Dimri, Manjari, Tyagi, Mudit
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.09.2019; MDPI
• Subjects: Acquired immune deficiency syndrome; AIDS; Antigens; Apoptosis; CD4 antigen; Cell cycle; Cell death; Cell proliferation; Cytokines; Cytotoxicity; Effector cells; eradication; Gene expression; Highly active antiretroviral therapy; HIV; HIV-1; Human immunodeficiency virus; Illnesses; Immune system; Immunological memory; Immunology; Infections; Latency; Life cycles; Lymphocytes; Lymphocytes T; Memory cells; Pathogens; Phenotypes; Progeny; Proviruses; resting memory CD4+ T-cells; Review; Transcription; Transcription factors; transforming growth factor-beta (TGF-β); Viruses; HIV-1; resting memory CD4+ T-cells; eradication; latency; transforming growth factor-beta (TGF-β)

Human immunodeficiency virus-1 (HIV-1) has the ability to infect latently at the level of individual CD4+ cells. Latent HIV-1 proviruses are transcriptionally silent and immunologically inert, but are still capable of reactivating productive lytic infection following cellular activation. These laten...