Roscovitine Targets, Protein Kinases and Pyridoxal Kinase[boxs]

• Published in: The Journal of biological chemistry Vol. 280; no. 35; pp. 31208 - 31219
• Main Authors: Bach, Stéphane, Knockaert, Marie, Reinhardt, Jens, Lozach, Olivier, Schmitt, Sophie, Baratte, Blandine, Koken, Marcel, Coburn, Stephen P., Tang, Lin, Jiang, Tao, Liang, Dong-cai, Galons, Hervé, Dierick, Jean-Francois, Pinna, Lorenzo A., Meggio, Flavio, Totzke, Frank, Schächtele, Christoph, Lerman, Andrea S., Carnero, Amancio, Wan, Yongqin, Gray, Nathanael, Meijer, Laurent
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 02.09.2005; American Society for Biochemistry and Molecular Biology
• Subjects: Adenosine Triphosphate - metabolism; Amino Acid Sequence; Animals; Biochemistry, Molecular Biology; Cell Cycle - physiology; Cell Survival; Cells, Cultured; Chromatography, Affinity; Fibroblasts - cytology; Fibroblasts - physiology; Humans; Life Sciences; Mice; Mice, Knockout; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - metabolism; Protein Kinases - metabolism; Protein Structure, Tertiary; Purines - chemistry; Purines - metabolism; Pyridoxal - metabolism; Pyridoxal Kinase - antagonists & inhibitors; Pyridoxal Kinase - genetics; Pyridoxal Kinase - metabolism; Pyridoxal Phosphate - metabolism; Rats; Roscovitine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tissue Distribution

(R)-Roscovitine (CYC202) is often referred to as a “selective inhibitor of cyclin-dependent kinases.” Besides its use as a biological tool in cell cycle, neuronal functions, and apoptosis studies, it is currently evaluated as a potential drug to treat cancers, neurodegenerative diseases, viral infec...