The adherens junction-associated protein 1 is a negative transcriptional regulator of MAGEA2, which potentiates temozolomide-induced apoptosis in GBM

• Published in: International journal of oncology Vol. 44; no. 4; pp. 1243 - 1251
• Main Authors: ZENG, LIANG, KANG, CHUNSHENG, DI, CHUNHUI, FEE, BRIAN E, RIVAS, MIRIAM, LIN, JAMES, ADAMSON, DAVID CORY
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.04.2014; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: adherens junction-associated protein-1; Adherens Junctions; Antigens; Antineoplastic Agents, Alkylating - pharmacology; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; bcl-2-Associated X Protein - biosynthesis; Brain cancer; Brain Neoplasms - drug therapy; Brain Neoplasms - pathology; Cancer; Cancer therapies; Caspase 3 - metabolism; Caspase 7 - metabolism; Cell Adhesion Molecules - genetics; Cell cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Chemotherapy; Cytochrome; Dacarbazine - analogs & derivatives; Dacarbazine - pharmacology; Deoxyribonucleic acid; DNA; DNA methylation; Dosage and administration; Drug Resistance, Neoplasm; Gene expression; Gene Expression Regulation, Neoplastic; gene regulation; Genomes; glioblastoma; Glioblastoma - drug therapy; Glioblastoma - pathology; Health aspects; HEK293 Cells; Histone Deacetylases - metabolism; Humans; In Situ Nick-End Labeling; MAGEA2; Medical prognosis; Melanoma-Specific Antigens - biosynthesis; migration; Mitochondria; Neoplasm Proteins - biosynthesis; Oncology, Experimental; Proteins; Studies; Temozolomide; Transcription factors; Transcription, Genetic; Tumor Suppressor Protein p53 - biosynthesis; Tumors; United States > US

Previous studies identified the frequent loss of adherens junction-associated protein 1 (AJAP1) expression in glioblastoma (GBM) and its correlation with worse survival. AJAP1 may suppress glioma cell migration, which plays an important role in tumor progression in malignant gliomas such as GBM. How...