Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2)

• Published in: NAR cancer Vol. 4; no. 2; p. zcac015
• Main Authors: Karmakar, Shilpita, Ramirez, Oscar, Paul, Kiran V, Gupta, Abhishek K, Kumari, Vandana, Botti, Valentina, de los Mozos, Igor Ruiz, Neuenkirchen, Nils, Ross, Robert J, Karanicolas, John, Neugebauer, Karla M, Pillai, Manoj M
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2022
• Subjects: Cancer-specific RNAs and RNA Processing

Musashi 2 (MSI2) is an RNA binding protein (RBP) that regulates asymmetric cell division and cell fate decisions in normal and cancer stem cells. MSI2 appears to repress translation by binding to 3′ untranslated regions (3′UTRs) of mRNA, but the identity of functional targets remains unknown. Here,...