Evidence for a Pan-Neurodegenerative Disease Response in Huntington's and Parkinson's Disease Expression Profiles

• Published in: Frontiers in molecular neuroscience Vol. 10; p. 430
• Main Authors: Labadorf, Adam, Choi, Seung H., Myers, Richard H.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 11.01.2018; Frontiers Media S.A
• Subjects: Apoptosis; Bioinformatics; bioinformatics and computational biology; Brain; Cyclic AMP response element-binding protein; DNA damage; Genes; Genomes; Human subjects; Huntington disease; Huntington's disease; Huntingtons disease; Inflammation; Lymphocytes B; Mitochondrial DNA; Movement disorders; mRNA-seq; Neurodegenerative diseases; neuroinflammation; Neuroscience; Neurosciences; NF-κB protein; Parameter estimation; Parkinson disease; Parkinson's disease; Protein interaction; Software packages; United States > US; neurodegenerative diseases; neuroinflammation; Huntington disease; bioinformatics and computational biology; Parkinson disease; immune system; mRNA-seq

Huntington's and Parkinson's Diseases (HD and PD) are neurodegenerative disorders that share some pathological features but are disparate in others. For example, while both diseases are marked by aberrant protein aggregation in the brain, the specific proteins that aggregate and types of n...