Cross-generational effects of parental low dose BPA exposure on the Gonadotropin-Releasing Hormone3 system and larval behavior in medaka (Oryzias latipes)

• Published in: Neurotoxicology (Park Forest South) Vol. 57; pp. 163 - 173
• Main Authors: Inagaki, T., Smith, N.L., Sherva, K.M., Ramakrishnan, S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2016; Elsevier BV
• Subjects: Animals; Animals, Genetically Modified; Benzhydryl Compounds - pharmacology; Bisphenol A; BPA; Brain; Brain - drug effects; Brain - embryology; Brain - growth & development; Chronic exposure; Cross-generational; Development; Differentiation (biology); Eggs; Embryo, Nonmammalian - drug effects; Embryogenesis; Embryology; Embryonic Development - drug effects; Embryonic growth stage; Embryos; Endocrine disrupters; Endocrine system; Estrogen; Estrogens; Exposure; Female; Fertilization; Fish; Fish eggs; Fluorescence; Gene Expression Regulation, Developmental - drug effects; Genetic crosses; GnRH; Gonadotropin-releasing hormone; Gonadotropin-Releasing Hormone - genetics; Gonadotropin-Releasing Hormone - metabolism; Gonadotropins; Green fluorescent protein; Green Fluorescent Proteins - genetics; Green Fluorescent Proteins - metabolism; Hatching; Hypothalamus; Japanese medaka; Larva - drug effects; Larva - physiology; Larvae; Larval development; Locomotor activity; Neurogenesis; Neurons; Offspring; Oryzias - embryology; Oryzias latipes; Parents; Phenols; Phenols - pharmacology; Pituitary (anterior); Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - physiopathology; Pyrrolidonecarboxylic Acid - analogs & derivatives; Pyrrolidonecarboxylic Acid - metabolism; Reproductive behavior; Sex differentiation; Sex Differentiation - drug effects; Synaptic transmission; Terminal nerves; Transgenic animals; Transgenic fish; Velocity; Windows (intervals); BPA; Estrogen; Terminal nerves; Development; Endocrine disrupters; Japanese medaka; GnRH; Locomotor activity; Transgenic fish; Cross-generational

•Developmental BPA exposure in parent altered GnRH3 neural development in offspring.•Locomotor activity of offspring larvae with BPA exposed parents was reduced.•Effects of developmental BPA exposure was cross-generational.•BPA effects in offspring was sensitive to BPA exposure timing and durations...