Hsp90 modulates CAG repeat instability in human cells

• Published in: Cell stress & chaperones Vol. 15; no. 5; pp. 753 - 759
• Main Authors: Mittelman, David, Sykoudis, Kristen, Hersh, Megan, Lin, Yunfu, Wilson, John H.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer 01.09.2010; Springer Netherlands; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cancer Research; Cell Biology; Cell Line; Cell lines; CHO cells; Genetic mutation; Genetic variation; Genomes; HSP90 Heat-Shock Proteins - genetics; HSP90 Heat-Shock Proteins - metabolism; Humans; Immunoblotting; Immunology; Messenger RNA; Microsatellite Instability; Neurosciences; Point mutation; Rad51 Recombinase - genetics; Rad51 Recombinase - metabolism; RNA, Small Interfering; SHORT COMMUNICATION; Small interfering RNA; Trinucleotide Repeats - genetics; Tumors; Vimentin; Stress-induced mutation; Hsp90 chaperone; Homologous recombination; Repeat instability

The Hsp90 molecular chaperone has been implicated as a contributor to evolution in several organisms by revealing cryptic variation that can yield dramatic phenotypes when the chaperone is diverted from its normal functions by environmental stress. In addition, as a cancer drug target, Hsp90 inhibit...